air News24 Business | TikTok billionaire becomes China's richest person By www.news24.com Published On :: Tuesday Oct 29 2024 11:05:06 ByteDance founder Zhang Yiming is China's richest person, with personal wealth of $49.3 billion (R872 billion), an annual rich list showed on Tuesday, although counterparts in real estate and renewables have fared less well. Full Article
air Why We Made a Home Air Purifier Part of Our Travel Lifestyle By vagabondish.com Published On :: Sat, 01 Aug 2020 18:05:40 +0000 A minimal design, compact size, and true HEPA filter make Sharp's FPK50UW Air Purifier an affordable clean-home solution for travelers. The post Why We Made a Home Air Purifier Part of Our Travel Lifestyle appeared first on Vagabondish. Full Article Modern Vagabond Review Air Purifier
air A.F. Branco Cartoon – DOJ vs Fair Elections By comicallyincorrect.com Published On :: Thu, 17 Oct 2024 12:00:27 +0000 A.F. Branco Cartoon – The DOJ is Suing Virginia over purging illegal registrations from their voter rolls. The Biden DOJ.. Full Article Political Cartoons DOJ
air On-Air Talent Will Not Be Spared as CNN Prepares Mass Layoffs in Wake of Election: Report By www.westernjournal.com Published On :: Tue, 12 Nov 2024 23:36:38 +0000 CNN reportedly will be making more cuts in the near future, including to its highly paid on-air personalities, following poor election ratings. The New York Post reported that Fox News […] The post On-Air Talent Will Not Be Spared as CNN Prepares Mass Layoffs in Wake of Election: Report appeared first on The Western Journal. Full Article News 2024 election CNN Entertainment Establishment media Liberal media Media bias Politics Television
air Sport | Here are the 3 candidates in line to replace Bill Beaumont as World Rugby chairman By www.news24.com Published On :: Wednesday Nov 13 2024 09:31:17 The race to succeed Bill Beaumont as chairman of World Rugby comes to a conclusion in a vote in Dublin at the governing body's headquarters on Thursday. Full Article
air The G20 will survive but needs major repair By www.chathamhouse.org Published On :: Tue, 15 Nov 2022 11:57:21 +0000 The G20 will survive but needs major repair Expert comment NCapeling 15 November 2022 Russia’s attack on Ukraine is the biggest challenge to the existence of the G20 since its foundation. The leader-level version of the G20 was founded in 2008 to coordinate the international response to the global financial crisis across advanced and major emerging economies. At the outset it was judged a great success. The 2009 London Summit demonstrated a high degree of unity among the world’s largest economies on a comprehensive action plan to tackle the crisis. The group’s subsequent performance has disappointed. Particularly during the pandemic and the Donald Trump presidency in the US, the group made only a limited additional contribution to policies which national governments were pursuing in any case. The existing G20 approach for tackling debt distress in low-income countries, the ‘Common Framework’, is progressing far too slowly Nonetheless, its members continued to see it as an essential forum without which it would be even harder to tackle a growing list of global economic challenges. This faith was partly repaid when, following the election of the Joe Biden administration in the US, agreement was reached on the $650 billion special drawing rights (SDR) general allocation by the International Monetary Fund (IMF) in summer 2021. Impact of the war in Ukraine Following Russia’s attack on Ukraine earlier this year, leading western members of the group called for Russia to be suspended from the G20 as Russia’s action ran directly against the key principles of the rules-based international system on which the G20 was founded. Western countries also walked out of meetings of the G20 Finance Ministers’ and International Monetary and Financial Committee this spring rather than sit at the same table as Russian representatives. This contrasted with 2014 when Russia was suspended indefinitely from the G7 for its takeover of Crimea but no action was taken against it in the G20. However, China and India, supported by several other emerging economies declined to suspend Russia, creating a standoff which could have resulted in a rapid collapse of the G20, particularly as its informal structure means that, in contrast to the international financial institutions (IFIs), there are no legal principles or procedures to determine how to address such a situation. It appears the West has now concluded (rightly) that the G20 is too important as a forum for working with China and the other major emerging economies to be allowed to disappear. This is likely to be because there are no straightforward alternatives. The G7 is too narrow to fill the role and China is now highly unlikely to attend a future G7 Summit as a guest. The boards of the IFIs are not equipped to coordinate across institutions, which is a vital role of the G20, and the United Nations (UN) system does not offer the scope, speed, leader-level engagement, or flexibility of the G20. Moreover, as evidenced by the chair’s summary of the third G20 Finance Ministers’ and Central Bank Governors’ meeting in July, once the group gets past the dispute over how to handle Russia, there is a