Methods, systems, and computer readable media for measuring multicast latency are disclosed. According to one method, the method includes emulating one or more Internet protocol television (IPTV) user devices by generating channel leave and join requests. The method further includes monitoring network responses to the channel leave and join requests and calculating, during a cycle of channel leave and join requests for a user device and prior to repeating the cycle, at least one metric of latency associated with the channel leave and join requests.

Methods, devices, and computer program products for providing instant messaging in conjunction with an audiovisual, video, or audio program are provided. The methods include providing an audiovisual, video, or audio program to a user. Viewer/listener input is received requesting activation of a program-based instant messaging function. A viewer/listener identifier corresponding to the viewer/listener is associated with a program identifier that uniquely identifies the audiovisual, video, or audio program being provided to the user to thereby generate a program viewer/listener record. The program viewer/listener record is transmitted to an electronic database. A list of other users who are viewing or listening to the program in addition to the viewer/listener is acquired from the electronic database. The list of other users is transmitted to the viewer/listener.

Systems and methods for optimizing system performance of capacity and spectrum constrained, multiple-access communication systems by selectively discarding packets are provided. The systems and methods provided herein can drive changes in the communication system using control responses. One such control responses includes the optimal discard (also referred to herein as “intelligent discard”) of network packets under capacity constrained conditions. Some embodiments inspect a video stream to determine priorities for various elements of the video stream. The elements may be discarding using the priorities. In various embodiments, the elements include frames, slices, macroblocks, and data partitions.

Disclosed herein is a receiving device for receiving AV contents, the receiving device including: an obtaining section configured to obtain a description document described in a program language for displaying contents from a server present on a network connected with the receiving device; a determining section configured to determine whether the obtained the description document is obtained from a first server managed on a broadcaster side broadcasting the AV contents; and a controlling section configured to control execution of the obtained the description document according to a result of determination by the determining section.

A digital broadcast receiver on a mobile body includes: a tuner that receives a broadcast signal of a physical channel; a signal intensity detector that detects a signal intensity of the broadcast signal; a current position detector that detects a current position of the mobile body; a movement direction detector that detects a movement direction of the mobile body; a reception judging unit that controls the tuner to judge whether the physical channel can be received; an area information storage unit that stores receivable area information indicating a receivable area of the physical channel; and an area information updating unit that determines, when it is judged that the physical channel can be received, a position apart from the current position in the movement direction according to the signal intensity as a receivable position, and updates the receivable area information to extend the receivable area to the receivable position.

A unified system of programming communication. The system encompasses the prior art (television, radio, broadcast hardcopy, computer communications, etc.) and new user specific mass media. Within the unified system, parallel processing computer systems, each having an input (e.g., 77) controlling a plurality of computers (e.g., 205), generate and output user information at receiver stations. Under broadcast control, local computers (73, 205), combine user information selectively into prior art communications to exhibit personalized mass media programming at video monitors (202), speakers (263), printers (221), etc. At intermediate transmission stations (e.g., cable television stations), signals in network broadcasts and from local inputs (74, 77, 97, 98) cause control processors (71) and computers (73) to selectively automate connection and operation of receivers (53), recorder/players (76), computers (73), generators (82), strippers (81), etc. At receiver stations, signals in received transmissions and from local inputs (225, 218, 22) cause control processors (200) and computers (205) to automate connection and operation of converters (201), tuners (215), decryptors (224), recorder/players (217), computers (205), furnaces (206), etc. Processors (71, 200) meter and monitor availability and usage of programming.

A method and apparatus for extracting advertisement keywords in association with situations of scenes of video include: establishing a knowledge database including a classification hierarchy for classifying situations of scenes of video and an advertisement keyword list, segmenting a video script corresponding to a received video in units of scenes, and determining a situation corresponding to each scene with reference to the knowledge database, and extracting an advertisement keyword corresponding to the situation of a scene of the received video with reference to the knowledge database.

