tor (H)Elping nerve growth factor: Elp1 inhibits TrkA’s phosphatase to maintain retrograde signaling By www.jci.org Published On :: Nerve growth factor (NGF) regulates many aspects of neuronal biology by retrogradely propagating signals along axons to the targets of those axons. How this occurs when axons contain a plethora of proteins that can silence those signals has long perplexed the neurotrophin field. In this issue of the JCI, Li et al. suggest an answer to this vexing problem, while exploring why the Elp1 gene that is mutated in familial dysautonomia (FD) causes peripheral neuropathy. They describe a distinctive function of Elp1 as a protein that is required to sustain NGF signaling by blocking the activity of its phosphatase that shuts off those signals. This finding helps explain the innervation deficits prominent in FD and reveals a unique role for Elp1 in the regulation of NGF-dependent TrkA activity. Full Article
tor SARS-CoV-2: a storm is raging By www.jci.org Published On :: The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design. Full Article
tor The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5 By www.jci.org Published On :: IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity. Full Article
tor It’s not all about muscle: fibroadipogenic progenitors contribute to facioscapulohumeral muscular dystrophy By www.jci.org Published On :: Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat. Full Article
tor Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control By www.jci.org Published On :: Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive. Full Article
tor Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic By www.jci.org Published On :: The editors of JCI and JCI Insight are revisiting our editorial processes in light of the strain that the COVID-19 pandemic places on the worldwide scientific community. Here, we discuss adjustments to our decision framework in light of restrictions placed on laboratory working conditions for many of our authors. Full Article
tor Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? By www.jci.org Published On :: Brown and beige adipose tissues contain thermogenic fat cells that can be activated by β3-adrenergic receptor agonists. In rodents, such drugs both diminish obesity and improve glucose homeostasis. In this issue of the JCI, O’Mara et al. and Finlin and Memetimin et al. report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis. Full Article
tor The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans By www.jci.org Published On :: BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998. Full Article
tor Star Maps: History, Artistry, and Cartography By www.maproomblog.com Published On :: Tue, 14 Apr 2020 15:38:47 +0000 Full Article Antique Maps Astronomy Book Reviews Map Collecting My Stuff books celestial maps map societies
tor The History of Cartography’s Fourth Volume, Now (Almost) Out By www.maproomblog.com Published On :: Tue, 14 Apr 2020 21:27:17 +0000 Full Article Antique Maps 1600s 1700s books history of cartography
tor Library of Congress Livestream on the History of Pandemic Maps By www.maproomblog.com Published On :: Wed, 22 Apr 2020 17:17:17 +0000 Full Article Health History 2019-nCoV coronavirus COVID-19 disease epidemics Library of Congress livestream pandemics
tor The Trader of Stories - Chapter 2 By jayisgames.com Published On :: Tue, 31 Mar 2020 06:02:13 -0500 Platform: Javascript/HTML5 — Bearing the fruit of thoughtful craftsmanship, Rudowski Brothers gifts us with The Trader of Stories - Chapter 2. After spending nearly a Blossoming in the human city of Bark, Little Willow's life seems fairly ordered. She works as a waitress... Tagged as: adventure, bigoldtreethatdreams, browser, free, game, html5, linux, mac, mobile, mrudowski, narrative, pointandclick, traderofstories Full Article point-and-click-adventure
tor Apple Stores in Germany to Begin Reopening May 11 With Enhanced Health and Safety Measures By www.macrumors.com Published On :: Fri, 08 May 2020 04:52:46 PDT Apple today announced that it will begin reopening its retail stores in Germany on May 11, nearly two months after they were closed due to the global health crisis. In a statement shared with German website Macerkopf, Apple said the stores will initially be focusing on Genius Bar service and support. Enhanced health and safety measures will be implemented, such as body temperature checks prior to entry, limits on how many customers can be in the store at once, social distancing, and reduced hours of operation. Apple operates 15 retail stores in Germany and will be posting specific hours of operation for each location on its website. Apple closed all of its retail stores outside of the Greater China region in mid-March. The company has since started to reopen some locations, including in South Korea, Austria, and Australia. All locations in the United States remain closed.Related Roundup: Apple StoresThis article, "Apple Stores in Germany to Begin Reopening May 11 With Enhanced Health and Safety Measures" first appeared on MacRumors.comDiscuss this article in our forums Full Article Apple Store
