Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.

OBJECTIVE

To examine the association between manganese intake and the risk of type 2 diabetes in postmenopausal women and determine whether this association is mediated by circulating markers of inflammation.

"Are all my elves ready? OK, off we go!" A group of Santa and his elves head out into Karuizawa, Japan, to share God’s love.

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(MENAFN - Gulf Times) Japan's ruthless animated hitman has become the latest victim of the coronavirus, as the nation's longest-running manga comic an... ......

Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.

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<strong>EXPECTATIONS</strong> As is the current trend with majority of Bollywood flicks, soundtrack of <em>Shubh Mangal Zyada Saavdhan</em> too has released alongside the arrival of the film in theatres. Though an early release of the jukebox can well help gain added popularity in days preceding to the film's release, one wonders if this trend would reverse in time to come. Moreover, yet again there are three recreated songs in this album which has over half a dozen numbers in there. <img class="aligncenter wp-image-1077562 size-full" title="Music Review: Shubh Mangal Zyada Saavdhan" src="https://www.bollywoodhungama.com/wp-content/uploads/2020/02/Music-Review-Shubh-Mangal-Zyada-Saavdhan.jpg" alt="Music Review: Shubh Mangal Zyada Saavdhan" width="720" height="450" /> <strong>MUSIC</strong> Yo Yo Honey Singh (composer), Kinder Deol (lyricist) and singer J-Star's <strong><em>'Gabru'</em> </strong>from the album International Villager is recreated by, who else but, Tanishk Bagchi as <strong><em>'Pyaar Tenu Karda Gabru'</em></strong>. A fun track all the way which is already quite popular, especially up North, this one is a celebratory outing with newer lyrics by Vayu. Singer Romy does quite well in rendering this hard-core Punjabi number that is set to be a chartbuster all over again. Tanishk - Vayu come together to create number of songs in <em>Shubh Mangal Zyada Saavdhan</em> and one of their first collaborations is <strong><em>'Mere Liye Tum Kaafi Ho'</em></strong>. Ayushmann Khurranna brings himself behind the mike for this Vayu written number and his voice actually comes across as quite different in here. A decent track which is easy on ears, it comes across as a situational number at best as it doesn't really have that punch in there to emerge as a chartbuster. Second recreated song in the album is <strong><em>'Arey Pyaar Kar Le'</em></strong> which is a take-off on Bappi Lahiri and Anjaan's <strong><em>'Yaar Bina Chain Kaha Re'</em></strong> from Anil Kapoor and Amrita Singh's <em>Saheb</em>. A good recreation by Tanishk Bagchi and Vayu, this one has Bappi Lahiri's voice been retained which actually works tremendously for the song. While Ayushmann Khurranna chips in as well, the real fun is to listen to Bappi Lahiri due to his unique vocals. A good take on 80s nostalgia. It's time for the Kakkar family to come together for <strong><em>'Ooh La La'</em></strong>. While Tony Kakkar writes and composes this one (along with Tanishk Bagchi), his sisters Sonu Kakkar and Neha Kakkar take centre-stage to let their hair down. A fun number all the way, its promotion surprisingly kick-started quite late in the film's campaign and it could well have been beneficial had this been earlier. Not that the song is a huge chartbuster in the making but still it has the kind of energy in there that would have pepped the film even further. Mika steps in soon after for Tanishk - Vayu created <strong><em>'Aisi Taisi'</em>.</strong> Though the fun element is intact this time around as well, as has been the case with most of the songs heard before, at the end of the day it only fits in the needs of being a situational outing. Same is the case with <strong><em>'Raakh'</em></strong> which is actually a melancholic outing and arrives out of nowhere. Though Arijit has sung for this Tanishk - Vayu creation, the punch is not really there and you don't quite crave to return and give this one a repeat hearing. There is some fun that comes to the proceedings though Anuradha Paudwal and Mohammad Aziz's <strong><em>‘Kya Karthe The Saajna’</em></strong> from Anand-Milind's <strong><em>'Lal Dupatta Malmal Ka'</em></strong> is sampled for <strong><em>'Kya Karte Thay'</em></strong> by Tanishk Bagchi and Vayu. Though Zara Khan tries to bring in something quirky to the proceedings, the fun element actually comes in when the original makes an appearance. <strong>OVERALL</strong> The music of <em>Shubh Mangal Zyada Saavdhan</em> turns out to be decent enough with a couple of songs making an impression, albeit both being recreations. Somehow the new songs that have been created for the film don't quite cover the distance and had there been a chartbuster ortwo there, it would have only helped the soundtrack further. <strong>OUR PICK(S)</strong> <em>‘Pyaar Tenu Karda Gabru’, ‘Arey Pyaar Kar Le’, ‘Ooh La La’</em>

