The judge said the law likely discriminates on the basis of transgender status in violation of the equal-protection clause of the U.S. Constitution.

Tennessee won easily over Mississippi State. Indiana and BYU won nail-biters. So why did they jump over the Vols? We asked the CFP committee chair.

Hannah Grotzinger
May 29, 2024; 44:e1856232024-e1856232024
BehavioralSystemsCognitive

Elle M. Murata
Sep 18, 2024; 44:e0573242024-e0573242024
BehavioralSystemsCognitive

Harmonics are an integral part of music, speech, and vocalizations of animals. Since the rest of the auditory environment is primarily made up of nonharmonic sounds, the auditory system needs to perceptually separate the above two kinds of sounds. In mice, harmonics, generally with two-tone components (two-tone harmonic complexes, TTHCs), form an important component of vocal communication. Communication by pups during isolation from the mother and by adult males during courtship elicits typical behaviors in female mice—dams and adult courting females, respectively. Our study shows that the processing of TTHC is specialized in mice providing neural basis for perceptual differences between tones and TTHCs and also nonharmonic sounds. Investigation of responses in the primary auditory cortex (Au1) from in vivo extracellular recordings and two-photon Ca²⁺ imaging of excitatory and inhibitory neurons to TTHCs exhibit enhancement, suppression, or no-effect with respect to tones. Irrespective of neuron type, harmonic enhancement is maximized, and suppression is minimized when the fundamental frequencies (F₀) match the neuron's best fundamental frequency (BF₀). Sex-specific processing of TTHC is evident from differences in the distributions of neurons’ best frequency (BF) and best fundamental frequency (BF₀) in single units, differences in harmonic suppressed cases re-BF₀, independent of neuron types, and from pairwise noise correlations among excitatory and parvalbumin inhibitory interneurons. Furthermore, TTHCs elicit a higher response compared with two-tone nonharmonics in females, but not in males. Thus, our study shows specialized neural processing of TTHCs over tones and nonharmonics, highlighting local network specialization among different neuronal types.

Aggression involves both sexually monomorphic and dimorphic actions. How the brain implements these two types of actions is poorly understood. We found that in Drosophila melanogaster, a set of neurons, which we call CL062, previously shown to mediate male aggression also mediate female aggression. These neurons elicit aggression acutely and without the presence of a target. Although the same set of actions is elicited in males and females, the overall behavior is sexually dimorphic. The CL062 neurons do not express fruitless, a gene required for sexual dimorphism in flies, and expressed by most other neurons important for controlling fly aggression. Connectomic analysis in a female electron microscopy dataset suggests that these neurons have limited connections with fruitless expressing neurons that have been shown to be important for aggression and signal to different descending neurons. Thus, CL062 is part of a monomorphic circuit for aggression that functions parallel to the known dimorphic circuits.

For the second year in a row, Grazer bested the massive male named Chunk to take the crown in the single elimination online popularity contest at Katmai National Park and Preserve

The pachyderm, named Kamala, was suffering from osteoarthritis when zoo staff chose to euthanize her

The team traveled from New Zealand to Tonga along a humpback highway to collect environmental DNA and raise awareness of the plight of the marine mammals

Historians say that Sarah Emma Edmonds exaggerated many aspects of her wartime experiences. Still, she bravely served in the Union Army, becoming one of hundreds of women who fought in the conflict in secret

A federal appeals court has struck down an Indiana school district's policy requiring short hair for boys on the basketball team, ruling that the lack of a similar policy for girls'-team basketball players results in illegal sex discrimination.

Over the last two decades, STEM teachers have become increasingly more likely to be female and well-qualified.

In a case involving a transgender track athlete, the Trump administration says female transgender athletes are seeking "special treatment" to compete in girls' or women's sports.

The judge said the law likely discriminates on the basis of transgender status in violation of the equal-protection clause of the U.S. Constitution.

Here are five takeaways on the teaching profession from the newly released 2017-18 National Teacher and Principal Survey.

