In this episode of the Brave Commerce podcast, hosts Rachel Tipograph, founder and CEO of MikMak, and Sarah Hofstetter, president of Profitero, sit down with Meghan Archer, vice president of digital commerce at PepsiCo. Archer shares her unique career journey from consumer electronics at T-Mobile, to a dynamic decade at Amazon, to her current role...

Bitcoin continued to make records as supportive inflation numbers raised the market's expectations of further interest rate cuts by the Federal Reserve. What Happened: The world's largest cryptocurrency sailed above $93,000 during U.S. trading hours Wednesday, before a sharp correction into the…

"Giving up on Nvidia here after its hit — Hopper — is like giving up on Apple at iPhone 1 or 2," Melius Research said.

Hamish Wilson, 18, from Crowborough, had just started university and was studying Philosophy.

OM Russia works to bring hope to neighbours affected by HIV and AIDS.

Epsilon, the global leader in creating connections between people and brands, today announced that it was named a Leader in the January 2016 report �The Forrester Wave�: Customer Loyalty Solutions For Large Organizations.

Moth orchid care or phalaenopsis orchid care are one of the easiest orchids to care for. Learn more....orchid care...You will be a success

What are these orchids? They will prove to be easy to care...Dtps will also show better blooms.

Print a coupon for $4 off five Pepsi or Frito Lay products or Frito Lay Snacks

Categoría: Artes:Varios
Conoce la psicología de los colores para aprender a combinarlos más eficientemente.

Summary: The overhead of performing even simple tasks online is getting larger and larger. I question the security of almost all these supposedly "secure" messaging systems. And I'm tired of the 'Utopia of Rules' mindset pervasive in every organization. It's exhausting how they expect customers to constantly adapt to their needs.

I don't know if you recall the game Kerplunk. It's a classic children's game that has been around for decades. I remember playing it with my sister. The basic setup involves a transparent plastic tube, a number of sticks, and marbles. The sticks are threaded through the tube to form a web or nest at the bottom on which the marbles rest. We'd take turns removing a stick at a time, trying not to let any marbles fall through the web and out of the tube. At some point, the remaining sticks can't hold the marbles and everything falls down.

The modern web reminds me more and more of a big Kerplunk game and I think the marbles are about to fall. What started out as an easier way to do things like shop, bank, and get health care information has become increasingly complex over time. More and more of the email I receive seems to be simply directing me to log into some bespoke system to retrieve a message or engage in some workflow. And even with a password manager, the act of logging in is often a chore with different user interfaces, custom MFA requirements, and weird rules for passwords. Once you're on the system, session time-outs induce their own form of anxiety since stepping away for a few minutes to attend to something else might require going through the whole Kafkaesque process all over again. The modern web has turned into a dystopian theater of the absurd where even reading a simple appointment reminder from your doctor requires several minutes of stress-inducing interaction with baroque systems and processes.

And it's not just doctors, of course, banks, government agencies, hospitals, ecommerce sites, and customer service systems all adopt these special purpose messaging systems. If you ask these organizations why they use bespoke messaging systems, they'll list things like "timely and improved communication," "convenience," and "privacy and security." But the real reason is that it's more convenient for them because these systems are integrated with their backends and make their processes more manageable. There's certainly nothing about them that's more convenient, timely, or better than email for their customers¹.

I also question the privacy and security premise. Email can be insecure. And your email provider can see the contents of your emails. But the messaging system run by your doctor or bank is likely less secure than the email systems run by Apple, Google, and the others. And achieving privacy by making everything incompatible so that you have to use a different system for each correspondent is like chopping off your finger to prevent hangnails.

How did we get here? Bureaucracy. Not just government bureaucracy, but bureaucracy of all kinds. In Utopia of Rules², David Graeber talks about how power imbalances force the less powerful group to perform what he calls interpretive labor, the work of understanding and implementing what's better or more convenient for the more powerful partner. People are not equal participants in online interactions. We don't have the tools to be fully embodied online³. Because of this we are forced to play by the rules organizations online who are digitally embodied with servers, identity systems, customer management systems, and so on. And part of that is being forced to use their inconvenient and anemic messaging systems.

What's the answer? People need tools. I think digital wallets (a bad name for an important tool), autonomic (peer) identifiers with strong cryptography, and verifiable credentials are a huge step forward. These tools provide the means for people to be peers online rather that mere ghosts in someone else's machine. That's why I insist on using the term self-sovereign rather than decentralized to describe these systems. Cogito Ergo Sum.

