A Tata group company seeks allocation of land, another company recently completes a beach resort in Srikakulam

Chief Minister mentioned about this road project in a recent meeting and we are currently preparing preliminary plans, says a senior VMRDA official

Vinesh was disqualified for being 100gm overweight at the time of the weigh-in on the morning of the women's 50kg freestyle final last week

Phogat had to stay back in Paris for the arbitration court verdict

Study shakes up scientists’ understanding of how bacterial infections develop

The fiancee of murdered journalist Jamal Khashoggi says Newcastle United and the Premier League must put moral values ahead of financial gains.

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.

Apart from being one of the most amazing book series, J.K. Rowling has beautifully captured the imagination of a whole generation, giving them lifelong memories!

The room is crowded, there's loud music and the liquor is flowing freely. One face catches the eye. Her hair falls onto, barely offering a glimpse of come-hither brown eyes.

The Communist Party of India (Marxist) has opposed a proposal to set up a Tamil Nadu State Marketing Corporation (Tasmac) outlet in the vicinity of Ho

A fabrication method comprising near-field holography (NFH) with an electron beam lithography (EBL)-written phase mask was developed to fabricate soft X-ray varied-line-spacing gratings (VLSGs). An EBL-written phase mask with an area of 52 mm × 30 mm and a central line density greater than 3000 lines mm−1 was used. The introduction of the EBL-written phase mask substantially simplified the NFH optics for pattern transfer. The characterization of the groove density distribution and diffraction efficiency of the fabricated VLSGs indicates that the EBL–NFH method is feasible and promising for achieving high-accuracy groove density distributions with corresponding image properties. Vertical stray light is suppressed in the soft X-ray spectral range.

Over the past decade, ptychography has been proven to be a robust tool for non-destructive high-resolution quantitative electron, X-ray and optical microscopy. It allows for quantitative reconstruction of the specimen's transmissivity, as well as recovery of the illuminating wavefront. Additionally, various algorithms have been developed to account for systematic errors and improved convergence. With fast ptychographic microscopes and more advanced algorithms, both the complexity of the reconstruction task and the data volume increase significantly. PtychoShelves is a software package which combines high-level modularity for easy and fast changes to the data-processing pipeline, and high-performance computing on CPUs and GPUs.

Mike Okamoto poses as Shogun Santa with visitors to Japanese Village. ; Credit: Chava Sanchez/KPCC

LA’s Asian Santa tradition is back. Shogun Santa has returned to Little Tokyo after a big loss in the community last year.  

This content is from Southern California Public Radio. View the original story at SCPR.org.

Constructed wetlands can remove disease-causing bacteria from wastewater, but their performance is highly dependent on the systems they use, a new study shows. Researchers reviewed results from a wide range of studies on constructed wetlands and found that combining different approaches increased removal of bacteria. However, further research and improvement of wetland systems is required to produce water that is safe for reuse.

The damaging impacts of the invasive alien plant, the giant hogweed, decline over time, new research from the Czech Republic has concluded. Although this plant initially reduces the native species richness of the grasslands it colonises, the study found that numbers of native species increased again in sites that had been colonised by hogweed for 40 years or longer.

Milder winters under climate change could increase the extent of alder tree (Alnus glutinosa) decline in Europe due to the increased spread of the pathogen Phytophthora alni, a recent study has found. However, this may be offset by hotter summers, which reduce the severity of the disease.

Soil biodiversity, soil quality, and soil health are integral to protecting the natural environment. Soils are crucial to food production and human well-being, as highlighted by the UN Sustainable Development Goals (SDGs). The abundance of soil biota is of great importance for the provision of associated ecosystem services (ES) and fundamental driver of self-regulation in soil. This study explores how the presence, or absence, of earthworms affects aspects of crop health and productivity, focusing on their shielding of winter wheat from the toxic plant fungi Fusarium.

These 'Groundhog Day' quotes are perfect for when you feel like you're living the same day over and over.

Bel Air: Champagne wishes and $90,000 water bill dreams.

Say it ain't so, Amy Poehler.

Beyond their undeniable cuteness, there's a lot more to discover about these wonderfully odd creatures.

A NOAA satellite captures the February 2011 snowstorm as it blankets the U.S.

