A few important life lessons amid rising prices

While the latest, fourth-generation Swift makes no pretence of being a performance car or the last word in luxury, what it does stand for is amply evident, notes Pavan Lall.

The dextransucrase DSR-OK from the Gram-positive bacterium Oenococcus kitaharae DSM17330 produces a dextran of the highest molar mass reported to date (∼109 g/mol). In this study, we selected a recombinant form, DSR-OKΔ1, to identify molecular determinants involved in the sugar polymerization mechanism and that confer its ability to produce a very-high-molar-mass polymer. In domain V of DSR-OK, we identified seven putative sugar-binding pockets characteristic of glycoside hydrolase 70 (GH70) glucansucrases that are known to be involved in glucan binding. We investigated their role in polymer synthesis through several approaches, including monitoring of dextran synthesis, affinity assays, sugar binding pocket deletions, site-directed mutagenesis, and construction of chimeric enzymes. Substitution of only two stacking aromatic residues in two consecutive sugar-binding pockets (variant DSR-OKΔ1-Y1162A-F1228A) induced quasi-complete loss of very-high-molar-mass dextran synthesis, resulting in production of only 10–13 kg/mol polymers. Moreover, the double mutation completely switched the semiprocessive mode of DSR-OKΔ1 toward a distributive one, highlighting the strong influence of these pockets on enzyme processivity. Finally, the position of each pocket relative to the active site also appeared to be important for polymer elongation. We propose that sugar-binding pockets spatially closer to the catalytic domain play a major role in the control of processivity. A deep structural characterization, if possible with large-molar-mass sugar ligands, would allow confirming this hypothesis.

MS Dhoni and his love affair with motorcycles need no introduction. Here we shed some light on Mahi's Yamaha RX135 that was one of his first bikes!

The March mayhem that saw domestic benchmark indices tank 24% in not behind investors despite a decent recovery in the month of April. However, the coming few months could be crucial for investors.

The Policy Framework for Investment (PFI) is a comprehensive and systematic tool for improving investment conditions. The pocket edition of the PFI contains the full text of the 2015 update minus the supplemental questions and reference lists. Find the integral text and other tools online at www.oecd.org/investment/pfi.htm

The digital economy is here, and growing every day, sometimes in surprising ways. As ministers gather for major meetings in Paris and Cancun, government leaders should be in no doubt about the key role they must play in securing the digital economy’s future as a driver of productive and inclusive progress.

Archives, Room Use Only - TK151.B43 1901

Archives, Room Use Only - HE7671.P63 1910

High-resolution single-crystal X-ray measurements of the monoclinic polymorph of bicalutamide and the aspherical atom databank approach have served as a basis for a reconstruction of the charge density distribution of the drug and its androgen receptor (AR) and albumin complexes. The contributions of various types of intermolecular interactions to the total crystal energy or ligand:AR energy were estimated. The cyan and amide groups secured the ligand placement in the albumin (Lys-137) and the AR binding pocket (Leu-704, Asn-705, Arg-752), and also determined the packing of the small-molecule crystals. The total electrostatic interaction energy on average was −230 kJ mol−1, comparable with the electrostatic lattice energy of the monoclinic bicalutamide polymorph. This is the result of similar distributions of electropositive and electronegative regions on the experimental and theoretical molecular electrostatic potential maps despite differences in molecular conformations. In general, bicalutamide interacted with the studied proteins with similar electrostatic interaction energies and adjusted its conformation and electrostatic potential to fit the binding pocket in such a way as to enhance the interactions, e.g. hydrogen bonds and π⋯π stacking.

Newark Mayor Cory Booker performs social media magic like no other politician.

Rutherford Seydel's Oxygen Project creates a sustainable Earth while creating financial sustainability for all. All it will take is a massive group action.

Good looking pants that protect your valuables.

Two student teams from the 2013 Solar Decathlon, USC and Santa Clara University, need to sell their innovative, solar-powered homes to private buyers.

Bees often flit around with yellow saddlebags, called pollen baskets, hanging from their hind legs.

Chair Pockets Can Be a Great Addition to Your Classroom Great references here. Get more here. Keywords: Dorm room organization, Dorm room organization, Seat sacks, How to decorate dorm room, Chair pocket, Stylish dorm rooms.

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This article describes the importance of cell phones in our everyday lives and the etiquettes one should follow in different occasions.

Book becomes #1 Best Seller in 4 categories on Amazon

Finally - a big screen laser cinema projector that ACTUALLY fits in your pocket. With standalone and Raspberry Pi compatible versions.

Reading the Constitution can help us to understand our rights as citizens, Norcross personal injury law firm says.

Access the 2020 Anders Tax Pocket Guide for this year’s corporate and individual tax rates, retirement plan contribution limits and more, including:

Estate tax and lifetime gift tax exemption increase to $11,580,000
AMT exemption increase
Standard deduction increase

View the… Read More

The post 2020 Tax Pocket Guide appeared first on Anders CPAs.