Notes

1. For a deeper dive into why one-off messaging systems are never as good as email, see Rich Sharing and Personal Channels. Email and other useful messaging systems exhibit a property called rich sharing that makes them much more robust that the simple idea of "sharing a message" would bring to mind.
2. If you're interested in power imbalances and how they come about, I can't recommend Graeber's book highly enough. He had such a keen understanding of this problem and wrote about it in a way that's both informative and entertaining.
3. I talk about this in more detail in Chapter 17 of Learning Digital Identity when I discuss authentic digital relationships.

Photo Credit: Playing Kerplunk from DALL-E (public domain) Prompt: Draw a picture of a boy and girl playing kerplunk that's 1200x500 pixels

Tags: web identity authentication authorization verifiable+credentials

King Shapur II of Persia conducted a fierce persecution of Christians in his realm for thirty-seven years. In the final years of this persecution he gave his magi authority to torture and kill any Christians who would not renounce their faith. Acepsimas, the aged and holy Bishop of Paka, was arrested along with Joseph the priest and Aithalas the deacon. All not only refused to deny Christ, but boldly preached Him before the magi and the king. The enraged king had them viciously tortured, then, as a final indignity, made prisoners of all the local Christians and forced them to stone their own shepherds to death. With their martyrdom the great persecution in Persia came to an end.

King Shapur II of Persia conducted a fierce persecution of Christians in his realm for thirty-seven years. In the final years of this persecution he gave his magi authority to torture and kill any Christians who would not renounce their faith. Acepsimas, the aged and holy Bishop of Paka, was arrested along with Joseph the priest and Aithalas the deacon. All not only refused to deny Christ, but boldly preached Him before the magi and the king. The enraged king had them viciously tortured, then, as a final indignity, made prisoners of all the local Christians and forced them to stone their own shepherds to death. With their martyrdom the great persecution in Persia came to an end.

King Shapur II of Persia conducted a fierce persecution of Christians in his realm for thirty-seven years. In the final years of this persecution he gave his magi authority to torture and kill any Christians who would not renounce their faith. Acepsimas, the aged and holy Bishop of Paka, was arrested along with Joseph the priest and Aithalas the deacon. All not only refused to deny Christ, but boldly preached Him before the magi and the king. The enraged king had them viciously tortured, then, as a final indignity, made prisoners of all the local Christians and forced them to stone their own shepherds to death. With their martyrdom the great persecution in Persia came to an end.

King Shapur II of Persia conducted a fierce persecution of Christians in his realm for thirty-seven years. In the final years of this persecution he gave his magi authority to torture and kill any Christians who would not renounce their faith. Acepsimas, the aged and holy Bishop of Paka, was arrested along with Joseph the priest and Aithalas the deacon. All not only refused to deny Christ, but boldly preached Him before the magi and the king. The enraged king had them viciously tortured, then, as a final indignity, made prisoners of all the local Christians and forced them to stone their own shepherds to death. With their martyrdom the great persecution in Persia came to an end.

King Shapur II of Persia conducted a fierce persecution of Christians in his realm for thirty-seven years. In the final years of this persecution he gave his magi authority to torture and kill any Christians who would not renounce their faith. Acepsimas, the aged and holy Bishop of Paka, was arrested along with Joseph the priest and Aithalas the deacon. All not only refused to deny Christ, but boldly preached Him before the magi and the king. The enraged king had them viciously tortured, then, as a final indignity, made prisoners of all the local Christians and forced them to stone their own shepherds to death. With their martyrdom the great persecution in Persia came to an end.

This week, the guys watch the Netflix original series "Stranger Things" and discuss friendship, transcendence, nostalgia, and our longing for eternity. They wrap up with their top 5 iconic '80s movies.

Fr. Tom reminds us that the spiritual life is full of ups and downs, but the downs are a provision from God for our salvation.

Significant work in service domain has focused on customer journey within e-service delivery system process (e-SDSP). Few studies have focused on process-centric approach to customer journey during delivery of e-services. This study aims to investigate the performance assessment of three online retailers (alternatives) using perceived service process during different stages of e-SDSP as a criterion for decision-making. TOPSIS is used in this paper to rate and evaluate multiple online retailers. Based on perceived service process as the criterion, results show that online retailer-2 outperforms other two online retailers. This study is one of the first to rate online retailers by utilising customer-perceived service process (latent variables) as a decision-making criterion throughout e-SDSP. The finding suggests that perceived searching process is the most essential criterion for decision-making, followed by the perceived after-sales service process, the perceived agreement process, and the perceived fulfilment process. Implications, limitations, and future scope are also discussed.

