In the second episode of the UK Tech Weekly Podcast host Matt Egan discusses the Mobile World Congress (MWC) with producer Chris Martin before he jets off to Barcelona, including what device launches we are expecting from the likes of LG, Sony and Samsung. Acting editor at Macworld.co.uk David Price chats about the row between Apple and the FBI over encryption (14:50). Finally Scott Carey from Techworld.com discusses challenger banks (25:00) what they are, what the technology looks like and why you should care.  

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In this week's UK Tech Weekly Podcast host Matt Egan is joined by online editor at Techworld.com Scott Carey to discuss all of the news coming out of Microsoft's Build 2016 developer conference, before being joined by producer Chris to talk about the company's genocidal AI chatbot Tay's public meltdown (13:00). Then, acting editor at Macworld.co.uk David Price jumps in to discuss the apparent resolution to the Apple vs FBI fight (29:00).  

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With Germany out of the World Cup what better way to celebrate than with a triptych of tech news'n'views? Henry Burrell hears from Scott Carey on Uber's London license while Sean Bradley explains why Facebook banned, and then allowed, cryptocurrency ads.

Henry then shows off the new BlackBerry and a collection of other phones that Scott finds insulting and ridiculous.

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(Stats Perform) - The upset wins tend to be few and far between, but for FCS programs, an FBS game is perhaps the most anticipated of the season.

Roosevelt, Theodore, 1858-1919.

A former FBI agent who investigated the Flint water scandal says the team was moving toward new charges when new prosecutors took over.

Following yesterday´s Supervisory Board meeting and the meeting on 19 March 2020, yesterday´s FBB shareholders’ meeting dealt with the results of the meeting and confirmed its main decisions. The shareholders recognised the business plan approved by th...

The US Air Force and Dover Air Force Base have notified Delaware’s Department of Natural Resources and Environmental Control and Division of Public Health, that four wells near the base sampled by the federal government for perfluoroalkyl substances (PFAS), including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), have returned elevated levels of PFOS and PFOA above the US Environmental Protection Agency’s health advisory for these substances of 70 parts per trillion (ppt).

Preliminary results show two wells near the base (AFB) have possible elevated levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA).

The war of words between the White House and the James Comey-era FBI has intensified, with Press Secretary Kayleigh McEnany accusing the agency of “manufacturing” a criminal case against Michael Flynn.
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How millennials Apoorva, Sujai and Dhananjai moved from the known, conventional path to embrace the risks and challenges of the unknown and the offbeat.

Hi, I am in the middle of a design and had no problem going back and forth between schematics and layout. Now I am getting the error message below. I am using Cadence 17.2.

ERROR: Layout database has probably been reverted to an earlier version than that, which was used in the latest flow or the schematic database was synchronized with another board.

The basecopy file generated by the last back-to-front flow not found.

ERROR: Layout database has probably been reverted to an earlier version than that, which was used in the latest flow or the schematic database was synchronized with another board.

The basecopy file generated by the last back-to-front flow not found.

Error: CMFBC-1: The schematic and the layout constraints were not synchronized as the changes done since the last sync up could not be reconciled. Syncing the current version of the schematic or layout databases with a previous version would result in this issue. The  constraint difference report is displayed.

Continuing with "changes-only" processing may result in incorrect constraint updates.

Thanks for your input

Claudia

મુકેશ અંબાણીએ જણાવ્યું કે, JioMart અને Whatsapp મળીને 3 કરોડ કરિયાણાના દુકાનદારોને વધુ સમર્થ બનાવશે

Jio અને FB વચ્ચેની ભાગીદારી ભારતને ડિજિટલ સોસાયટીમાં અગ્રેસર બનાવશેઃ Mukesh Ambani

Write up detailing how to defeat file browsing restrictions on Windows 98 running Novell 3.2.0.0.

Apache OFBiz version 17.12.03 suffers from a cross site request forgery vulnerability.

Adebayo Obajemu First Bank of Nigeria Holdings (FBNH) in the first quarter of 2020 reported a profit after tax of N25.7 billion. This represents a growth of 62.74% when compared to the profit after tax of N15.79 billion reported in the first quarter of 2019. The unaudited financial statement for Q1 2020 of the big […]

The post FBN Holdings declares N25.7bn profit in Q1 2020 appeared first on Hallmarknews.