tor Apple to Start Reopening U.S. Stores Next Week By www.macrumors.com Published On :: Fri, 08 May 2020 12:16:50 PDT Apple will begin reopening its retail stores in the United States next week, reports CNBC, starting with locations in Idaho, South Carolina, Alabama, and Alaska. Apple plans to limit the number of customers in the store at a time, and temperature checks will be performed at the door. Apple also has a number of other measures in place to keep customers and employees safe, as we outlined this morning."We're excited to begin reopening stores in the US next week, starting with some stores in Idaho, South Carolina, Alabama and Alaska. Our team is constantly monitoring local heath data and government guidance, and as soon as we can safely open our stores, we will." "Our new social distance protocol allows for a limited number of visitors in the store at one time so there may be a delay for walk-in customers. We recommend, where possible, customers buy online for contactless delivery or in-store pick up."Reopened Apple Stores will operate on reduced hours and will primarily focus on repairs, with Apple encouraging customers to purchase online where possible. Most stores are not listing hours at this time with the exception of Apple Boise Towne Square, which reopens Monday at 11:00 a.m. During last week's earnings call, Apple CEO Tim Cook said that Apple planned to start reopening some stores in the United States in May. Store reopenings are done on a city by city, county by county basis, with Apple taking into account local data and guidelines. Apple has already reopened stores in South Korea, Austria, and Australia, with plans to also reopen stores in Germany next week.Related Roundup: Apple StoresTag: Apple retailThis article, "Apple to Start Reopening U.S. Stores Next Week" first appeared on MacRumors.comDiscuss this article in our forums Full Article Featured Apple Store Apple retail
tor Top Stories: New 13" MacBook Pro, WWDC Starts June 22, AirPods Pro Firmware Update, and More By www.macrumors.com Published On :: Sat, 09 May 2020 06:00:48 PDT This week saw a couple of big announcements, led by the launch of an update for the 13-inch MacBook Pro line. Most notably, the update brought the improved Magic Keyboard previously introduced on its 16-inch sibling and the MacBook Air, with high-end models also receiving updated processors. Subscribe to the MacRumors YouTube channel for more videos. The second significant announcement this week was that Apple's first all-digital Worldwide Developers Conference will kick off on June 22. Other news this week included a firmware update for the AirPods Pro, an update on Apple's Mini-LED efforts, and more. Read on below and check out our video above for recaps of all of this week's most important stories! New 13-Inch MacBook Pro Announced With Magic Keyboard, 10th-Gen Processors, Up to 32GB RAM and 4TB SSD, and More Apple this week refreshed its 13-inch MacBook Pro lineup, with key features including the same Magic Keyboard as the 16-inch MacBook Pro, up to 80 percent faster Intel graphics than the previous generation, up to 32GB of RAM, up to 4TB of SSD storage, and 6K display support. First introduced on the 16-inch MacBook Pro last year, the Magic Keyboard features a far more reliable scissor mechanism with 1mm of key travel. After five years, Apple has finally transitioned its entire notebook lineup away from its issue-prone butterfly keyboard. 10th-generation Intel processor options are only available on higher-end models, with the $1,799 configuration proving to be up to 16.5% faster than the $1,299 base model with an older 8th-generation processor. Apple's Virtual WWDC Event to Kick Off on June 22 Apple has announced that its first-ever online-only WWDC will begin Monday, June 22 via the Apple Developer app and website. The weeklong event will include a virtual keynote, sessions, and labs, with more details to be shared in June. And it's free! Apple is expected to introduce iOS 14, iPadOS 14, macOS 10.16, tvOS 14, and watchOS 7 at WWDC 2020, with beta testing to take place over the summer. Student developers from all over the world can enter Apple's Swift Student Challenge by creating an interactive scene in Swift Playgrounds that can be experienced in three minutes. Winners will receive an exclusive WWDC20 jacket and pin set. Submissions are open through May 17. Apple Updates AirPods Pro Firmware to Version 2D15 Apple this week released a new firmware version 2D15 for the AirPods Pro, replacing version 2C54. In recent months, some AirPods Pro owners have been complaining about reduced noise cancellation and crackling or static sounds, so users have listened for any improvements following the update. Perhaps proving how subjective sound quality can be, feedback has been decidedly mixed, with some users noticing an improvement, some noticing no change, and some noticing further degradation to noise cancellation. Apple has offered some help in the form of two new support documents for users to troubleshoot noise cancellation or crackling sound issues. 