Aspects of a method and system for data processing in a device with integrated set-top-box and femtocell functionality are provided. Data may be received via an integrated femtocell and set-top-box device and may be synchronously processed, utilizing a common clock, to perform one or more femtocell functions and/or set-top-box functions. The common clock may be derived from global navigation satellite system signals. The integrated femtocell and set-top-box device may convert the received data from a first to a second format. The converted data may be transmitted to a cellular enabled communication device via a cellular transmitter within said integrated femtocell and set-top-box device and/or to a multimedia device via a multimedia interface within said integrated femtocell and set-top-box device. The received data may comprise multimedia content. The integrated femtocell and set-top-box device may be operable to encode, decode, transcode, encrypt, decrypt, scramble, descramble, and present the received multimedia content.

A video-on-demand (VOD) content delivery system has a VOD Application Server which manages a database of templates ordered in a hierarchy for presentation of video content elements of different selected types categorized in hierarchical order. The templates include those for higher-order displays which have one or more links to lower-order displays of specific content. The VOD Application Server, in response to viewer request, displays a high-order templatized display, and in response to viewer selection of a link, displays the lower-order display of specific content. The hierarchical templatized displays enable viewers to navigate to an end subject of interest while having a unique visual experience of moving through a series of displays to the end subject of interest.

Sag in ceiling tiles is reduced by the present coated ceiling tile and method which decreases sag in the coated ceiling tiles. Calcined gypsum and water are combined to form a coating which is applied to the back side of a base ceiling tile in a thin layer of about 100 micrometer to about 1000 micrometers. The coating optionally includes a set time modifier. This method makes a coated ceiling tile from a base ceiling tile having a front side and a back side opposing the front side. The coating is applied to the back side of the base ceiling tile, the coating comprising an interlocking matrix of calcium sulfate dihydrate. Optionally, remnants of the set time modifier are present within interstices in the gypsum matrix. The remnants of the set time molecule include ions, molecules, particles or combinations thereof.

This invention relates to whitlockite and a method for manufacturing the same. The method includes adding, to water, a calcium ion supplying material and a cation supplying material containing a cation (X) other than the calcium ion to prepare a cation aqueous solution, adding a phosphoric acid supplying material to the cation aqueous solution, and aging the cation aqueous solution including the phosphoric acid supplying material. As a result, whitlockite having high purity and high crystallinity can be mass produced using a simple process.

In one aspect, hollow nanoparticles are described herein. In some embodiments, a hollow nanoparticle comprises a metal shell and a cavity substantially defined by the shell, wherein the shell has a thickness greater than or equal to about 5 nm and the cavity has a curved surface. In another aspect, methods of making hollow nanoparticles are described herein. In some embodiments, a method of making hollow nanoparticles comprises forming a plurality of gas bubbles and forming a shell on the surface of at least one of the plurality of gas bubbles, wherein at least one of the gas bubbles is electrochemically generated. In another aspect, composite particles are described herein. In some embodiments, a composite particle comprises at least one nanoparticle and a polycrystalline metal shell substantially encapsulating at least one nanoparticle, wherein at least one surface of at least one nanoparticle is not in contact with the shell.

A flat steel product having a base layer of a steel material and a multilayer coating applied thereto, and a method for producing the flat steel product. The method having the following steps: providing a steel base layer; applying a zinc layer to the base layer by electrolytic coating; applying an aluminum layer to the surface of the zinc layer, wherein no treatment is made to the surface of the zinc layer in regard to the oxides and sulfides present thereon at the end of the electrolytic zinc coating step or occurring during the course of the aluminum coating step; applying a magnesium layer to the aluminum layer; and subsequently heat treating the flat steel product in such a way that an MgZn2 layer forms in the coating above the Al layer.

An optical film has a cellulose acylate film base material containing cellulose acylate and a plurality of sugar ester compounds having different ester substitution degrees in which an average ester substitution degree of the plurality of sugar ester compounds is from 60 to 94%, and an antistatic hardcoat layer formed from a coating composition containing at least an organic antistatic agent and a curable compound having a (meth)acryloyl group in a molecule of the curable compound.

A low profile, wrappable spacer and method for maintaining a pair of elongate members in fixed, spaced relation to one another is provided. The wrappable spacer includes a flexible elongate body having oppositely facing inner and outer faces extending along laterally spaced, lengthwise extending edges between opposite ends. The inner face has an adhesive surface. At least one member extends between the edges transversely to the lengthwise extending edges. The member extends outwardly from the adhesive surface, wherein the adhesive surface is configured for adhesion to at least one of the member, the elongate members or the outer face.

