drug

Detection of drugs and their metabolites in oral fluid / Robert M. White, Sr. (Retired from RTI International, Research Triangle Park, NC; RMW Consulting, Inc., Naples, FL, USA), Christine M. Moore (Immunalysis Corporation (now a part of Abbott), Pomona,

White, Robert M., author




drug

Frequently prescribed medications : drugs you need to know / [edited by] Michael A. Mancano, PharmD, Jason C. Gallagher, PharmD




drug

Pharmacology clear & simple : a guide to drug classifications and dosage calculations / Cynthia J. Watkins, RN, MSN, CPN (Pediatric Intensive Care Staff Nurse, Halifax Health, Daytona Beach, Florida)

Watkins, Cynthia J., author




drug

Calculation of drug dosages : a work text / Sheila J. Ogden, Linda K. Fluharty

Ogden, Sheila J., 1949- author




drug

Excessive Social Media use Comparable to Drug Addiction

Excessive social media use has negative consequences that include the kind of risky decision-making associated with drug and gambling addicts, new research shows.  

Researchers at Michigan State University had 71 study participants take a survey gauging their Facebook dependence; it included questions about users feelings when unable to access the website, the influence Facebook has had on a users job or education, and attempts to quit.  

complete article




drug

Structural bioinformatics tools for drug design: extraction of biologically relevant information from structural databases / Jaroslav Koča [and six more]

Online Resource




drug

[ASAP] Phospholipid-Decorated Glycogen Nanoparticles for Stimuli-Responsive Drug Release and Synergetic Chemophotothermal Therapy of Hepatocellular Carcinoma

ACS Applied Materials & Interfaces
DOI: 10.1021/acsami.0c02785




drug

Quantifying the hygroscopic properties of cyclodextrin containing aerosol for drug delivery to the lungs

Phys. Chem. Chem. Phys., 2020, Accepted Manuscript
DOI: 10.1039/D0CP01385D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Calum Patrick Fred Day, Anatolij Miloserdov, Kate Wildish-Jones, Emma Pearson, Antonia Erika Carruthers
Aerosol dynamics is important to quantify in drug delivery to the lungs with the aim of delivering therapeutics to a target location and optimising drug efficacy. The macrocycle (2-hydroxypropyl)-β-cyclodextrin (2-HP-β-CD)...
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

[ASAP] MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <italic toggle="yes">Mycobacterium tuberculosis</italic>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00003




drug

[ASAP] Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00117




drug

[ASAP] Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02092




drug

[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02126




drug

[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00337




drug

[ASAP] Drug Research Meets Network Science: Where Are We?

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01989




drug

[ASAP] Can Drug Repositioning Work as a Systematical Business Model?

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00122




drug

[ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00022




drug

Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01856B, Communication
Miantai Ye, Wei Hu, Meng He, Chenchen Li, Shuyang Zhai, Zhihong Liu, Yanying Wang, Huijuan Zhang, Chunya Li
A near-infrared two-photon fluorescent probe for selective detection and deep-depth imaging of NO helps to discover the relationship between NO and resistance to antitumor drugs.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Is breaking of a hydrogen bond enough to lead to drug resistance?

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02164D, Communication
María José Dávila-Rodríguez, Thales Souza Freire, Erik Lindahl, Ignez Caracelli, Júlio Zukerman-Schpector, Ran Friedman
Drug resistance is a serious problem in cancer, viral, bacterial, fungal and parasitic diseases. Examination of crystal structures of protein-drug complexes is often not enough to explain why a certain...
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Nanoformulations of core–shell type hydroxyapatite-coated gum acacia with enhanced bioactivity and controlled drug delivery for biomedical applications

New J. Chem., 2020, 44,7175-7185
DOI: 10.1039/D0NJ00668H, Paper
Varun Prasath Padmanabhan, Subha Balakrishnan, Ravichandran Kulandaivelu, Sankara Narayanan T. S. N., Muthukrishnan Lakshmipathy, Suresh Sagadevan, Faruq Mohammad, Hamad A. Al-Lohedan, Suriati Paiman, Won Chun Oh
In this work, nanospherical hydroxyapatite (HAP) was prepared that has combined properties of controlled drug delivery, biocompatibility, and antibacterial activity to have applications in the biomedical sector.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

New J. Chem., 2020, Advance Article
DOI: 10.1039/D0NJ00939C, Paper
Hasan Keshavarz, Alireza Khavandi, Somaye Alamolhoda, M. Reza Naimi-Jamal
Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Novel phthalocyanine-based micelles/PNIPAM composite hydrogels: spatial/temporal-controlled drug release triggered by NIR laser irradiation