10 Tips and Tricks for the iPad Pro Magic Keyboard Have you recently picked up a new Magic Keyboard for the iPad Pro? Here's a list of our favorite tips and tricks that you need to know. The tips and tricks relate to adjusting the backlight brightness, customizing the cursor's behavior, enabling tap-to-click on the trackpad, other trackpad gestures, accessing the Emoji keyboard, and more. Apple's Mini-LED Product Roadmap May Have Been Pushed Back to 2021 Disappointed that the new 13-inch MacBook Pro was not the rumored 14-inch model? That may be due to a slight delay in Apple's plans to release a range of new products with Mini-LED backlit displays. Kuo believes Apple's first Mini-LED products might not launch until 2021. The analyst has previously said these products would include a new 14.1-inch MacBook Pro, 16-inch MacBook Pro, 12.9-inch iPad Pro, and more. Kuo has previously said that Mini-LED displays will allow for thinner and lighter product designs, while offering many of the same benefits of OLED displays used on the latest iPhones, including good wide color gamut performance, high contrast and dynamic range, and local dimming for truer blacks. NFC-Based Digital Key Specification Released Ahead of Apple's Rumored CarKey Feature on iPhone Amid rumors that Apple is working on a digital "CarKey" feature for iPhone, the Car Connectivity Consortium has announced that its NFC-based Digital Key Release 2.0 specification has been finalized and made available to its members, which includes Apple. "CarKey" will allow an iPhone or Apple Watch to unlock, lock, and start an NFC-compatible vehicle. Just like credit cards and boarding passes, users will be able to add a digital car key to the Wallet app, eliminating the need to use a physical car key or key fob. MacRumors Newsletter Each week, we publish an email newsletter like this highlighting the top Apple stories, making it a great way to get a bite-sized recap of the week hitting all of the major topics we've covered and tying together related stories for a big-picture view. So if you want to have top stories like the above recap delivered to your email inbox each week, subscribe to our newsletter!This article, "Top Stories: New 13" MacBook Pro, WWDC Starts June 22, AirPods Pro Firmware Update, and More" first appeared on MacRumors.comDiscuss this article in our forums Full Article Featured
tor 'Effects Achieved as I Had Hoped for This Dosage', by DoctorB (Phenibut) By erowid.org Published On :: Tue, 05 May 2020 22:10:01 GMT Erowid Exp98591 Full Article Erowid : Experience :
tor Senator Bernie Sanders on This Week With George Stephanopoulos – ABC News By www.cpa-connecticut.com Published On :: Mon, 04 May 2015 00:43:56 +0000 "I think I'm the only candidate who's prepared to take on the billionaire class," Sanders, I-Vt., told ABC's George Stephanopoulos on "This Week." "We need a political revolution in this country involving millions of people who are prepared to stand up and say, enough is enough, and I want to help lead that effort." Continue reading → Full Article Accountants CPA Hartford Articles ABC News Bernie Sanders George Stephanopoulos Hillary Clinton interview May 3 2015 Presidential Primary 2016 Sen. Bernie Sanders Says America Needs 'Political Revolution' in 2016 Senator Bernie Sanders on This Week With George Stephanopoulos - ABC News This Week This Week With George Stephanopoulos - ABC News transcript United States video
tor The response of Senator Richard Blumenthal to my letter in opposition to the Trans-Pacific Partnership (TPP) By www.cpa-connecticut.com Published On :: Tue, 05 May 2015 15:14:46 +0000 The response of Senator Richard Blumenthal to my letter in opposition to the Trans-Pacific Partnership (TPP). Ask yourselves how American labor can compete against Vietnamese workers earning on average $0.56 per hour. Continue reading → Full Article Accountants CPA Hartford Articles foreign government contributions to the Clinton Foundation Hillary Clinton Senator Bernie Sanders Senator Elizabeth Warren Senator Richard Blumenthal The Clinton Foundation The response of Senator Richard Blumenthal to my letter in opposition to the Trans-Pacific Partnership (TPP) Trade Promotion Authority (TPA) Trans-Pacific Partnership (TPP)
