This article explores the impact of abandonment abuse and neglect, not only on children but, centrally, on the foster carers, adopters and kinship carers who parent children where it has been deemed that a return home to birth parents is not in their interests. (For purposes of simplicity we will refer to these carers as ‘parenting figures’.) In doing this we aim to provide parenting figures with support and understanding as well as reducing the feelings of isolation that is often integral to parenting ‘looked after’ children.

The race to succeed Bill Beaumont as chairman of World Rugby comes to a conclusion in a vote in Dublin at the governing body's headquarters on Thursday.

Even with remote learning, there are steps schools can take to reach stressed-out students without pathologizing them.

Large-scale genome-wide association studies (GWASs) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine the effects of PDE4B variation on phenotypes with translational relevance to psychiatric disorders, we focused on PDE4B missense variant M220T, which is present in the human genome as rare coding variant rs775201287. When expressed in HEK-293 cells, PDE4B1-M220T exhibited an attenuated response to a forskolin-elicited increase in the intracellular cAMP concentration. In behavioral tests, homozygous Pde4b^M220T male mice with a C57BL/6JJcl background exhibited increased reactivity to novel environments, startle hyperreactivity, prepulse inhibition deficits, altered cued fear conditioning, and enhanced spatial memory, accompanied by an increase in cAMP signaling pathway-regulated expression of BDNF in the hippocampus. In response to a traumatic event (10 tone–shock pairings), neuronal activity was decreased in the cortex but enhanced in the amygdala and hippocampus of Pde4b^M220T mice. At 24 h post-trauma, Pde4b^M220T mice exhibited increased startle hyperreactivity and decreased plasma corticosterone levels, similar to phenotypes exhibited by PTSD patients. Trauma-exposed Pde4b^M220T mice also exhibited a slower decay in freezing at 15 and 30 d post-trauma, demonstrating enhanced persistence of traumatic memories, similar to that exhibited by PTSD patients. These findings provide substantive mouse model evidence linking PDE4B variation to PTSD-relevant phenotypes and thus highlight how genetic variation of PDE4B may contribute to PTSD risk.

When the brain experiences an injury, it can be difficult to definitively diagnose a concussion as the trauma is often limited to inside the skull and cannot be accurately assessed, according Reuben Kraft, a professor of mechanical engineering at Penn State. Kraft's research team is using computational methods and tools — such as custom mouthguard sensors — to model and predict injury in the human brain. 

Paul Frank Baum, Evan Pugh University Professor of Mathematics at Penn State, has been honored by Penn State with the title of Atherton Professor. The University created the Atherton Professorship to recognize the continuing high level of scholarly or creative activity Evan Pugh Professors may pursue after their retirement.

Aumento de tarifa es uno de los más grandes solicitados por la empresa El 15 de diciembre de 2022, Delmarva Power presentó una solicitud ante la Comisión de Servicios Públicos para aumentar sus tarifas de distribución eléctrica en $72,3 millones. De conformidad con la ley estatal, este aumento entrará en vigencia de manera temporal el […]

Spirit Film Festival brings films on resilience, spirituality, and healing to Tel Aviv.

Title: ER Study Shows Drop in Deaths After Trauma Injury
Category: Health News
Created: 8/28/2012 8:05:00 PM
Last Editorial Review: 8/29/2012 12:00:00 AM

Title: False-Positive Mammogram Result Traumatic for Most Women: Study
Category: Health News
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/26/2015 12:00:00 AM

Title: AHA News: Understanding Connection Between Poverty, Childhood Trauma and Heart Disease
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Approximately 8.5%–16.2% of childhood cancers are associated with a pathogenic/likely pathogenic germline variant—a prevalence that is likely to rise with improvements in phenotype recognition, sequencing, and variant validation. One highly informative, classical hereditary cancer predisposition syndrome is Li–Fraumeni syndrome (LFS), associated with germline variants in the TP53 tumor suppressor gene, and a >90% cumulative lifetime cancer risk. In seeking to improve outcomes for young LFS patients, we must improve the specificity and sensitivity of existing cancer surveillance programs and explore how to complement early detection strategies with pharmacology-based risk-reduction interventions. Here, we describe novel precision screening technologies and clinical strategies for cancer risk reduction. In particular, we summarize the biomarkers for early diagnosis and risk stratification of LFS patients from birth, noninvasive and machine learning–based cancer screening, and drugs that have shown the potential to be repurposed for cancer prevention.