On July 10, 1941, Christian Poles hunted down, clubbed, drowned, gutted, and burned alive 1,600 Jewish men, women, and children-all but seven of the town's Jews.

  Matthias Schmale is the Assistant Secretary-General, UN Resident and Humanitarian Coordinator in Ukraine. Schmale brings more than 30 years of experience in humanitarian and development work. He previously served as Senior Adviser to the UN Development Coordination Office’s regional team for Africa, as Resident and Humanitarian Coordinator (a.i) in Nigeria, and in several high-level […]

During an in-house podcast interview, the Economic Freedom Fighters leader said he had been surprised by the suggestion

Sean Diddy Combs faces another lawsuit filed by GF Cassandra Ventura in 2023Sean 'Diddy' Combs, has been shifted to another unit where inmates can peep on female convicts, as he awaits his May 5 trial.A former inmate, Gene Borrello explained the environment at the respective 4 North unit of...

During a fight between two male mice, one will often run to a female mouse to distract their aggressor, a bait-and-switch strategy that could help abate social conflicts

The skull of Shanidar Z was found in the Shanidar cave in the Kurdistan region of Iraq, and has been painstakingly put back together

Tonje Bøe Birkeland's photographs imagine the exploits of fictional female scientists and adventurers from the past

Title: New Policy Supports Choice for Male Circumcision
Category: Health News
Created: 8/27/2012 11:00:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: In Showdowns Between Sexes, Male Ego Bruises Easily
Category: Health News
Created: 8/30/2013 9:35:00 AM
Last Editorial Review: 8/30/2013 12:00:00 AM

Title: Too Few Female Urologists to Meet Aging Patients' Demand
Category: Health News
Created: 8/22/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM

Title: What Are the Main Parts of the Male Reproductive System?
Category: Diseases and Conditions
Created: 7/7/2022 12:00:00 AM
Last Editorial Review: 7/7/2022 12:00:00 AM

ABSTRACTDespite global consensus on the importance of male involvement in family planning, disparities persist in low- and middle-income countries, where women continue to bear the responsibility for these initiatives. The Philippines, with a high fertility rate and unmet family planning needs, exemplifies this challenge. We present the experiences and lessons learned from implementing the no-scalpel vasectomy (NSV) program in Davao City, showcasing its potential for increasing male engagement in family planning decisions. Launched in 2008, the program aimed to address gender disparity by promoting NSV as a safe and effective contraceptive alternative to female-centric methods. Through the use of culturally sensitive information campaigns and couple-focused counseling, the program challenged traditional notions of masculinity and encouraged shared decision-making. Strong local government commitment and public-private partnerships played key roles in driving the program’s success. Results showed an average annual increase of 80% in NSV clients over the past 3 years compared to before the COVID-19 pandemic, underscoring its effectiveness. The program presents a compelling intervention model for similar initiatives, highlighting how overcoming cultural barriers, infrastructure limitations, and budgetary constraints through policy advocacy, strategic partnerships, and tailored approaches can significantly boost male involvement in family planning and improve reproductive health outcomes within communities.

Previous studies demonstrated that sigma receptor (R) antagonists alone fail to alter cocaine self-administration despite blocking various other effects of cocaine. However, R antagonists when combined with dopamine transporter (DAT) inhibitors substantially decrease cocaine self-administration. To better understand the effects of this combination, the present study examined the effects of R antagonist and DAT inhibitor combinations in male rats discriminating cocaine (10 mg/kg, i.p.) from saline injections. The DAT inhibitors alone [(–)-2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate (WIN 35,428) and methylphenidate] at low (0.1-mg/kg) doses that were minimally active failed to shift the dose-effect function for discriminative-stimulus effects of cocaine to the left more than 2-fold. At 0.32 mg/kg the DAT inhibitors alone shifted the cocaine dose-effect function leftward 24- or 6.6-fold, respectively. The R antagonists (BD1008, BD1047, and BD1063) failed to fully substitute for cocaine, although BD1008 and BD1047 substituted partially. At 10 mg/kg, BD1008, BD1047, or BD1063 alone shifted the cocaine dose-effect function leftward less than 6.0-fold. In combination with 0.1 mg/kg WIN 35,428, the 10 mg/kg doses of R antagonists shifted the cocaine dose-effect function from 12.3- to 36.7-fold leftward, and with 0.32 mg/kg WIN 35,428 from 14.3- to 440-fold leftward. In combination with 0.1 mg/kg methylphenidate, those R antagonist doses shifted the cocaine dose-effect function from 5.5- to 55.0-fold leftward, and with 0.32 mg/kg methylphenidate from 10.5- to 48.1-fold leftward. The present results suggest that dual DAT/R inhibition produces agonist-like subjective effects that may promote decreases in self-administration obtained in previous studies.

