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AI Breakthrough: Accelerating Effective Antibiotic Therapy for Sepsis

medlinkSepsis/medlink poses a life-threatening infection complication, leading to 1.7 million hospitalizations and 350,000 deaths annually in the U.




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Want to Spot Sepsis in Newborns Before Symptoms Arise? Here's How

Neonatal sepsis can be predicted even before symptoms appear with the help of a genetic signature, according to a new study. The study, led by UBC and




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Pepsico News: భారతీయులంటే ఇంత చులకనా పెప్సీ-యూనీలివర్? సంచలన రిపోర్ట్ ఔట్..

Hindustan Uniliver News: భారతీయుల విషయంలో మల్టీనేషనల్ కంపెనీలు వ్యవహరిస్తున్న తీరు గురించి మరోసారి సంచలన విషయాలు బయటకు వచ్చాయి. స్వాతంత్ర్యం వచ్చి ఇన్ని దశాబ్ధాలు గడుస్తున్నా భారతీయులను వారు చూస్తున్న చిన్నచూపు చాలా మందిలో ఆగ్రహానికి దారితీస్తోంది. వివరాల్లోకి వెళితే అమెరికాకు చెందిన వ్యాపార దిగ్గజాలు పెప్సికో, హిందుస్థాన్ యూనీలివర్ అనేక వ్యాపారాల్లో వివిధ ఉత్పత్తులను




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Intracellular microbial rhodopsin-based optogenetics to control metabolism and cell signaling

Chem. Soc. Rev., 2024, 53,3327-3349
DOI: 10.1039/D3CS00699A, Review Article
Anastasiia D. Vlasova, Siarhei M. Bukhalovich, Diana F. Bagaeva, Aleksandra P. Polyakova, Nikolay S. Ilyinsky, Semen V. Nesterov, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Egor V. Zinovev, Anatolii E. Mikhailov, Alexey V. Vlasov, Alexander I. Kuklin, Valentin I. Borshchevskiy, Ernst Bamberg, Vladimir N. Uversky, Valentin I. Gordeliy
Organelle optogenetics is an approach to control cell physiology by targeted expression of microbial rhodopsins in membranes of subcellular organelles.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effects of silylene ligands on the catalytic activity of [PSiP] pincer cobalt(II) chloride for N2 silylation

New J. Chem., 2024, 48,7334-7339
DOI: 10.1039/D4NJ00883A, Paper
Min Zhang, Yanhong Dong, Qingshuang Li, Xiaoyan Li, Hongjian Sun
Three silyl [PSiP] pincer cobalt(II) chlorides [(2-Ph2PC6H4)2MeSiCo(Cl)(PMe3)] (1), [(2-iPr2PC6H4)2MeSiCo(Cl)(PMe3)] (2) and [(2-Ph2PC6H4)2MeSiCo(Cl)(LSi:)] (LSi: = {PhC(NtBu)2}SiCl) (3) were used as catalysts for dinitrogen silylation was studied.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring the Science of a Relapsing MS Treatment | WIRED Brand Lab, Sponsored by Biogen

Produced by WIRED Brand Lab with Biogen | Many unknowns surround relapsing multiple sclerosis. Watch as WIRED Brand Lab looks deeper at how the condition manifests within the central nervous system and how a treatment aims to reduce relapses and disability progression.See full Prescribing Info, Boxed Warning & Med Guide




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Viral capsid structural assembly governs the reovirus binding interface to NgR1

Nanoscale Horiz., 2024, 9,1925-1937
DOI: 10.1039/D4NH00315B, Communication
Open Access
Rita dos Santos Natividade, Andra C. Dumitru, Alessandro Nicoli, Michael Strebl, Danica M. Sutherland, Olivia L. Welsh, Mustafa Ghulam, Thilo Stehle, Terence S. Dermody, Antonella Di Pizio, Melanie Koehler, David Alsteens
We reveal how viral capsid protein organization and curvature critically influence the stability of reovirus–NgR1 interactions, with distinct differences observed between single proteins, 2D assemblies, and 3D viral particles.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pepsi rolls out new shape for bottle




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How Upside-Down Models Revolutionized Architecture, Making Possible St. Paul’s Cathedral, Sagrada Família & More

For 142 years now, Sagrada Família has been growing toward the sky. Or at least that’s what it seems to be doing, as its ongoing construction realizes ever more fully a host of forms that look and feel not quite of this earth. It makes a kind of sense to learn that, in designing the […]




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Racing extinction (2015) / starring and directed by Louie Psihoyos [DVD].

[U.K.] : Discovery Communications, [2016]




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Coke pants and pepsi saris




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Jurnal Pengukuran Psikologi dan Pendidikan Indonesia [electronic journal].

UIN Syarif Hidayatullah Jakarta




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Avaliação Psicológica [electronic journal].