tor Senator Bernie Sanders speaks out against the Trans Pacific Partnership Trade Agreement to the United States Senate May 12 2015 By www.cpa-connecticut.com Published On :: Tue, 12 May 2015 23:01:25 +0000 The Senate considered H.R. 1314, the legislative vehicle for trade promotion authority reauthorization.?It would give the president broad fast-track authority when negotiating trade agreements and require Congress to consider treaties without an amendment process. Senator Bernie Sanders speaks out against this bill before the Senate on May 12, 2015. Continue reading → Full Article Accountants CPA Hartford Articles H.R. 1314 the legislative vehicle for trade promotion authority reauthorization May 12 2015 Senator Bernie Sanders Senator Bernie Sanders speaks out against the Trans Pacific Partnership Trade Agreement to the United States Senate May 12 2015 TPA TPP trade promotion authority Trans Pacific Partnership transcript United States Senate video
tor CNN Brianna Keilar interviews Senator Bernie Sanders on State of the Union May 17 2015 By www.cpa-connecticut.com Published On :: Sun, 17 May 2015 17:07:01 +0000 CNN Brianna Keilar interviews Senator Bernie Sanders on State of the Union May 17 2015. Senator Bernie Sanders says the American people want and deserve a serious debate on the serious issues facing our country today instead of merely the same old, endless 30 second, ad hominem, attack ads. Continue reading → Full Article Accountants CPA Hartford Articles 2016 Presidential race Brianna Keilar CNN CNN Brianna Keilar interviews Senator Bernie Sanders on State of the Union May 17 2015 CNN SR. WHITE HOUSE CORRESPONDENT Democratic Primary 2016 Elizabeth Warren Hillary Clinton income inequality May 17 2015 Path to Victory Senator Bernie Sander State of the Union Trans-Pacific Partnership (TPP) transcript video
tor Senator Bernie Sanders interviewed by Chris Hayes on May 6 2015 By www.cpa-connecticut.com Published On :: Mon, 18 May 2015 23:43:58 +0000 The Vermont senator and presidential candidate talks to Chris Hayes about his differences with Hillary Clinton and the prospects for his presidential candidacy. Continue reading → Full Article Accountants CPA Hartford Articles All in with Chris Hayes 5/6/15 Chris Hayes Hillary Clinton interview May 6 2015 Senator Bernie Sanders Senator Bernie Sanders interview by Chris Hayes May 6 2015 Today MSNBC transcript transcript from the Wednesday show video
tor Senator Bernie Sanders does not think that Hillary Clinton can stand up and fight for the middle class By www.cpa-connecticut.com Published On :: Tue, 19 May 2015 17:50:22 +0000 Senator Bernie Sanders does not think that Hillary Clinton can stand up and fight for the middle class. Continue reading → Full Article Accountants CPA Hartford Articles Citizens United Supreme Court decision Hillary Clinton Interview of Senator Bernie Sanders by Judy Woodruff on PBS Newshour on May 18 2015 Judy Woodruff Senator Bernie Sanders Taxes TPP trade agreeements Trans Pacific Partnership transcript video
tor College for ALL Act presented by Senator Bernie Sanders on May 19 2015 By www.cpa-connecticut.com Published On :: Wed, 20 May 2015 03:27:56 +0000 Read the text of Senator Bernie Sanders bill to make college tuition free for students and to be financed by a tax on Wall Street speculation. WASHINGTON, May 19 – Sen. Bernie Sanders (I-Vt.) today introduced legislation to make 4-year public colleges and universities tuition free. “We live in a highly competitive global economy. If our economy is to be strong, we need the best educated work force in the world. That will not happen if every year hundreds of thousands of bright young people cannot afford to go to college and if millions more leave school deeply in debt,” Sanders said. Under the legislation, $70 billion a year in assistance – two-thirds from the federal government and one-third from states – would replace what public colleges and universities now charge in tuition and fees. The federal share of the cost would be offset by imposing a tax on Wall Street transactions by investment houses, hedge funds and other speculators. The legislation also would overhaul student loan programs so students and their parents could reduce crushing debt loads which now exceed Americans’ credit card debt. Federal profits on loans would be eliminated, work-study programs expanded and incentives offered for colleges and universities to keep costs down. “We once led the world in the percentage of our people with a college degree, now we are in 12th place.” Sanders said. “Countries like Germany, Denmark, Sweden and many more are providing free or inexpensive higher education for their young people. They understand how important