Electron transport chain (ETC) disorders are a group of rare, multisystem diseases caused by impaired oxidative phosphorylation and energy production. Deficiencies in complex III (CIII), also known as ubiquinol–cytochrome c reductase, are particularly rare in humans. Ubiquinol–cytochrome c reductase core protein 2 (UQCRC2) encodes a subunit of CIII that plays a crucial role in dimerization. Several pathogenic UQCRC2 variants have been identified in patients presenting with metabolic abnormalities that include lactic acidosis, hyperammonemia, hypoglycemia, and organic aciduria. Almost all previously reported UQCRC2-deficient patients exhibited neurodevelopmental involvement, including developmental delays and structural brain anomalies. Here, we describe a girl who presented at 3 yr of age with lactic acidosis, hyperammonemia, and hypoglycemia but has not shown any evidence of neurodevelopmental dysfunction by age 15. Whole-exome sequencing revealed compound heterozygosity for two novel variants in UQCRC2: c.1189G>A; p.Gly397Arg and c.437T>C; p.Phe146Ser. Here, we discuss the patient's clinical presentation and the likely pathogenicity of these two missense variants.

The Irish actor, who won our hearts as Connell’s mum Lorraine in ‘Normal People’, is back as Bibi Garvey in Sharon Horgan’s pitch-black comic caper ‘Bad Sisters’. She tells Ellie Harrison about misogyny on certain sets, why authenticity casting can close doors, and why these days a part has to be really good for her to say yes

The 12th Annual MORE/FITNESS/SHAPE Women�s Half-Marathon on April 19, 2015 in New York�s Central Park

Behind the scenes with Elizabeth Goodman Artis, Natalie Morales, Danielle Brooks, Padma Lakshmi and Sara Bareilles at the 2016 MORE/SHAPE Women�s Half-Marathon in Central Park on April 17.

Highlights: Male pattern hair loss is a common, progressive form of baldness that affects up to 50% of men by the a

Secondary infertility arises when a couple has at least one child, but doesn't conceive after at least one year of trying. In many cases, about one-third

A team of research scientists said that they have developed a male oral contraceptive pill that didn't cause observable side effects, with the drug expected to enter human trials by the end of 2022.

The abnormalities associated with aging sperm cells might be exacerbated by elevated body mass index (BMI), suggests research that appears in the journal iDevelopmental Cell/i.

A novel genetic mechanism that can cause severe forms of male infertility has been discovered by Newcastle University scientists. This breakthrough

Male contraceptive drugs DMAU and 11 beta-MNTDC effectively reduce testosterone without causing unacceptable side effects, says a new study. The

Sub-chronic psychological stress may adversely affect male fertility, reports a latest study conducted in the Banares Hindu University, (BHU) a Central

Rapidly shifting trends show that men's skincare extends beyond traditional practices, such as using herbal soap and post-shave products, as self-care

Is there any connection between social isolation and medlinkbone health/medlink? According to research presented at ENDO 2023, the annual meeting

Lack of a gene that produces the "MC2 protein," which is critical for creating a functional connection between the sperm head and tail, can result in

You may be familiar with the gut microbiome's impact on overall health. Surprisingly, a similar principle applies to the semen microbiome, which may significantly

Notice medlinkweight gain/medlink, hot flashes, or decreased libido? Male menopause, often disregarded, mirrors female menopause stemming from dwindling ovarian reserve.