Universidade São Francisco




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Correction: An impedimetric sensor based on molecularly imprinted nanoparticles for the determination of trypsin in artificial matrices – towards point-of-care diagnostics

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY90029D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sabrina Di Masi, Marco Costa, Francesco Canfarotta, Antonio Guerreiro, Alicia Hartley, Sergey A. Piletsky, Cosimino Malitesta
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Cargo companies upsize for new business

Booming demand for ecommerce delivery spurs freight handlers to open more centres, digitise for efficiency




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PSI, head constable suspended in Brahmavar lock up death case




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The World Turned Upside Down

The Fifes and Drums of Colonial Williamsburg carry forward the tradition of military music heard on the battlefields of Yorktown.




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Continuous-flow Synthesis of Cyclic Carbonates with Polymer-supported Imidazolium-based Ionic Liquid (Im-PSIL) Catalysts

Green Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4GC04499A, Communication
Open Access
Zhibo Yu, Haruro Ishitani, Shu Kobayashi
Carbon dioxide (CO2), a major greenhouse gas emitted through human activities, represents a valuable carbon source for chemical production. However, maximizing its efficiency requires novel methods for CO2 conversion that...
The content of this RSS Feed (c) The Royal Society of Chemistry




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'Varun Was Hanging, Upside Down...'

'Varun was so exhilarated with the intense physical action sequences.' 'Samantha is very agile.' 'I don't know how they did it. It's really hard.'




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'Varun Was Hanging, Upside Down...'

'Varun was so exhilarated with the intense physical action sequences.'




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Disease modifying therapies for relapsing multiple sclerosis




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Your life turned upside down in 10 minutes

OM Russia works to bring hope to neighbours affected by HIV and AIDS.




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A Synopsis of the Synopses, 2013-2014




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About This Synopsis Book




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Computer Programs and Systems, Inc. (CPSI) CEO John Douglas on Q1 2020 Results - Earnings Call Transcript




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Computer Programs and Systems, Inc. (CPSI) CEO John Douglas on Q1 2020 Results - Earnings Call Transcript




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TDPC Ministerial 2013 Synopsis

The summary document of the TDPC Ministerial held in Marseille on 5-6 December 2013 is now availalble.




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This Stock Could See An Upside Of 75 percent

Brokerage firm, Motilal Oswal is bullish on the stock of Jindal Steel and Power and says there could be an upside of as much as 75 per cent on the stock. Here are a few highlights from the Motilal Oswal report.




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Synopsis of the signal systems based upon the dot and dash and two-arm semaphore codes.

Archives, Room Use Only - UG582.S4 S96 1914




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Solution structure and assembly of β-amylase 2 from Arabidopsis thaliana

Solution structure of β-amylase 2 from Arabidopsis thaliana shows the role of the conserved N-terminus in enzyme tetramer formation.




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Bis(4-acet­oxy-N,N-di­methyl­tryptammonium) fumarate: a new crystalline form of psilacetin, an alternative to psilocybin as a psilocin prodrug

The title compound (systematic name: bis­{2-[4-(acet­yloxy)-1H-indol-3-yl]ethan-1-aminium} but-2-enedioate), 2C14H19N2O2+·C4H2O42−, has a single protonated psilacetin cation and one half of a fumarate dianion in the asymmetric unit. There are N—H⋯O hydrogen bonds between the ammonium H atoms and the fumarate O atoms, as well as N—H⋯O hydrogen bonds between the indole H atoms and the fumarate O atoms. The hydrogen bonds hold the ions together in infinite one-dimensional chains along [111].




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The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin

The solid-state structures of the salts of two substituted tryptamines, namely N-isopropyl-N-methyl­tryptaminium (MiPT) fumarate {systematic name: [2-(1H-indol-3-yl)eth­yl](meth­yl)propan-2-yl­aza­nium 3-carb­oxy­prop-2-enoate}, C14H21N2+·C4H3O4−, and 4-hy­droxy-N-isopropyl-N-methyl­tryptaminium (4-HO-MiPT) fumarate monohydrate {systematic name: [2-(4-hy­droxy-1H-indol-3-yl)eth­yl](meth­yl)propan-2-yl­aza­nium 3-carb­oxy­prop-2-enoate monohydrate}, C14H21N2O+·C4H3O4−·H2O, are reported. Both salts possess a proton­ated tryptammonium cation and a 3-carb­oxy­acrylate (hydrogen fumarate) anion in the asymmetric unit; the 4-HO-MiPT structure also contains a water mol­ecule of crystallization. Both cations feature disorder of the side chain over two orientations, in a 0.630 (3):0.370 (3) ratio for MiPT and a 0.775 (5):0.225 (5) ratio for 4-HO-MiPT. In both extended structures, N—H⋯O and O—H⋯O hydrogen bonds generate infinite two-dimensional networks.