Cuyahoga Valley National Park — a swath of green river valley stretching from Akron north to the southern edge of Cleveland — is Ohio’s only national park

GCVI Summit, Monterey – 29-30 January 2020

Whether it's delivering excitement through his extreme hunting antics and tough guy mentality, or focusing on the little things in life - fans should stay tuned for big news surrounding the reality TV star.

Tom's freakish knowledge and physical ability in the woods leaves him in a position of consistently redefining the hunting experience between guided adventures and charity events.

While his approval rating among Democrats is above 60 percent, the poll shows Gov. Larry Hogan draws less than 50 percent of the vote, in head-to-head matchups with leading Democratic candidates.

A COVID-19 outbreak at a Maryland nursing home contributed to an increase in virus cases Sunday across the state that the governor described as “frightening.”

Most of the bills were passed before the COVID-19 crisis forced lawmakers to bring the session to a close.

A COVID-19 outbreak at a Maryland nursing home contributed to an increase in virus cases Sunday across the state that the governor described as “frightening.”

We conducted an experimental study of infection, transmission, and persistence of a nucleopolyhedrovirus (NPV) of Douglas-fir tussock moth (Orgyia pseudotsugata) to better understand mechanisms determining the efficacy of the virus when it is used as a microbial control agent. In a field experiment, we quantified infection rates of larvae exposed to either Tussock Moth Biocontrol-1, the strain currently used for control by the U.S. Forest Service, or a wild-type strain isolated from a natural population. We first allowed each pathogen to decay on experimental branches for 0, 1, or 3 days before allowing uninfected larvae to feed on the branches, and then we fit both a generalized linear model and an epidemiological model of virus transmission to the infection data. Longer decay of the NPV resulted in lower infection rates, but evidence that overall virus transmission differed between wild and pesticide isolates of NPV was weak. The short persistence time of the virus suggests that it does not last long on foliage, in turn suggesting that application of TM Biocontrol-1 must be carefully timed to ensure maximum mortality.

In this application, a set of orthogonal functions is introduced whose power spectral densities are all rectangular shape. To find the orthogonal function set, it was considered that their spectrums (Fourier transforms of the functions) are either real-valued or imaginary-valued, which are corresponding to even and odd real-valued time domain signals, respectively. The time domain functions are all considered real-valued because they are actually physical signals. The shape of the power spectral densities of the signals are rectangular thus, the Haar orthogonal function set can be employed in the frequency domain to decompose them to several orthogonal functions. Based on the inverse Fourier transform of the Haar orthogonal functions, the time domain functions with rectangular power spectral densities can be determined. This is equivalent to finding the time-domain functions by taking the inverse Fourier transform of the frequency domain Walsh functions. The obtained functions are sampled and truncated to generate finite-length discrete signals. Truncation destroys the orthogonality of the signals. The Singular Value Decomposition method is used to restore the orthogonality of the truncated discrete signals.

In a method for fracturing or mask data preparation or mask process correction for charged particle beam lithography, a plurality of shots are determined that will form a pattern on a surface, where shots are determined so as to reduce sensitivity of the resulting pattern to changes in beam blur (βf). In some embodiments, the sensitivity to changes in βf is reduced by varying the charged particle surface dosage for a portion of the pattern. Methods for forming patterns on a surface, and for manufacturing an integrated circuit are also disclosed, in which pattern sensitivity to changes in βf is reduced.

A method for mask data preparation or mask process correction is disclosed in which a set of charged particle beam shots is determined which is capable of forming a pattern on a surface, wherein critical dimension uniformity (CDU) of the pattern is optimized. In some embodiments the CDU is optimized by varying at least two factors. In other embodiments, model-based techniques are used. In yet other embodiments, the surface is a reticle to be used in an optical lithographic process to form a pattern on a wafer, and CDU on the wafer is optimized.

A method and system for optical proximity correction (OPC) is disclosed in which a set of shaped beam shots is determined which, when used in a shaped beam charged particle beam writer, will form a pattern on a reticle, where some of the shots overlap, where the pattern on the reticle is an OPC-corrected version of an input pattern, and where the sensitivity of the pattern on the reticle to manufacturing variation is reduced. A method for fracturing or mask data preparation is also disclosed.

Template and method of making high aspect ratio template, stamp, and imprinting at nanoscale using nanostructures for the purpose of lithography, and to the use of the template to create perforations on materials and products.