21/02/2020

Just like how Eid is synonymous with a Salman Khan release, the Independence Day holiday isn’t complete without an Akshay Kumar starrer. From 2013 to 2018, he has had a release during this beneficial weekend, barring 2014. 2019 is no exception and this time, he is out with MISSION MANGAL, based on an important chapter of India’s history. The mood of the film is also apt, considering that just last month, the Indian Space Research Organisation (ISRO) launched Chandrayaan-2 towards the moon. MISSION MANGAL has all the trappings of a blockbuster. So does it turn out to be as exciting and entertaining as expected? Or does the content fails to entice? Let’s analyse. <img class="aligncenter size-full wp-image-1008325" src="https://www.bollywoodhungama.com/wp-content/uploads/2019/08/Mission-Mangal-Review-IMG.jpg" alt="" width="750" height="450" /> MISSION MANGAL is the incredible true story behind India’s mission to Mars. The film begins in 2010. At the Indian Space Research Organisation (ISRO), a space mission under Rakesh Dhawan (Akshay Kumar) fails after Tara Shinde (Vidya Balan) in his team makes an error in judgement. As a punishment posting, he’s asked to handle India’s Mars program, which is not expected to take off anytime soon. A few days later, Tara while cooking puris in her home has a Eureka moment. She realises that through innovative methods, they can try to get our satellite reach Mars in just two years. She tells Rakesh about the plan and he realises it’s a golden opportunity. Rakesh approaches his senior (Vikram Gokhale) for approval who finds the idea unfeasible. Also Rupert Desai (Dalip Tahil) who has come from NASA to join ISRO feels that Rakesh's idea is ridiculous. Rakesh however manages to persuade and begins work. He asks for the best of the men from ISRO for this project. However he’s given inexperienced colleagues like Kritika Aggarwal (Taapsee Pannu), Eka Gandhi (Sonakshi Sinha), Varsha Gowda (Nithya Menen), Neha Siddiqui (Kirti Kulhari) and Parmeshwar Naidu (Sharman Joshi) and a very senior employee Ananth Iyer (H G Dattatreya). What happens next forms the rest of the film. Jagan Shakti's story is superb and also very challenging. It’s not easy to pen down a mainstream film with such a plot. Also many are not aware of what transpired behind the making of India’s Mars mission. Hence it’ll be exciting for them to witness the whole journey. Also there are so many twists and turns in the plot that one might not believe that some of the plot points are actually true incidents. R Balki, Jagan Shakti, Nidhi Singh Dharma and Saketh Kondipathi's screenplay not only simplifies the proceedings but also make it massy. The screenplay blends science and entertainment seamlessly. The film’s goings on are extremely easy to comprehend. R Balki, Jagan Shakti, Nidhi Singh Dharma and Saketh Kondipathi's dialogues are effective and funny. Jagan Shakti's direction is terrific for a first timer. He had a winning screenplay in his hand and he takes it to another level with his execution. The film has also has subplots of each of the main characters and even these are very well woven in the narrative. And through these tracks too, the makers have made some important comments about religion, parenting, marriage, religious bias etc. and all these contribute to the film hugely. MISSION MANGAL starts off beautifully showing Tara running a house efficiently on the day ISRO has an important launch. Rakesh's entry and the confrontation scene when he’s offered Mars program is intriguing as well as entertaining. It also makes it clear that the film won’t get serious and that the entertainment quotient will be maintained. The rest of the team is introduced