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Short-term participant uses Transform trip to confirm God’s call for long-term work in North Africa.

Vatican City, May 5, 2020 / 08:10 am (CNA).- The Vatican’s migrant and refugee office has released a booklet with guidance on how the Church might respond to the problem of people internally displaced within their own countries due to conflict or disaster.

Many people might be unaware of the existence of internally displaced people, or IDPs, Cardinal Michael Czerny, under-secretary of the migrants and refugees section, said May 5.

Speaking during a livestreamed press conference, he noted that internal displacement “is a current, contemporary reality in a surprising number of countries.”

Internally displaced persons are defined as those who have had to flee their home or residence due to violence, conflict, disaster, or development projects to find refuge in another part of the country. Since IDPs have not crossed international borders, they do not have the legal status of refugee or migrant and do not receive the legal protections those categories can give.

Czerny’s office, which is a part of the Dicastery for Promoting Integral Development, published a booklet May 5 called “Pastoral Orientations on Internally Displaced People.”

The document is directed primarily at dioceses, parishes, Catholic NGOs, and other Catholic organizations. It has short paragraphs on key issues related to the welcome, protection, promotion, and integration of IDPs, interspersed with quotes from relevant Church documents and speeches by Pope Francis.

The importance of spiritual care for Catholics who are internally displaced in their countries is one of the topics addressed. Cardinal Czerny said Tuesday he would like to highlight the response an average Catholic parish might give when it “discovers IDPs in its midst and learns how to reach out to them.”

“To me, this is a great sign of hope,” he said.

“When the Holy Father asks us to go to the peripheries, we might think of going to a faraway foreign land where we will do exotic things,” the cardinal said. “But the real peripheries which hurt are the ones that are very near at hand, the ones where people among us are invisible, are set aside, are discarded, are overlooked.”

According to data from the Internal Displacement Monitoring Centre (IDMC), at the end of 2019, 45.7 million people were living internally displaced from their homes worldwide for reasons of conflict. Including other causes of displacement, the number of IDPs is more than 50 million.

The IDMC reported that the countries with the highest numbers of internally displaced people are Syria, Democratic Republic of Congo, Afghanistan, Iraq, Yemen, and Colombia, though nearly every country in the world has IDPs.

In the United States, the IDMC says there were 916,000 people newly displaced internally due to disaster in 2019. The majority of these new displacements were caused by Hurricane Dorian and the California wildfires.

The Church can do something so that “those among us who have been forced to flee and find themselves among us will receive Christian welcome and the response the Body of Christ wants to give them,” Czerny explained.

He said the aim of “Pastoral Orientations” is for the more than 50 million IDPs “to be recognized and supported, promoted and eventually reintegrated, so that they can play an active, constructive role in their country even if powerful causes, both natural and unjust human causes, have forced them to flee from home and take refuge somewhere.”

“In the post-COVID-19 world that is emerging, their contribution will be very much needed,” the cardinal added.

He explained that publishing the document on internal displacement is “not a lessening on the priority of refugees, migrants, asylum seekers, victims of human trafficking,” but a matter of “continuing to respond to the full range of people’s needs and vulnerabilities,” even in the midst of a global pandemic.

“There are very many needs which didn’t go away just because we were focused on other things in the past weeks,” he underlined. “It’s not a question of COVID-19 displacing priorities. It’s a question of both/and…”

Problems such as internal displacement were already there, “and, on top of it all we also have the challenge as a human family of resisting and overcoming this pandemic.”

The Church, he said, is able “to take on a new challenge without jettisoning other problems as if they suddenly became irrelevant.”

OM Ireland's Mobilising director shares her thoughts about going "into all the world."

A group of 10 students, including a translator, participate in a two months training programme in Panama. The Mission Extreme Outreach has its students work amongst Panamanians and indigenous tribes. Un grupo de 10 estudiantes,incluyendo la traductora, participan durante los dos meses de gira en Panamá. Una vez más Misión Extrema está en acción con los latinos y grupos indígenas.

ONCE a staple of drive-thrus and fast food restaurants, burgers have had something of an image overhaul in recent years.