it is to be investing in their youth. We should be doing the same,” he added. Tuition at 4-year public colleges and universities rose by 50 percent in the United States during the past decade. As state governments have cut support for higher education, the burden has shifted to students and their parents. With this spring’s college commencement season underway, the class of 2015 is the most indebted class in American history, according to Mark Kantrowitz, publisher of Edvisors, a website on college costs and financial aid. Continue reading → Full Article Accountants CPA Hartford Articles College for All Act free tuition bill of Senator Bernie Sanders Robin Hood tax on Wall Street Summary of Senator Sanders' College for All Act text of Senator Bernie Sanders bill transcript video
tor Senator Bernie Sanders tells Ed Schultz to make college tuition free for students and pay for it with a tax on Wall Street speculation By www.cpa-connecticut.com Published On :: Wed, 20 May 2015 03:28:19 +0000 Presidential candidate Bernie Sanders says he wants to offer tuition free at public colleges and universities, paid for with a new tax on Wall Street. Ed Schultz and Sanders discuss the senator’s proposal. Continue reading → Full Article Accountants CPA Hartford Articles 50 cent tax on every $100 of stock trades address student debt Bernie Sanders discusses Hillary Clinton Bernie Sanders for free college education Bernie Sanders introduces bill for free tuition Bernie Sanders tells Wolf Blitzer that college tuition should be free and paid for by a tax on Wall Street Speculation climate change Clinton Questioned about Income Inequality CNN CNN Wolf Blitzer interview Bernie Sanders college education paid for by Wall Street speculation tax Congressman Keith Ellison Robin Hood bill create job rebuilding infrastructure Democratic presidential primary 2016 Ed Schultz Keith Ellison kitchen table issues make college affordable Make State College Tuition Free May 19 2015 millions leaving school in large debt Race for the White House raise minimum wage robin hood bill Senator Bernie Sanders Senator Bernie Sanders tells Ed Schultz to make college tuition free for students and pay for it with a tax on Wall Street speculation stop endless wars in Middle East student debt $1.2 trillion the Ed Show transcript video Wall Street shake down Wolf Blitzer
tor Senator Bernie Sanders before the Senate December 2 2014 presenting an Economic Agenda for America: 12 Steps Forward By www.cpa-connecticut.com Published On :: Thu, 21 May 2015 19:21:54 +0000 THE AMERICAN PEOPLE IN THIS PARTICULAR MOMENT IN OUR HISTORY MUST MAKE A VERY FUNDAMENTAL DECISION, AND THAT DECISION IS DO WE CONTINUE THE STATUS QUO WHICH INCLUDES A 40-YEAR DECLINE OF OUR MIDDLE CLASS AND A HUGE AND GROWING GAP BETWEEN THE VERY, VERY RICH AND EVERYONE ELSE, OR DO WE FIGHT FOR A BOLD AND MEANINGFUL ECONOMIC AGENDA THAT CREATES JOBS, RAISES WAGES, PROTECTS OUR ENVIRONMENT AND PROVIDES HEALTH CARE FOR EVERY AMERICAN Continue reading → Full Article Accountants CPA Hartford Articles An Economic Agenda for America: 12 Steps Forward Senator Bernie Sanders Senator Bernie Sanders before the Senate December 2 2014 presenting an Economic Agenda for America: 12 Steps Forward transcript video
tor Senator Bernie Sanders appeals to the media to cover the serious issues of our country instead of political gossip during political campaigns By www.cpa-connecticut.com Published On :: Sun, 24 May 2015 17:37:46 +0000 SANDERS: ... there is more coverage about the political gossip of a campaign, about raising money, about polling, about somebody saying something dumb, or some kid works for a campaign sends out something stupid on Facebook, right? We can expect that to be a major story. But what your job is, what the media's job is, is to say, look, these are the major issues facing the country. We're a democracy. People have different points of view. Let's argue it. Continue reading → Full Article Accountants CPA Hartford Articles Accountants Accountants CPA Hartford Connecticut LLC barefoot accountant Berlin Connecticut Bernie Sanders Brian Stelter Certified Public Accountants CNN CNN Host CNN Reliable Sources Hartford Connecticut Hillary Clinton May 24 2015 media press campaign coverage Race to 2016 Reliable Sources Sanders asks why his only coverage is for attacking Clinton Sanders slams press coverage CNN Senator Bernie Sanders appeals to the media to cover the serious issues of our country instead of political gossip Senator Bernie Sanders appeals to the media to cover the serious issues of our country instead of political gossip during political campaigns Stelter William Brighenti CPA