worthwhile agenda of issues which can be agreed on. Russia is unlikely to play a disruptive role as preserving its membership of the group will be its key objective, and it will not want to undermine support among other emerging economies As the 2022 president of the G20, Indonesia has been determined to produce a final communique for the leaders’ summit and it looks increasingly like this will be achieved, even though it was impossible to agree concluding statements for some earlier G20 ministerial meetings. The key will be to deal with the differences over Ukraine between the West and emerging economies with a short opening paragraph reflecting both views. This would then be followed by a consensus text on all the areas where the two groups do agree. Russia is unlikely to play a disruptive role as preserving its membership of the group will be its key objective, and it will not want to undermine support among other emerging economies by blocking issues that all agree on. However, even with a final communique achieved, returning to a fully functioning agenda setting, coordination, and decision-making role for G20 will be very challenging, particularly while the war in Ukraine continues. Tackling sovereign debt distress should be a top priority There are critically important issues on which G20 action is urgently needed. Top of the list is the acute problem of sovereign debt distress. Some 60 per cent of low-income countries are now judged to be in debt distress or at high risk of debt distress. But the existing G20 approach for tackling debt distress in low-income countries, the ‘Common Framework’, is progressing far too slowly, and there is no agreed mechanism for handling the growing list of emerging economies in debt distress. Without tackling debt distress, it is extremely hard to see how it will be possible to generate the vast flow of private sector climate finance necessary to help the developing world progress to net zero. And yet the G20 is one of the few forums in which a high-level approach to debt distress can be defined because China – along with the IFIs and the western-based private sector – is a key player in any solution. Urgent repairs needed However, there is a critical lack of trust among G20 participants which, although in part a reflection of the disagreements over handling Russia, is also about longer-term factors such as the growing geopolitical tensions between China and the US on trade and investment in high tech. An example of how this has played out was the action China and India took at the Rome G20 Summit in 2021 in blocking Italy’s efforts to establish a new ministerial task force designed to address the threat of future pandemics – a subject which all G20 countries agree is important. Full Article
air Labour Party Conference – International affairs networking brunch By www.chathamhouse.org Published On :: Mon, 16 Sep 2024 10:32:13 +0000 Labour Party Conference – International affairs networking brunch 24 September 2024 — 11:00AM TO 12:00PM Anonymous (not verified) 16 September 2024 Labour – Grace 1 Suite, Hilton Hotel, Liverpool Hosted by Sir Simon Fraser, Chairman of Chatham House. This event is taking place at the Hilton Hotel, Grace 1 Suite, Liverpool. You are warmly invited to join us for an exclusive networking brunch at the 2024 Labour Party Conference.Sir Simon Fraser, Chairman of Chatham House, and Olivia O’Sullivan, Director of Chatham House’s UK in the World Programme, will deliver opening remarks, followed by an interactive networking session where you will have the chance to engage with a wide range of stakeholders. Join us to connect with key senior parliamentary, corporate and media attendees at the Labour Party Conference.This event will be taking place outside of the secure zone. Full Article
air Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP3Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gillespie syndrome, and generalized anhidrosis. However, how these mutations affect IP3R function, and how the perturbation of as-sociated calcium signals contribute to the pathogenesis and severity of these diseases remains largely uncharacterized. Moreover, many of these diseases occur as the result of autosomal dominant inheritance, suggesting that WT and mutant subunits associate in heterotetrameric channels. How the in-corporation of different numbers of mutant subunits within the tetrameric channels affects its activities and results in different disease phenotypes is also unclear. In this report, we investigated representative disease-associated missense mutations to determine their effects on IP3R channel activity. Additionally, we designed concatenated IP3R constructs to create tetrameric channels with a predefined subunit composition to explore the functionality of heteromeric channels. Using calcium imaging techniques to assess IP3R channel function, we observed that all the mutations studied resulted in severely attenuated Ca2+ release when expressed as homotetramers. However, some heterotetramers retained varied degrees of function dependent on the composition of the tetramer. Our findings suggest that the effect of mutations depends on the location of the mutation in the IP3R structure, as well as on the stoichiometry of mutant subunits assembled within the tetrameric channel. These studies provide insight into the pathogenesis and penetrance of these devastating human diseases. Full Article
