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On paper characterisation of droplet and evaporation study using impedance spectroscopy

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00303A, Paper
O. Kare Siva Prakasam, Akashlina Basu, Koel Chaudhury, Soumen Das
A paper chip employs an impedance method to determine the characteristics of the droplet. We compare the traditional evaporation method with the electrical method to study the evaporation of various liquids.
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Direct detection of dithiocarbamate fungicides by SALDI/MS using porous TiC ceramic powder as a substrate

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY01533E, Paper
Hiroshi Moriwaki, Issey Osaka, Kotaro Hashimoto, Osamu Yamada
Direct detection of dithiocarbamate fungicides (DTCs) has been achieved by SALDI/MS using porous titanium carbide (TiC) ceramic powder as a substrate.
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Near-infrared responsive gold nanorods for highly sensitive colorimetric and photothermal lateral flow immuno-detection of SARS-CoV-2

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00347K, Paper
Xiaohui Liu, Jingwen Li, Kun Wang, Xiang Li, Shenming Wang, Gengchen Guo, Qiaowen Zheng, Maosheng Zhang, Jingbin Zeng
We developed a colorimetric and photothermal dual-mode LFIA platform for sensitive and selective SARS-CoV-2 N protein detection based on gold nanorods.
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Discrimination of Diptera order insects based on their saturated cuticular hydrocarbon content using a new microextraction procedure and chromatographic analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00214H, Paper
Open Access
Lixy Olinda León-Morán, Marta Pastor-Belda, Pilar Viñas, Natalia Arroyo-Manzanares, María Dolores García, María Isabel Arnaldos, Natalia Campillo
The nature and proportions of hydrocarbons in the cuticle of insects is characteristic of the species and age. Chemical analysis of cuticular hydrocarbons allows species discrimination, which is of great...
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Field method for preservation of total mercury in waters, including those associated with artisanal scale gold mining

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02216A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
David C. P. King, Michael J. Watts, Elliott M. Hamilton, Robert J. G. Mortimer, Mike Coffey, Odipo Osano, Maureene Auma Ondayo, Marcello Di Bonito
A method was developed for sampling and preserving total Hg from water samples, recovering >75% Hg over 4 weeks of storage. The method was assessed using water samples at artisanal gold mining sites in Kenya.
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Direct solid sample analysis of low-cost jewelry using spectroanalytical techniques: exploratory chemical data evaluation and metal migration with synthetic sweat

Anal. Methods, 2024, 16,2286-2291
DOI: 10.1039/D4AY00325J, Paper
Thaila Lorena de Araújo, Fabiola Manhas Verbi Pereira, Edenir Rodrigues Pereira-Filho
Jewelry samples were directly analyzed using LIBS and XRF.
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Characterizing a visual lateral flow device for rapid SARS-CoV-2 virus protein detection: pre-clinical and system assessment

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02075D, Paper
Natpapas Wiriyachaiporn, Jetnapang Kongrueng, Kannika Sukkuea, Rattana Tanrattanawong, Jarunee Vanichtanankul, Thanaya Saeyang, Tararat Jantra, Deanpen Japrung, Weerakanya Maneeprakorn, Suwussa Bamrungsap, Pareena Janchompoo, Ekawat Pasomsub
Analytical and pre-clinical evaluation of a visual screening lateral flow device for SARS-CoV-2 virus protein detection and its system characterization.
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A complementary method with PFBBr-derivatization based on a GC-EI-MS platform for the simultaneous quantitation of short-, medium- and long-chain fatty acids in murine plasma and feces samples

Anal. Methods, 2024, 16,2330-2339
DOI: 10.1039/D3AY02271D, Paper
Hong-Xu Zhou, Qing Jiang, Xin He, Xian Fu, Jun-Yan Liu
Fatty acids (FAs) are essential molecules in all organisms and are involved in various physiological and pathophysiological processes.
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A chemiluminescence immunoassay for type IV collagen as a promising marker for liver fibrosis and cirrhosis

Anal. Methods, 2024, 16,2248-2255
DOI: 10.1039/D3AY02240D, Paper
Xiaoling Fu, Fan Zhang, Fangda Zhen, Lian Duan, Jian Zhou, Jianguo Ma
Herein, a magnetic bead-based chemiluminescence assay is reported to detect type IV collagen (col-IV) in serum samples.
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An immunochromatographic strip sensor for rapid and sensitive detection of candesartan, olmesartan medoxomil, and irbesartan in herbal beverages

Anal. Methods, 2024, 16,2359-2367
DOI: 10.1039/D4AY00151F, Paper
Dingyu Li, Aihong Wu, Liqiang Liu, Hua Kuang, Chuanlai Xu, Xiaoling Wu
Sartans, as a class of antihypertensive drugs, pose a threat to human health when illegally added to herbal beverages.
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Paper-based sensors: affordable, versatile, and emerging analyte detection platforms

