Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.

The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.

The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of aortic fibrosis and other associated conditions.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

A data storage and retrieval system includes a head carriage unit adapted for rotational motion and having multiple heads disposed at a working surface. The system also includes a tape drive unit configured to move a tape media past the working surface of the head carriage unit, the tape media having a width approximately equal to a width of the working surface. As the head carriage unit rotates and the tape moves past the working surface, a first head is configured to write a data track to the tape and a second head is configured to thereafter read the data track, where data read by the second head is for use in verifying data integrity and performing error correction.

A fixing structure of an optical component is composed of a device chassis; a holder holding an optical component; first and second plate parts for joint to the device chassis and a connecting part of both the plate parts are formed in the holder; a plurality of joint holes are formed in the second plate part; a U-groove into which the connecting part of the holder is fitted and a plurality of through-holes are formed in the device chassis; and an adhesive that is extended in a circular columnar shape and is made by inserting the holder into the U-groove of the device chassis, and applying a UV-curing adhesive in such a manner that the UV-curing adhesive is bonded to the first plate part of the holder and is continuous to the inside of the joint hole via the inside of the through-hole, and radiating UV light along the through-hole.

A compact disc (CD) player and method for ejection control thereof is provided. The CD player has: a CD tray, an eject button, a front-end module, a back-end module, and a fast response eject module, wherein the front-end module and the back-end module are coupled to each other and integrated in an integrated circuit (IC). The fast response eject module has a second tray control module for detecting a status of the eject button, and a second ejection detection module for controlling the ejecting/inserting of the CD tray according to the detected status of the eject button after the CD player is powered up and before initialization of the first ejection detection module is completed. Accordingly, the CD player of the invention may quickly respond to the status of the eject button and control ejecting/inserting of the CD tray immediately after the CD player is powered up.

A lightweight radio/CD player for vehicular application is virtually “fastenerless” and includes a case and frontal interface formed of polymer based material that is molded to provide details to accept audio devices such as playback mechanisms (if desired) and radio receivers, as well as the circuit boards required for electrical control and display. The case and frontal interface are of composite structure, including an insert molded electrically conductive wire mesh screen that has been pre-formed to contour with the molding operation. The wire mesh provides EMC, RFI, BCI and ESD shielding and grounding of the circuit boards via exposed wire mesh pads and adjacent ground clips. The PCB architecture is bifurcated into a first board carrying common circuit components in a surface mount configuration suitable for high volume production, and a second board carrying application specific circuit components in a wave soldered stick mount configuration. The major components and subassemblies are self-fixturing during the final assembly process, eliminating the need for dedicated tools, fixtures and assembly equipment. The major components and subassemblies self-interconnect by integral guide and connection features effecting “slide lock” and “snap lock” self-interconnection. The radio architecture includes improved push buttons employing 4-bar living hinge linkage and front loaded decorative trim buttons.

A wobble determining apparatus is provided with: a calculating device for calculating (i) a first time required until reaching a number of revolutions of a motor which allows a predetermined linear velocity, and (ii) a second time required to move an optical head to a position which allows the predetermined linear velocity, on the basis of the number of revolutions of the motor and the position of the optical head; a judging device for judging whether to keep the optical head in accordance with the calculated first time and the calculated second time; and a controlling device for controlling a moving device not to move the optical head if it is judged to keep the optical head, and for controlling the moving device to move the optical head to the position which allows the predetermined linear velocity if it is judged not to keep the optical head.

Provided is an optical pickup device that compensates for an aberration caused by a beam splitter. When a beam of light is reflected from a disc and proceeds towards a beam splitter, the beam splitter is designed to allow the reflected beam to pass therethrough. However, the beam splitter can cause an astigmatism in the reflected beam due to diffraction. According to various aspects herein, an optical pickup device may include a compensation device that generates an inverse astigmatism to compensate for the astigmatism generated by the beam splitter.

A disk device and a method of driving a tray of the disk device. The method includes outputting a tray driving control signal in response to a tray opening instruction, and maximizing an output voltage of the tray driving control signal during a time period in which the tray is expected to be stalled.

A lightweight radio/CD player for vehicular application includes a case and frontal interface formed of polymer based material molded to provide details to accept audio devices and radio receivers, as well as the circuit boards required for electrical control and display. The case and frontal interface are of composite structure, including an insert molded electrically conductive wire mesh screen that has been pre-formed to contour with the molding operation. The wire mesh provides shielding and grounding of the circuit boards via exposed wire mesh pads and adjacent ground clips.