air Reflections at 100: Women in international affairs By www.chathamhouse.org Published On :: Mon, 19 Dec 2022 10:52:02 +0000 Reflections at 100: Women in international affairs Audio MVieira 19 December 2022 How have women contributed to international relations? The last episode of Reflections at 100, marking the centenary of International Affairs, looks at women’s contributions to international thought. Isabel and Krisztina speak to Dr Katharina Rietzler about women’s contributions to the journal and international relations, especially in the UK. Then, Krisztina speaks to Professor Barbara Savage about Black women’s contributions to international relations in the US. To wrap up this episode, Leah de Haan sheds light on Chatham House’s Equality, Diversity and Inclusion (EDI) initiative and Jo Hills shares their thoughts about putting together the archive collections. Reflections at 100 is a mini-series accompanying the journal’s centenary Archive Collections. The collections bring together articles from our archive which speak to the past, present and future of current affairs issues. In each podcast episode, we speak to contributors from a specific collection and explore what the research tells us about policy-making today. Explore the Archive Collection freely until the end of December 2022, including Katharina’s introduction: 100 years of women in International Affairs.International Affairs was started at Chatham House in 1922 to communicate research to members who could not attend in person. Over the last 100 years it has transformed into a journal that publishes academically rigorous and policy relevant research. It is published for Chatham House by Oxford University Press. Read the latest issue here. Full Article
air Saturday Club introduces young people to international affairs By www.chathamhouse.org Published On :: Thu, 24 Feb 2022 17:15:53 +0000 Saturday Club introduces young people to international affairs News release jon.wallace 24 February 2022 Clubs will help 13-16 year-olds learn more about the forces that are shaping the world and discover how young people can influence the future. National Saturday Club and Chatham House are delighted to announce the launch of the Society&Change Saturday Club. This new programme creates opportunities for UK 13–16-year-olds to develop a global mindset and build awareness of trends that will shape the world in the coming decades. Three pilot Society&Change Clubs will be hosted by the University of Sussex, Manchester Metropolitan University, and the University of Huddersfield. Chatham House will provide speakers and generate ideas for the clubs. National Saturday Club gives 13–16-year-olds across the country the opportunity to study subjects they love at their local university, college or cultural institution, for free. Society&Change Club members will be introduced to a wide range of careers including policy making and diplomacy, advocacy, media and journalism, international trade and business, and the international development and humanitarian sector. Weekly classes will be led by led by professional tutors from the host institutions. Club members will also take part in masterclasses with industry professionals, as well as an end of year summer show and graduation ceremonies. Lucy Kennedy, Chief Executive of the Saturday Club Trust said: ‘We are delighted to be partnering with Chatham House to launch the Society&Change Saturday Club, the sixth subject within the National Saturday Club programme. Over the past 12 years, working nationally with 13–16-year-olds, we have seen that young people are eager to share their hopes and ideas for the future and address the issues the world faces. ‘We hope this new Saturday Club will empower them to shape their own futures and will bring the urgent voice of young people to international debate.’ Rose Abdollahzadeh, Managing Director for Research Partnerships at Chatham House said: ‘We are really excited about the potential for this partnership to encourage young people across the UK to explore their role in the world. The National Saturday Club network will also give Chatham House opportunities to harness the energy, ideas and passion of young people towards positive change. ‘By introducing Club members to contemporary debates on global issues and a range of professions in foreign policy and international relations, our hope is that some Club members will choose to follow a career path into this sector.’ Learn more about the Society&Change Saturday Club. Full Article