in a quick but interesting montage like sequences and it adds a lot to the film. The first half moves swiftly with no complaints. The second half is longer and the commencing portions are where the film drops. Also to see the team renovating their work station at a time when they are running against time is a bit too much. Thankfully the film soon picks up. The best is obviously reserved for the finale. There are a lot of obstacles faced by the team here and it makes the film even more gripping. The finale is applause worthy. <p class="entry-title name"><strong><span style="text-decoration: underline;">Mission Mangal | Public Review | FDFS | Akshay Kumar | Vidya Balan | Taapsee Pannu | Sharman Joshi</span></strong></p> <iframe id="jwiframe" class="playerFrame" src="https://www.bollywoodhungama.com/videos/first-day-first-show/mission-mangal-public-review-akshay-kumar-vidya-balan-taapsee-nithya-movie-review-first-day-first-show/?jwembed=1" width="800" height="340" frameborder="0" allowfullscreen="allowfullscreen"></iframe> MISSION MANGAL is embellished with some fine performances. Akshay Kumar is in top form. He gets to play such a splendid role and gets into the skin of his character. And he’s very much there throughout the film! The way his character rarely gets serious and makes even serious discussions light and funny is seen to be believed. One of the greatest sequences of the film is when he makes an imaginary call to none other than APJ Abdul Kalam. Vidya Balan dominates most of the first half and suits her character to the T. It’s also admirable that she has no qualms playing mother to teenagers. Sonakshi Sinha is lovely and gets to shine. It’s great to see how she makes an impact in a supporting role. Taapsee Pannu is also quite efficient and gives her best in the climax. Nithya Menen has a smaller role but it serves as a great debut. Kirti Kulhari manages to score and many would be able to relate to her character's struggles. Sharman Joshi is funny and would surely make viewers smile. H G Dattatreya is adorable and the scene where he teaches Kirti's ex hubby a lesson is too good! Dalip Tahil is appropriate as the pessimist. Sanjay Kapoor (Sunil Shinde) is the surprise of the film. He delivers a fine performance and post interval he goes in another mode that would be greeted with whistles in cinemas! Purab Kohli (Vivek) and Mohd. Zeeshan Ayyub (Rishi) lend able support. Rohan Joshi (Dilip Shinde) is hilarious and even heartening as Vidya Balan's son. Kashmira Pardeshi (Anya Shinde) gets no scope. Vikram Gokhale is decent. Others are also good in their respective parts. Amit Trivedi's music is well interspersed with the proceedings. <em>'Dil Mein Mars Hai' </em>is entertaining and catchy. <em>'Shaabaashiyaan'</em> is played at a crucial juncture. Amit Trivedi's background score is engaging. S Ravi Varman's cinematography is quite simple and has the big screen effect. Sandeep Ravade's production design is praiseworthy as it’s straight out of life. Debashish Mishra's sound design is also as real as it gets. Sham Kaushal's action is good in the lone action scene inside the metro. Famulus Media and Entertainment's VFX is top class without which the long climax would not have worked so well. Theia Tekchandaney's costumes are appealing yet not too glamorous. Kirti Kolwankar and Maria Tharakan's costumes for Vidya Balan are authentic. Chandan Arora's editing is just perfect as the film neither moves too fast nor drags. On the whole, MISSION MANGAL is engaging and entertaining while being patriotic in its feel. At the box office, it will be accepted whole heartedly by the audiences and has the potential to emerge as Akshay Kumar's highest grosser ever!

