NASA engineers fired the engines on the X-59 research aircraft in advance of planned test flights to determine if the aircraft can reduce sonic booms and make supersonic flight over land quieter.

After the midterm elections, Oklahoma teacher Amanda Becker reflects on the future of teacher activism in the state.

"I'm running because I'm not happy with the state of education," said veteran educator Kevin Leineweber, who is one of several teachers running for the state's legislature this year.

The daughter of Hmong refugees was an outspoken advocate for minority communities. She was elected to the St. Paul, Minn., school board in 2017.

Georgia football tumbled nine spots in the College Football Playoff rankings Tuesday and fell out of the 12-team bracket. What committee chair said

Cochlear hair cells (HCs) sense sound waves and allow us to hear. Loss of HCs will cause irreversible sensorineural hearing loss. It is well known that DNA damage repair plays a critical role in protecting cells in many organs. However, how HCs respond to DNA damage and how defective DNA damage repair contributes to hearing loss remain elusive. In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin induced the expression of Brca1, a DNA damage repair factor, in OHCs. Deficiency of Brca1 induced OHC and hearing loss, and further promoted cisplatin-induced DNA damage in OHCs, accelerating OHC loss. This study provides the first in vivo evidence demonstrating that cisplatin mainly induces DNA damage in OHCs and that BRCA1 promotes repair of DNA damage in OHCs and prevents hearing loss. Our findings not only demonstrate that DNA damage–inducing agent generates DNA damage in postmitotic HCs but also suggest that DNA repair factors, like BRCA1, protect postmitotic HCs from DNA damage–induced cell death and hearing loss.

The capabilities of the human ear are remarkable. We can normally detect acoustic stimuli down to a threshold sound-pressure level of 0 dB (decibels) at the entrance to the external ear, which elicits eardrum vibrations in the picometer range. From this threshold up to the onset of pain, 120 dB, our ears can encompass sounds that differ in power by a trillionfold. The comprehension of speech and enjoyment of music result from our ability to distinguish between tones that differ in frequency by only 0.2%. All these capabilities vanish upon damage to the ear's receptors, the mechanoreceptive sensory hair cells. Each cochlea, the auditory organ of the inner ear, contains some 16,000 such cells that are frequency-tuned between ~20 Hz (cycles per second) and 20,000 Hz. Remarkably enough, hair cells do not simply capture sound energy: they can also exhibit an active process whereby sound signals are amplified, tuned, and scaled. This article describes the active process in detail and offers evidence that its striking features emerge from the operation of hair cells on the brink of an oscillatory instability—one example of the critical phenomena that are widespread in physics.

Q: Ambassador, how did the Programme Committee in its recent session judge FAO's contribution to the eradication of hunger, food insecurity and malnutrition?

Ambassador Hoogeveen: [...]

Take a calming breath, then watch this video to find out

To find out, we need to get down to the basics. Eric Schulze explains

The first plane to fly nonstop from New York to Paris will reside on the ground level of the National Air and Space Museum for the next five months as it undergoes preservation (Courtesy of the National Air and Space Museum)

http://j.mp/196BLpQ From her salon in Maryland, Camille Reed sees more black women embracing natural hair

Take in the sights and sounds of the European influences of Argentina's capital city (Produced by: Brendan McCabe). Read more at: https://www.smithsonianmag.com/travel/daniel-politi-on-hola-buenos-aires-138874294/

The photographer talks about what he aims for in his shots of industrial scars on the American landscape. Read more at http://www.smithsonianmag.com/science-nature/Devastation-From-Above.html.

But at speeds nearing 100 mph, there's a fine line between helping and hurting

The discovery has implications for human health, since the microbes included some that were still viable, some that could be infectious to humans and others that carried drug-resistant genes

No one was injured in the blast, and authorities are investigating why the ordnance detonated after so many years underground

The two artifacts donated by Blue Origin achieved record-breaking feats and will extend the museum's story of trailblazing space travel into the present

The success is a giant leap toward the company's goal to take humans and cargo all the way to Mars on the world's biggest and most powerful launch vehicle

It's not the first time savvy entrepreneurs have marketed canned air to tourists. Similar products have been sold at vacation destinations for decades

These grounded planes in the Congo have captured the imagination of these children

The A.C. Hunter Public Library wants people in St. John’s to know that it’s open and accessible, despite how the entrance looks. The main staircase is under repair but there’s plenty of signs directing folks to other entrances. Still, librarians say people are judging this book by its cover and assuming the library is closed.