“It is wonderful and we are very grateful to God that we can live here,” Javid said. “Finally we have found a place where we can live our faith in Jesus in peace."

"Everyone in the kingdom of God is essential to the mission that He has called us to," I'Ching says. "Unfortunately, while we may profess this, often we don’t practise it."

One of the loveliest towns in Italy is the walled city of San Gimignano, an hour’s drive from Florence. When I first visited it was bleak midwinter and all but a few shops and cafes were shuttered against the sleet. Its claim to fame is a profusion of medieval towers, hence its hyperbolic label as the Manhattan of Tuscany. When I arrived these fortresses soared overhead, making shadowy streets even darker.

Abuse, alcohol, drugs, gangs and poverty are the daily realities for many in the slums. Many arrive at OM MTI looking for food, safety, conversation, advise and help.

St Kilda

It has been the major success story of the alcohol industry in recent years. Once thought of as a drink for the older generation, now you will find that gin, be it pink, flavoured or colour changing, has become one of the most popular spirits in the country. There have been no shortage of bars leaping on the bandwagon, to offer up drinks to connoisseurs, but where are the best places to go in Scotland? We’ve narrowed it down to 10 of the best.

THE SNP is so rotten it may have to be replaced by a new independence party, its former deputy leader has said.

It crosses one of the most scenic waterways in Scotland and is the second busiest by volume of passengers in the country.

If Scotland really does have such fabulous seafood, why do ordinary citizens find it so hard to tap into this much eulogised catch? The problem has been that subsequent governments have fixated on international exports, not food for citizens.

An internationally known gifted-education center is scouting—and helping to develop—gifted students in after-school programs and pullout classes in one of Maryland’s most challenged school districts.

Industry observers attribute the rise to heightened interest in ed-tech initiatives, decreasing technology costs, and the move to Common Core standards.

Infantile colic affects almost 10% of all infants and is characterized by crying and fussing in an otherwise healthy and well-fed infant. Prenatal exposure to tobacco smoking is a risk factor, but it is unclear whether nicotine causes the association.

Infants exposed to nicotine replacement therapy during pregnancy had elevated infantile colic risk of the same magnitude as infants exposed to tobacco smoking. Intrauterine exposure to nicotine may play a causal role in the pathogenesis of infantile colic. (Read the full article)

Dimenhydrinate, an antihistaminic agent, is a widely used drug in Canada and Europe. It limits stimulation of the vomiting center via the vestibular system. Multiple studies have shown its effectiveness in the treatment of vertigo and postoperative nausea and vomiting.

Dimenhydrinate, when given orally, did not significantly decrease the frequency of vomiting in children with acute gastroenteritis compared with placebo. The reported adverse effect proportions were similar for the dimenhydrinate and placebo groups. (Read the full article)

Omega-3 fatty acids (O3FA) are commonly used as complementary treatments in pediatric psychiatric disorders, including Tourette’s disorder (TD), and are well known to have anti-inflammatory properties. However, no studies to date have examined the effects of O3FA on pediatric TD.

This is the first double-blind, placebo-controlled clinical trial of O3FA in pediatric TD. The results indicate that O3FA supplementation may be beneficial in the reduction of tic-related impairment for some children and adolescents with TD, but not tics per se. (Read the full article)

Children in foster care are at elevated risk for adverse outcomes. Placement instability and failure to achieve timely permanence exacerbate that risk. A handful of studies have found that parent-management training is effective in promoting placement stability and timely permanence.

Unlike parent-management training, youth focused interventions have not been systematically evaluated for their impact on placement and permanency outcomes. A mentoring and skills group intervention for preadolescents in foster care demonstrated better placement and permanency outcomes, especially for high-risk subgroups. (Read the full article)

Children with obstructive sleep apnea (OSA) are usually treated by surgical removal of their upper airway lymphadenoid tissue. Recently, medications were offered to patients with nonsevere OSA. Montelukast, for this indication, had never been studied in a randomized controlled manner.