A machine which provides for both leaf stripping and grading can be used to process plants, such as burley tobacco plants, by continuously moving the plants in a first direction while simultaneously varying the position of the plants in a second direction relative to a defoliating apparatus. The plants may be moved horizontally through a machine by a transporter engaging the plant stalks while the vertical distance between the transporter (and thus the plants) is varied relative to the defoliating apparatus. The transporter and defoliating apparatus may be positioned at an angle to one another. Due to the changing amount of vertical distance, leaves from different sections of the plants, such as leaves at different stalk heights, can be contacted and removed at different corresponding horizontal locations in the machine. Accordingly, leaves can be graded based on the location(s) from which they are retrieved after removal.

The airflow through a harvesting machine is adjusted by calculating a G-factor at a first point on an upper chaffer to determine if it is greater than 1+n, where n represents a desired factor. A blower is adjusted to reduce an airstream if the G-factor is greater than 1+n. A MOG factor is calculated if the G-factor is less than 1+n. The blower is adjusted to increase the airstream if the MOG-factor is less than 1+x, where x represents a desired factor. A MOG-factor is calculated at a second point if the MOG-factor at the point is greater than 1+x and the blower is adjusted to reduce the airstream if the MOG-factor at the second point is greater than 1+y, where y represents a desired factor or adjusted to increase the airstream if the MOG-factor at the second point is less than 1+y.

A system and method for controlling spreader output from a harvester includes a distribution chamber for receiving an agricultural material removed from a field. The harvester includes a spreader system configured to distribute the agricultural material onto the field, and an opening configured to receive the agricultural material from the distribution chamber. Moreover, the distribution chamber includes a first panel rotatably coupled to a first side of the distribution chamber, and a second panel rotatably coupled to a second side of the distribution chamber. The first and second panels are configured to direct the agricultural material toward the opening of the spreader system. An angle of the first panel is independently adjustable to control a first amount of agricultural material directed toward a first inlet portion. An angle of the second panel is independently adjustable to control a second amount of agricultural material directed toward a second inlet portion.

A method and device for harvesting threshed crops including a threshing assembly (3) arranged downstream of a cutting assembly (2) of a combine harvester (1) for separating the grain-chaff mixture (12) from the straw. A chaffing device (4) is arranged downstream of the threshing assembly (3) for separating the total straw fraction into a first and a second straw fraction (5.1, 5.2). A comminution device (8) is arranged downstream of the chaffing device (5) for comminuting the second straw fraction (5.2). A blower (10) having a suction pipe (9) draws in and mixes the grain-chaff mixture (12) and the second straw fraction (5.2) to form a mixture (18) of grain, chaff, and second straw fraction and conveys the mixture (18) into a silo (14).

Methods and systems for extending or stretching muscles on an animal carcass by separating a hip joint of the carcass. Hip joint separation may be carried out while the carcass is suspended from a conveyor system as part of a commercial meat processing operation.

A stuffing tube centering device for concentric alignment of the stuffing tube to a casing stick and a corresponding method, and where two oppositely disposed centering members movable towards each other between which the stuffing tube can be held and centered.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein the organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause the harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

A paw cutting system for removing a poultry paw from a shackle conveyed along a shackle conveyor line and then cutting the leg of the paw to remove the knuckle is provided. The paw cutter has a guide bar substantially aligned with the shackle conveyor line that urges the paw to a central cavity of the shackle. The paw is discharged from the central cavity into a lateral notch formed in two opposed discs positioned adjacent to an end of the guide bar. The two opposed discs are rotatable and move the paw from the guide bar to a blade. As the paw is moved to the blade, the two discs stretch the paw so that the blade can cleanly cut the paw. The cut paw product can be placed onto a belt or other device in an ordered manner.

A method for filling sausages with a paste-like substance by means of a filling machine and to a filling machine for performing this method, including a sensor unit capable of determining at least one parameter that varies differently for different paste-like substances as a function of time. Depending on the at least one determined parameter, a controller determines whether a measure to be implemented on one or more wearing parts is necessary, the wearing parts wearing out at different times depending on the different paste-like substances.

