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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Property owners block the entrance to Balasubramanya temple in Karur




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560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS!

After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS.




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565: The Hurdy-Gurdy, OKLCH, Edge Dev Tools, and Ad Blocking

Dave doesn't hate the hurdy-gurdy, but it's creation is an interesting parallel to software development. OKLCH follow up, @media, Edge drops new dev tools, CSS and Astro theming, JavaScript devs discover PHP, how many people block ads, and accessibility and grids.




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576: Blocks, Components, Linting Images, Engines, and “Web Integrity”

We're talking how we stay online - or not - on vacation, is create-guten-block the future for us WP developers? Can we get a state of the web component address from the President of web components? Have we seen the last new browser engine? And deciding whether to add features or remove them from your app.




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634: Fabian Kägy on WordPress, Blocks, and Enterprise Dev

Fabian Kägy helps us understand the modern WordPress development process, Gutenberg vs Block editor vs full site editing, building with blocks or pages, what's coming in the Twenty Twenty-Five Theme, and whether the theme authoring process has been made too difficult in 2024?




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Go local is the mantra

Angela Brady, director, Brady Mallalieu Architects, London, tells Nidhi Adlakha why we need to focus on creating sustainable cities with low carbon footprints




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Unlocking renewable energy from industrial waste: Biogas production from spent wash

It is a sustainable solution for industrial waste management and renewable energy generation




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HC refuses to entertain plea to enhance funds allocated to MCD councillors

The Hight Court expressed surprise that members of the Legislative Assembly (MLAs) and Municipal Corporation of Delhi (MCD) councillors were approaching courts with their grievances and asked them to raise the issue in the House or before the public




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After snails, farmers in Idukki battling spotted locust infestation; experts say change in climate pattern could be a cause

Plantations of over 70 farmers severely affected by the spotted locust infestation at Konnathady and Vathikudy panchayats




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Annoyed over tardy paddy lifting, farmers block roads in Punjab

The AAP and the BJP sparred over who was to be assigned blame for the delays in procurement 




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Local investment banks edge out global brands in managing IPOs

Domestic banks win on consistency, efficiency; HSBC is only foreign bank on top-10 list




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Shoppers’ paradise lost? Singapore’s malls suffer as locals, tourists curb spending




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Polls to rural local bodies, due late December, may be delayed

This is because the process of re-organisation of local bodies in general and village panchayats in particular is not yet complete. An official, who handled the previous round of local bodies’ polls, says this may take three to four months




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T.N. CM Stalin inaugurates new buildings for rural local bodies




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A macroscopic magneto-optical response resulting from local effects in ferronematic liquid crystals

Soft Matter, 2024, 20,8363-8372
DOI: 10.1039/D4SM00577E, Paper
Xiangshen Meng, Xiaowei Li, Jian Li, Yueqiang Lin, Xiaodong Liu, Zhenghong He
The dynamic rotational behavior of composite chains under a rotating magnetic field was observed. The birefringence and dichroism variations in FNLCs mainly stem from the magnetic response of the composite chains, indicating local effects.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Linking local microstructure to fracture location in a two-dimensional amorphous solid under isotropic strain

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00486H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Max Huisman, Axel Huerre, Saikat Saha, John C. Crocker, Valeria Garbin
Machine learning predicts possible crack location in experiments of a fracturing colloid monolayer, shown along with the actual crack path.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Tuning collective actuation of active solids by optimizing activity localization

Soft Matter, 2024, 20,8570-8580
DOI: 10.1039/D4SM00868E, Paper
Davi Lazzari, Olivier Dauchot, Carolina Brito
Active solids, more specifically elastic lattices embedded with polar active units, exhibit collective actuation when the elasto-active feedback, generically present in such systems, exceeds some critical value.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Light scattering study of algal floc growth and structure: alum vs. polymeric plant-derived flocculant

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00837E, Paper
Temitope Orimolade, Ngoc-Tram Le, Lyle Trimble, Bandaru Ramarao, Sitaraman Krishnan
Algal flocculation using alum shows dynamic fractal restructuring over time, while Moringa oleifera protein induces faster densification, enhancing floc strength.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Vizianagaram MLC election: A.P. High Court sets aside disqualification of Raghu Raju; election to local bodies hangs in balance

As per the earlier schedule, the election will take place on November 28 and counting is scheduled for December 1.