New J. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0NJ01882A, Letter
Tao Jia, Lu Li, Enna Ha, Zheng Qu, Lei Shi, Tiedong Sun, Shengnan Tan, Wancheng Zhao
Near-infrared (NIR) light-responsive hydrogels hold significant potential for biomedical application, especially in remote-controlled release of anticancer drugs. Herein we report a novel NIR light responsive composite hydrogel system that undergoes...
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

[ASAP] A Chemically Stable Fluorescent Mimic of Dihydroartemisinin, Artemether, and Arteether with Conserved Bioactivity and Specificity Shows High Pharmacological Relevance to the Antimalarial Drugs

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.9b00430




drug

[ASAP] Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.0c00017




drug

Review of the Narcotic Drugs Act 1967 : final report / Professor John McMillan AO

McMillan, John, 1949- author




drug

Social Services Legislation Amendment (Drug Testing Trial) Bill 2019 [Provisions] / The Senate, Community Affairs Legislation Committee

Australia. Parliament. Senate. Community Affairs Legislation Committee, author, issuing body




drug

Discovery of new polymorphs of the tuberculosis drug isoniazid

CrystEngComm, 2020, 22,2705-2708
DOI: 10.1039/D0CE00440E, Communication
Keke Zhang, Noalle Fellah, Alexander G. Shtukenberg, Xiaoyan Fu, Chunhua Hu, Michael D. Ward
Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Repurposing of the anti-HIV drug Emtricitabine as a hydrogen-bonded cleft for bipyridines via cocrystallization

CrystEngComm, 2020, Accepted Manuscript
DOI: 10.1039/D0CE00474J, Communication
Gonzalo Campillo-Alvarado, Elizabeth Keene, Dale C. Swenson, Len R MacGillivray
We report supramolecular repurposing of Emtricitabine (FTC, trade name: Emtriva®), a blockbuster FDA-approved anti-HIV agent. FTC is revealed to act as a hydrogen-bonded cleft for bipyridine recognition. The supramolecular repurposing...
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

A crystalline solid adduct of sulfathiazole-amantadine: The first dual-drug molecular salt containing both antiviral and antibacterial ingredients

CrystEngComm, 2020, Accepted Manuscript
DOI: 10.1039/D0CE00368A, Paper
Ling-Yang Wang, Yueming Yu, Ming-Chao Yu, Yan-Tuan Li, Zhi-Yong Wu, Cui-Wei Yan
The first molecular salt concurrently combining antibacterial drug sulfathiazole (SFZ) and antiviral constituent amantadine (ATD) is designed and successfully synthesized via salification strategy. The precise structure of the newly obtained...
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Carbon nanotubes for targeted drug delivery / Md Saquib Hasnain, Amit Kumar Nayak

Online Resource




drug

As China stumbles, India plans big exports push in bulk drugs

The government is mulling incentives for reviving old pharmaceutical ingredient units.




drug

Two drug dealers arrested in Kolkata

Two drug dealers were arrested with 275 grams of brown sugar here, a Kolkata Police officer said on Wednesday.




drug

Nanotechnology-based targeted drug delivery systems for lung cancer / edited by Prashant Kesharwani

Barker Library - T174.7.N37347 2019




drug

Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

Org. Biomol. Chem., 2020, 18,3229-3233
DOI: 10.1039/D0OB00265H, Communication
Ying Han, Yifan Da, Mingjia Yu, Yaping Cheng, Xin Wang, Jiale Xiong, Guoying Guo, Yan Li, Xianxing Jiang, Xiaoqing Cai
An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

GlaxoSmithKline (GSK): Seeking AI and ML experts for data-driven drug discovery and development

GlaxoSmithKline (GSK) is creating a data-focused culture and a global machine-learning team.




drug

[ASAP] Applicability Domains Enhance Application of PPAR? Agonist Classifiers Trained by Drug-like Compounds to Environmental Chemicals

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00498




drug

[ASAP] Computational Approaches to Identify Structural Alerts and Their Applications in Environmental Toxicology and Drug Discovery

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00006




drug

The Capybara May Be Chill, But It Still Says No to Drugs

Get to know the biggest, most chillest rodent on Earth (all 175 pounds of it).




drug

2017: The Year Ahead - WIRED's 2017 Predictions: Drug Reform Will Beat Criminalization

WIRED predicts the biggest trends for the year ahead. In this segment, Matt Simon looks at how the drug crisis in the US is being reframed as a health problem instead of a criminal one.