air Mark Carney to chair Chatham House senior advisers By www.chathamhouse.org Published On :: Tue, 17 May 2022 10:05:23 +0000 Mark Carney to chair Chatham House senior advisers News release NCapeling 17 May 2022 Former Bank of England Governor Mark Carney will succeed Sir John Major as chair of Chatham House’s Panel of Senior Advisers. Chatham House is pleased to announce Mark Carney will succeed Sir John Major as chair of the institute’s Panel of Senior Advisers. Chatham House senior advisers bring deep, first-hand experience of the policy and business worlds and use their experience, knowledge and networks to advise the institute’s research agenda and disseminate its policy ideas. Mark Carney is currently United Nations (UN) Special Envoy on Climate Action and Finance, UK prime minister Boris Johnson’s special finance adviser on COP26, as well as vice chairman and head of transition investing at Brookfield Asset Management. We are delighted to benefit from Mark Carney’s wealth of experience at the highest levels of decision-making on international financial policy, crisis management, and sustainability. Robin Niblett, director and chief executive of Chatham House He served as Governor of the Bank of England between 2013 and 2020 and as Governor of the Bank of Canada between 2008 and 2013. Robin Niblett, director and chief executive of Chatham House says: ‘We are delighted to benefit from Mark Carney’s wealth of experience at the highest levels of decision-making on international financial policy, crisis management, and sustainability. ‘His personal commitment to leveraging economic and finance policies to combat climate change aligns with a central plank of the institute’s mission to help governments and societies build a sustainable future. ‘I also want to thank Sir John Major for his invaluable advice and support through such a pivotal time in the institute’s history; we are delighted that he will retain an affiliation as a President Emeritus of Chatham House.’ Sir Nigel Sheinwald, chair of Chatham House, says: ‘Mark Carney is perfectly placed to lead the institute’s Panel of Senior Advisers and help ensure our research is focused on improving international relations in practical ways. ‘His experience and expertise will be of great value as the institute undertakes a leadership transition and welcomes Bronwen Maddox as its new director in the autumn. ‘The Chatham House council greatly appreciates Mark Carney’s engagement in our future success, as we do Sir John’s commitment to the institute these past thirteen years.’ Mark Carney says: ‘I have long respected Chatham House as one of the world’s leading independent institutes on international policy and am honoured to take up the reins from Sir John Major of chairing its eminent Panel of Senior Advisers. Alongside other members of the panel, I look forward to contributing to the relevance and impact of Chatham House’s important work.’ In addition to having been Governor of the Bank of England and the Bank of Canada, Mark Carney also chaired the Financial Stability Board from 2011 to 2018 and, in 2015, established the Task Force on Climate Related Financial Disclosures. In 2021, he launched the Glasgow Financial Alliance for Net Zero, to unite net-zero financial sector-specific alliances from across the world into one industry-wide strategic alliance. Chatham House established the Panel of Senior Advisers in 2009, under Sir John’s Major’s chairmanship, to support the institute in achieving its mission to build a sustainably secure, prosperous and just world. Individually and collectively, members of the panel support the institute in achieving its mission by advising on new topics for debate, offering input to the institute’s research, contributing to its private and public meetings, and disseminating the institute’s ideas across their networks. The panel does not have governance responsibilities, which reside fully with the Chatham House council. Full Article
air Undercurrents: Episode 10 - Artificial Intelligence in International Affairs, and Women Drivers in Saudi Arabia By f1.media.brightcove.com Published On :: Fri, 15 Jun 2018 00:00:00 +0100 Full Article
air Undercurrents: Episode 13 - India's Billionaires, and Sexual Exploitation in the UN By f1.media.brightcove.com Published On :: Thu, 26 Jul 2018 00:00:00 +0100 Full Article
air Undercurrents: Episode 17 - Alastair Campbell on New Labour and Brexit, Alistair Darling on the Financial Crisis By f1.media.brightcove.com Published On :: Thu, 20 Sep 2018 00:00:00 +0100 Full Article
air Evan Davis In Conversation With Sir Howard Davies, Chairman of RBS By f1.media.brightcove.com Published On :: Wed, 31 Oct 2018 00:00:00 +0000 Full Article
air Undercurrents: Bonus Episode - How Technology is Changing International Affairs By f1.media.brightcove.com Published On :: Mon, 20 May 2019 00:00:00 +0100 Full Article
air Tackling Toxic Air Pollution in Cities By f1.media.brightcove.com Published On :: Wed, 27 Nov 2019 00:00:00 +0000 Full Article
air MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling [Gene Regulation] By www.jbc.org Published On :: 2020-12-25T00:06:30-08:00 Evolving evidence suggests that nicotine may contribute to impaired asthma control by stimulating expression of nerve growth factor (NGF), a neurotrophin associated with airway remodeling and airway hyperresponsiveness. We explored the hypothesis that nicotine increases NGF by reducing lung fibroblast (LF) microRNA-98 (miR-98) and PPARγ levels, thus promoting airway remodeling. Levels of NGF, miR-98, PPARγ, fibronectin 1 (FN1), endothelin-1 (EDN1, herein referred to as ET-1), and collagen (COL1A1 and COL3A1) were measured in human LFs isolated from smoking donors, in mouse primary LFs exposed to nicotine (50 μg/ml), and in whole lung homogenates from mice chronically exposed to nicotine (100 μg/ml) in the drinking water. In selected studies, these pathways were manipulated in LFs with miR-98 inhibitor (anti-miR-98), miR-98 overexpression (miR-98 mimic), or the PPARγ agonist rosiglitazone. Compared with unexposed controls, nicotine increased NGF, FN1, ET-1, COL1A1, and COL3A1 expression in human and mouse LFs and mouse lung homogenates. In contrast, nicotine reduced miR-98 levels in LFs in vitro and in lung homogenates in vivo. Treatment with anti-miR-98 alone was sufficient to recapitulate increases in NGF, FN1, and ET-1, whereas treatment with a miR-98 mimic significantly suppressed luciferase expression in cells transfected with a luciferase reporter linked to the putative seed sequence in the NGF 3'UTR and also abrogated nicotine-induced increases in NGF, FN1, and ET-1 in LFs. Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1. Taken together, these findings demonstrate that nicotine-induced increases in NGF and other markers of airway remodeling are negatively regulated by miR-98. Full Article
air Total despair in Idlib By www.chathamhouse.org Published On :: Fri, 06 Mar 2020 16:19:34 +0000 Source Arab News URL https://www.arabnews.com/node/1631256 Release date 21 February 2020 Expert Haid Haid In the news type Op-ed Hide date on homepage Full Article
air Driving Up Air Pollution By www.ams.org Published On :: Tue, 28 Jun 2022 10:38:14 -0400 Karen Rios Soto explains how mathematics illuminates the link between air pollution from motor vehicle emissions and asthma. Air pollution causes the premature deaths of an estimated seven million people each year, and it makes life worse for all of us. People with asthma can experience chest tightness, coughing or wheezing, and difficulty breathing when triggered by air pollution. One major source is gas- and diesel-powered cars and trucks, which emit "ultrafine" particles less than 0.1 micrometers across. That's about the width of the virus that causes COVID-19, so tiny that these particles are not currently regulated by the US Environmental Protection Agency. Yet ultrafine particles can easily enter your lungs and be absorbed into your bloodstream, causing health issues such as an asthma attack or even neurodegenerative diseases. Mathematics can help us understand the extent of the problem and how to solve it. Full Article
air Key polynomials and preminimal pairs By www.ams.org Published On :: Fri, 08 Nov 2024 14:08 EST Yu. L. Ershov St. Petersburg Math. J. 35 (), 461-465. Abstract, references and article information Full Article
air COMAC says Air China is the first customer for C929 widebody jet By finance.yahoo.com Published On :: 2024-11-12T04:03:58Z Full Article
air Vietnam Airlines to request bids for 50 narrowbody jets next year By finance.yahoo.com Published On :: 2024-11-13T05:54:37Z Full Article
air Haiti's main airport and capital frozen after a day of violence By jamaica-star.com Published On :: Tue, 12 Nov 2024 12:00:31 -0500 PORT-AU-PRINCE, Haiti (AP) — Haiti's main airport remained closed on Tuesday, a day after violence erupted as the country swore in its new prime minister in a politically tumultuous transition. Full Article
air Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease [Research Articles] By www.jlr.org Published On :: 2020-10-01T00:05:17-07:00 Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates S1P, has been shown to increase in liver and adipose of obese humans and mice and to regulate inflammation in hepatocytes and adipose tissue, insulin resistance, and systemic inflammation in mouse models of obesity. Previous studies by us and others have demonstrated that global sphingosine kinase 1 KO mice are protected from diet-induced obesity, insulin resistance, systemic inflammation, and NAFLD, suggesting that SPHK1 may mediate pathological outcomes of obesity. As adipose tissue dysfunction has gained recognition as a central instigator of obesity-induced metabolic disease, we hypothesized that SPHK1 intrinsic to adipocytes may contribute to HFD-induced metabolic pathology. To test this, we depleted Sphk1 from adipocytes in mice (SK1fatKO) and placed them on a HFD. In contrast to our initial hypothesis, SK1fatKO mice displayed greater weight gain on HFD and exacerbated impairment in glucose clearance. Pro-inflammatory cytokines and neutrophil content of adipose tissue were similar, as were levels of circulating leptin and adiponectin. However, SPHK1-null adipocytes were hypertrophied and had lower basal lipolytic activity. Interestingly, hepatocyte triacylglycerol accumulation and expression of pro-inflammatory cytokines and collagen 1a1 were exacerbated in SK1fatKO mice on a HFD, implicating a specific role for adipocyte SPHK1 in adipocyte function and inter-organ cross-talk that maintains overall metabolic homeostasis in obesity. Thus, SPHK1 serves a previously unidentified essential homeostatic role in adipocytes that protects from obesity-associated pathology. These findings may have implications for pharmacological targeting of the SPHK1/S1P signaling axis. Full Article