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Two independent candidates file nominations for Vizianagaram local body MLC seat




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Allocations to Rayalaseema: Andhra govt. aims to develop Tirupati and Kurnool




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Kota Srinivas Poojary urges Union government to employ people who know local language in nationalised banks




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Govt. Wenlock Hospital’s new surgical super speciality block begins functioning in Mangaluru

The building was constructed at the cost of ₹56 crore with grants from the Mangaluru Smart City Mission




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Udupi police to handover Sunday’s lock up death case to CID




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PSI, head constable suspended in Brahmavar lock up death case




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Bangalore University makes U-turn on 50% seats for locals condition for providing seven additional acres to NLSIU

The condition of reserving seats for students from Karnataka has been left to the discretion of the government




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Emotions in failure: An excerpt from Productive Failure: Unlocking deeper learning through the science of failing

In his new book, learning scientist Manu Kapur discusses how to deliberately design for and transform failure into a deep learning signal




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Homebuyers gain from removal of differential tax rates on preferred locations, lowering overall costs

One third of the transaction value of an immovable property is attributed to land, which is excluded from and it is not included for calculation of GST calculation




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GHMC’s claims for budget allocations delayed due to absence of full time commissioner




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Hundreds relocated in Gujarat as heavy rains flood districts, disrupt daily life

Due to heavy rains, the district administration has declared a holiday for all educational institutions




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Assam group opposes Meghalaya ban on cave worship, threatens road blockade

Meghalaya’s Tourism Minister justifies a ban by the local village council as a move against promoting a tourist spot as a religious site




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NSCN (I-M) seeks third-party intervention to break talks deadlock

Accusing the Centre of betraying the Framework Agreement of 2015, the Naga extremist group led by Thuingaleng Muivah threatened to return to violent ways




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Serhou Guirassy scores twice in Dortmund's 4-2 comeback win over local rival Bochum

In five minutes, Matus Bero scored off a smartly executed one-two through the center, then Dani de Wit made it 2-0 after teammate Myron Boadu had snatched the ball off Dortmund's goalkeeper Gregor Kobel




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Investors flock to Sovereign Gold Bonds despite price rises, FY24 sees record subscriptions

SGBs offer a hedge against gold price fluctuations, with investors receiving the ongoing market price at redemption



  • Gold & Silver

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Godrej & Boyce launches ISI-certified lockers for jewellers and pawnbrokers

To improve security standards and ensure compliance with government regulations, all high-security safes are now mandated to carry an ISI mark




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Bullion Cues: Roadblock ahead

Traders wait for a breakout




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Beyond the triple bond: unlocking dinitrogen activation with tailored superbase phosphines

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02703E, Paper
Vilakkathala U. Krishnapriya, Cherumuttathu H. Suresh
Dinitrogen activation has long been a challenging goal in chemistry. Tailored superbase phosphines offer a promising approach to overcome this challenge by going beyond the traditional triple bond.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Shedding light on local history

It’s the lifeblood of community identities and is vital for preserving cultural heritage




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Allocation for development works nails BJP’s lie of resource crunch in State, says Siddaramaiah




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BSNL on higher gear with seven new services, including spam blocking solution

Sporting a brand new logo, BSNL also introduced low latency 5G connectivity for mining operations in partnership with the Centre for Development of Advanced Computing




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Row over relocation of school gate, allegedly for a bar hotel to get licence




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Vizhinjam poised to clock half a million cargo throughput this FY, eight times higher than targeted volume

While the initial projection for Phase I was 1 to 1.5 million cargo units per annum, the seaport has already handled 1.08 lakh cargo units – just three months into the trial run period




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Holocaust survivors mark 80 years since mass Paris roundup

French President Emmanuel Macron has decried his Nazi-collaborator predecessors and vigorously vowed to stamp out Holocaust denial




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UK tribunal quashes Meta-Giphy deal block, regulator to reconsider ruling

The Competition Appeals Tribunal said it had quashed the CMA’s ruling and referred the matter back for a new decision




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Antier’s EduBlock Pro uses blockchain to prevent exam paper leaks

India’s exam integrity crisis tackled with blockchain innovation




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IIT Indore develops e-shoes for live location tracking

The shoe harnesses energy from human motion to power electronic devices and with help of a satellite-based GPS module offers precise live location tracking




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Aakash to expand reach, move deeper into under-served locations

Most of these centres would be spread in Tier 4 cities in the hinterland or in different areas within the larger metropolises, says MD & CEO Deepak Mehrotra




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Glasses for Indian students with poor vision could unlock ₹156 billion annually, says study 

“If these children were to get glasses, India would stand to gain nearly 1.2 million years of schooling every year, amounting to a future economic productivity boost of ₹156 billion”




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Division in Bengal, Punjab in INDIA bloc not a blow to INDIA bloc: Sitaram Yechury

“As far as INDIA bloc, in Maharashtra, you have the Maharashtra Vikas Agadi, in Bihar you have the Mahagathbandhan and in Tamil Nadu you have DMK-led secular front. So, in each State these talks are already on. And I am sure by the end of this month, the situation will be far clearer,” says CPI(M) general secretary