Provided is a zinc-plated steel sheet for hot pressing having outstanding surface characteristics, comprising: a steel foundation plate comprising a metal surface diffusion layer of which the Gibbs free energy reduction per mole of oxygen during oxidation is less than that of Cr; an aluminum-rich layer containing at least 30 wt. % of aluminum formed on the surface diffusion layer, and a zinc plating layer formed on the aluminum-rich layer. In this way, a metal having a low affinity for oxygen is coated to an effective thickness prior to annealing and thus the creation of annealing oxides at the surface of the steel sheet is suppressed and a uniform zinc plating layer is formed, and alloying of the zinc plating layer is promoted during press-processing heat treatment. Cracking in the steel foundation plate during hot press molding is prevented.

A method of controlling a pump for a hybrid transmission includes commanding a first line pressure of the transmission and deriving a first torque value—an open-loop torque value—from the first line pressure command, and commanding the pump to operate at the first torque value. The method monitors actual speed of the pump and derives a second torque value—a closed-loop torque value—therefrom. A third torque value is derived from the first and second torque values, and the pump commanded to operate at the third torque value. A first speed value may be derived from the first line pressure command, and the second torque value derived from the difference between the monitored and the first speed values. Deriving the third torque value may include a substantially-linear combination of the first and second torque values.

A belt drive arrangement for an auxiliary unit of a motor vehicle includes, but is not limited to a belt pulley for receiving a drive belt, a shaft of the auxiliary unit that can be driven with the torque of the belt pulley, and a clutch device for the releasable torque transmission between the belt pulley and the shaft of the auxiliary unit. The clutch device includes, but is not limited to an electromagnet and a spring element. The spring element is preloaded in such a manner that the clutch in a currentless state of the electromagnet is closed.

Methods and systems are provided for performing a multiple gear downshift of a transmission gear by transiently operating in an intermediate gear. In response to air mass flow not reaching a threshold for CAC self-cleansing for a set duration, the transmission gear may be downshifted from a higher gear to an intermediate gear, and then to a requested lower gear. Downshifting through an intermediate gear may also be controlled based on the gear shift request and maximum air mass flow levels for engine misfire.

In a motor vehicle having a manual transmission, for, in particular, limiting the engine speed during the start-up operation when fulfilling at least one permission criterion for the engine torque, the criterion depending on the driving state of the motor vehicle, a default engine torque is preset, which is specified according to at least one engine characteristic value and which can be reduced with regard to the set engine torque called for by the position of the accelerator pedal of the motor vehicle.

Systems and methods are disclosed for aircraft braking and taxiing systems for use in, for example, an aircraft. In this regard, system comprising an electric motor coupled to a first transmission, a first clutch for selectively engaging the first transmission to a propulsion transmission and a brake clamping system, wherein, in response to engagement with the propulsion transmission, the electric motor drives an aircraft wheel, wherein, in response to engagement with the actuator ram, the electric motor drives the brake clamping system to apply force to an aircraft brake disk stack.

A method for operating a brake system for a work machine that includes at least one operating brake acting directly or indirectly on at least one ground engagement element of the work machine and at least one operating brake actuator which is movable between a fully engaged position and a fully released position and an accelerator actuator for activating propulsion of the work machine. In an activated state of the brake system the operating brake actuator is moved automatically to its fully engaged position when the accelerator actuator is released.