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Norpsilocin: freebase and fumarate salt

The solid-state structures of the naturally occurring psychoactive tryptamine norpsilocin {4-hy­droxy-N-methyl­tryptamine (4-HO-NMT); systematic name: 3-[2-(methyl­amino)­eth­yl]-1H-indol-4-ol}, C11H14N2O, and its fumarate salt (4-hy­droxy-N-methyl­tryptammonium fumarate; systematic name: bis­{[2-(4-hy­droxy-1H-indol-3-yl)eth­yl]methyl­aza­nium} but-2-enedioate), C11H15N2O+·0.5C4H2O42−, are reported. The freebase of 4-HO-NMT has a single mol­ecule in the asymmetric unit joined together by N—H⋯O and O—H⋯O hydrogen bonds in a two-dimensional network parallel to the (100) plane. The ethyl­amine arm of the tryptamine is modeled as a two-component disorder with a 0.895 (3) to 0.105 (3) occupancy ratio. The fumarate salt of 4-HO-NMT crystallizes with a tryptammonium cation and one half of a fumarate dianion in the asymmetric unit. The ions are joined together by N—H⋯O and O—H⋯O hydrogen bonds to form a three-dimensional framework, as well as π–π stacking between the six-membered rings of inversion-related indoles (symmetry operation: 2 − x, 1 − y, 2 – z).




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Charles Doolittle Walcott (1850-1927) family campsite in the Canadian Rockies

Collecting trips for Charles Doolittle Walcott (1850-1927), paleontologist and fourth Secretary of the Smithsonian Institution, were often a family affair. This 1910 photograph shows their […]

The post Charles Doolittle Walcott (1850-1927) family campsite in the Canadian Rockies appeared first on Smithsonian Insider.



  • Dinosaurs & Fossils
  • History & Culture
  • Research News
  • Science & Nature
  • Spotlight
  • National Museum of Natural History

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NASA’s Chandra sees eclipsing planet in X-rays for first time

For the first time since exoplanets, or planets around stars other than the sun, were discovered almost 20 years ago, X-ray observations have detected an […]

The post NASA’s Chandra sees eclipsing planet in X-rays for first time appeared first on Smithsonian Insider.




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The saddest little video of smokestacks collapsing that you'll ever see

Your heart may break as you watch anthropomorphic cooling towers and smokestacks tumble to the ground.




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The upside-down world of the Gulf's dead zone

Farming runoff turns the sea floor into a wet desert and forces species onward or upward.



  • Wilderness & Resources

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Dumpster-dwelling professor upsizes (just a bit) to portable urban micro-homes

At 208-square-feet, Kasita smart apartments are roughly the size of 6 garbage receptacles.



  • Remodeling & Design

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Sonoma County is getting an Airstream glampsite

It's just like camping ... but with free WiFi and Malin + Goetz shampoo.



  • Remodeling & Design

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Review: Life Without Plastic Freezycup steel popsicle mold

The Freezycup popsicle mold makes it easy to make your own frozen treats without using a bit of plastic. It's a great product, if a bit pricey.




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This is how flies land upside-down

A new study and videos show how flies are able to land upside-down on any surface by making lightning-fast adjustments.




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Paleolithic campsites depicted in cave etchings

The world's oldest depiction of a campsite may have been unearthed outside a cave in Spain.



  • Wilderness & Resources

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Dead frog found in a Diet Pepsi can

The FDA has now confirmed that the disgusting sludge a man poured from a freshly opened Pepsi can was a dead frog or toad.



  • Fitness & Well-Being

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DIY Upside-Down Planter - What Not to Do

Upside down planters are an option if you can not grow tomatoes for many reasons including space, sunlight, rodents and other critters. Otherwise, it is easier to grow them right side up. When you grow tomatoes upside down, you don't have to worry about cutworms or ground fungus too.



  • Garden / Landscaping / Patio

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Bruce David Lipsius, MD, Presented with the Albert Nelson Marquis Lifetime Achievement Award by Marquis Who's Who

Dr. Lipsius has been endorsed by Marquis Who's Who as a leader in the field of neurology




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New Book Release - Munchausen by Proxy Case Turns World Class Olympic Skier's World Upside Down - From Racing Down Slopes to Racing to Reinvent Herself in Buenos Aires

WE CAME HERE TO FORGET - A Novel by acclaimed author Andrea Dunlop - A MUST Read for Holiday




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Synopsis Launches a Kickstarter Campaign to Bring a Reimagined British Party Game to the USA

Synopsis, a party game that encourages creative writing, inside jokes and laughter has launched a Kickstarter campaign to raise $5000 to kick-off production. Casual gamers young and old have early access to the initial set of storylines.




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The Upside

Adrian Slywotzky, author of "The Upside: The 7 Strategies for Turning Big Threats into Growth Breakthroughs."




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PepsiCo CEO Indra Nooyi on Design Thinking

How PepsiCo is harnessing the power of design.




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PCCM: The 1st International Sepsis Forum on Sepsis in Infants and Children with Dr. Adrienne Randolph

Adrienne Randolph, MD, MSc, served as guest editor for the May 2005 supplement to Pediatric Critical Care Medicine. Dr. Randolph shares her thoughts on the importance of the 1st International Sepsis Forum on Sepsis in Infants and Children and the Pediatric Acute Lung Injury and Sepsis Investigator's (PALISI) Network. She also highlights the most important aspects from the supplement, which she played such an instrumental role in producing. (Pediatr Crit Care Med 2005 Vol. 6, No. 3 (Suppl.)