Access the 2020 Anders Tax Pocket Guide for this year’s corporate and individual tax rates, retirement plan contribution limits and more, including: Estate tax and lifetime gift tax exemption increase to $11,580,000 AMT exemption increase Standard deduction increase View the 2020 Anders Tax Pocket Guide. Contact an Anders advisor to learn how these rates affect you...

The post 2020 Tax Pocket Guide appeared first on Anders CPA.

There is a lot to be said for the therapeutic benefits of sewing. Life has certainly been challenging lately. Concern over elderly family members and family members with high risk medical conditions, together with working long hours, has left little energy or inclination to be creative. I knew I needed a colourful scrappy project to... 

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The post Patchwork Pocket Pouch appeared first on A Spoonful of Sugar.

Stake pocket formations are secured to a cargo bed frame of a land vehicle such as trailers and flatbed trucks for removably supporting sidewall supporting members. The formations include sidewalls secured to and projecting from the frame and an end wall extending between the sidewalls. An opening extends through the end wall and is adapted to receive the terminal end of a J-hook therethrough. The J-hook is secured to the formation by inserting the terminal end thereof into the pocket placing an upper edge of the end wall into the J-hook gap and rolling/rotating the J-hook thereby inserting the terminal end into the opening. The J-hook cannot be removed from the pocket unless it is rolled/rotated in the opposite direction. While within the stake pocket and without strap tension, the J-hook abuts the trailer frame and formation end wall and is, thereby, maintained within the pocket.

A binding cover having a transparent overlay cover disposed over and around the spine of the binding is configured to provide a label pocket on the spine portion of the binding cover wherein a label may be inserted easily without tools or rigid label material. In several embodiments the label pocket provides a fixed label space. In another embodiment the label pocket opens along the spine when the binding cover is opened, and returns to a closed position when closed, thereby retaining a label inserted therein. In another embodiment a method for forming the label pocket is provided.

A multi-pocketed decorative fabric organizer that resembles a folding file and serves as a workspace when opened and then folds up in seconds keeping all the items and materials stored in it intact, and provides a portable and compact organizer for various purposes. The organizer consists of a hard surface that folds out to a writing or working space consisting of conveniently located plastic storage pockets and an exterior of decorative fabrics.

The invention relates to a bag of variable volume able to contain fluids and designed to be introduced into a container through the container's neck, said bag consisting of a pouch with one closed end and one open end, the open end being dimensionally stable over temperature ranges of from −30 to 55° C., to a device incorporating said bag and to a process for filling it.

A system and a device for anti-thief protection, especially for open pockets of trousers, bags and the like, includes a mobile protection strip element (1) to be applied on the pockets hooks (12). The aim is attained by superposing the strip (1) on the pocket (T) and blocking the strip (1) using a plurality of hooks (12) in the form of clips located in the lower part (5) of the strip (1), the strip (1) supported by support elements (G), located in the upper part (2) thereof, which insert or hook in the zone overlying the pocket (T) to be protected.

A one-piece ice chest cover for changing the appearance of an ice chest includes a flexible main pocket portion having a front side, two lateral sides, and a back side forming a main pocket opening for receiving a main body of the ice chest. It also includes a flexible lid pocket portion formed of an inner portion configured to face an inner-facing surface of a lid of the ice chest and an outer portion for covering an outer-facing surface of the lid. The lid pocket portion may include a lid pocket opening sized smaller than a size of the main pocket opening. The lid pocket opening may be sized to receive a portion of the lid of the ice chest. The outer portion of the lid pocket portion may be connected to the back side of the main pocket portion so that the ice chest cover flexes when the lid is pivoted to open and close the ice chest.

The present invention relates to a pocketbook system that allows to easily mix and match how many pocketbooks, other carriers, and/or straps will suffice for that day or evenings' use while this pocketbook system is easy to use and inexpensive to manufacture. More particularly, the pocketbook system has a primary pocketbook for carrying contents, one or more removably attached secondary carrier for carrying contents, a device(s) for removably attaching the secondary carrier(s) to the inside or outside of the primary pocketbook, or for attaching the primary pocketbook and secondary carrier together, and preferably has at least one removable flexible strap(s) and a device(s) for removably attaching the strap(s) to the primary pocketbook and/or secondary carrier. The user makes use of the pocketbook system by attaching, detaching, re-attaching, exchanging, and switching different parts and/or elements to form a suitable pocketbook structure for a particular use at a particular time.

A pocket knife including a first body portion including a first engaging member, and a second body portion including a second engaging member arranged to engage the first body portion with the second body portion. The first body portion and the second body portion are separated from each other when not engaged. A tool element is arranged to be housed in the first body portion when in a closed state and displaced outward when in an opened state. A first locking member is arranged to be actuated by the tool element, and cooperates with a second locking member provided on the second body portion, and wherein when the first engaging member is engaged with the second engaging member, and when the first locking member and the second locking member are prevented from moving, the first body portion and the second body portion are prevented from being separated.