air Comment se débarrasser des glaires coincées dans la gorge ? By www.orthodfr.org Published On :: Fri, 26 Jul 2024 07:52:46 +0000 Gêne constant, difficulté à respirer : avez-vous une impression de glaires coincées dans la gorge actuellement ? Cette impression peut être due à plusieurs facteurs parfois bénignes mais aussi graves. Fort heureusement, il existe quelques astuces naturelles qui vous permettront d’avoir un soulagement en attendant de consulter un médecin ORL. Mais avant, l’impression de glaires coincées dans la gorge est […] L’article Comment se débarrasser des glaires coincées dans la gorge ? est apparu en premier sur Ortho Doc France. Full Article Santé
air Quels sont les effets secondaires de seroplex ? By www.orthodfr.org Published On :: Fri, 02 Aug 2024 09:39:45 +0000 Les médicaments utilisés pour le traitement des troubles mentaux peuvent avoir des effets secondaires plus ou moins graves sur la santé des patients. C’est le cas de seroplex, un médicament largement utilisé comme traitement dans le domaine de la santé mentale. Mais en réalité, quelle est la composition de ce médicament et quels sont ses […] L’article Quels sont les effets secondaires de seroplex ? est apparu en premier sur Ortho Doc France. Full Article Santé
air Croq’Kilos : programme minceur, rééquilibrage alimentaire By www.orthodfr.org Published On :: Tue, 29 Oct 2024 15:18:06 +0000 Pour de nombreuses personnes, perte de poids rime obligatoirement avec privations. Et si vous appreniez aujourd’hui que vous pouvez perdre efficacement vos kilos en trop sans pour autant vous priver excessivement ? De nombreux programmes minceur et de rééquilibrage, notamment Croq’kilos offrent ce genre d’alternative. Mais de quoi s’agit-il réellement ? C’est quoi Croq’Kilos ? Croq’Kilos […] L’article Croq’Kilos : programme minceur, rééquilibrage alimentaire est apparu en premier sur Ortho Doc France. Full Article Minceur
air Centenary Series: Exploring the International Affairs Archive By www.chathamhouse.org Published On :: Mon, 14 Sep 2020 09:18:37 +0000 Centenary Series: Exploring the International Affairs Archive dora.popova 14 September 2020 International Affairs has been a central part of the institute’s history, both as a record of speeches made by dignitaries such as Mahatma Gandhi and Henry Kissinger, and as a forum for policy-relevant academic research. Delving into the International Affairs archive brings out stories behind some of the most significant players of the last century. Full Article
air Gender, think-tanks and international affairs: A toolkit By www.chathamhouse.org Published On :: Tue, 09 Feb 2021 15:02:41 +0000 Gender, think-tanks and international affairs: A toolkit Other resource NCapeling 9 February 2021 Encouraging a more gender-sensitive approach for think-tank activities such as convening and debate, research and analysis, and communications and publishing. Compiled by staff at Chatham House, the Centre for Feminist Foreign Policy and the British American Security Information Council, the toolkit provides think-tanks with guidance on ways of adapting organizational structures, activities and practices in order to embed greater awareness of gender issues and adopt gender-sensitive approaches throughout their work. The toolkit is designed for all people working in international affairs think-tanks, regardless of role, experience or level of seniority. It will be particularly useful for those think-tanks that are just beginning the process of raising greater awareness of gender issues internally, as well as for those that have already begun to make changes but wish to expand this work further. The work to develop the toolkit came as a response to the commonly gendered nature of think-tanks and their activities. The toolkit recognizes the discrimination and under-representation that women often experience within the sector, as well as the relative absence of women among executive leadership, governance structures and senior researcher positions in many think-tanks. The toolkit’s focus on gender is a starting point for wider intersectional analysis and action within the think-tank community. Embedding inclusive research, convening and communication practices is not just ‘the right thing to do’. When diversity and inclusion initiatives succeed, organizations are more resilient, innovative and better at decision-making. While there has already been incremental change within think-tanks, the toolkit’s authors intend that their work will build on the important body of research and practices that already exist by encouraging think-tanks to examine their own processes and develop ways of working that focus not just on women’s representation, but on the structures and systems that perpetuate biases and inequalities. Gender, think-tanks and international affairs: a toolkit (PDF) Full Article