Systems and methods for liquid deposition photolithography are described. In particular, some embodiments relate to systems and methods for using photolithography to control the 2D structure of a thin layer of material (e.g., photopolymer) using various masks, projection optics and materials. In one or more embodiments, this thin layer can be manipulated by micro-fluidic techniques such that it can be formed, patterned and post-processed in a liquid environment, vastly simplifying the creation of multi-layer structures. Multiple layers are rapidly built up to create thick structures of possibly multiple materials that are currently challenging to fabricate by existing methods.

An extreme ultraviolet lithography (EUVL) process is performed on a target, such as a semiconductor wafer, having a photosensitive layer. The method includes providing a one-dimensional patterned mask along a first direction. The patterned mask includes a substrate including a first region and a second region, a multilayer mirror above the first and second regions, an absorption layer above the multilayer mirror in the second region, and a defect in the first region. The method further includes exposing the patterned mask by an illuminator and setting the patterned mask and the target in relative motion along the first direction while exposing the patterned mask. As a result, an accumulated exposure dose received by the target is an optimized exposure dose.

A method includes scanning a lithography mask with a repair process, and measuring back-scattered electron signals of back-scattered electrons generated from the scanning. An endpoint is determined from the back-scattered electron signals. A stop point is calculated from the endpoint. The step of scanning is stopped when the calculated stop point is reached.

A projection exposure tool for microlithography for imaging mask structures of an image-providing substrate onto a substrate to be structured includes a measuring apparatus configured to determine a relative position of measurement structures disposed on a surface of one of the substrates in relation to one another in at least one lateral direction with respect to the substrate surface and to thereby simultaneously measure a number of measurement structures disposed laterally offset in relation to one another.

Substrates for detecting microorganisms are provided, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example, X1, is a D-amino acid and the others, for example, X2 and X3, may be any D- or L-amino acid. The substrate preferably is used for the detection of Bacillus anthracis. Also provided are substrates for detecting Pseudomonas aeruginosa, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties to a tri-, tetra-, or pentapeptide consisting of glycine amino acids. The invention further comprises methods for detecting microorganisms, specifically B. anthracis and P. aeruginosa, with the substrates of the invention and use of the substrate(s) in such a method.

A floorplan for a Structured ASIC chip is shown having a core region containing memory and VCLB logic cells surrounded by a plurality of IO connection fabrics that include a first IO connection fabric comprising IO sub-banks connecting the core of the chip to pins for external signals to the core, a first high-speed routing fabric disposed along the east-west vertical top of the core and connects the core to high-speed IO such as SerDes; a network-aware connection fabric connects the core to a microcontroller primarily for testing and repair of the memory in the core; and a second-high speed routing fabric is disposed on the north-south vertical sides of the core and communicates with the IO sub-banks. The VCLB Structured ASIC chip is manufactured on a 28 nm CMOS process lithographic node or smaller, having several metal layers and preferably is programmed on a single via layer.

A method and to a device for dispensing data from a tachograph to an endless printing medium. A first division is plotted in the longitudinal direction of the printing medium, and a second division is plotted transversely with respect to the longitudinal direction of the printing medium. The first division represents a predetermined unit of time, in particular a day in generalized time coordinates, and the second division represents at least one variable recorded by the tachograph during the unit of time, the at least one variable is depicted by at least one graph.

Disclosed are methods of lithography using a tip array having a plurality of pens attached to a backing layer, where the tips can comprise a metal, metalloid, and/or semi-conducting material, and the backing layer can comprise an elastomeric polymer. The tip array can be used to perform a lithography process in which the tips are coated with an ink (e.g., a patterning composition) that is deposited onto a substrate upon contact of the tip with the substrate surface. The tips can be easily leveled onto a substrate and the leveling can be monitored optically by a change in light reflection of the backing layer and/or near the vicinity of the tips upon contact of the tip to the substrate surface.

A mirror for the EUV wavelength range (1) having a layer arrangement (P) applied on a substrate (S), the layer arrangement having a periodic sequence of individual layers, where the periodic sequence has at least two individual layers—forming a period—composed respectively of silicon (Si) and ruthenium (Ru). Also disclosed are a projection objective for microlithography (2) including such a mirror, and a projection exposure apparatus for microlithography having such a projection objective (2).