drug

Reversibly-regulated drug release using poly(tannic acid) fabricated nanocarriers for reduced secondary side effects in tumor therapy

Nanoscale Horiz., 2020, Advance Article
DOI: 10.1039/D0NH00032A, Communication
Chao Chen, Tonghao Ma, Wen Tang, Xiaoli Wang, Yibing Wang, Jiafeng Zhuang, Yucheng Zhu, Ping Wang
This article introduced a reversibly pH-responsive and targeting nanocarrier based on mesoporous silica nanoparticles which could be utilized to reduce the “secondary” side effects on normal tissues.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Light-triggered dual-modality drug release of self-assembled prodrug-nanoparticles for synergistic photodynamic and hypoxia-activated therapy

Nanoscale Horiz., 2020, 5,886-894
DOI: 10.1039/D0NH00034E, Communication
Dongyang Zhao, Wenhui Tao, Songhao Li, Lingxiao Li, Yixin Sun, Guanting Li, Gang Wang, Yang Wang, Bin Lin, Cong Luo, Yongjun Wang, Maosheng Cheng, Zhonggui He, Jin Sun
Prodrug-nanoparticles turn the disadvantage of the aggregation-caused quenching effect into an advantage to promote dual-modality PR104A release. Besides, photodynamic therapy-induced hypoxia activates PR104A for high-efficiency synergistic therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Enhancing the chemotherapeutic efficacy of platinum prodrug nanoparticles and inhibiting cancer metastasis by targeting iron homeostasis

Nanoscale Horiz., 2020, Advance Article
DOI: 10.1039/D0NH00148A, Communication
Fang Ding, Lingpu Zhang, Hao Chen, Haiqin Song, Shiguo Chen, Haihua Xiao
Combination of cisplatin prodrug nanoparticles and Dp44mT results in enhanced anticancer and anti-metastatic efficiencies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

[ASAP] Revealing Acquired Resistance Mechanisms of Kinase-Targeted Drugs Using an on-the-Fly, Function-Site Interaction Fingerprint Approach

Journal of Chemical Theory and Computation
DOI: 10.1021/acs.jctc.9b01134




drug

'New drug combo shows promise against Covid'

A two-week course of an antiviral therapy, started within 7 days of experiencing Covid-19 symptoms, may improve clinical recovery of patients and reduce their hospital stay duration, according to the first randomised trial of this triple drug combination. The treatment combination, according to the scientists, also appeared safe and well tolerated by patients.




drug

Hydroxychloroquine no wonder drug for treating COVID-19, can be fatal: Experts

While frantic efforts are underway to develop a vaccine and doctors all over try and control the spread of the disease for which there is yet no cure, hydroxychloroquine, or HCQ, has emerged as a prime focus area of treatment.




drug

Repurposed drugs offer hope in India’s Covid fight

ICMR has identified over a dozen other drugs, including remdesivir, mycobacterium W, disulfiram and resveratrol, which could be used for treating Covid-19. Some of these drugs are undergoing clinical trials in India, sources said.




drug

Gilead under gun to mass-produce virus drug or risk exclusivity

All of that could add up to market wins if remdesivir lives up to expectations and Gilead can ramp up to sufficiently respond to Covid-driven demand. But if it can’t, Gilead could be “very vulnerable” to the federal government using its powers to compel the licensure of remdesivir patents, Roth said.




drug

Zydus Cadila launches generic prostate cancer drug at nearly 70% less price in India

"Our aim is to make a preferred choice of therapy like Obynx available and more accessible to people suffering from cancer. Bridging these unmet gaps comes from our patient-first approach," Zydus Cadila MD Sharvil Patel told .




drug

Chinese drugmaker in talks to test virus vaccine globally

With China having largely curbed its growth of new infections, its drugmakers will need to seek international cooperation to test their vaccine candidates in other countries — a task that may be complicated by tensions between China and some nations, especially the US, over how and where the virus originated.




drug

Ten drugs: how plants, powders, and pills have shaped the history of medicine / by Thomas Hager

Browsery RM45.H34 2019




drug

A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

Chem. Soc. Rev., 2020, 49,2426-2480
DOI: 10.1039/C9CS00556K, Review Article
Kaitlind C. Howard, Emily K. Dennis, David S. Watt, Sylvie Garneau-Tsodikova
The emergence of new fungal pathogens makes the development of new antifungal drugs a medical imperative that in recent years motivates the talents of numerous investigators across the world.
The content of this RSS Feed (c) The Royal Society of Chemistry