tor Senator Bernie Sanders warns the press not to underestimate him in the 2016 campaign for the Democratic nomination for President of the United States By www.cpa-connecticut.com Published On :: Mon, 25 May 2015 23:36:33 +0000 Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading → Full Article Accountants CPA Hartford Articles Elizabeth Warren Hillary Clinton May 25 2015 Senator Bernie Sanders warns the press not to underestimate him in the 2016 campaign for the Democratic nomination for President of the United States super PAC Washington Post
tor Senator Bernie Sanders formally announces his candidacy for the Democratic nomination for President By www.cpa-connecticut.com Published On :: Wed, 27 May 2015 16:16:29 +0000 “Thank you all very much for being here and for all the support that you have given me over the years: as the mayor of this great city, as Vermont’s only congressman and now as a U.S. senator. Thanks also … Continue reading → Full Article Accountants CPA Hartford Articles Burlington Vermont May 26 2015 Senator Bernie Sanders formally announces his candidacy for the Democratic nomination for President transcript video
tor Glenn Greenwald on Democracy Now reports that Hillary Clinton Has Embraced Some of the Most Brutal Dictators in the World By www.cpa-connecticut.com Published On :: Sat, 26 Mar 2016 14:49:40 +0000 With the Republican establishment attempting to stop real estate mogul Donald Trump from receiving the GOP nomination, a new anti-Trump ad produced by the Emergency Committee for Israel alleges that Trump supports dictators. But what about Democratic presidential candidate Hillary Clinton’s record on dictators? Earlier this week, Clinton addressed the annual AIPAC conference, seeking to cast herself as a stronger ally to Israel than Donald Trump. We examine her record on Israel and U.S. foreign relations at large with Pulitzer Prize-winning journalist Glenn Greenwald, co-founder of The Intercept. Continue reading → Full Article Accountants CPA Hartford Articles Amy Goodman Bernie Sanders Democracy Now Donald Trump Glenn Greenwald Glenn Greenwald on Democracy Now reports that Hillary Clinton Has Embraced Some of the Most Brutal Dictators in the World Hillary Clinton NERMEEN SHAIKH the barefoot accountant
tor SHUT IN THEATER: What are Dynamite creators in quarantine up to? By www.comicsbeat.com Published On :: Fri, 08 May 2020 17:00:07 +0000 The publisher is adding videos of their creators entertaining themselves while sheltering in place. The post SHUT IN THEATER: What are Dynamite creators in quarantine up to? appeared first on The Beat. Full Article Dynamite coronavirus COVID-19 Creators in Quarantine erik burnham Joseph Rybrandt shut in theater
tor Heroes always come home in David Rubín’s free COVID-19 SUPERMAN story (version en español incluída) By www.comicsbeat.com Published On :: Fri, 08 May 2020 18:15:20 +0000 Real heroes deserve their own comics/Los héroes reales merecen sus propios comics The post Heroes always come home in David Rubín’s free COVID-19 SUPERMAN story (version en español incluída) appeared first on The Beat. Full Article Comics DC COVID-19 David Rubin ECC Ediciones en español free comics Jesus Merino Mikel Janin paco roca pandemic
tor IBM Gets High Marks on CRN’s 2017 Annual Report Card for Analytics and Storage By www.ibm.com Published On :: Mon, 14 Aug 2017 01:01:45 GMT IBM announced today that it has been recognized as the winner in the Business Analytics category and the Enterprise Network Storage sub-category in CRN’s 2017 Annual Report Card (ARC) awards program. The Annual Report Card summarizes results from a comprehensive survey that details solution provider satisfaction across product innovation, support and partnership for the hardware, services and software vendors they team up with. The vendors with the highest ratings are named to the prestigious Annual Report Card list of winners and celebrated as best-in-class by their partners. The results also provide the IT vendor community with valuable feedback—directly from their solution providers—that can be used to refine product offerings, enhance support offerings and improve communication with partners. Full Article IBM Analytics
tor As Fifth Anniversary of Superstorm Sandy Approaches, U.S. Utility Companies Still Feel Underprepared for Weather-Related Outages By www.ibm.com Published On :: Thu, 24 Aug 2017 12:01:59 GMT Each year, weather-related power outages cost the U.S. economy as much as $33 billion a year. Additionally, one severe weather event has the potential to impact the daily lives and routines of millions of people. As 2017 marks the fifth anniversary of Superstorm Sandy, The Weather Company, an IBM Business (NYSE: IBM) and Zpryme are releasing the results of a survey that found that U.S. utility companies still feel underprepared for weather-related outages and that their reactive approach to outage prediction leads to lost time and resources. Full Article IBM Analytics