In a method for removing blood released during filleting from the backbone and the indentations therein in the region of the vertebrae of fish that are conveyed in a row with the head forwards and the belly downwards, the removal of blood is carried out at the same time and in the same place as the cutting of the backbone. The backbone, which is freed of ray bones and rib bones, is guided through a cutting gap and is cut clear on the belly side of the fish over the entire length of the fish as far as the root of the dorsal fin to leave a backbone stump. The fish fillet flesh is covered by covering surfaces which converge at the cutting gap and of which at least two covering surfaces form the cutting gap. Pressurized cleaning fluid is sprayed onto the backbone that is guided between the covering surfaces through the cutting gap during cutting. A device for removing said released blood comprises a backbone cutting device having two backbone cutting circular blades, which are arranged obliquely in an inverted V shape and form the covering surfaces, and having fish guiding means forming covering surfaces that cover the fish fillet flesh. A cleaning device comprises at least one cleaning nozzle aligned with the cutting gap. An actuating device actuates the cleaning device and the backbone cutting device simultaneously. The covering surfaces protect the fish fillet flesh from being sprayed with the cleaning fluid.

A poultry front half processing module is shown and described. The module includes a rotatable wing bracket for securely engaging the wings of the front half to allow more accurate processing and easier deboning and transfer operations.

A method is disclosed for cutting tendons within the drumstick of a poultry leg while leaving the fibula of the drumstick intact. The drumstick has first and second opposing sides where no fibula extends and opposing third and fourth sides along one of which the fibula extends. The method includes suspending the drumstick from its ankle joint, moving the suspended drumstick in a downstream processing direction, cutting the meat and tendons extending along the first side of the drumstick, cutting the meat and tendons extending along the second side of the drumstick, pushing and stretching the meat and tendons of the drumstick to form a bulge projecting in the direction of the third side of the drumstick, cutting through the meat and tendons within the bulge while insuring that the cut is not made completely to the tibia, orienting the suspended drumstick so that its fourth side faces in the direction of a knife blade, pushing and stretching the meat and tendons of the drumstick to form a bulge projecting in the direction of the fourth side of the drumstick, and cutting through the meat and tendons within the bulge while insuring that the cut is not made completely to the tibia. An apparatus for carrying out the method also is disclosed.

The invention concerns an apparatus for processing meat, in particular fish, comprising a processing tool, an actuating unit associated with the processing tool for moving the processing tool out of a starting position into a processing position and vice versa, and a control device which is operatively connected to the processing tool or actuating unit for control of the processing tool, which is distinguished in that the actuating unit comprises a cylinder unit having two pressure cylinders which are arranged one behind the other and connected to each other, wherein the processing tool is arranged on one of the two pressure cylinders of the cylinder unit and the two pressure cylinders can be controlled independently of each other. Furthermore, the invention concerns a corresponding method.

This invention relates to automated systems and methods for hanging live poultry for further processing. The system has an alignment conveyor, an alignment stunner, a hanging box, and a shackle. The alignment conveyor conveys poultry from an input point to the alignment stunner. The alignment stunner urges the poultry to move to a desired position on the alignment conveyor and stuns the poultry. The hanging box grasps the stunned poultry and places the poultry into the shackle for further processing. A computer and at least one sensor control operation of the system so that human intervention is minimized.

A filleting device and method for harvesting fillets from poultry carcasses that are moved in a conveyer-line supported on carriers is provided. In one exemplary embodiment, the first guide rails are provided to guide at least a part of the fillets so as to increase this part's distance from the carcass and break the tissue connections that connect the fillet or fillets in their natural position to the keel-bone of the carcass. Flexible elements are provided that complete the harvesting of the fillets by peeling the fillets entirely loose from the keel-bone.

A work hanging apparatus includes a hanger line continuously conveying hangers each having a hook, a robot that has a hand with which a work having a hole is held and transfers the held work to a hanging location set in the hanger line, a controller controlling a movement of the hand to catch the hook of one of the hangers with the hole of the held work at the hanging location, a hole deviation detector that detects a positional deviation of the hole of the work, an attitude deviation detector that detects an attitudinal deviation of the hanger, and a corrector that corrects the movement of the hand according to the positional and attitudinal deviations.

Methods and systems for processing fish are provided which enable cutting of the fish and removal of the viscera without damage to either the viscera or the remaining fish product. The systems may include a gutting device to severe a gullet of the fish from the fish body and to gather and remove the viscera without significant damage to the viscera or the remaining fish product. Extractors for severing the connection between the gullet and the fish with one or more underlying cutting members are also provided to assist in removal of the viscera.

A method for processing poultry suspended by the feet from a conveyor hook is provided. The method and apparatus allow the quality of the poultry to be classified and graded in a simpler and more effective manner to realize higher yields or an extra added value. In one exemplary embodiment, a processing apparatus for a foot of the poultry is provided that includes a foot pad inspection apparatus.