Provided is activewear with hidden pockets. More particularly, athletic garments such as pants comprising one or more waistband pocket, preferably concealable, are included. In embodiments, athletic garments with an interior concealed pocket in the fold-over portion of a fold down waistband are provided. The waistband pocket enables the wearer to store items such as car keys, hotel room keys and/or smart phones relatively inconspicuously and securely in the waistband of the garment. A purpose of the concealment includes minimizing attention from the items stored within the pocket and allowing the wearer to participate in a variety of athletic sports or events while carrying personal items in a secure manner. Preferred embodiments include athletic pants comprising (i) a fold down waistband, (ii) an annular storage pocket capable of retaining items without any additional material added to the pant, and (iii) one or more slits for the opening for the pocket.

A data security pocket and garment is disclosed for better positioning and protecting data and information contained in a card or device for housing such information from its theft or misappropriation when it is placed in the pocket portion of the invention. The pocket portion of the invention is specially positioned on and secured to a portion of the garment or clothing surface near or adjacent to the arm-pit area with which it is used in combination, with its own design, to provide a more protective pocket environment for placement and transportation of a card, chip or other data/information carrying or storing device or means. The pocket and the garment in combination make up four layers from which the pocket is constructed, secured and positioned. These layers include the top pocket layer (12); the top security layer (14) and the bottom security layer (16), each fabricated from security anti-RFID material; and the garment, clothing or base layer (18). These layers are connected one to the other so that the pocket portion has a first accessible opening (40) and a second accessible opening (42) when secured in proper position on the garment (18). Further provided is the trim security flap cover (22), also fabricated from security anti-RFID material, and the upper cover enclosure (20), each of which is secured above the pocket portion on the garment layer (18), and which pivot and close over the top pocket layer (12). Coupling is provided for both the upper cover enclosure (20) and the top pocket layer (12); and the trim security flap cover (22) and the top pocket layer (12). In another aspect of the invention an auxiliary security area (39) is provided on the top pocket layer (12) adjacent or near the coupling for the trim security flap (22).

An article having a panel secured between two layers of a trim piece and having a pocket affixed to a zipper, where a first zipper tape is affixed to the panel, and a second zipper tape is secured between the two layers of the trim piece such that the pocket is in communication with an incised opening in the panel is provided. The panel may be secured between the two layers of the trim piece at a first edge, and the incised opening may be formed proximate to the first edge such that the article comprises a pocket presented proximate to the trim piece. The present invention further comprises a method of manufacturing the article including a pocket presented proximate to the trim piece.

This week on Open Air, KALW’s radio magazine for the Bay Area performing arts in times of Coronavirus , host David Latulippe talks with AJ Baker, founder and executive artistic director of 3Girls Theatre Company , about their 8th New Works Festival, titled Hindsight is 2020: Reimagining Women’s History . The festival runs from runs from March 20-29 at Z Below (470 Florida St.) in San Francisco.

Austin's Pocket Sounds is the solo project of singer, songwriter, multi-instrumentalist and arranger Mike St Clair. Listen as he describes how hearing Dionne Warwick's version of the Burt Bacharach/Hal David classic "Do You Know the Way to San Jose"  at a kiddie pool party inspired him to meld the classical, jazz, pop and rock parts of himself, and influenced his new song "Radio Song."

The heavy industrial area of Kwinana is home to Perth's only remaining beach shack community, but there are fears a new container port could destroy the simple lifestyle the locals have worked so hard to preserve.

The only unburnt area of bushland around the Conjola National Park, on the South Coast, is set to be cleared this week for a new housing development.

This 83-year-old ketch, Julie Burgess, is the last survivor of more than 100 built by the Burgess family and all were named after Burgess women.

A man and woman are arrested after allegedly threatening a woman with a pocket knife and stealing her car before leading police on a chase in the Mid North of South Australia.

Самый распространенный размер экрана обычного электронного ридера - 6 дюймов. Такой размер позволяет достаточно комфортно читать художественную литературу, да и носить с собой ридер подобного размера удобно, он много места не занимает. Однако если у человека не слишком хорошее зрение, то подобный экран для него будет маловат: конечно, никто не мешает увеличить шрифт, но на небольшом экране крупным шрифтом будет мало что помещаться, замучаешься странички листать. 

Creepiness In this Pocket-Sized episode #1005, Marc Abrahams shows an unfamiliar research study to Jean Berko Gleason. Dramatic readings and reactions ensue. The research mentioned in this episode is featured in the special Psychology issue (vol. 26, #1) of the Annals of Improbable Research magazine. Remember, our Patreon donors, on most levels, get access to each podcast episode before it is made public. 1. […]

Hot Sauce Aggression In this Pocket-Sized episode #1006, Marc Abrahams shows an unfamiliar research study to Dany Adams. Dramatic readings and reactions ensue. The research mentioned in this episode is featured in the special Ig: the Triumph of Miss Sweetie Poo issue (Vol. 7, #1) of the Annals of Improbable Research Magazine. Remember, our Patreon donors, on most levels, get […]

Bereitschaftspotential In this Pocket-Sized episode #1007, Marc Abrahams shows an unfamiliar research study to Jean Berko Gleason. Dramatic readings and reactions ensue. The research mentioned in this episode is featured in the special Psychology issue (vol. 26, #1) of the Annals of Improbable Research magazine. Remember, our Patreon donors, on most levels, get access to each podcast episode before it is made public. 1. […]