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02258G, Critical Review
Open Access
Sumit Malik, Joginder Singh, Kajal Saini, Vivek Chaudhary, Ahmad Umar, Ahmed A. Ibrahim, Sheikh Akbar, Sotirios Baskoutas
The schematic representation of distance based paper sensor to identify lead in food samples.
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Simple fluorescence “turn-off” assay for Congo red using commercial 2-aminophthalic acid

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00506F, Paper
Jiaqi Qian, Jie Li, Yihan Jiang, Chaoyong Liu, Jiayao Zhu, Liyu Gu, Yongming Guo
2-Aminophthalic acid with a high quantum yield of 38.49% was utilized for fluorescence “turn-off” sensing of Congo red with a linear range of 0.05–50 μM and a limit of detection of 1.72 μM.
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Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00264D, Paper
Mariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia Doss
Fabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.
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Α simplified lateral flow immunosensor for the assay of carcinoembryonic antigen in low-resource settings

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00381K, Paper
Open Access
Ioanna Tsogka, Electra Mermiga, Varvara Pagkali, Christos Kokkinos, Anastasios Economou
Carcinoembryonic antigen (CEA) is a glycoprotein widely used as a tumor marker. In this work, a colorimetric lateral flow immunosensor is developed for rapid and low-cost quantification of CEA in...
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Novel advanced materials and magnetic solid phase extraction as approaches in sample preparation to enhance the analysis of ochratoxin A in peanuts

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00246F, Paper
Bingchen Wang, Yifan Wang, Xiuyuan Zhang, Kuo He
In order to improve the detection efficiency of ochratoxin, a superparamagnetic nano-material was synthesized for solid phase extraction of ochratoxin.
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How to Disable JavaScript in Almost Any Browser

In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile.

I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit.

The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs.




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​Weather gods: On ‘Mission Mausam’

Attempts at controlling the weather are still in the realm of uncertainty




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Take the gauntlet: On safety and the Indian Railways

‘Kavach’ implementation is a priority but will not be a silver bullet




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
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Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article
Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
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Property-based optimisation of PROTACs

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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Doctor assaulted inside Tiruchi ESI Hospital




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Data crucial for building climate resilience, says ISRO scientist




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Agro-tourism push needs industry-specific policies, say farmers




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Paddy crop loss compensation pegged at ₹36,500




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Three arrested for assaulting doctor in ESI hospital




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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550: Sanity with Simen Svale Skogsrud and Espen Hovlandsdal

Simen and Espen from Sanity stop by to talk about the origins of Sanity, how Sanity Studio works, good use cases for Sanity, how Sanity does real time updates, what Groq is, and where to start with Sanity.




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585: Blog Redesign, Sounds on a Website, Accessibility Tests, and Safari 17

Chris redesigned his blog, using sounds on your website to make it seem fancy, what can't automated accessibility tests test, and what's new in Safari 17.




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598: Jen Simmons on Interop, WebKit Releases, and New CSS Features in Safari

Jen Simmons, Apple Evangelist on the Web Developer Experience team for Safari & Webkit, stops by to talk about what Interop is, and a look ahead at new CSS features in Webkit and Safari such as JPEG XL, masks, a round function, JavaScript improvements, styling form controls, content unblocks, masonry, and more!




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641: Passkey Usage, Writing Code with a Bot, and What’s Up With Java?

We've got a few leftovers from Halloween to process, what's been happening with Passkeys in late 2024, have you tried to write HTML faster than a bot can suggest it to you, CSS anchor positioning and popover polyfills, scroll driven animation thoughts, CSS nesting, and what's the reason for Java?




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Saving six rivers

Unless an institution is created and armed with powers to manage the Nandi Hills range we will see the gradual demise of a culture centered around water and the death of six rivers.




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How to save power

U. V. Krishna Mohan Rao tells Hema Vijay how families waste electricity




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Guidelines for green urbanisation

The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports




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Give high priority to fire safety

In majority of high-rise buildings, power supply distribution and meter panels are located in the basement floors making them vulnerable to fire mishaps, writes Avala Buchi Reddy




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Say ‘no’ to joints and mortars

It would lead to lesser material consumption, zero wastage, faster construction and better aesthetics




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Saving on time, money

Experts feel pre-cast technology could solve housing problems for the economically weaker sections, despite limitations in additions, alterations and repairs.




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Urban Safari

Old or new, whichever iteration of the Tata Safari you look at, there’s a lot of charm, utility, and driving appeal, but which one gets our vote?




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Cold plunges, hot saunas, smoothies, and fasting

Fitness regimen on the go




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Flat organisation believers: Can you imagine a world without managers?

What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important?




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The secret sauce behind ITC’s enduring restaurant brands

The promise of an unchanged, consistent menu and supreme culinary artistry has drawn food lovers to ITC’s tables for decades




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‘Our goal is beauty for each,’ says L’Oréal India chief

Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey