[Written by Dale Butler] The fifth Pastoral-Parishioners’ Anniversary took place on the grounds of the Christ Anglican Church, Devonshire, on Saturday, September 21, 2024 at 6.00pm with a very appetizing dinner by Kenny’s Kitchen and water donated by John Barritt & Son Limited; an exceptional night of entertainment followed. The tent, lighting, and stage backdrop […]
[Written by Stephen Wright] Entrepreneur Shi-Vaughn Lee will celebrate the third anniversary of her online skincare business, Dove & Butterfly, by hosting a “Sniff and Shop” event on Friday and Saturday [June 23 and 24]. Created during the height of the Covid-19 pandemic, Dove & Butterfly offers products made in Bermuda by Bermudians, including whipped […]
Davidrose Studio is inviting the public to its Front Street store on Friday [Dec 15] to celebrate its upcoming 11th anniversary. A spokesperson said, “Davidrose Studio is inviting the public to pop by its Front Street store on Friday, December 15 to celebrate its 11th anniversary. Guests will enjoy free sweet treats [no purchase necessary] […]
Featuring intricately crafted wooden-style puppets with hand-drawn eyes and mouths, the short serves as a fitting coda to McHale’s masterpiece.
Angola Forum 2018: 30th Anniversary of the Battle of Cuito Cuanavale 23 March 2018 — 10:00AM TO 2:30PM Anonymous (not verified) 8 March 2018 Chatham House, London
Reflections on Southern Africa’s Turning Point
23 March 2018 marks the 30th anniversary of the final assault of what became known as the Battle of Cuito Cuanavale.
The confrontation between the Angolan army, supported by Cuba and the Soviet Union, and the armed opposition UNITA, supported by the South African Defence Force, is the largest land battle to have taken place in Africa since World War Two.
The battle was a watershed in Angolan and southern African history, but its significance continues to be contested. Today, although the battlefield has a monument and museum, it remains one of the most landmine-contaminated parts of Angola and this hinders development plans for international tourism.
This event brings together veterans and experts to contribute towards developing a deeper understanding of the battle. Discussions will further focus on the significance of the wider events around the battle, its regional implications, as well as the legacy of the battlefield.
On the occasion of the fifth anniversary of the Paris Agreement, the event will highlight the key role of the agricultural sectors in supporting the Paris Agreement. The Paris Agreement, [...]
Sending a man to the moon required an overhaul of the entire space program, involving more powerful rockets and new spacecraft (Video: Lauren Hogan, Beth Py-Lieberman, Brian Wolly)
OM Ships International celebrates five years of God’s faithfulness through the ministry of Logos Hope around the world.
Sudha Murty and Narayana Murthy appeared on the latest episode of The Great Indian Kapil Show
Subhash Ghai, who produced the original film through his production company Mukta Arts, revealed that the sequel is already in the works
GEARING UP FOR THE CELEBRATIONS The State of Delaware hires 250th Anniversary Coordinator The Delaware Heritage Commission and the Delaware Public Archives are pleased to announce the hiring of Ms. Margaret Hughes for the position of The State of Delaware’s 250th Anniversary Coordinator. Ms. Hughes will be responsible for communicating, coordinating, and collaborating with individuals, […]
The Delaware Heritage Commission and the Delaware Public Archives are pleased to announce the hiring of Ms. Margaret Hughes for the position of The State of Delaware's 250th Anniversary Coordinator.
The post The State of Delaware hires 250th Anniversary Coordinator appeared first on Delaware Public Archives - State of Delaware.
The 2024-2025 school year marks the 20th anniversary of Poetry Out Loud®, an arts education program and dynamic poetry recitation competition for high school students that lifts poetry off the page, creating community and connection. A partnership of the National Endowment for the Arts (NEA), Poetry Foundation, and state and jurisdictional arts agencies, Poetry Out Loud takes place in all 50 states, American Samoa, District of Columbia, Guam, Puerto Rico, and the U.S. Virgin Islands.
Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.
Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.
Rwandans should be proud of the immense progress they have made since the genocide, but economic inequality and political abuses still plague the country.
Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 30 Years of Kazakhstan-ADB Anniversary Reception, 8 November 2024
Karolinska Institutet is a medical university encompassing 21 departments distributed across three departmental or campus groups. Pharmacological research has a long and successful tradition at the institute with a multitude of seminal findings in the areas of neuronal control of vasodilatation, cardiovascular pharmacology, neuropsychopharmacology, receptor pharmacology, and pharmacogenomics that resulted in, among many other recognitions, two Nobel prizes in Physiology and Medicine, one in 1970 to Ulf von Euler for his discovery of the processes involved in storage, release, and inactivation of neurotransmitters and the other in 1982 to Sune Bergström and Bengt Samuelsson for their work on prostaglandins and the discovery of leukotrienes. Pharmacology at Karolinska Institutet has over the last decade been ranked globally among the top 10 according to the QS World University Ranking. With the Department of Physiology and Pharmacology now celebrating its 75-year anniversary, we wanted to take this as an opportunity to showcase recent research achievements and how they paved the way for current activities at the department. We emphasize examples from preclinical and clinical research where the dpartment's integrative environment and robust infrastructure have successfully facilitated the translation of findings into clinical applications and patient benefits. The close collaboration between preclinical scientists and clinical researchers across various disciplines, along with a strong network of partnerships within the department and beyond, positions us to continue leading world-class pharmacological research at the Department of Physiology and Pharmacology for decades to come.
Pharmacological research at Karolinska Institutet has a long and successful history. Given the 75-year anniversary of the Department of Physiology and Pharmacology, this perspective provides an overview of recent departmental achievements and future trajectories. For these developments, interdisciplinary and intersectoral collaborations and a clear focus on result translation are key elements to continue its legacy of world-leading pharmacological research.
Hearing disorders pose significant challenges to individuals experiencing them and their overall quality of life, emphasizing the critical need for advanced pharmacological approaches to address these conditions. Current treatment options often focus on amplification devices, cochlear implants, or other rehabilitative therapies, leaving a substantial gap regarding effective pharmacological interventions. Advancements in our understanding of the molecular and cellular mechanisms involved in hearing disorders induced by noise, aging, and ototoxicity have opened new avenues for drug development, some of which have led to numerous clinical trials, with promising results. The development of optimal drug delivery solutions in animals and humans can also enhance the targeted delivery of medications to the ear. Moreover, large genome studies contributing to a genetic understanding of hearing loss in humans combined with advanced molecular technologies in animal studies have shown a great potential to increase our understanding of the etiologies of hearing loss. The auditory system exhibits circadian rhythms and temporal variations in its physiology, its vulnerability to auditory insults, and its responsiveness to drug treatments. The cochlear clock rhythms are under the control of the glucocorticoid system, and preclinical evidence suggests that the risk/benefit profile of hearing disorder treatments using chronopharmacological approaches would be beneficial. If translatable to the bedside, such approaches may improve the outcome of clinical trials. Ongoing research into the molecular and genetic basis of auditory disorders, coupled with advancements in drug formulation and delivery as well as optimized timing of drug administration, holds great promise of more effective treatments.
Hearing disorders pose significant challenges to individuals and their overall quality of life, emphasizing the critical need for advanced pharmacological approaches to address these conditions. Ongoing research into the molecular and genetic basis of auditory disorders, coupled with advancements in drug delivery procedures and optimized timing of drug administration, holds the promise of more effective treatments.