Recently, abundant evidence has clarified that long noncoding RNAs (lncRNAs) play an oncogenic or anticancer role in the tumorigenesis and development of diverse human cancers. Described as a crucial regulator in some cancers, MIR22HG has not yet been studied in laryngocarcinoma and therefore the underlying regulatory role of MIR22HG in laryngocarcinoma is worth detecting. In this study, MIR22HG expression in laryngocarcinoma cells was confirmed to be downregulated, and upregulated MIR22HG expression led to suppressive effects on laryngocarcinoma cell proliferation and migration. Molecular mechanism assays revealed that MIR22HG sponges miR-5000-3p in laryngocarcinoma cells. Besides, decreased expression of miR-5000-3p suppressed laryngocarcinoma cell proliferation and migration. Moreover, the FBXW7 gene was reported to be a downstream target gene of miR-5000-3p in laryngocarcinoma cells. More importantly, rescue assays verified that FBXW7 depletion or miR-5000-3p upregulation countervailed the repressive effects of MIR22HG overexpression on laryngocarcinoma progression. In addition, E2F6 was proved to be capable of inhibiting MIR22HG transcription in laryngocarcinoma cells. To sum up, E2F6-induced downregulation of MIR22HG promotes laryngocarcinoma progression through the miR-5000-3p/FBXW7 axis.

Antiretroviral therapy (ART) suppresses HIV-1 replication but fails to cure the infection. The presence of an extremely stable viral latent reservoir, primarily in resting memory CD4⁺ T cells, remains a major obstacle to viral eradication. The "shock and kill" strategy targets these latently infected cells and boosts immune recognition and clearance, and thus, it is a promising approach for an HIV-1 functional cure. Although some latency-reversing agents (LRAs) have been reported, no apparent clinical progress has been made, so it is still vital to seek novel and effective LRAs. Here, we report that thiostrepton (TSR), a proteasome inhibitor, reactivates latent HIV-1 effectively in cellular models and in primary CD4⁺ T cells from ART-suppressed individuals ex vivo. TSR does not induce global T cell activation, severe cytotoxicity, or CD8⁺ T cell dysfunction, making it a prospective LRA candidate. We also observed a significant synergistic effect of reactivation when TSR was combined with JQ1, prostratin, or bryostatin-1. Interestingly, six TSR analogues also show reactivation abilities that are similar to or more effective than that of TSR. We further verified that TSR upregulated expression of heat shock proteins (HSPs) in CD4⁺ T cells, which subsequently activated positive transcriptional elongation factor b (p-TEFb) and NF-B signals, leading to viral reactivation. In summary, we identify TSR as a novel LRA which could have important significance for applications to an HIV-1 functional cure in the future.

The U.S. Justice Department on Thursday abruptly asked a judge to drop criminal charges against Donald Trump's former national security adviser Michael Flynn following mounting pressure from the Republican president and his political allies on the right.

Newly released FBI documents suggest a federal judge in Washington was swayed by apparent misrepresentations from a top prosecutor when he issued a memorandum opinion in December 2019 -- a ruling that marked one of the lowest points in former U.S. national security adviser Michael Flynn's effort to withdraw a guilty plea on a charge of lying to investigators.

In a Fox News interview Friday, President Trump was noncommittal on whether FBI Director Christopher Wray would remain in the job following the Justice Department’s decision to drop its case against Michael Flynn.

FBI Director Christopher Wray said Thursday that “I have not” read special counsel Robert Mueller’s final report on Russian election...

A Kansas woman pleaded guilty to making a false statement to the FBI during an investigation into allegations of fraud against the Federal Communications Commission’s (FCC) E-Rate program. According to the plea agreement, filed today in U.S. District Court in Kansas City, Kan., Mary Jo LaDuron, aka Mary Jo Gault, of Leavenworth, Kan., lied to FBI agents who were investigating allegations of fraud against the E-Rate program.

Diego Montoya Sanchez, 48, one of the leaders of the Norte Valle Colombian drug cartel and a former FBI Top Ten Fugitive, pleaded guilty today in Miami to drug trafficking, murder and racketeering charges.

Hosam Maher Husein Smadi, 19, has been arrested and charged in a federal criminal complaint with attempting to use a weapon of mass destruction.