Psiphon is a censorship circumvention tool designed to give access to the internet where censors and firewalls block it. Psiphon is portable and when run, automatically connects to the fastest country near you by default. A drop-down is right there where you can choose from one of nine countries or easily disconnect. [License: Open Source | Requires: 11|10|8|7|Android|macOS | Size: 8 MB ]

Chance Gainer's death marks the 12th football player to have died this year

On the 26th of August, the "100PSI" Contest will take place again at the Skatepark Lingnerallee in Dresden. After the Contest there will be an afterparty at Club "OSTPOL".

More infos here:

With hard-pumped tires we welcome BMX-Riders from all over Germany and Europe in Dresden on August 26th. 2016. Our slogan “ „BMX Flatland Contest on Asphalt“ will celebrate the sport for the sixth time that developed more than 30 years ago on parking lots in California.

Like in the years before, the riders can expect a clean and bumpless 400m² black asphalt floor to perform their tricks. All in front of Dresdens town hall in the center of the city.

The Competition is held in two classes, amateur and pro. We will start with the Amateur Practice at 1 O'clock in the afternoon. The winners of the pro class will be awarded with 600€ price money. Amateurs get a hole bunch of parts and goodys from our sponsors to motivate them to perform their tricks. In the evening the price ceremony is held in Dresdens hippest borough Neustadt at the club Ostpol. So heat your tires and practice your skills – see you in Double D-Town!

Where: 01069 Dresden, Skatepark Lingner Allee

Contest: German Flatland-BMX Championship

Class: Pro & AM

Website: 100PSI Contest on Facebook

Kevin Nikulski - 2nd Pro Class - 100PSI BMX Flatland Contest 2017

Kevin Nikulski was back at the 100PSI BMX Flatland Contest in Dresden this year and came home with second place, congrats Kevin! Have fun with the video, Your kunstform BMX Shop.

Video: ChefkochBMX



Subscribe our youtube channel: https://www.youtube-nocookie.com/kunstformbmxshop

Donald Trump's victory may bring some relief for the leaders of three authoritarian Southeast Asian nations caught in the influence struggle between the U.S. and China -- Myanmar, Laos and Cambodia.

It’s very important to instill good posture habits at the piano. Sitting squarely at the keyboard, feet on the floor (or on a low stool ... Read more

The post Piano Playing Upside Down – Party Tricks at the Piano appeared first on CMUSE.

Doordeck, a leader in smartphone NFC keyless entry, has joined the PSIA board, enhancing the push for industry-wide integration and interoperability.

Collapsible Gate Valve Lockouts are durable and versatile lockout-covering devices available in three sizes to effectively secure valves with 3-inch to 18-inch diameter handles.

Siete products will bring a rich, new aspect to the PepsiCo multicultural portfolio with food that plays an important role in meal occasions and culinary experiences.

PSILLI™ will use a variety of mushroom types to create five distinct formulations: Brain Boost to support cognitive and immune function; Study Buddy, a Nootropic supplement; Energizer, a natural energy enhancer; Good Mood a mood optimizer and appetite moderator; and Bedtime, for relaxing.

By leveraging Einride's offering of connected electric trucks, charging infrastructure and digital freight platform that optimizes operations with data-driven insights, PepsiCo aims to reduce its Scope 3 emissions.

PepsiCo has moved up from #2 to take the top spot. The company reported a 20.5% increase in net revenue in its Q2 results, raising its full-year guidance for organic revenue growth. 

PepsiCo said investments made in its brands, consumer insights, manufacturing and go-to-market execution are fueling growth across the portfolio.

PBNA tripled its local warehouse footprint with the relocation of its former downtown Nashville distribution warehouse facility.

PepsiCo says the acquisition will complement its portfolio with the addition of an authentic, Mexican-American brand, while also growing its better-for-you food offerings.

The post Low-Income Group Psilocybin Assisted Therapy for Depression (LIGPATD) was curated by information for practice.