Over the last three decades, Bollywood has come up with quite a few films on homosexuality like FIRE [1996], MY BROTHER NIKHIL [2005], EK LADKI KO DEKHA TOH AISA LAGA [2019], ALIGARH [2016], MARGARITA WITH A STRAW [2015] etc. Aanand L Rai and T-Series are now all set to bring SHUBH MANGAL ZYADA SAAVDHAN and unlike other gay-themed films, this one is light-hearted and looks quite commercial. Moreover, it stars Ayushmann Khurrana, who has become a brand in himself. So does SHUBH MANGAL ZYADA SAAVDHAN manage to entertain? Will it succeed in becoming the first legitimate LGBT-themed hit film of Bollywood? Or does it fail to succeed? Let’s analyse. <img class="aligncenter size-full wp-image-1077035" src="https://www.bollywoodhungama.com/wp-content/uploads/2020/02/Shubh-Mangal-Zyada-Saavdhan-1-26.jpg" alt="" width="720" height="450" /> SHUBH MANGAL ZYADA SAAVDHAN is the story of two men in love in Section 377 era. Aman Tripathi (Jitendra Kumar) is the son of Shankar Tripathi (Gajraj Rao) and Sunaina (Neena Gupta), who are based in Allahabad. Aman works in Delhi and unknown to his family, he's a gay and is living in with Kartik (Ayushmann Khurrana). Jitendra's cousin sister Goggle (Maanvi Gagroo) is getting married and Neena calls Aman to come back to attend her marriage. Aman at first refuses but then gives in. Kartik also joins him and they meet the entire Tripathi family in a marriage special train called Vivah Express. In the train, Aman and Kartik kiss when they assume that no one is looking. Sadly for them, Shankar sees them and he gets the shock of his life. He doesn't tell anyone about it out of shame. At Goggle's marriage, Aman, in front of everyone, kisses Kartik, thus astonishing the Tripathi family. Thanks to this development, Goggle's to be husband refuses to get married. In anger, Goggle runs away. Kartik is asked to leave and Shankar's brother and Goggle's father Chaman (Manurishi Chadha) drops him off to Allahabad station. At the railway station, Kartik bumps into Goggle and stops her from ending her life. She tells Kartik that he shouldn't run away and that he should fight for his love. This motivates Kartik and he decides to return to win over not just Jitendra but the entire Tripathi family. What happens next forms the rest of the film. Hitesh Kewalya's story is decent and had the potential to be a game-changer. Hitesh Kewalya's screenplay however is a big culprit. Under the pretext of making situations funny, he resorts to too many difficult-to-digest situations. This was prevalent in SHUBH MANGAL SAAVDHAN as well but there, they kept a nice balance. Here, the balance is just not there. The first half is still decent. But in the second half, it all goes downhill. Hitesh Kewalya's dialogues are witty but some of them are just over the top. It won’t be wrong to say that even the one-liners, which are supposed to be funny, take away the realism from the film. Hitesh Kewalya's direction is weak. The film has lot of subplots but he doesn’t put it together well. A major chunk of the film is about rift within the family and during such times, the principle homosexuality angle takes a backseat. Also, he should have succeeded completely in two aspects – comedy and messaging. Sadly in both these areas, he doesn’t do justice. Even the black cauliflower angle that provided laughs initially proved to be the biggest downer of the film in the climax. It gave a bad déjà vu of the ‘kala bandar’ angle of DELHI-6 [2009]. On the positive side, he handles few scenes with élan and some scenes genuinely raise laughs. SHUBH MANGAL ZYADA SAAVDHAN’s starts off on a funny note and the subplot of black cauliflower appears hilarious. Devika's (Bhumi Pednekar) scene too adds to the fun. The scene where Shankar Tripathi catches the lovers kissing brings the house down. Scenes like Aman kissing Kartik in full public view and Aman talking to his parents about dopamine and other such stuff keep the interest going. Post interval however, the film drops. The scenes are supposed to be funny but don't make you laugh. Also it becomes too preachy and unconvincing. The makers try their best to make things interesting but it doesn't work. <span style="text-decoration: underline;"><strong>Shubh Mangal Zyada Saavdhan | Public Review | Ayushmann Khurrana | Jitendra Kumar | First Day First Show</strong></span> <iframe id="jwiframe" class="playerFrame" src="https://www.bollywoodhungama.com/videos/first-day-first-show/shubh-mangal-zyada-saavdhan-public-review-ayushmann-khurrana-jitendra-kumar-first-day-first-show/?jwembed=1" width="800" height="340" frameborder="0" allowfullscreen="allowfullscreen"></iframe> Ayushmann Khurrana shockingly is not in his usual form. He has always played the victim but here, he plays the instigator and an actor of his calibre should have hit the ball out of park. Shockingly, he goes overboard. The other bigger shocker is that his screen time is very limited. Believe it or not, Gajraj Rao has the maximum screen time followed by Jitendra and then comes Ayushmann! Gajraj Rao however is too good as always and performs as per the script. Jitendra Kumar fits the role to the T and few of his scenes in the first half are great. Neena Gupta is average. Manurishi Chadha and Sunita Rajwar (Champa) do justice to their respective parts. Pankhuri Awasthy (Kusum) is quite funny. Maanvi Gagroo raises few laughs. Neeraj Singh (Keshav) is decent. Bhumi Pednekar is passable while Gopal Dutt (Doctor in the train) is okay. Music is peppy and gels with the film. <em>'Pyaar Tenu Karda Gabru'</em> is the best followed by <em>'Arey Pyaar Kar Le'</em>, which is played in the end credits. <em>'Ooh La La'</em> comes at a great point while <em>'Mere Liye Tum Kaafi Ho'</em> is forgettable. The recreated version of <em>'Kya Karte The Saajna'</em> sounds great but is not utilised well. Karan Kulkarni's background score adds to the quirkiness of the film. Chirantan Das's cinematography is appropriate. Ravi Srivastava's production design is in sync with the film’s setting. Ankita Jha's costumes are realistic and special mention should go to Ayushmann’s look. Ninad Khanolkar's editing is sans complaints. On the whole, SHUBH MANGAL ZYADA SAAVDHAN is a decent attempt and makes an interesting comment on homophobia which exists in our country. At the box office, it has the chance to work with the urban audiences, especially the youth. However, it will be a challenge to bring in family audiences and the audiences from small towns and cities. The presence of Ayushmann Khurrana may give a boost to its collections.

