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[ Politics ] Open Question : Is Trump going to have to invade California?

The state leads the nation in poverty and homelessness while it's socialist elites live in absolute luxury. It's like some third world nation the US is obligated to invade on the basis of humanitarianism.




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[ Law & Ethics ] Open Question : If a relict population of Neandertals were found to be living in a certain cave, on a certain remote island, or in a certain house on?

Pennsylvania Avenue, would placing some of them in zoos be unethical? Would they be considered human enough to receive human rights?




ue

[ Religion & Spirituality ] Open Question : My mother keeps turning water into wine, walking on water and resurrecting from the dead. Is she a witch?




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[ Politics ] Open Question : Libtards, don't get your panties in a bunch when those two Georgia 2nd amendment warriors are found innocent of killing that black guy?

He shouldn't have fought back when the guy pointed the shot gun at him




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[ Politics ] Open Question : Why hasn't there ever been a great Democrat presidents' face on Mount Rushmore?

Maybe because there's never been a great Democrat president?  And never will be.  They're all horrible.




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[ Religion & Spirituality ] Open Question : IMAGINE YOU HEARD KIDS ON PHONE TALKING about their difficult reducing MASTURBATION?




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[ Singles & Dating ] Open Question : The man that’s showed clear/obvious interest in me had no contact with me yesterday, is this normal?

I’ve been talking to a man, we have mutual interest in each other. We talked on the phone for over an hour the night before last and it was an amazing conversation. The next day he had no contact with me, which in my mind it didn’t bother me and still kind of isn’t I think he just is doing his own thing and likes his personal space. I’m not too bothered or worried but still questioning why? Is it normal for a man to kinda disappear and have no contact for a day?




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[ Politics ] Open Question : Why are other countries like New Zealand and Australia destroying the virus while America is killing people off to restart the economy?




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[ Other - Australia ] Open Question : Where is the to go menu for Outback?




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[ Politics ] Open Question : Why do so me people worship celebrities?




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[ Singles & Dating ] Open Question : What is this?  What is it for?




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[ Women's Health ] Open Question : Ovulation like discharge before period?

I have a 23 day cycle and around day 19 up until my period I produce a ovulation like discharge, it’s clear/ white and super stretchy. I don’t get this during the “ovulation” time frame, it tends to be thick and cloudy then. Why? And when am I ovulating?




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[ Polls & Surveys ] Open Question : What is your opinion on neofolk?




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[ Religion & Spirituality ] Open Question : Atheists, I always thought Roger Daltrey led the WHO, and not this Ted Ross guy. Who is he anyway? What instrument does he play?

What band was he with before?




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[ Other - Business & Finance ] Open Question : Can I apply for unemployment as a gig worker?

If so, can you do it online? I don't want to catch COVID-19 waiting in some packed line, as I live with an 80 year old.




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[ Politics ] Open Question : IF Cons rewrote the Constitution of the United States would it have less laws, more liberty, & move power from DC to the State Capitals?

Oh would that 'less laws/more liberty/more state capital power' look anything like Mike Pence's Religious Freedom Restoration Act or in other words the 'we Conservative Republican Christians are such oppressed persecuted victims WAAAAA WAAAA' Bill. https://www.youtube.com/watch?v=KIikqPmbgvI 




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[ Baby Names ] Open Question : Which boy name do you prefer: Stephen, Thomas, Sean or Ethan?

For Stephen we'd  use the nickname "Stevie" and for Thomas we'd use the nickname "Tommy" if that helps.




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[ Politics ] Open Question : When will the democrats be arrested for being trators to SAmerica by conspiring with chine to make trump looik bad?




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[ Politics ] Open Question : Trump supporters: Do you watch Disney and Pixar movies even though they carry hidden liberal agendas?

Do you let your kids watch Disney and Pixar movies? They're all created by liberals.




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[ Politics ] Open Question : Is it true many British and American banks and companies(Bank of England,UIC,Prescott Bush,etc) gave money and goods to Hitler secretly?




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[ Rock and Pop ] Open Question : Rock was invented by blacks? R.I.P Little Richard?




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[ Engineering ] Open Question : How can I determine data rate of wireless device given this information?

802.11n device 20 MHz band 32 QAM 1/2 coding rate What's formula?




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[ Marriage & Divorce ] Open Question : 5 year old doesn’t want to go to her dads?

