Edward Howard saw hygiene as a civil rights issue and a matter of treating homeless people with dignity.

Steve Dalkowski, a hard-throwing, wild left-hander whose minor league career inspired the creation of Nuke LaLoosh in 'Bull Durham,' died. He was 80.

At the mercy of Mother Nature, Mt. Waterman has reopened. Snow is good at the landmark resort in the Angeles National Forest. It will be running on Saturdays and Sundays.

What do I know about anything? But these pre-measured meals are helping us kick the winter doldrums.

We raised four kids in this old house. There were birthdays and proms, bloody knees and Scout meetings. We changed a million diapers here. We matched a lot of socks.

There's sloppy play and misfires. At times, it's like you're watching a blooper reel. But L.A. Wildcats games are a Lambeau-leaping hoot. And a great value.

Doesn't really pay for me to be appealing to my captors. They are snarky, and increasingly restless. They pass the long evenings mixing up different flavors of White Claw just for kicks, the way Millennials will.

My daughter would've been married this weekend. Like a lot of life events, it was postponed. But when it comes, what a day it will be.

If you're self-isolating, then you have time to watch "Queen & Slim" and fall for those boots. The film is now available through streaming platforms and on DVD.

Beauty experts says stress and lack of sunlight during the COVID-19 era can play a role in how your skin looks. Here are DIY solutions to make it look better.

Three off-duty firefighters save man’s life using vital first aid skills learnt at work

Millions of homeowners have signed up for mortgage forbearance programs. But there is confusion and concern over how they will pay back what they owe.

By removing unemployment benefits, states are forcing workers to risk their lives

As part of his hit YouTube series, John Krasinski hosted a virtual potluck with Stanley Tucci, Martha Stewart, Guy Fieri and David Chang. Yes, really.

In "The World Without Us," Alan Weisman imagined how the Earth would look if humans vanished. Is the COVID-19 lockdown making that a reality?

He's interviewed Neko Case, Jeff Tweedy and Maria Bamford about depression. With his new memoir, "The Hilarious World of Depression," John Moe looks inward.

Convicted rapist Roman Polanski wins a César, France's equivalent of the Oscar, for directing "An Officer and a Spy," sparking immediate backlash.

The luckiest traveller in Europe in the past nine days? Andrew Gardner, an engineer from Milton Keynes. On Thursday morning, 15 April, he flew from Stansted to Oslo. About 10 minutes after he landed, the air-traffic control shutters came down over northern Europe, and remained closed for the next six days.

Siobhan Mulholland, a self-conscious teenager, found a five-day hike exhilarating and memorable – 'for reasons both universal and particular'

Jean Dujardin and Adèle Haenel star in "Deerskin," director Quentin Dupieux's latest darkly absurdist comedy.

Christine Baranski explains how she came to sing "The Ladies Who Lunch" with Meryl Streep and Audra McDonald for Stephen Sondheim's virtual birthday.

PINK sunsets, shady pines and views stretching for miles across the vivid blue waters of the Aegean… hotel settings don’t come more spectacular than this.

MUSICALS star Layton Williams has opened up about how to keep positive in the lockdown in an exclusive chat with Express.co.uk.

Prophet Brown's wide-ranging skill set could bring possibilities for Notre Dame.

"For some kids, success is probable. For her, it may be inevitable. She works and takes others with her."

Oh no, I'm skint again! Today's Authentic Real English word is especially useful in the week before pay-day.

They may be uncomfortable but they are the height of fashion right now. Stay trendy with Authentic Real English.

Where's the beef? In California, it is still available, but meat eaters might need to settle for cuts other than prime steaks. The industry is dealing with production backups caused by coronavirus pandemic.

Indianapolis Mayor Joe Hogsett strained to embody unity Thursday at a time when it would have been easy to perceive friction.

Germany's Lukas Podolski is named young player of the World Cup as Cristiano Ronaldo's antics for Portugal cost him the prize.

"Onward" and "Soul" deal with the eternal and the ethereal.

Smith has lived up to expectations in 2018, completing 66 of 96 passes (career-high 69 percent) for 767 yards, four touchdowns and one interception.