Nitric oxide (NO) from endothelial NO synthase importantly contributes to vascular homeostasis. Reduced NO production or increased scavenging during disease conditions with oxidative stress contribute to endothelial dysfunction and NO deficiency. In addition to the classical enzymatic NO synthases (NOS) system, NO can also be generated via the nitrate-nitrite-NO pathway. Dietary and pharmacological approaches aimed at increasing NO bioactivity, especially in the cardiovascular system, have been the focus of much research since the discovery of this small gaseous signaling molecule. Despite wide appreciation of the biological role of NOS/NO signaling, questions still remain about the chemical nature of NOS-derived bioactivity. Recent studies show that NO-like bioactivity can be efficiently transduced by mobile NO-ferroheme species, which can transfer between proteins, partition into a hydrophobic phase, and directly activate the soluble guanylyl cyclase-cGMP-protein kinase G pathway without intermediacy of free NO. Moreover, interaction between red blood cells and the endothelium in the regulation of vascular NO homeostasis have gained much attention, especially in conditions with cardiometabolic disease. In this review we discuss both classical and nonclassical pathways for NO generation in the cardiovascular system and how these can be modulated for therapeutic purposes.
After four decades of intensive research, questions persist about the transduction and control of nitric oxide (NO) synthase bioactivity. Here we discuss NO signaling in cardiovascular health and disease, highlighting new findings, such as the important role of red blood cells in cardiovascular NO homeostasis. Nonclassical signaling modes, like the nitrate-nitrite-NO pathway, and therapeutic opportunities related to the NO system are discussed. Existing and potential pharmacological treatments/strategies, as well as dietary components influencing NO generation and signaling are covered.
The class F of G protein-coupled receptors (GPCRs) consists of 10 Frizzleds (FZD1–10) and Smoothened (SMO). FZDs bind and are activated by secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, and SMO is indirectly activated by the Hedgehog (Hh) family of morphogens acting on the transmembrane protein Patched. The advance of our understanding of FZDs and SMO as dynamic transmembrane receptors and molecular machines, which emerged during the past 14 years since the first-class F GPCR IUPHAR nomenclature report, justifies an update. This article focuses on the advances in molecular pharmacology and structural biology providing new mechanistic insight into ligand recognition, receptor activation mechanisms, signal initiation, and signal specification. Furthermore, class F GPCRs continue to develop as drug targets, and novel technologies and tools such as genetically encoded biosensors and CRISP/Cas9 edited cell systems have contributed to refined functional analysis of these receptors. Also, advances in crystal structure analysis and cryogenic electron microscopy contribute to the rapid development of our knowledge about structure-function relationships, providing a great starting point for drug development. Despite the progress, questions and challenges remain to fully understand the complexity of the WNT/FZD and Hh/SMO signaling systems.
The recent years of research have brought about substantial functional and structural insight into mechanisms of activation of Frizzleds and Smoothened. While the advance furthers our mechanistic understanding of ligand recognition, receptor activation, signal specification, and initiation, broader opportunities emerge that allow targeting class F GPCRs for therapy and regenerative medicine employing both biologics and small molecule compounds.
Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in the pathophysiology of neurologic and psychiatric diseases. A number of KP enzymes, such as tryptophan 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 and IDO2), kynurenine aminotransferases (KATs), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilic acid oxygenase (3-HAO), and quinolinic acid phosphoribosyltransferase (QPRT), control brain KP metabolism in health and disease and are therefore increasingly considered to be promising targets for the treatment of disorders of the nervous system. Understanding the distribution, cellular expression, and regulation of KP enzymes and KP metabolites in the brain is therefore critical for the conceptualization and implementation of successful therapeutic strategies.
Studies have implicated the kynurenine pathway of tryptophan in the pathophysiology of neurologic and psychiatric diseases. Key enzymes of the kynurenine pathway regulate brain metabolism in both health and disease, making them promising targets for treating these disorders. Therefore, understanding the distribution, cellular expression, and regulation of these enzymes and metabolites in the brain is critical for developing effective therapeutic strategies. This review endeavors to describe these processes in detail.:
Beloved roguelike traumatic-childhood-em-up The Binding Of Issac: Rebirth turned 10 yesterday, and it’s half off on Steam to celebrate. What’s more, maker Edmund McMillen has announced that the foretold online co-op update is due on the 18th of this month, alongside a “considerable” balance update. Consider me considering the considerability of said considerable update!