My step daughter is 5 and her dad lives states away. He calls her maybe once a month (not even on holidays) he hasn’t had her since she was one (when they lived in the same state) he had told my wife if our daughter wanted to see him we could bring her to him but he wasn’t coming to our state. My wife asked him beginning of this year if he’d sign his rights over. He doesn’t talk to her and he was behind on child support. He said no and that we was going to finally pick her up. He is getting married and didn’t include the little one we told him if he is going to get her he needs to tell her that it’s not just him living there and he is getting married. Our daughter was hurt by it that he hid this from her (they’ve been engaged for 4 years). She’s been crying she doesn’t want to go and he isn’t willing to come stay the week here to visit. He said he is taking her back to his state for a month. Yes it’s in their agreement but is there anything we can do? She really doesn’t want to go to a “strangers” house is what my daughter says. 




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[ Religion & Spirituality ] Open Question : How come there are different writers attributed to the Gospel of Mark.... why would Mark need different people to write his Gospel.?




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[ Polls & Surveys ] Open Question : How do you like your toilet paper?




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[ Law & Ethics ] Open Question : Why isn't COVID called the Wuhan Flu?

Sounds better than some made up nonsense. Might as well have called it the rumoponosisack 77 syndrome H.




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Amid Economic Crisis and Political Turmoil, Venezuelans Form a New Exodus

Record number of Venezuelans are emigrating to escape the country's economic mismanagement, insecurity, and shortages. This article examines the causes of the current crisis and draws from a study of thousands of Venezuelans abroad to examine who is leaving, where they have headed, and what their hopes are for the future of Venezuela. It also scopes future opportunities for diaspora engagement.




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Eight Key U.S. Immigration Policy Issues: State of Play and Unanswered Questions

Amid a significant reshaping of immigration policy by the Trump administration, a range of immigration topics that have not been at the forefront of debate merit further information sharing with the public and policymakers. This report examines eight issues areas that are deserving of additional review and could form the basis for future action by Congress, including H-1B reform and treatment of unaccompanied minors.




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The Multicultural Dilemma: Amid Rising Diversity and Unsettled Equity Issues, New Zealand Seeks to Address Its Past and Present

New Zealand drew global attention for its unity and support for the Muslim community targeted during the horrific Christchurch attacks. Yet the country's road to inclusion has been far from straightforward, and amid rising diversity it is grappling with the best way to achieve inclusion for its multiethnic population, including indigenous Māori peoples and migrants. This article outlines the opportunities and challenges to fostering multiculturalism against a backdrop of bicultural policies.




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Plagued With Relationship Troubles? Blame Your Parents.

So, Valentine's Day is two days away, but you know he isn't going to bring you any flowers. And instead of a cuddle and a kiss, you know she is going to dig up that old canard about your mother.




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In Face of Tragedy, 'Whodunit' Question Often Guides Moral Reasoning

When nearly 200 people in India were killed in terrorist attacks late last month, the carnage received saturation media coverage around the globe. When nearly 600 people in Zimbabwe died in a cholera outbreak a week ago, the international response was far more muted.




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Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin [Computational Biology]

In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune clearance. A previous structural comparison of the SC(1–325) fragment bound to thrombin and its inactive precursor prethrombin 2 has indicated that SC activates ProT by inserting its N-terminal dipeptide Ile1-Val2 into the ProT Ile16 pocket, forming a salt bridge with ProT's Asp194, thereby stabilizing the active conformation. We hypothesized that these N-terminal SC residues modulate ProT binding and activation. Here, we generated labeled SC(1–246) as a probe for competitively defining the affinities of N-terminal SC(1–246) variants preselected by modeling. Using ProT(R155Q,R271Q,R284Q) (ProTQQQ), a variant refractory to prothrombinase- or thrombin-mediated cleavage, we observed variant affinities between ∼1 and 650 nm and activation potencies ranging from 1.8-fold that of WT SC(1–246) to complete loss of function. Substrate binding to ProTQQQ caused allosteric tightening of the affinity of most SC(1–246) variants, consistent with zymogen activation through occupation of the specificity pocket. Conservative changes at positions 1 and 2 were well-tolerated, with Val1-Val2, Ile1-Ala2, and Leu1-Val2 variants exhibiting ProTQQQ affinity and activation potency comparable with WT SC(1–246). Weaker binding variants typically had reduced activation rates, although at near-saturating ProTQQQ levels, several variants exhibited limiting rates similar to or higher than that of WT SC(1–246). The Ile16 pocket in ProTQQQ appears to favor nonpolar, nonaromatic residues at SC positions 1 and 2. Our results suggest that SC variants other than WT Ile1-Val2-Thr3 might emerge with similar ProT-activating efficiency.




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Introduction to The Old Ways: A Journey on Foot, continued

Macfarlane likes to walk. In The Wild Places, he visits mountains, woods, water. In The Old Ways, he follows the ancient paths that cross the British isles, that go through wood, by the sea shore, and over the downs. His England (and Scotland) however, is multilayered; he is aware not only of the physical landscape surrounding him but of the history of the land through which he walks. A walk take him from point A to point B in physical space, as well as through centuries of time. In his author's note, Macafarlane observes:

"It is an exploration of the ghosts and voices that haunt ancient paths, of the tales that tracks keep and tell, of pilgrimage and trespass, of songlines and their singers and of the strange continents that exist within countries" (p.xi).