A method and apparatus for removing fat from one face of a meat cut, where a knife tool cuts a layer of fat and possibly skin from the face. The knife tool is adapted to cut across the entire width of said meat cut along a desired trimming interface. The knife tool includes at least two controllable blade parts, each having a cutting edge, the blade parts extending between the first face and a fat-to-lean interface without intersecting said first face. The position of said cutting edges and the angle of the blade parts are continuously adapted, by controlling the at least two controllable blade parts, to cut following the desired trimming interface, whereby the fat and possible skin is trimmed from the lean in one single piece of fat.

The present invention relates to a device for processing carcasses of livestock such as cattle, pigs and sheep, comprising: at least two dressing tools for performing a dressing process on livestock carcasses, and a robot arm carrying the dressing tool. The invention also relates to a method for processing carcasses of livestock using such a device.

A knife having a hook incorporated into the blade for skinning, wherein the hook is a belly hook that is positioned on the belly side or under side of the knife opposite a finger guard area. Methods of the using the knife include steps for using the cutting edge to cut and using the hook to cut by pressure applied away from the user's body.

A shoulder blade removal device of bone-in meat includes: a bottom holder which is configured to be in contact with a lower side of the bone-in meat such that the lower side of the bone-in meat is lifted upward and moved in a horizontal direction; a support member for bending the bone-in meat in cooperation with the bottom holder such that an end of the shoulder blade; and a chuck unit attached to a robot arm and gripping the tip part of the shoulder blade in cooperation with the robot arm. The chuck unit includes: a base member fixed to the robot arm; a grip member; and a lock member supported by the base member such that the lock member can be advanced or retracted toward or away from the lateral plate part, the lock member pinching the shoulder blade in cooperation with the lateral plate part.

A food source information transferring system for a livestock meat-packing facility and a related method are disclosed. In one embodiment, the food source information transferring system is capable of reading tag-identifying information in a hook RFID tag incorporated in a hook that can be hung on a hook machine. An animal carcass attached to the hook then undergoes meat chopping, cutting, and/or packing operations in the meat-packing facility. For each meat package produced, a data set associated with the tag-identifying information in the hook RFID tag can be paired with a data set associated with a meat package label attached to the meat package. This dynamic and robust data association between the hook RFID tag and the meat package label enables a food source information database in the food source information transferring system to preserve and trace detailed food source information at various levels of meat production and processing.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein said organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

A slaughtered pig leg parts conveyor device is provided for conveying individual pig leg parts, wherein an individual pig leg part includes at least a portion of a pig leg and the pig foot. The conveyor device includes a track and one or more pig leg part carriers movable along said track, each carrier being adapted to carry an individual pig leg part. Each carrier has one pig foot retaining assembly adapted to engage on a single pig foot so as to retain the pig leg part in a position suspended from the carrier. The retaining assembly includes a pig foot aperture adapted to receive the pig foot.

A vacuum apparatus and method for recovering poultry breast sub-tenders or other trim products from poultry or meat carcass shells, or for recovering other materials. The apparatus has a cover which can be lowered on to a base to form a vacuum chamber. One or more vacuum hoses extend from the apparatus for suctioning the product into the vacuum chamber. A product container is removably positioned in the vacuum chamber such that the product suctioned into the vacuum chamber will fall into the product container by gravity.

A method for stunning poultry in a slaughterhouse by means of supplying a stunning gas into a closed chamber wherein the poultry is advanced through a plurality of successive ambients between an inlet, wherein the stunning gas concentration is at a minimum, and an outlet, at which the stunning gas concentration is at a maximum. The stunning gas concentration increases progressively from each ambient to the successive ambient, initially with a minimum increase rate and thereafter with a higher increase rate up to the maximum concentration.

A poultry processing device for removing skin from the meat of poultry is provided. The device can include a conveyor line for moving the poultry in their conveying path and one or more de-skinning devices in or adjacent to the conveying path for processing the passing poultry. Each of the de-skinning devices can include a rotatable gripper roll which is circumferentially provided with longitudinally extending teeth having radial ends facing away from a rotational axis of the roll and providing a frictional outer surface to the roll for catching engagement with the skin. Each of the de-skinning devices can further include pinch devices adjacent to the rotatable gripper roll to pinch or trap the skin between the gripper roll and the pinch devices.

A method for producing frozen oysters on the half shell, which comprises the steps of freezing live oysters in their shells, so that the oysters hinges will break open; subjecting the frozen oysters to a water treatment to promote disengagement of the oysters' flesh from one thin shell; and percussing the water treated oysters, so that at least one shell will be knocked off.