We’re still a week away from Blizzard’s Warcraft 30th Anniversary Direct next Wednesday the 13th of November, but art from an apparent remaster of 1995 real time strategy game Warcraft II: Tides Of Darkness has leaked online, via Xibbly user Stiven. It’s a thin one, as far as leaks go, but does show what looks to be cover, logo art, and a Battle.net icon. Thanks for the spot, Percy Coswald Gamer.
U.S. President Joe Biden spent five hours in the Ukrainian capital on Monday, meeting President Volodymyr Zelensky and even taking a stroll through the streets of Kyiv – despite the sound of air sirens – to visit The Wall of Remembrance, which displays portraits of the approximately 4,500 Ukrainian soldiers who have died since Russia annexed Crimea in 2014.
The trip was kept under a media blackout until a few hours after Biden’s arrival, with the president’s official schedule only saying he would fly in the evening to Warsaw for a planned visit. The New York Times reported, quoting an anonymous official source, that Biden arrived in Kyiv early this morning after making the same 10-hour long journey from Poland that every world leader visiting Ukraine since the start of the war has.
This paper delves into the evolution and future prospects of Global Navigation Satellite Systems (GNSS), with a particular focus on the United States' Global Positioning System (GPS) and Europe's Galileo. As GPS celebrates its 50th anniversary, it is a timely moment to assess its historical trajectory, current status, and future directions, especially considering the emergence of new competitors like China's BeiDou. Based on interviews with two GNSS experts from the European Commission, this study aims to analyze the potential for cooperation between GPS and Galileo, exploring avenues for collaboration and mutual learning.
Stag�s Leap Wine Cellars celebrates the 40th anniversary of The Judgment of Paris, which helped to elevate the esteem of American wine worldwide
Clayton uses an average of 40,000 tons of steel in the homes it builds annually. Find more facts about Clayton in this video.
Special series of Topolinos mini-cars by FIAT
The post Fiat celebrating Disney anniversary first appeared on peopleofdesign.American heritage brand GANT marked its 75th anniversary...
The post Gant 75 anniversary first appeared on peopleofdesign.CGIAR Executive Managing Director Ismahane Elouafi and IWMI Director General Mark Smith met Sri Lanka's Prime Minister Dinesh Gunawardena.
The post IWMI-CGIAR to launch new program for water and nutrition to mark 40th anniversary first appeared on International Water Management Institute (IWMI).
The Caring Generation(TM) Celebrates One Year Anniversary by Honoring Women Nursing Home Residents On Mother's Day
Jennifer Hudson, Weight Watchers(R) Spokesperson, Celebrates O, the Oprah Magazine's 10th Year Anniversary
Rocking Star Yash and Power Star Puneeth Rajkumar took part in the 6th anniversary celebration of Hombale Films, which made blockbuster movies like Raajakumara and KGF: Chapter 1.
On Saturday's episode co-founder of Infosys Narayana Murthy and his wife Sudha Murthy, Zomato CEO Deepinder Goyal and his wife Grecia Munoz graced the Kapil Sharma show. The couple delighted the viewers with their charming personalities and candid stories.
The Prime Minister also asserted that this event is not just a praise of history. It is a great opportunity for every person like him, who has grown up with unflinching faith in Vadtal Dham.
Hindustan Trading Company turns 50 this week with new products, and a documentary on late founder PN Venketakrishnan
Legendary designer, Jony Ive, shares the unique opportunities and technologies that contributed to the success of the iPod.
The Consul General designate at the Consulate General of France in Pondicherry and Chennai, Etienne Rolland-Piegue led the Armistice Day memorial service that began with the gathering observing a moment’s silence at the Monument aux Morts on Goubert Avenue
Two of Raja Ravi Varma’s unfinished works will be unveiled at Kilimanoor Palace near Thiruvananthapuram, adding to the artist’s legacy in Indian art