tor IBM Named a Leader in Gartner’s Magic Quadrant for its Flash Storage Solutions By www.ibm.com Published On :: Mon, 24 Jul 2017 09:31:30 GMT IBM has been recognized as a Leader in the Gartner Magic Quadrant for Solid-State Arrays (SSA) for the fourth year in a row. Full Article IBM Storage
tor IBM sets new record for magnetic tape storage; makes tape competitive for cloud storage By www.ibm.com Published On :: Wed, 02 Aug 2017 05:58:48 GMT IBM Research scientists have achieved a new world record in tape storage – their fifth since 2006. The new record of 201 Gb/in2 (gigabits per square inch) in areal density was achieved on a prototype sputtered magnetic tape developed by Sony Storage Media Solutions. The scientists presented the achievement today at the 28th Magnetic Recording Conference (TMRC 2017) here. Full Article IBM Storage
tor IBM Announces New Capabilities to Help On-Premises Customers Effectively Manage Compliance Data with Object Storage By www.ibm.com Published On :: Mon, 09 Oct 2017 02:01:10 GMT IBM today announced two significant milestones in making the on-premises IBM Cloud Object Storage System much more accessible for customers with new compliance-enabled vaults and concentrated dispersal mode capabilities. Full Article IBM Storage
tor Pets at Home Creates an In-Store Digital Experience with iPad App Developed By IBM By www.ibm.com Published On :: Tue, 11 Jul 2017 01:01:34 GMT Pets at Home, the UK’s leading pet specialist retailer and IBM today announced the launch of Sales Assist, an IBM MobileFirst for iOS app for iPad which will be used across 440 stores nationwide to make it easier and simpler for customers to purchase the products they need. Full Article IBM MobileFirst
tor IBM Announces Planned Acquisition of Promontory to Transform Regulatory Compliance with Watson By www.ibm.com Published On :: Thu, 29 Sep 2016 03:01:01 GMT IBM today announced plans to acquire Promontory Financial Group, a global market-leading risk management and regulatory compliance consulting firm. Upon close, the capabilities of Promontory combined with IBM's deep industry expertise and Watson’s cognitive capabilities will directly address the massive operational effort and manual cost of escalating regulation and risk management requirements. Full Article Global Financing
tor Not Just the End of IT, the End of IT Contractors By www.cringely.com Published On :: Mon, 30 Mar 2020 20:10:12 +0000 Earlier this week I predicted the demise of conventional IT caused by the wide adoption of SD-WAN and SASE, accelerated by the emergency demands of everyone working from home. Now that Congress has passed a $2.2 trillion COVID-19 bail-out, let’s throw-in the implications of that legislation to see what effect it is all likely to have on what used to be IT. The short version is to expect an even bigger bloodbath as IT employees at all levels are let go forever. Please understand that some version of this bloodbath was going to happen anyway. What matters right now is how we respond to it. While my previous column was generally about turning lower-level IT nerds into Uber drivers, this one goes a little further […] Digital Branding Web Design Marketing Full Article 2020 cloud computing computer networks Predictions strategy COVID-19 economics IBM recession SASE SD-WAN
tor IBM Combines All-Flash and Storage Software Optimized for Hortonworks By www.ibm.com Published On :: Mon, 24 Jul 2017 06:29:28 GMT IBM today announced a new all-flash, high-performance data and file management solution for enterprise clients running exabyte-scale big data analytics, cognitive and AI applications. The combined flash and storage software solution has been certified with the Hortonworks Data Platform (HDP) to provide clients with more choice in selecting the right platform for their big data analytics on data processing engines like Hadoop and Spark. Full Article Education
tor IBM Launches New Storage Software to Simplify Data Protection By www.ibm.com Published On :: Wed, 23 Aug 2017 01:01:29 GMT IBM today announced a new data protection software that is easy to set up, easy to manage and helps simplify data recovery. IBM Spectrum Protect™Plus can be set up quickly making data protection available in as little as one hour. Full Article Education
tor IBM Elects Two New Members to its Board of Directors By www.ibm.com Published On :: Mon, 30 Oct 2017 08:15:57 GMT The IBM board of directors today elected Joseph R. Swedish and Frederick H. Waddell to the board. Full Article Investors