Montelukast effectively reduced polysomnographic findings, symptoms, and the size of the adenoidal tissue in children with nonsevere OSA. The findings support the potential of a leukotriene modifier as a novel, safe, noninvasive alternative for children with mild to moderate OSA. (Read the full article)

Honey is recommended as a cough medication by the World Health Organization. To date, the efficacy of this treatment has been shown in 2 studies: one tested only buckwheat honey and the other study was not blinded.

In a randomized controlled trial, we compared 3 types of honey versus placebo as a treatment of upper respiratory tract infection–associated cough. These types of honey were superior to placebo in alleviating cough. (Read the full article)

Stressful events adversely affect the immune system, particularly the natural killer (NK) cells. Infants in the NICUs are exposed to stressful stimuli. The effect of massage therapy on the immune system of preterm infants has not been investigated.

This randomized placebo-controlled study found daily massage performed in stable preterm infants for a minimum of 5 days was associated with an increase in NK cell cytotoxicity despite lower absolute NK cell numbers compared with controls. (Read the full article)

Preterm infants in the NICU receive the greatest number of transfusions of any patient population. The administration of the long-acting erythropoiesis stimulating agent (ESA) darbepoetin to reduce or eliminate transfusions in preterm infants has not been evaluated.

Infants receiving ESAs received half the number of transfusions and were exposed to approximately half the donors compared with the placebo group. More than half of the ESA recipients (59% darbepoetin recipients, 52% erythropoietin recipients) remained untransfused during their hospitalization. (Read the full article)

Although a number of randomized controlled trials of erythropoietin administration to preterm infants have been performed, few studies have reported 2-year or longer neurodevelopmental outcomes, and no studies have evaluated neurodevelopmental outcomes of infants randomized to receive Darbepoetin.

This is the first prospectively designed study to evaluate the neurocognitive outcomes of preterm infants randomized to receive Darbepoetin or erythropoietin compared with placebo. Infants in the ESA groups had significantly higher cognitive scores compared with the placebo group. (Read the full article)

Concern exists about the ability of new general pediatricians to find jobs that match their career goals.

A large majority of new pediatricians secure positions consistent with their career goals and desired responsibilities. (Read the full article)

Smoking has been found to increase the risk of some specific congenital anomalies; however, results remain inconsistent. Nicotine replacement therapy (NRT) is increasingly being used as for smoking cessation in pregnancy although little is known about its association with congenital anomalies.

Being prescribed NRT while pregnant was not associated with major congenital anomalies (MCA), except a small increase in respiratory anomalies (3/1000 births). This must be considered in context of the rarity of MCAs and higher morbidities in the NRT group. (Read the full article)

Trainee success rates with infant lumbar puncture are poor. The model of just-in-time learning via simulation has produced clinical improvement for other medical skills such as cardiac compressions and central line dressing changes.

This is the first study to evaluate the impact of just-in-time-and-place simulation-based learning on success with infant lumbar puncture. The intervention improved clinical behaviors associated with success without making a significant impact on success with the procedure. (Read the full article)

Children’s time with parents is critical for healthy development. Lack of control over parents’ schedules and limited supervisor support for personal and family life can interfere with parents’ family time.

This is the first group randomized controlled field trial demonstrating effects of a workplace intervention, designed to increase schedule control and supervisor support, on working parents’ time with their children, as assessed by using longitudinal daily telephone interviews. (Read the full article)

Strictly-defined pediatric bipolar I disorder (BP-I) is a serious condition. Although lithium is a benchmark treatment and has shown effectiveness in adults for decades, no definitive efficacy or long-term safety studies had been performed in pediatric patients with BP-I.

This study provides evidence to support the efficacy of lithium in the acute treatment of youths with BP-I who are currently in a manic or mixed state. Lithium had an adverse effect profile that was acceptable for most patients. (Read the full article)