Manganese increased 15 Yuan/Mt or 47.62% since the beginning of 2020, according to trading on a contract for difference (CFD) that tracks the benchmark market for this commodity. Historically, Manganese Ore reached an all time high of 58.79 in October of 2019. Manganese Ore is primarily used in steel and iron production among other uses like as an additive in unleaded gasoline and as pigments for the coloring of ceramics and glass. This page refers to the Manganese Ore with 32% manganese, and 20% iron in North China, Tianjin port from South Africa. This page provides - Manganese Ore - actual values, historical data, forecast, chart, statistics, economic calendar and news. Manganese Ore - actual data, historical chart and calendar of releases - was last updated on March of 2018.

The Modern Family star, 47, took to Instagram to post different snaps of herself sightseeing in Paris, France, recently.

They tied the knot in November 2015, after a whirlwind romance. 

He's a Hollywood favourite thanks to his rippling muscles and beefy frame.

TOKYO, May 9 (Reuters) - Japan's ruthless animated hitman has become the latest victim of the coronavirus, as the nation's longest-running manga comic...

It’s quite hard to say just what manga is. The attempt to define it has defeated many observers.

A recent Supreme Court order has said that the Government shall build a second runway only in full compliance the law.

Cyber experts have recorded 30-35% rise in fake news on social media during the lockdown while the internet usage has gone up by 30%.

Bandra, Majestic and now Mangaluru railway station. Misled by fake forwards on social media that trains were being run to take them home, more than 800 migrant workers from Uttar Pradesh, Jharkhand, Madhya Pradesh, Rajasthan, Assam and Bihar gathered at the station on Thursday and held protests after their hopes were dashed.

Akshay Kumar's Mission Mangal recounts the story of this mammoth event in the tried and tested, personal anecdotal style.

Mission Mangal is enjoyable and entertaining. With Akshay Kumar and Vidya Balan, director Jagan Shakti delivers a space movie that lifts off and frequently soars.

Sab Kushal Mangal Movie Review: The film does have a few redeeming features but it is unlikely to make the list of memorable comedies in Hindi cinema. A pity really, for a good comedy, would have been the perfect way to kick off the New Year.

The gay characters are self-respecting men dead against the idea of marrying a woman out of convenience. Parental denial is also addressed head-on, and frowned upon using clap-trap dialogues.

If one were to rewind a bit, we have had Dostana, which introduced the idea of two brawny men as a pretend gay couple and the hilarity it would induce.

Police quoted the migrants as saying that they were stuck in the city without jobs, money and adequate food and that they were even willing to walk to their home states if the special trains were not operated immediately.

The crowding of workers at the railway station is learnt to be prompted by a social media post which went viral giving false information that free special trains have been arranged for workers, sources said.

Mamangam follows the story of a brave warrior of Malabar and his loyal soldiers who fought in the medieval fair called Mamankam.

Japan's ruthless animated hitman has become the latest victim of the coronavirus, as the nation's longest-running manga comic announced it would take its first hiatus in its 52-year history as social restrictions to contain the virus have made it difficult to produce the hand-drawn series.

Hayden Library - PN6790.J3 M37 2016

Tornio Manga LNG terminal

Damanganga-Pinjal river link project

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Mangalore Refinery

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All you wanted to know about Shubh Mangal zyada Saavdhan.

Vinod Mirani gives us the weekly box office verdict.

Banks, C. Kenneth (Charles Kenneth), 1940-

'We have actually made the film for children and intellectual people.'