id Palladium-catalyzed (Z)-selective allylation of phosphine oxides with vinylethylene carbonates to construct phosphorus allyl alcohols By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3068-3072DOI: 10.1039/D4OB00354C, PaperHua Huang, Yi-Qi Wu, Lu-Yao Han, Lu Jiang, Zhuo-Zhuo Zhang, Xiang Zhang, Bo Han, Wei Huang, Jun-Long LiA general and efficient method for the highly stereoselective synthesis of (Z)-phosphorus allylalcohols has been developed using the Pd-catalyzed cross-coupling of phosphine oxides with vinylethylene carbonates.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2974-2977DOI: 10.1039/D4OB00278D, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthew Nutter, Henry Stone, Michael Shipman, Stefan RoesnerStereoselective synthesis of both enantiomers of orthogonally protected 1,2-diazetidine-3-carboxylic acid (aAze) from homochiral glycidol and its application in peptidomimetics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3025-3034DOI: 10.1039/D4OB00279B, PaperJouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale ClivioEvidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Iron-catalyzed selective construction of indole derivatives via oxidative C(sp3)–H functionalization of indolin-2-ones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3073-3079DOI: 10.1039/D4OB00133H, PaperWei Chen, Lang-Qi Wen, Xiao-Bing Lu, Hui ZhouWe have developed a clean and efficient iron-catalyzed C(sp3)–H functionalization of indolin-2-ones for the chemodivergent synthesis of value-added indole derivatives, including isatins, and symmetrical and non-symmetrical isoindigos.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Direct access to pyrrole anhydrides via oxidative self-coupling of pyrrole carboxaldehydes By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3045-3052DOI: 10.1039/D4OB00052H, PaperSurabhi Panday, Tapas Maity, Pratibha Bhatti, Joydev K. LahaAn elegant synthesis of pyrrole-2-carboxylic acid anhydrides from pyrrole-2-carboxaldehydes using TBAI as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant is described herein.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Exploring the mechanism of the reductive amination of acetophenones via Borch approach: the role of the acid catalyst By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00160E, PaperJoão Pedro Albuquerque Souza, Amanda Krauskopf Jacobs, Leandro Piovan, Renan Borsoi CamposThe energetic viability of several mechanistic variations of the reductive amination of acetophenones via the Borch approach was reexamined through density functional theory calculations. The crucial involvement of the acid...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id 3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00391H, CommunicationAlexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov3-Halo-1,2-oxazine N-oxide derivatives act as surrogates of vinyl nitrile oxides in tandem [3 + 2]-cycloaddition/[3 + 2]-cyclofragmentation with arynes leading to benzisoxazoles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00240G, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. FalconerHerein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess–Martin periodinane oxidising agent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00432A, PaperPeng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00040D, PaperSidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar AhmedDespite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00015C, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. MendesAn effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Recent developments in the enzymatic modifications of steroid scaffolds By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00327F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Huibin Wang, Ikuro AbeThis review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00302K, CommunicationQiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo ZhaoThe aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00315B, PaperShoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang HuangA series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00479E, CommunicationCao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh NguyenA cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00348A, PaperYong-Xiang Lü, Xinqian Wang, Ying-Ming Pan, Keyume AblajanA method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Deep tech is helping airlines sustain operations during Covid By www.thehindubusinessline.com Published On :: Mon, 24 Jan 2022 09:51:21 +0530 Integrated biometric-enabled frameworks for real-time test results, travel details and vaccine status are key to making air travel safe Full Article Flight Plan
id Corporate travel is unlikely to reach pre-Covid levels By www.thehindubusinessline.com Published On :: Sun, 03 Apr 2022 18:42:20 +0530 However, with offices opening up, many airlines are seeing increased demand with an uptick for premium cabins Full Article Flight Plan