The invention relates to a method for operating a drive device (1) of a motor vehicle, said drive device (1) comprising at least one combustion engine (3) and at least one electric machine (9), as well as a dual clutch transmission (4) which can be functionally connected to the combustion engine (3) and which comprises a first sub-transmission (5), a first clutch (6) being associated therewith, and a second sub-transmission (7), a second clutch (8) and the electric machine (9) being associated therewith. In a purely electrical driving operation, the electric machine (9) is operated in a motorized manner, a driving gear is engaged in the second sub-transmission (7), and both clutches (6, 8) are disengaged. According to the invention, in order to start the combustion engine (3) during the electric driving operation, the second clutch (8) is engaged so as to drive the combustion engine (3) by means of the electric machine (9), a gear is engaged in the first sub-transmission (5), said gear having a lower gear ratio than the engaged driving gear of the second sub-transmission (7), the first clutch (6) is brought into a slip position and the second sub-transmission (7) is subsequently brought into a neutral position, the rotational speed of the electric machine (9) is increased at least to a starting rotational speed for the combustion engine (3) with the slip of the first clutch (6) being adjusted to maintain a forward torque of the motor vehicle, and the combustion engine (3) is started once its starting rotational speed has been reached. In addition, the invention relates to a device for operating a drive device of a motor vehicle.

A coast stop vehicle which stops an engine during the travel of the vehicle is provided with a variator including a pair of pulleys and a belt mounted between the pulleys and capable of continuously changing a speed ratio. A controller judges whether or not coast stop conditions to stop the engine during the travel of the vehicle hold, stops the engine when the coast stop conditions hold, and prevents the speed ratio from being upshifted to a higher side than a speed ratio at the time of starting the coast stop control during the coast stop control.

A method and transmission control unit configured to improve shift event performance in a vehicle with an automatic transmission by determining a vent time for release of a clutch assembly in a transmission of a vehicle. The vehicle must be stopped and a gear selector in the vehicle must be set to a drive condition. If these conditions are met, the clutch assembly is vented. The vent time from when venting begins to when a turbine (or input shift) speed of the transmission rises is tracked. Once the turbine speed of the transmission rises, the clutch assembly is reapplied. The clutch assembly vent time is set based on the tracked vent time.

A battery charging method for a hybrid vehicle and the hybrid vehicle using the same are disclosed. The hybrid vehicle includes an engine and a motor as power source and includes the battery in which electrical energy for driving the motor is stored. The method and system may include: determining whether the battery needs to be charged while the vehicle is stopped; transitioning a transmission to a neutral position (N position) when the battery needs to be charged; starting the engine and engaging an engine clutch to connect the engine with the motor so that the motor generates electrical energy via power from the engine. The electrical energy generated by the motor is then stored in the battery accordingly.

A control method for idling anti-rollback of a pure electric vehicle is provided, where the pure electric vehicle has a vehicle controller, a motor controller, a motor, a brake pedal, a handbrake device, an accelerator pedal, and a power battery. The method makes use of the differences between a pure electric vehicle from conventional cars, and collects the states of individual parts of the vehicle through the vehicle controller, and controls the output of the torque of the motor based on the state information of various control components, to prevent the vehicle located on a slope from rolling back, and makes the vehicle move forward at idle.

A method for controlling a transmission of a powertrain system includes executing a single source shortest path search to identify a preferred shift path originating with an initial powertrain state and terminating at a target powertrain state, wherein the single source shortest path search employs transition-specific costs and situational costs to identify the preferred shift path. The preferred shift path is executed to achieve the target powertrain state.

A transmission controller increases an indicated hydraulic pressure to a starting frictional engagement element to a normal hydraulic pressure, causes a hydraulic piston to stroke and executes a learning control of the indicated hydraulic pressure so that a time until the starting frictional engagement element starts generating a transmission capacity after the range is switched from the neutral range to the drive range becomes a target time when a range is switched from a neutral range to a drive range. The transmission controller further detects a driver's starting intention and increases the indicated hydraulic pressure to the starting frictional engagement element to a starting time hydraulic pressure higher than the normal hydraulic pressure and prohibits the learning control if the starting intention is detected before the starting frictional engagement element starts generating the transmission capacity.

A kinetic hybrid device and method for a vehicle may include a planetary gear system configured as a continuously variable transmission comprised of three or four ports. The kinetic hybrid device and method may include a flywheel connected to a first port of the system, a final drive connected to a second port of the system, and the variator for the flywheel connected to a third or fourth port of the system. The prime mover and/or other power sources may share a port with the flywheel, but do not share a port with the final drive.