On March 8, McDonald's fast food restaurant chain announced a temporary closure of all of its restaurants in Russia. It goes about 850 outlets that employ 62,000 employees. McDonald's CEO Chris Kempczinski said that employees would still be paid their salaries during this period, but did not specify for how long and in what amount. McDonalds' decided to suspend its activities in Russia due to the ongoing crisis in Ukraine as the company cannot ignore the human suffering. Starbucks coffee chain made a similar decision the same day. Starbucks CEO Kevin Johnson said that all activities in Russia were suspended, including all shipments of all products.

The title compound, C12H16N2O, is a hy­droxy-substituted mono­amine alkaloid, and the primary metabolite of the naturally occurring psychedelic compound psilocybin. Crystalline forms of psilocin are known, but their characterization by single-crystal structure analysis is limited. Herein, two anhydrous polymorphic forms (I and II) of psilocin are described. The crystal structure of polymorphic Form I, in space group P21/c, was first reported in 1974. Along with the redeterm­ination to modern standards and unambiguous location of the acidic H atom and variable-temperature single-crystal unit-cell determinations for Form I, the Form II polymorph of the title compound, which crystallizes in the monoclinic space group P21/n, is described for the first time. The psilocin mol­ecules are present in both forms in their phenol–amine tautomeric forms (not resolved in the 1974 report). The mol­ecules in Forms I and II, however, feature different conformations of their N,N-dimethyl ethyl­ene substituent, with the N—C—C—C link in Form I being trans and in Form II being gauche, allowing the latter to bend back to the hydroxyl group of the same mol­ecule, leading to the formation of a strong intra­molecular O—H⋯N hydrogen bond between the hydroxyl moiety and ethyl­amino-nitro­gen group. In the extended structure of Form II, the mol­ecules form one-dimensional strands through N—H⋯O hydrogen bonds from the indole group to the oxygen atom of the hydroxyl moiety of an adjacent mol­ecule. Form II exhibits whole-mol­ecule disorder due to a pseudo-mirror operation, with an occupancy ratio of 0.689 (5):0.311 (5) for the two components. In contrast, Form I does not feature intra­molecular hydrogen bonds but forms a layered structure through inter­molecular N—H⋯O and O—H⋯N hydrogen bonds.

Source: Dr. Joseph Pantginis 11/04/2024

H.C. Wainwright & Co. analysts Dr. Joseph Pantginis, Dr. Lander Egaña Gorroño, Dr. Joshua Korsen, Dr. Matthew Keller, and Dr. Sara Nik, in a research report published on November 4, 2024, maintained their Buy rating on Lexicon Pharmaceuticals Inc. (LXRX:NASDAQ) with a price target of US$6.00. The report follows Lexicon's presentation of preclinical data for LX9851, its ACSL5 inhibitor for obesity, at ObesityWeek 2024.

The analysts highlighted key findings from the presentations, stating, "LX9851 promotes reduction of fat mass without affecting lean body mass" and "LX9851 improves and sustains GLP-1 RA-mediated weight loss, even after semaglutide discontinuation." They added that "Mechanistic studies suggest that LX9851-mediated ACSL5 inhibition activates the ileal brake."

Regarding the drug's potential, they noted, "LX9851 is a first-in-class, oral small molecule ACSL5 inhibitor designed to enhance and maintain weight loss promoted by incretin mimetics (GLP-1 receptor agonists), and offer improved treatment alternatives for obesity and related metabolic disorders."

The report also addressed recent developments with sotagliflozin, detailing the AdCom voting results and potential scenarios for FDA action. The analysts stated, "Although we anticipate favorable feedback from the agency regarding eGFR ≥60 to <90 range, our bet is that a confirmatory trial may be required to validate sota's efficacy in this subpopulation and obtain approval."

H.C. Wainwright & Co.'s valuation methodology is based on a clinical net present value (NPV) model. The analysts explained, "Our valuation is based on our clinical net present value (NPV) model, which allows us to flex multiple assumptions affecting a drug's profile. We currently value Lexicon solely on sotagliflozin sales in the U.S. for HF (INPEFA), HCM, and LX9211 for DPNP."

They added, "We believe significant upside potential exists, based on: (1) attaining higher market penetration for HF, and HCM; and (2) adding the earlier stage assets."

In conclusion, H.C. Wainwright & Co.'s maintenance of their Buy rating and US$6 price target reflects confidence in Lexicon's pipeline potential, particularly with LX9851 and sotagliflozin. The share price at the time of the report of US$1.22 represents a potential return of approximately 392% to the analysts' target price, highlighting the significant upside potential if the company's development programs prove successful.

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Disclosures for H.C. Wainwright & Co., Lexicon Pharmaceuticals Inc., November 4, 2024

This material is confidential and intended for use by Institutional Accounts as defined in FINRA Rule 4512(c). It may also be privileged or otherwise protected by work product immunity or other legal rules. If you have received it by mistake, please let us know by e-mail reply to unsubscribe@hcwresearch.com and delete it from your system; you may not copy this message or disclose its contents to anyone. The integrity and security of this message cannot be guaranteed on the Internet. H.C. WAINWRIGHT & CO, LLC RATING SYSTEM: H.C. Wainwright employs a three tier rating system for evaluating both the potential return and risk associated with owning common equity shares of rated firms. The expected return of any given equity is measured on a RELATIVE basis of other companies in the same sector. The price objective is calculated to estimate the potential movements in price that a given equity could reach provided certain targets are met over a defined time horizon. Price objectives are subject to external factors including industry events and market volatility.

H.C. Wainwright & Co, LLC (the “Firm”) is a member of FINRA and SIPC and a registered U.S. Broker-Dealer. I, Joseph Pantginis, Ph.D., Lander Egaña Gorroño, Ph.D., Joshua Korsen, Ph.D., Matthew Keller, Ph.D. and Sara Nik, Ph.D. , certify that 1) all of the views expressed in this report accurately reflect my personal views about any and all subject securities or issuers discussed; and 2) no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report; and 3) neither myself nor any members of my household is an officer, director or advisory board member of these companies. None of the research analysts or the research analyst’s household has a financial interest in the securities of Lexicon Pharmaceuticals, Inc. (including, without limitation, any option, right, warrant, future, long or short position). As of September 30, 2024 neither the Firm nor its affiliates beneficially own 1% or more of any class of common equity securities of Lexicon Pharmaceuticals, Inc..

Neither the research analyst nor the Firm knows or has reason to know of any other material conflict of interest at the time of publication of this research report. The research analyst principally responsible for preparation of the report does not receive compensation that is based upon any specific investment banking services or transaction but is compensated based on factors including total revenue and profitability of the Firm, a substantial portion of which is derived from investment banking services. The firm or its affiliates received compensation from Lexicon Pharmaceuticals, Inc. for non-investment banking services in the previous 12 months. The Firm or its affiliates did not receive compensation from Lexicon Pharmaceuticals, Inc. for investment banking services within twelve months before, but will seek compensation from the companies mentioned in this report for investment banking services within three months following publication of the research report. The Firm does not make a market in Lexicon Pharmaceuticals, Inc. as of the date of this research report.

The securities of the company discussed in this report may be unsuitable for investors depending on their specific investment objectives and financial position. Past performance is no guarantee of future results. This report is offered for informational purposes only, and does not constitute an offer or solicitation to buy or sell any securities discussed herein in any jurisdiction where such would be prohibited. This research report is not intended to provide tax advice or to be used to provide tax advice to any person. Electronic versions of H.C. Wainwright & Co., LLC research reports are made available to all clients simultaneously. No part of this report may be reproduced in any form without the expressed permission of H.C. Wainwright & Co., LLC. Additional information available upon request. H.C. Wainwright & Co., LLC does not provide individually tailored investment advice in research reports. This research report is not intended to provide personal investment advice and it does not take into account the specific investment objectives, financial situation and the particular needs of any specific person. Investors should seek financial advice regarding the appropriateness of investing in financial instruments and implementing investment strategies discussed or recommended in this research report. H.C. Wainwright & Co., LLC’s and its affiliates’ salespeople, traders, and other professionals may provide oral or written market commentary or trading strategies that reflect opinions that are contrary to the opinions expressed in this research report. H.C. Wainwright & Co., LLC and its affiliates, officers, directors, and employees, excluding its analysts, will from time to time have long or short positions in, act as principal in, and buy or sell, the securities or derivatives (including options and warrants) thereof of covered companies referred to in this research report. The information contained herein is based on sources which we believe to be reliable but is not guaranteed by us as being accurate and does not purport to be a complete statement or summary of the available data on the company, industry or security discussed in the report. All opinions and estimates included in this report constitute the analyst’s judgment as of the date of this report and are subject to change without notice. Securities and other financial instruments discussed in this research report: may lose value; are not insured by the Federal Deposit Insurance Corporation; and are subject to investment risks, including possible loss of the principal amount invested.

( Companies Mentioned: LXRX:NASDAQ, )