Contezolid (MRX-I), a new oxazolidinone, is an antibiotic in development for treating complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. This was a thorough QT study conducted in 52 healthy subjects who were administered oral contezolid at a therapeutic (800 mg) dose, a supratherapeutic (1600 mg) dose, placebo, and oral moxifloxacin 400 mg in 4 separate treatment periods. The pharmacokinetic profile of contezolid was also evaluated. Time-point analysis indicated that the upper bounds of the two-sided 90% confidence interval (CI) for placebo-corrected change-from-baseline QTc (QTc) were <10 ms for the contezolid therapeutic dose at each time point. The upper bound of the 90% CI for QTc were slightly more than 10 ms with the contezolid supratherapeutic dose at 3 and 4 hours postdose, and the prolongation effect on the QT/QTc interval was less than that of the positive control, moxifloxacin 400 mg. At 3 and 4 h after the moxifloxacin dose, the moxifloxacin group met the assay sensitivity criteria outlined in ICH Guidance E14 with having a lower confidence bound ≥5 ms. The results of a linear exposure-response model which were similar to that of a time point analysis demonstrated a slightly positive relationship between contezolid plasma levels and QTcF interval with a slope of 0.227 ms per mg/L (90% CI: 0.188 to 0.266). In summary, contezolid did not prolong the QT interval at a therapeutic dose and may have a slight effect on QT interval prolongation at a supratherapeutic dose.

Background

Optimal concentrations of unbound antimicrobials are essential for maximum microbiological effect. Although hypoalbuminemia and albumin fluid resuscitation are common in critical care, the effects of different albumin concentrations on the unbound concentrations of highly protein-bound antimicrobials are not known. The aim of this study was to compare effects of different albumin states on total and unbound concentrations of ertapenem and ceftriaxone using an ovine model.

Methods

Design

Prospective, three phase intervention observational study.

Subjects

Healthy Merino sheep.

Interventions

Eight sheep were subject to three experimental phases; normoalbuminemia, hypoalbuminemia using plasmapheresis and albumin replacement using a 25% albumin solution. In each phase, ceftriaxone 40 mg/kg and ertapenem 15 mg/kg were given intravenously. Blood samples were collected at pre-defined intervals and analyzed using an ultra-high-performance liquid chromatography tandem mass spectrometry method. Pharmacokinetic parameters such as area under the curve (AUC_0-24), plasma clearance (CL) and apparent volume of distribution in the terminal phase (V_d) were estimated and compared between the phases.

Results

The protein and albumin concentrations were significantly different between phases. Hypoalbuminemia resulted in a significantly lower AUC_0-24 and higher CL of total and unbound concentrations of ceftriaxone compared to the other phases. Whereas albumin replacement led to higher AUC_0-24 and lower CL compared to other phases for both drugs. The V_d for total drug concentrations for both drugs were significantly lower with albumin replacement.

Conclusions

For highly protein-bound drugs such as ceftriaxone and ertapenem, both hypoalbuminemia and albumin replacement may affect unbound drug exposure.

Anne Jenks, Michelle Shory, Ed.S, Irina V. McGrath, Ph.D, Kim Jaxon, Dr. Beth Gotcher, Elizabeth Stringer Keefe, Ph.D., and Keisha Rembert share their suggestions for using tech effectively in class.

Arizona's ambitious expansion of its school voucher program has officially been put on hold after opponents filed enough signatures to at least temporarily block the new law.

T. Michael O'Shea
Jul 1, 1999; 104:15-21
ARTICLES

The Unremembered Places

The Ratline: Love, Lies and Justice on the Trail of a Nazi Fugitive

Entries from two Penn State students were among winners in categories for professional television journalists as part of the Keystone Media Awards.

AP has managed to dodge the partisan pitfalls that have felled other ambitious curricular efforts—so far, write Chester E. Finn Jr. and Andrew E. Scanlan.

More than 100 third-placed teams have advanced from group stages in UEFA and FIFA international tournaments over the years, but Portugal have become the first to actually win the trophy.

Loans for Heroes, which provides veterans with reduced mortgage rates, has funded $3.3 million in mortgage loans since it launched in May of 2012.

DSHA has partnered with the Department of Education (DOE) to offer reduced interest rates on mortgages for teachers in the Delaware Talent Cooperative, a group of high performing educators who have committed to work in schools with a significant proportion of disadvantaged students

MVFC Berettyóújfalu will represent Hungary in the UEFA Futsal Champions League after ETO FC Győr withdrew.

Defender Sergio Ramos reckons Bilbao will be party central at UEFA EURO 2020.

A sex worker in Kazakhstan finds freedom in Christ.