A method of controlling a multiple step downshift is disclosed. Two offgoing shift elements are released and two oncoming shift elements are engaged to complete the downshift. During a first phase of the downshift, one of the offgoing shift elements controls the rate of increase of input shaft speed. During a second phase of the downshift, one of the oncoming shift elements controls the rate of increase of the input shaft speed. The method computes target torque capacities such that output torque and input shaft acceleration are continuous during the transition between phases. Furthermore, the method computes target torque capacities such that both oncoming clutches reach zero relative speed simultaneously as the input shaft reaches the final speed ratio.

A hybrid vehicle in which at least two shift ranges can be selected for a single running direction includes an engine, a motor generator, an EHC raising the temperature of a catalyst for cleaning up an exhaust gas from the engine, and an ECU. While the vehicle is running, if the engine is stopped and, of the two shift ranges, a shift range where larger decelerating force is produced by regenerative braking of the motor generator has been selected, the ECU causes the EHC to raise the temperature of the catalyst using electric power generated by the motor generator.

A method for optimized launch of a vehicle is provided wherein a driveline of the vehicle at least includes an engine, an automatic transmission, a system for exhaust gas recirculation, which are controlled by a driveline management system, wherein the management system is able to determine the mass of the vehicle, and whereby a launching gear of the transmission is calculated dependent at least on the determined mass of the vehicle, whereby a launching gear is chosen dependent of the power loss caused by the EGR and wherein the power loss caused by the EGR is determined, the available power to launch the vehicle is determined, and the launching gear is recalculated dependent of the available power, and selecting said recalculated launching gear before launch of the vehicle, launch the vehicle with the recalculated launching gear.

A vehicle travel control apparatus that controls state of travel of a vehicle by adjusting force that acts on the vehicle includes: an acting force adjustment portion that adjusts the force that acts on the vehicle, according to the state of travel of the vehicle; an operating state detection portion that detects an operating state of an operation member that is operated to control the state of travel of the vehicle; and an adjustment degree alteration portion that alters degree of adjustment made by the acting force adjustment portion, according to the operating state of the operation member.

A method of operating a drive-train of a vehicle that comprises a combustion engine whose torque for driving the vehicle can be transmitted to a drive output via a transmission, with a hydraulically actuated clutch when the clutch is engaged. An electric machine provides torque which can act upon the drive-train. The clutch is closed by filling the clutch with hydraulic fluid through a circuit by way of a pump which can be driven by the engine and the electric machine. The method is to engage the clutch when the combustion engine is initially off and/or when the electric machine is initially switched off, determining a driving dynamic based on the behavior of the driver and adjusting the speed of the electric machine based on the determined driving dynamic such that the greater the determined driving dynamic is, the more rapidly the clutch is filled by the pump.

In hydraulic control, an electronic control unit controls controlled hydraulic pressure of a control valve in order to control a hydraulic oil amount in a torque converter and a hydraulic oil pressure of a forward-reverse travel switching mechanism, and the electronic control unit increases the controlled hydraulic pressure when the hydraulic oil amount in the torque converter is insufficient at an engine start or immediately after the engine start in comparison with a case where the hydraulic oil amount in the torque converter is sufficient. The hydraulic control device includes: the torque converter; the forward-reverse travel switching mechanism; the control valve configured to change the hydraulic oil amount in the torque converter and the hydraulic oil pressure of the forward-reverse travel switching mechanism by changing the single controlled hydraulic pressure; and electronic control unit.

A two-wheeled inverted pendulum vehicle includes: single-winding first and second motors respectively rotating one of two wheels; first and second control systems respectively supplying drive currents to the first and second motors; a sensor detecting a physical quantity that varies with a turn of the vehicle; a dynamic brake unit being able to switch between active and inactive states of dynamic brake being applied to the first motor; and a control unit, when the control unit has determined that the vehicle is turning about the second motor side on the basis of the physical quantity while supply of drive current from the first control system to the first motor is inhibited, activating dynamic brake in the dynamic brake unit. The first control system, when an abnormality has been detected in the first control system, inhibits supply of drive current from the first control system to the first motor.

A method for control of a gearbox installed in a motor vehicle (1), which method effects a downshift of the gearbox (20) from a first gear (G1), for which the acceleration a of the vehicle (1) is negative, to a second gear (G2), for which the acceleration a is positive or substantially equal to nil. The downshift involves at least one intermediate gear step between the first gear (G1) and second gear (G2), with a maximum engine speed at each intermediate gear step which is as high as, or higher than, a highest engine speed at a preceding intermediate gear step. Also, a system, a motor vehicle, a computer program and a computer program product for performing the method are disclosed.