air 100 years of International Affairs By www.chathamhouse.org Published On :: Wed, 01 Mar 2023 08:00:00 +0000 100 years of International Affairs Other resource dora.popova 1 March 2023 Charting a century of key moments in international relations and International Affairs. International Affairs was created to be a record of speeches given by visiting dignitaries at Chatham House. Over the last 100 years, the journal has evolved into an independent academic journal publishing work of the highest quality. On the fringes of the Paris peace conference Lionel Curtis called for an organization whose purpose would be to foster mutual understanding of and between nations. Chatham House was established in 1920 and for much of the time since, International Affairs has been a central part of the institute’s publishing output. As such, for most of its history, contributions to the journal have reflected the prevailing attitudes of the time, both in terms of who was published and the content of their work. Perhaps the most important change over the last century has been the increasing diversity of voices and perspectives published in IA’s pages. Today, as the journal enters its second century, it publishes authors from across the globe. Yet the editorial team is all too aware there is still much to do. Keep reading to explore the journal’s history and to find out more about our second century. The drawings in this timeline were commissioned by the International Affairs team from Sequential Potential Comics. Full Article
air Mycobacteria excise DNA damage in 12- or 13-nucleotide-long oligomers by prokaryotic-type dual incisions and performs transcription-coupled repair [Genomics and Proteomics] By www.jbc.org Published On :: 2020-12-11T00:06:21-08:00 In nucleotide excision repair, bulky DNA lesions such as UV-induced cyclobutane pyrimidine dimers are removed from the genome by concerted dual incisions bracketing the lesion, followed by gap filling and ligation. So far, two dual-incision patterns have been discovered: the prokaryotic type, which removes the damage in 11–13-nucleotide-long oligomers, and the eukaryotic type, which removes the damage in 24–32-nucleotide-long oligomers. However, a recent study reported that the UvrC protein of Mycobacterium tuberculosis removes damage in a manner analogous to yeast and humans in a 25-mer oligonucleotide arising from incisions at 15 nt from the 3´ end and 9 nt from the 5´ end flanking the damage. To test this model, we used the in vivo excision assay and the excision repair sequencing genome-wide repair mapping method developed in our laboratory to determine the repair pattern and genome-wide repair map of Mycobacterium smegmatis. We find that M. smegmatis, which possesses homologs of the Escherichia coli uvrA, uvrB, and uvrC genes, removes cyclobutane pyrimidine dimers from the genome in a manner identical to the prokaryotic pattern by incising 7 nt 5´ and 3 or 4 nt 3´ to the photoproduct, and performs transcription-coupled repair in a manner similar to E. coli. Full Article
air Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination [Cell Biology] By www.jbc.org Published On :: 2020-12-18T00:06:18-08:00 Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products. A mismatch repair factor, MLH3 endonuclease, produces the majority of crossovers during meiotic HR, but it remains elusive whether mismatch repair factors promote HR in nonmeiotic cells. We disrupted genes encoding the MLH3 and PMS2 endonucleases in the human B cell line, TK6, generating null MLH3−/− and PMS2−/− mutant cells. We also inserted point mutations into the endonuclease motif of MLH3 and PMS2 genes, generating endonuclease death MLH3DN/DN and PMS2EK/EK cells. MLH3−/− and MLH3DN/DN cells showed a very similar phenotype, a 2.5-fold decrease in the frequency of heteroallelic HR-dependent repair of restriction enzyme–induced double-strand breaks. PMS2−/− and PMS2EK/EK cells showed a phenotype very similar to that of the MLH3 mutants. These data indicate that MLH3 and PMS2 promote HR as an endonuclease. The MLH3DN/DN and PMS2EK/EK mutations had an additive effect on the heteroallelic HR. MLH3DN/DN/PMS2EK/EK cells showed normal kinetics of γ-irradiation–induced Rad51 foci but a significant delay in the resolution of Rad51 foci and a 3-fold decrease in the number of cisplatin-induced sister chromatid exchanges. The ectopic expression of the Gen1 HJ re-solvase partially reversed the defective heteroallelic HR of MLH3DN/DN/PMS2EK/EK cells. Taken together, we propose that MLH3 and PMS2 promote HR as endonucleases, most likely by processing JMs in mammalian somatic cells. Full Article
air Long term aircraft noise is linked to incidence of high blood pressure By www.bmj.com Published On :: Wednesday, June 14, 2017 - 05:33 Full Article
air Former chair of BMA GP Committee wins right to tribunal for unfair dismissal By www.bmj.com Published On :: 2024-11-12T01:31:10-08:00 An employment judge has cleared the way for Farah Jameel, a former chair of the BMA’s General Practitioners Committee for England (GPCE), to go ahead with claims of discrimination and unfair dismissal against the association over her removal from the post during maternity leave.Jameel, who was elected the first female chair in November 2021, was put on temporary suspension in 2022 after complaints by BMA staff. The BMA told her in August 2023 that her contract was being terminated.The contract described her as a contractor providing consultancy services rather than an employee. But in a preliminary ruling the employment judge Natasha Joffe has held that Jameel was in reality an office holder and an employee, opening the way for her claims to proceed to a full hearing by an employment tribunal.The GPCE passed a vote of no confidence in Jameel in July 2023, as a means of electing a new... Full Article
air Amazon starts air drone deliveries near Phoenix By www.upi.com Published On :: Tue, 05 Nov 2024 14:08:24 -0500 Amazon Prime Air drone deliveries are underway and delivering small packages within an hour in the West Valley of the Phoenix metro area. Full Article