While Americans are criticized for being such a highly mobile society, humans have always traveled. Early hunter-gatherers did not stay in one place, but roamed within a fairly wide territory. The early sea-farers such as the Phoenicians, the Greeks, the Carthaginians, the Romans (marine archaeology has shown that they sailed more than we have associated with them) and the Vikings all traveled the roads of the sea. The medieval Crusades were holy wars, but they were also the mass movement of men, women, and children walking across Europe, then by boat from southern Italian ports to the Holy Land. Within Europe itself, bands of pilgrims walked from their homes along the tracks to Canterbury or St. James de Campostela. Merchants in ancient and medieval times traveled in caravans along the land and sea routes of the Silk Roads.

The difference between the modern traveler of today and that of the past is that travelers today are less exposed to the world around them. When you are encased in a plane or enclosed in a fast car, you lose awareness of the physical world outside of you. The electronic devices that we use to distract ourselves during our journeys - our DVD players, Ipods, tablets and ebook readers, all cut us off from the landscape and  fellow travelers around us. Macfarlane deliberately chooses to travel on foot (and by small boat) to connect with the physical world around him during his modern secular pilgrimage.





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Open Door for Venezuelan and Nicaraguan Migrants in Latin America & Caribbean Closes a Bit amid Scale of Flows, Strains on Public Services

WASHINGTON – Even as governments in Latin America and the Caribbean have taken generous and innovative steps to address forced displacement from Venezuela and more recently Nicaragua, the warm welcome has cooled in places amid the vast scale of the inflows, strains on public services and growing public concern.




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Las puertas abiertas para los migrantes venezolanos y nicaragüenses en América Latina y el Caribe se cierran un poco a medida que aumenta la escala de los flujos y la presión en los servicios públicos

WASHINGTON – A pesar de que los gobiernos de América Latina y el Caribe han tomado medidas generosas e innovadoras para lidiar con el desplazamiento forzado desde Venezuela y más recientemente desde Nicaragua, la cálida bienvenida se ha enfriado en algunos lugares a medida que el número de entradas, la presión sobre los servicios públicos y la preocupación del público aumenta.




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Frequently Requested Statistics on Immigrants and Immigration in the United States

Interested in answers to some of the most frequently asked questions about immigration and immigrants in the United States? This incredible resource collects in one place top statistics from authoritative government and nongovernmental sources, offering a snapshot of the immigrant population, visa and enforcement statistics, and data on emerging trends, including the slowing of growth of the foreign-born population, changing origins, and increasing educational levels.




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Buckwheat polenta with roasted vegetables, blue cheese, pine nuts and thyme

As the cold weather sets in, this nourishing winter dish is perfect to warm hands, feet and heart. The addition of buckwheat flour to polenta gives it a delicious smoky earth flavour and adds to the nutrition level of this dish. Rich in fibre and silica, gluten free buckwheat contain rutin, a bioflavonoid that is know to increase blood circulation and reduce high blood pressure. Perfect for winter!




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Prosciutto and cheese croquettes

75g butter 75g (1/2 cup) plain flour 500ml (2 cups) milk 75g finely grated parmesan 1 small red onion, finely diced 200g prosciutto, finely chopped 2 tablespoons chopped fresh parsley 3 eggs, lightly whisked 1 cup plain flour 270g (3 cups) dried breadcrumbs Vegetable oil, to deep-fry




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Calamari and fermented celeriac, barbecued peas and beef fat

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Dan Hunter, chef and owner of Otways' restaurant Brae.




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Lemon Meringue Pie

For the pastry casing: 200g plain flour 100g butter 50g sugar zest of half a lemon 1g vanilla seed 1/2 egg (beat egg, then halve it - should be about 25g) For the curd: 450ml water 180g sugar 75g cornflour 3ea lemons 45g butter 4 eggs For the Italian meringue: 4 x egg whites 270g caster sugar 1 x drop lemon juice 100ml water




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The Colombian Response to the Venezuelan Migration Crisis: A Dialogue with Colombia’s Migration Czar

Felipe Muñoz, Advisor to the President of Colombia for the Colombian-Venezuelan Border, discusses how Colombia is coping with the influx of Venezuelan migrants, plans for future policy decisions surrounding this migration, and developments in regional and international cooperation.




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Latin American Responses to the Venezuelan and Nicaraguan Migration Crises

Leading policymakers and key stakeholders from Latin America, as well as representatives of major international institutions, offer their views on the challenges ahead as Latin American governments seek to chart strategies for responding to large-scale forced migration flows, such as those from Venezuela and Nicaragua.