L’ex-maire, qui a passé cette année le cap des cinq ans depuis son diagnostic, continue de s’impliquer pour sensibiliser les hommes à ce fléau.

Conoce a la familia Méndez, pionera en la transformación extrema de camiones. Texas Trocas, nueva serie de Discovery en Español. Estreno 15 de septiembre a las 10PM E/P.

The BBC speaks to social media moderators, whose job it is to find and remove distressing and illegal content.

medlinkBurnout/medlink and race-based traumatic stress take a toll on Black mental health professionals (BMHPs), reports a new study. h2COVID-19

Individuals suffering from both medlinkposttraumatic stress disorder/medlink (PTSD) and medlinktype 2 diabetes/medlink experience significantly

Children with severe injuries brought to an emergency department by their parents or caregivers often experience longer wait times than those who arrive

Berlin ; Boston : De Gruyter, [2023]

Bloomington, Indiana : Indiana University Press, [2023]

Berlin ; Boston : De Gruyter, [2023]

[s.l.] : Mohr Siebeck GmbH & Co. KG, 2023.

Ithaca, NY : Cornell University Press, [2023]

Melbourne ; London : Scribe, 2020.

Cambridge, Mass. : National Bureau of Economic Research, 2023

London ; Philadelphia : Jessica Kingsley Publishers, 2024.

Paris : Presses Sorbonne nouvelle, 2024.

Los Angeles-based trauma surgeon Annie Onishi documents 10 weeks of her life working inside a hospital during the Covid-19 pandemic. Annie chronicles what everything has been like, from her first patients and deaths until the present. Annie Onishi is a trauma surgeon and surgical critical care doctor in Los Angeles, California.

Los Angeles-based trauma surgeon Annie Onishi documents 12 days of her life working inside a hospital during this summer's surge in Covid-19 cases. While dealing with increasing numbers of infections, Annie reflects on how the entire hospital is coping with the stresses brought upon the healthcare system. Annie Onishi is a trauma surgeon and surgical critical care doctor in Los Angeles, California.

Trauma surgeon Annie Onishi is back with WIRED, this time to go over the Home Alone films (you know, the ones that MATTER). Annie breaks down every injury from the first two films, explaining what would happen if Harry and Marv actually experienced the physical trauma that they sustain in the films.

Shutdowns in India in 2019 are estimated to have led to a loss of over $1.3 billion. Forum Gandhi reports on the cost and the pain

[France] : Potemkine, [2019]

[France] : Potemkine, [2019]

Currently, there are about 55 beds in the emergency ward

Tallahassee, FL : Green Cross Foundation

For the quarter ended September 30, 2024, the company’s net profit surged by 34 per cent to ₹268 crore, up from ₹199 crore

New York, NY : Oxford University Press , 2018.

Baltimore : Johns Hopkins University Press, [2024]

El triclorofluorometano probablemente se origine en fábricas del este de Asia

Lewis Library - ML410.R6255 W56 2019

OM Philippines send staff to assess the earthquake damages in Surigao City and provide needed disaster relief training.

Credit risk funds have seen assets decline by nearly Rs 19,000 crore in April as investors rushed to redeem their money after the closure of six debt schemes by Franklin Templeton Mutual Fund, data showed.

Hereditary Grand Duke Guillaume and Hereditary Grand Duchess Stephanie of Luxembourg have...