air At least 56 people, including 20 children, killed in Israeli airstrikes in Lebanon and Gaza By www.upi.com Published On :: Mon, 11 Nov 2024 12:20:12 -0500 Dozens of people were killed in Israeli military strikes on northern Lebanon and the Gaza strip, including as many as 20 children, authorities said. Full Article
air Spirit Airlines flight hit by bullets while flying over gang-war region of Haiti By www.upi.com Published On :: Mon, 11 Nov 2024 17:42:04 -0500 A flight of Florida-based Spirit Airlines was hit by gunfire while attempting to land in Haiti with a crew member that sustained "minor injuries." Full Article
air Malfunctioning B-2 bomber damaged during landing at Missouri Air Force base By www.upi.com Published On :: Thu, 16 Sep 2021 15:23:16 -0400 A B-2 Spirit stealth bomber made an emergency landing at Whiteman Air Force Base in Missouri earlier this week after the high-tech aircraft malfunctioned during a training flight. Full Article
air Air Force secretary: Branch focused on confronting China, must retire old platforms By www.upi.com Published On :: Mon, 20 Sep 2021 15:58:29 -0400 Air Force Secretary Frank Kendall said the branch is looking toward confronting China, as well as unity in its ranks, and added that the service needs to retire older aircraft and programs -- and focus on ones that work. Full Article
air Air Force Special Operations looking to test amphibious MC-130J in 2022 By www.upi.com Published On :: Mon, 20 Sep 2021 17:51:07 -0400 Air Force Special Operations aims to test the MC-130J Hercules transport aircraft's amphibious capability in 2022, the commander said Monday. Full Article
air U.S. Air Force seeing ‘good progress’ on new B-21 Raider stealth bombers By www.upi.com Published On :: Tue, 21 Sep 2021 13:02:09 -0400 An arms contractor is making "good progress" on the production of five B-21 Raider stealth bombers, U.S. Air Force Secretary Frank Kendall disclosed during a speech on Monday. Full Article
air Four Marines remain hospitalized month after suicide bombing at Afghan airport By www.upi.com Published On :: Fri, 24 Sep 2021 12:13:49 -0400 Four U.S. Marines remain hospitalized after an attack near Hamid Karzai International Airport in Kabul, Afghanistan, last month as service members were evacuating foreign nationals and refugees. Full Article
air AlmaLinux OS Foundation Chair to Discuss Embracing Diversity in Open Source at SC24 By www.hpcwire.com Published On :: Thu, 07 Nov 2024 14:00:42 +0000 FORT MYERS, Fla., Nov. 7, 2024 — The AlmaLinux OS Foundation, the nonprofit that stewards the free and community-governed open source enterprise Linux distribution, today announced that chair benny Vasquez is […] The post AlmaLinux OS Foundation Chair to Discuss Embracing Diversity in Open Source at SC24 appeared first on HPCwire. Full Article
air Repairs to Tampa Bay Rays' Tropicana Field from Hurricane Milton put at $55.7 million By www.upi.com Published On :: Tue, 12 Nov 2024 17:27:58 -0500 It will cost $55.7 million to repair Tropicana Field, home to the MLB Tampa Bay Rays, in time for the 2026 home opener, St. Petersburg., Fla., city officials said Tuesday. Full Article
air Altair’s HPC and Simulation Solutions Advance Motivo’s Aerospace Prototyping By www.hpcwire.com Published On :: Fri, 18 Oct 2024 03:48:32 +0000 TROY, Mich., Oct. 17, 2024 — Altair, a global leader in computational intelligence, is proud to announce its collaboration with Motivo, a product engineering firm for clients in the mobility, […] The post Altair’s HPC and Simulation Solutions Advance Motivo’s Aerospace Prototyping appeared first on HPCwire. Full Article
air Motivair to Showcase MI300X Cold Plates at SC24 for AI Servers By www.hpcwire.com Published On :: Mon, 11 Nov 2024 14:36:49 +0000 BUFFALO, N.Y., Nov. 11, 2024 — Motivair Corporation, a leading global provider of advanced liquid cooling solutions, will be showcasing its cutting-edge MI300X Dynamic Cold Plates at the upcoming International […] The post Motivair to Showcase MI300X Cold Plates at SC24 for AI Servers appeared first on HPCwire. Full Article
air Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation By www.hpcwire.com Published On :: Wed, 13 Nov 2024 02:57:36 +0000 TROY, Mich., Nov. 12, 2024 — Altair, a global leader in computational intelligence, has entered into collaboration agreement with the European Space Agency (ESA) through the ESA Partnership Initiative for […] The post Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation appeared first on HPCwire. Full Article
air Kevin Costner didn't know about 'Yellowstone' character's death until it aired By www.upi.com Published On :: Tue, 12 Nov 2024 08:22:15 -0500 Kevin Costner says he didn't know about his "Yellowstone" character John Dutton's death until after the episode aired on Sunday. Full Article
air Former Air National Guardsman Jack Teixeira sentenced to 15 years for documents leak By www.upi.com Published On :: Tue, 12 Nov 2024 18:16:18 -0500 A federal judge on Tuesday sentenced former Massachusetts Air National Guardsman Jack Teixeira to 15 years in prison for stealing classified information and sharing it online. Full Article