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Respuestas latinoamericanas a las crisis migratorias venezolanas y nicaragüenses

Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua.




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    Welcome Wears Thin for Colombians in Ecuador as Venezuelans Become More Visible

    Though Colombians displaced by a decades-long civil war found a welcome refuge in Ecuador, life has become more difficult for them in recent years, in part as a result of the influx of Venezuelans seeking safety. This article draws on surveys of migrants in Quito, comparing and contrasting the experiences of Colombians and Venezuelans, and assessing their perceptions of discrimination, victimization, trust in institutions, and hopes for the future.




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    Is the Door Closing? Latin American and Caribbean Responses to Venezuelan Migration

    This webinar marks the release of MPI's Latin American and Caribbean Migration Portal that offers up-to-date, authoritative research and data on migration trends and policies, and a report examining the policy responses of 11 countries in Latin America and the Caribbean to increased Venezuelan and Nicaraguan migration.




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    ¿Se Están Cerrando las Puertas? Respuestas a la Migración Venezolana en América Latina y el Caribe

    MPI llevó a cabo un seminario en línea para marcar el lanzamiento de: Un portal sobre Migración en América Latina y el Caribe; y un informe que examina los efectos de las políticas migratorias y de integración en 11 países en América Latina y el Caribe ante el aumento de la migración venezolana y nicaragüense.




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    An Uneven Welcome: Latin American and Caribbean Responses to Venezuelan and Nicaraguan Migration

    Large-scale displacement from Venezuela and Nicaragua is reshaping the migration landscape in much of Latin America and the Caribbean. This report, accompanied by the launch of a new Migration Portal offering research and analysis on the region, examines the immigration and integration policy responses of 11 countries, including pathways to legal status and measures to integrate newcomers into schools, health-care systems, and labor markets.




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    Bienvenidas asimétricas: Respuestas de América Latina y el Caribe a la migración venezolana y nicaragüense

    El gran desplazamiento forzado de personas en Venezuela y Nicaragua está transformando el panorama migratorio en gran parte de América Latina y el Caribe. Este informe examina las respuestas de las políticas de inmigración e integración de once países, incluyendo vías de regularización y medidas para integrar a los recién llegados en las escuelas y mercados laborales. Este informe acompaña el lanzamiento de un Portal Sobre Migración que ofrece investigación y análisis actualizados sobre tendencias y políticas de inmigración en la región.




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    Venezuelan Immigrants in the United States

    Until recently, the Venezuelan immigrant population in the United States was relatively small compared others from South America. But it has grown significantly, reaching 394,000 in 2018, as Venezuela's destabilization has driven large-scale emigration. Compared to other immigrants in the United States, Venezuelans have higher levels of education but are also more likely to live in poverty, as this Spotlight explores.




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    Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study

    OBJECTIVE

    The Diabetes Control and Complications Trial (DCCT) and its observational follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) demonstrated the dominant role of glycemia, second only to age, as a risk factor for a first cardiovascular event in type 1 diabetes (T1D). We now investigate the association between established risk factors and the total cardiovascular disease (CVD) burden, including subsequent (i.e., recurrent) events.

    RESEARCH DESIGN AND METHODS

    CVD events in the 1,441 DCCT/EDIC participants were analyzed separately by type (CVD death, acute myocardial infarction [MI], stroke, silent MI, angina, percutaneous transluminal coronary angioplasty/coronary artery bypass graft [PTCA/CABG], and congestive heart failure [CHF]) or as composite outcomes (CVD or major adverse cardiovascular events [MACE]). Proportional rate models and conditional models assessed associations between risk factors and CVD outcomes.

    RESULTS

    Over a median follow-up of 29 years, 239 participants had 421 CVD events, and 120 individuals had 149 MACE. Age was the strongest risk factor for acute MI, silent MI, stroke, and PTCA/CABG, while glycemia was the strongest risk factor for CVD death, CHF, and angina, second strongest for acute MI and PTCA/CABG, third strongest for stroke, and not associated with silent MI. HbA1c was the strongest modifiable risk factor for a first CVD event (CVD: HR 1.38 [95% CI 1.21, 1.56] per 1% higher HbA1c; MACE: HR 1.54 [1.30, 1.82]) and also for subsequent CVD events (CVD: incidence ratio [IR] 1.28 [95% CI 1.09, 1.51]; MACE: IR 1.89 [1.36, 2.61]).

    CONCLUSIONS

    Intensive glycemic management is recommended to lower the risk of initial CVD events in T1D. After a first event, optimal glycemic control may reduce the risk of recurrent CVD events and should be maintained.