Pat White, an entrepreneur who launched EVAS Air and the Gander Flight Training, has died. He was 69 years old.

Volunteers will be cutting hair at a salon based inside a Cape Breton food bank. The goal is to provide clients with the same salon experience paying customers would receive.

Families of Norton Elementary School won’t be seeing their kids return anytime soon. Repairs are going to take longer than expected and students are expected to be back in the school by the start of the next school year.

Atlantic salmon returns were at their lowest level ever this year, say researchers, who are nevertheless refusing to give up hope that the population can rebound.

An intimate look at the lessons and legacy of Murray Sinclair, chair of the Truth and Reconciliation Commission, and how he changed Canada.

The United States took the lead in the pairs and ice dance on the first day of the Four Continents figure skating championships on Thursday, and Japan's Mai Mihara led the women's event.

A federal judge sentenced a Massachusetts Air National Guard member to 15 years in prison Tuesday for leaking classified military documents about the war in Ukraine, actions prosecutors said put the country's national security at risk, endangered other military members and damaged U.S. relationships with its allies.

The cancellation of the mixed doubles curling trials has generated a wide variety of emotions among players — illuminating a handful of issues, particularly about scheduling and the selection process as a whole.

Chief Financial Officer Lynne Fitzpatrick Appointed to President and CFO Chief Operating Officer Julie Holzrichter to Step Down and Assume Advisory Role Suzanne Sprague to Succeed Holzrichter CHICAGO,

SolidWorks Drives Custom 3D CAD Models, Helping the Company Outperform Competition

Island Sky invents green humanitarian solution using SolidWorks 3D CAD and Simulation software

New design increases user leverage and mobility, and keeps hands clean

Electronics air filter manufacturer sees dramatic 30 percent increase in Web site traffic, reduces customer product development by two months

Pneumatic product manufacturer sees more than 80 percent increase in 3D model downloads in first two months

U.K. firm designs smaller scale, more affordable custom test rigs for companies like Rolls Royce to help meet new regulations

Jewers Doors switched to SolidWorks to design products that enclose the world's largest hangars, protect against explosions at weapons depots, and mute sound at large plants

3D CAD and analysis products help Groen Brothers Aviation, Inc. develop advanced gyroplanes and gyrodynes for recreational, law enforcement, commercial, and military uses

3D CAD software lets U.K. firm compete with engineering departments 50 times its size to develop air brake systems for John Deere, Massey Ferguson, and Case

Designed and Tested in SOLIDWORKS and SOLIDWORKS Simulation, Each Reee Chair Made of Plastic From Nine Recycled Game Consoles

Team ETHOS Uses SolidWorks Design and Simulation for Punkin’ Chunkin’ World Championship

3DVision Helps Leading Ventilation Manufacturer Visualize Air Flow, Saving Time and Money

Gustavo Nader, professor of kinesiology and physiology in the Penn State College of Health and Human Development, has been named the Dorothy Foehr Huck and J. Loyd Huck Chair in Molecular, Cellular and Integrative Physiology by the Huck Institutes of the Life Sciences. 

Repair parts for the iPhone 16 lineup are now available to order in the US and other countries, including for those wanting to fix their iPhone for themselves.

Apple's 1TB M4 MacBook Pro 14-inch is eligible for a material early Black Friday discount at Amazon, along with savings on the 2024 Mac mini M4 and a record low price on the 13-inch MacBook Air 16GB.

The lowest prices of the year are here well before Black Friday, with MacBook Air models with 16GB RAM dropping to as low as $749.99.

Apple's update for Find My in iOS 18.2 will let users share the location of AirTags with other people, which could help airlines track down your lost luggage faster.