id The art of avoiding accidents in air By www.thehindubusinessline.com Published On :: Sun, 10 Jul 2022 16:52:28 +0530 Flying distance may vary based on flight phases, altitudes and regions Full Article Flight Plan
id Yoke vs. sidestick: Jury still out on what works best for pilots By www.thehindubusinessline.com Published On :: Sun, 24 Jul 2022 21:00:00 +0530 Why do Airbus commercial aircraft have sidesticks and Boeing have yokes as control units? Full Article Logistics
id Why opening the emergency door mid-flight is not possible By www.thehindubusinessline.com Published On :: Sun, 16 Oct 2022 21:00:00 +0530 Full Article Flight Plan
id Boeing bids farewell to ‘Queen of the skies’ By www.thehindubusinessline.com Published On :: Sun, 05 Feb 2023 21:00:00 +0530 The first Boeing 747 took off from New York on Jan 22, 1970 and now the final 747 freighter was delivered to Atlas Air on February 1, 2022. Full Article Logistics
id Apple AirPods Pro’s new hearing aid feature could help people face a problem they’d rather ignore By www.thehindu.com Published On :: Tue, 29 Oct 2024 08:47:33 +0530 Millions who could benefit from hearing aids have never tried them, but the Apple AirPods could change this Full Article Technology
id Instagram downgrades quality of less popular videos By www.thehindu.com Published On :: Tue, 29 Oct 2024 11:38:32 +0530 Last year, Meta had admitted in a blog to having separate encoding configurations for different videos based on how popular they were Full Article Technology
id Jio’s Diwali Dhamaka plan offers year-long prepaid plan for ₹3,599 By www.thehindu.com Published On :: Tue, 29 Oct 2024 13:14:07 +0530 Jio is offering a prepaid plan of 2.5 GB of data per day for an entire year, priced at₹3,599, as part of a Diwali offer Full Article Technology
id Crypto firm Consensys to cut 20% of workforce amid macroeconomic, regulatory headwinds By www.thehindu.com Published On :: Wed, 30 Oct 2024 11:42:41 +0530 The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment” Full Article Technology
id Perplexity AI CEO says “still haven’t gotten” a green card amid immigration debate ahead of U.S. Presidential Election 2024 By www.thehindu.com Published On :: Fri, 01 Nov 2024 16:12:23 +0530 Srinivas went on to work with OpenAI for a year before co-founding Perplexity AI in 2022 Full Article Technology
id I Didn’t Realize How Much I Rely on GitHub Codespaces Until This week By htmlcssjavascript.com Published On :: Wed, 10 Apr 2024 16:15:24 +0000 How much do I rely on GitHub Codespaces for open source development? Super double-plus much. I can illustrate exactly how much with one short anecdote. Gulp 5 was recently released and I created several PRs across repos in the H5BP organization to update Gulp across the board. I missed one issue with the encoding of […] Full Article HTML JavaScript github h5bp
id Rapid assessment of pulse polio campaign shows high vaccine coverage, highlights gaps in Chennai By www.thehindu.com Published On :: Tue, 22 Oct 2024 15:41:02 +0530 Chennai accounted for nearly 21% of the non-vaccinated children, highlighting the gaps in an urban area and the need for targeted community outreach Full Article Chennai
id Should men be allowed into operation theatres when their wives are having a baby? Doctors weigh in after YouTuber’s video sparks controversy By www.thehindu.com Published On :: Tue, 22 Oct 2024 21:52:17 +0530 YouTuber Irfan recently posted a video on social media that showed him cutting the umbilical cord of his newborn, in the operation theatre of a private hospital in Chennai; consent of the medical personnel involved to being videoed was another aspect doctors say needs discussion Full Article Health
id Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained By www.thehindu.com Published On :: Wed, 23 Oct 2024 14:26:23 +0530 India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy Full Article Health
id Why did the Centre sanction a 50% hike in prices of commonly-used drugs? By www.thehindu.com Published On :: Fri, 25 Oct 2024 06:00:00 +0530 According to the government the recent 50% hike in prices of eight drugs was sanctioned keeping in mind the larger public interest and to ensure continued availability of drugs Full Article Health
id Covid lessons learned? U.N. summit mulls plan for healthy planet, and humans By www.thehindu.com Published On :: Sat, 26 Oct 2024 16:41:39 +0530 At the U.N. summit in Cali, delegates are working on a “biodiversity and health action plan” proposed for adoption by the 196 member nations of the Convention on Biological Diversity Full Article Health
id Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies By www.thehindu.com Published On :: Sun, 27 Oct 2024 12:06:33 +0530 Global efforts to understand and manage long Covid post-pandemic, with varied symptoms and limited treatment guidelines worldwide Full Article Health
id OpenAI’s Whisper transcription tool used in hospitals invents things no one ever said, researchers claim By www.thehindu.com Published On :: Mon, 28 Oct 2024 08:21:00 +0530 Whisper is a popular transcription tool powered by artificial intelligence, but it has a major flaw Full Article Technology