A system and method of controlling a fail-safe for a vehicle is provided. The method includes determining, by a controller, that remaining hydraulic pressure exists in the clutch when the clutch is not opened and a target value of oil pressure for opening the clutch is maintained for a predetermined time period. In addition, whether a vehicle is stopped is confirmed in response to determining that remaining hydraulic pressure exists in the engine clutch. The controller is further configured to transmit a signal to shift to the vehicle to a neutral (N) stage to a transmission controller and shift to the vehicle to the N-stage in response to determining that the vehicle is stopped. Then, the engine is driven by the controller in response to determining that the vehicle is shifted to the N-stage.

Systems and methods for improving operation of a hybrid vehicle are presented. In one example, an electrical load may be automatically activated to consume electrical energy produced during driveline braking so that driveline braking may be extended. The electrical load may be a windscreen heater or other device.

A method of controlling an automated transmission for motor vehicles with one or several pressure activated positioning cylinders (6, 8, 20), via the assigned shift valves (10, 12), at least one main cut-off valve (4) which is positioned prior to the shift valves, and a control device for controlling the shift and main cut-off valves. The pressure requests, for the shifting, are determined and the respective main cut-off valves are triggered depending on the determined pressure requests. To enable a variable match of the supply pressure during transmission shifts, respective optimized pressures or pressure patterns are determined for certain shift scenarios which, for instance, consider a mass to be synchronized, the existence of a tooth-on-tooth position, or the like. Through this method, for instance, the load on shift elements, the shift timing, and the shift noise can be positively influenced.

Systems and methods for improving operation of a hybrid vehicle are presented. In one example, torque transferred via a driveline disconnect clutch is estimated based on characteristics of a torque converter to improve driveline operation.

Methods and systems are provided for controlling an engine system with a variable cam timing device. In one example, the variable cam timing device is operated to adjust engine valve timing differently at engine stop based on whether the engine stop is in response to an operator request or in response to an automatic controller initiated engine stop without an operator request.

The present invention provides for a transmission shift assembly for a vehicle and methods of monitoring and controlling the same. The transmission shift assembly includes a transmission having a shift position member movable between a plurality of gear positions, an actuator configured to move the shift position between the gear positions, and a linkage coupled to the actuator and movable between a plurality of positions in response to movement of the actuator. The assembly further includes a controller to control the actuator, an ignition to receive a key, and at least one key sensor positioned within the ignition and configured to transmit a signal to the controller upon sensing removal of the key, the controller controlling the actuator to move the shift position member to a predetermined gear position upon receiving the signal from the key sensor that the key has been removed from the ignition.

A battery charge/discharge control device which performs battery charge/discharge control in a working machine with a battery capable of storing electric energy generated by a generator motor coupled to an engine and driving the generator motor or at least one of other electric actuators by the stored electric energy and a controller which controls a distribution of the electric energy among the battery, the generator motor, and the electric actuator, wherein the controller performs the charge/discharge control in which the electric energy of the battery is discharged when the engine is driven and recharging to the battery is permitted on a condition that a state in which an engine speed is equal to or lower than a predetermined engine speed is maintained for a predetermined time after the battery is completely discharged.

The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells.

This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This invention relates to soluble forms of the lymphotoxin-β receptor extracellular domain that act as lymphotoxin-β receptor blocking agents. This invention also relates to the use of antibodies directed against either the lymphotoxin-β receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-β receptor blocking agents. A novel screening method for selecting soluble receptors, antibodies and other agents that block LT-β receptor signalling is provided.

A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon.

The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.

The present invention relates to compositions and methods for inhibiting the activity of an enzyme, for example, Protein Kinase B, p70S6K and/or Abl using the catalytic subunit of Protein Kinase A (PKAc), or at least one PKAc fragment or variant PKAc fragment thereof. In this regard, methods for preventing or treating cancer or a neurodegenerative disease or disorder are also provided.