tor IBM Inventors Receive Record-Breaking 8,000+ U.S. Patents in 2016 By www.ibm.com Published On :: Tue, 09 Jan 2018 09:01:58 GMT IBM today announced that it broke the U.S. patent record with 8,088 patents granted to its inventors in 2016, marking the 24th consecutive year of innovation leadership. IBM’s 2016 patent output covers a diverse range of inventions in artificial intelligence and cognitive computing, cognitive health, cloud, cybersecurity and other strategic growth areas for the company. Full Article Investors
tor Workshop FX adopts IBM enterprise storage solution to future proof 3D film and TV production By www.ibm.com Published On :: Tue, 02 Aug 2011 01:01:40 GMT IBM (NYSE: IBM) announced today that Workshop FX, a Wellington 3D Computer Animation and Visual FX company, is the first New Zealand customer to implement IBM SONAS, its scalable enterprise-class network attached storage array. SONAS (Scale Out Network Attached Storage) has enabled Workshop FX to significantly increase rendering productivity while preparing the studio for future business growth and emerging industry standards including 3D film production. Full Article Storage
tor IBM es designada en el reporte MarketScape de IDC como líder mundial en Servicios de Desarrollo de Aplicaciones Móviles y de Consultoría de Pruebas By www.ibm.com Published On :: mar, 07 abr 2015 02:51:27 GMT IBM anunció que fue designada como líder en el prestigiado modelo de evaluación de proveedores “IDC MarketScape: Worldwide Mobile Application Development and Testing Services 2014 Vendor Assessment”. Full Article Mobile
tor Estudio de IBM indica que 64% de los Directores de Marketing estará listo para adoptar Inteligencia Artificial en los próximos 3 años By www.ibm.com Published On :: lun, 14 ago 2017 04:19:52 GMT IBM reveló un nuevo estudio acerca de la manera en que los profesionales de marketing y ventas están adoptando soluciones cognitivas o de Inteligencia Artificial (IA). A pesar de que el 64% de los Directores de Marketing -CMOs por sus siglas en inglés- y líderes de ventas encuestados cree que sus industrias estarán listas para adoptar ese tipo de tecnologías en los próximos tres años, sólo 24% de los encuestados cree que tiene una estrategia establecida para hacerlo en la actualidad. Full Article IBM Watson
tor IBM y MIT Emprenden Investigación Conjunta en Inteligencia Artificial y Establecen el Laboratorio de IA MIT-IBM Watson By www.ibm.com Published On :: vie, 08 sep 2017 11:55:37 GMT IBM y el Instituto Tecnológico de Massachusetts (MIT) anunciaron los planes de IBM para realizar una inversión de 240 millones de dólares por 10 años a fin de crear el Laboratorio de Inteligencia Artificia MIT-IBM Watson. El laboratorio llevará a cabo investigaciones fundamentales de IA y buscará impulsar avances científicos que desbloqueen su potencial. La colaboración tiene como objetivo avanzar en el desarrollo del hardware, el software y los algoritmos de IA relacionados con el aprendizaje profundo y otras áreas, aumentar el impacto de la misma en industrias tales como el cuidado de la salud y la seguridad cibernética, así como explorar sus implicaciones económicas y éticas en la sociedad. La inversión de IBM de 240 millones de dólares en el laboratorio apoyará la investigación de científicos de IBM y del MIT. Full Article IBM Watson
tor IBM Award to Victoria University of Wellington Supports the Murchison Widefield Array Pathfinder Project for SKA By www.ibm.com Published On :: Mon, 11 Apr 2011 09:43:11 GMT (NYSE: IBM) will strengthen Australia and New Zealand’s chances of co-hosting the world’s biggest radio telescope project (SKA), one of the largest scientific projects ever undertaken. The IBM SUR Award of IBM high performance Graphical Processor Unit (GPU) based computer hardware, management software and implementation services, will enable Victoria University to support the Murchison Widefield Array (MWA) project, a low frequency SKA pathfinder project hosted in Australia in collaboration with Curtin University, MIT, the Smithsonian Institute, and the Raman Research Institute. Full Article Education
tor University of Canterbury adopts IBM enterprise storage solution to enhance user experience By www.ibm.com Published On :: Wed, 14 Dec 2011 11:56:44 GMT The University of Canterbury (UC) is upgrading its centralised IT storage system with the IBM XIV and SONAS network attached storage arrays, to protect valuable research data and better meet user long term needs, while reducing operational costs. Full Article Education
tor IDC reconoce liderazgo de IBM en consultoría de movilidad empresarial By www.ibm.com Published On :: mar, 11 jun 2013 11:33:07 GMT IBM anunció que fue nombrada líder en el informe 2013 IDC MarketScape, que analiza a los proveedores de consultoría en movilidad empresarial a nivel mundial. El informe cita al recientemente anunciado Customer Experience Lab y la iniciativa Mobile First de IBM como ejemplos de su liderazgo en Consultoría en Movilidad Empresarial. Full Article Services and solutions