id Bridging the gap in mental healthcare services: NGOs launch dementia clinics in Hyderabad’s slums By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:10 +0530 India continues to grapple with a dearth of mental healthcare services, even as the number of persons with dementia is expected to rise over the next two decades Full Article Hyderabad
id COVID-19 resulted in nearly half a million excess deaths, WHO’s global TB report states By www.thehindu.com Published On :: Tue, 29 Oct 2024 22:45:16 +0530 Thirty high TB burden countries accounted for 87% of the world’s TB cases in 2022 and two-thirds of the global total was in eight countries including India Full Article Health
id AIIMS-Bibinagar to boost tuberculosis care in Telangana with aerial aid By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:04:31 +0530 Inaugurated virtually by Prime Minister Narendra Modi, the drone service is part of a series of health projects designed to enhance access to essential services in remote and underserved areas Full Article Telangana
id As breast cancer incidence rises, doctors raise importance of early detection, need for women to be breast aware By www.thehindu.com Published On :: Wed, 30 Oct 2024 15:49:26 +0530 Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors Full Article Health
id Following WHO guidelines for sodium content in packaged food could prevent 3 lakh deaths in India in 10 years: study By www.thehindu.com Published On :: Fri, 01 Nov 2024 16:35:02 +0530 Additionally, about 1.7 million new cardiovascular disease cases and 7,00,000 new chronic kidney disease cases could be prevented compared to current practices, the study said Full Article Health
id ICMR announces ‘First in the World Challenge’ to encourage scientists to find innovative ideas to tackle health issues By www.thehindu.com Published On :: Sat, 02 Nov 2024 19:57:07 +0530 The Council said that the scheme proposes to foster novel, out of the box, futuristic ideas, new knowledge generation, discovery / development of breakthrough health technologies Full Article Health
id Bengaluru start-up strives to bridge India’s genomics data gap to aid precision oncology By www.thehindu.com Published On :: Thu, 07 Nov 2024 09:00:00 +0530 The company, 4baseCare, has come up with a gene panel for the Indian population after extensive research. This, according to the founders, will allow doctors to provide more evidence-based and data-backed treatment for cancer patients in the country Full Article Bengaluru
id WHO identifies 17 pathogens in urgent need of vaccines By www.thehindu.com Published On :: Thu, 07 Nov 2024 13:30:00 +0530 The list reconfirms longstanding priorities for vaccine research and development: HIV, malaria, and tuberculosis -- three diseases that collectively kill nearly 2.5 million people each year Full Article Health
id Can mid-level healthcare providers compensate for physician shortages in rural India? By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:30:00 +0530 To make up for doctor shortages, several countries around the world have introduced a cadre of MLHPs into their health systems; however, in India, mainstreaming of MLHPs has time and again been met with resistance from organised medicine Full Article Health
id 'Katrina didn't want to do Tamil version' By www.rediff.com Published On :: Tue, 16 Jan 2024 09:39:37 +0530 'It would have made (Producer) Ramesh Taurani very happy if I taken two Bombay stars, but the reason why I kept mentally rejecting the regular sort of casting was to discover this excitement, you know, can I crack it?' Full Article
id 'Ranbir said, 'Yaar, what a shot you gave!'' By www.rediff.com Published On :: Wed, 17 Jan 2024 11:31:48 +0530 'Ranbir helped me a lot with emotions and dialogues. As an actor, he makes us very secure.''He guides us with his experiences. He makes the work really, really easy and wonderful for his co-stars.' Full Article Animal Ranbir Kapoor Sandeep Reddy Vanga Manjot Singh Royal Bollywood Film Punjabi Actor Rediff Interview
id Why Did Kiran Rao Struggle? By www.rediff.com Published On :: Tue, 27 Feb 2024 12:04:01 +0530 'I was very keen to make another film and I was dying to say action and cut and get back into creating characters and creating worlds.''But I just didn't have a script I was happy with.''I was working every day on the writing and I was struggling with that.' Full Article
id 'I didn't make any money through TV' By www.rediff.com Published On :: Tue, 05 Mar 2024 11:13:47 +0530 'I will never look down upon television. But do I want to do it again? I don't think so.' Full Article
id 'I was the highest paid actress' By www.rediff.com Published On :: Fri, 05 Apr 2024 12:06:31 +0530 'I never had any nakhras, never threw tantrums, so I got along with all my heroes.' Full Article
id 'India Is No.1 Country Outside The US...' By www.rediff.com Published On :: Wed, 10 Apr 2024 10:40:19 +0530 'India has the largest slate of local original content outside the US.' Full Article