Cam Newton is 4-0 against the Redskins, with 11 touchdowns (nine passing, two rushing) and zero interceptions for his career.

Washington is a good bet to win at least two of their next three games (42 percent chance), with 3-to-1 odds to win all three.

Giants' offensive line is allowing an adjusted sack rate of over eight percent, the eighth-worst in the NFL.

According to Football Outsiders, Atlanta has the second-worst defense this season after adjusting its performance for strength of schedule.

It's a bad week to own a Washington skill position player, but a great time to get Tevin Coleman and other into your lineup.

Washington will be without their starting right guard, right tackle, left guard, left tackle, center and starting quarterback on Sunday, making the Dallas defense a very solid pickup.

Baltimore has a good chance at nine wins with 10 and possibly 11 wins within reach.

Monday night's game figures to have a big impact on the NFC playoff race.

The Redskins need two more victories to close out the season, including one against the Eagles in the regular-season finale, just to get their playoff chances to 80 percent.

Famous supporters flocked to social media as Sen. Bernie Sanders ended his presidential campaign.

How can you get free things on your next cruise, and get much more bang for your cruising bucks? I discuss the 6 main areas of cruise freebies that are available, if you go and ask for them or seek them out. They are not things that cruise brochures and websites usually reveal, or talk about. I tell you the things to focus on and how to get as many free things as you possibly can, including drinks, special food, gifts, spa treatments, better and improved cabins and more.

** Buy my Cruise T-shirts: http://bit.ly/TFTStore
** USA cruisers get great cruise deals CRUISEDIRECT.COM: http://bit.ly/TFTBookCruise
** UK Cruisers get great cruise deals with CRUISE.CO.UK: http://bit.ly/BookCruiseUK

Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

Follow Tips For Travellers on:
- Instagram: http://www.instagram.com/garybembridge
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MacOS Catalina introduced a handy way to tile windows for multitasking, improving upon the split screen multitasking features that were available in previous MacOS releases. These new simple tiling window multitasking options are available from any window, and now you can easily choose to tile a window to the left or right side of the ... Read More

Guy Fieri — one of the most popular celebrity chefs— has spent nearly 15 years starring in and hosting entertaining culinary shows. But one of Fieri's favorite things to watch on television isn't food-focused. It's the workplace comedy, The Office.

That's right, the Mayor of Flavortown is obsessed with the employees of Dunder Mifflin's Scranton branch. And much to his delight, he recently got to team up with one of the show's former stars, John Krasinski, to help lift spirits and raise money for restaurant workers in need.

Fieri guest starred on the potluck episode of Some Good News, in which Krasinski invited famous chefs to cook viewer-submitted recipes on video chat. Fieri made a "Dynamite," which has Big Sloppy Joe Energy. And then Krasnski surprised him by announcing a $3 million PepsiCo donation to his Restaurant Employee Relief Fund, which provides financial assistance to restaurant workers impacted coronavirus. Read more...

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation of its promoter in acute myeloid leukemia (AML). However, why SKIP activity is silenced in primary AML cells is unclear. Here, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of SKIP re-expression in leukemic cell lines. Using targeted ultra-HPLC-tandem MS (UPLC-MS/MS), we measured sphingolipids (including S1P and ceramides) in AML and control cells. Primary AML cells had significantly lower SK activity and intracellular S1P concentrations than control cells, and SKIP-transfected leukemia cell lines exhibited increased SK activity. These findings show that SKIP re-expression enhances SK activity in leukemia cells. Furthermore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells. Of note, SKIP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling protein extracellular signal-regulated kinase, and increased apoptosis following serum deprivation or chemotherapy. These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apoptosis in leukemia cells. The findings of our study contrast with previous results indicating that SKIP inhibits SK function in fibroblasts and therefore challenge the notion that SKIP always inhibits SK activity.

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.

27 September 2017

US policymakers should give special consideration to a more open immigration policy for highly skilled professionals from the EU. This would ultimately benefit the US economy.

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.

Hany Farid talks about fighting fake videos: "Mathematically, there's a lot of linear algebra, multivariate calculus, probability and statistics, and then a lot of techniques from pattern recognition, signal processing, and image processing."