se Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se Supreme Court stays order for CBI probe into sexual assault of minor in Chennai By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:07:47 +0530 Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre Full Article Tamil Nadu
se Amaran is a film about a soldier’s life, nothing more: Seeman By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:55:42 +0530 Full Article Tamil Nadu
se Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:48 +0530 Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme Full Article Tamil Nadu
se IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
se Southern Railway refuses to share inquiry report of Perumon train tragedy By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:15:33 +0530 105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988 Full Article Tamil Nadu
se Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:01 +0530 There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff Full Article Tamil Nadu
se Delhi airport sees seven flight diversions owing to bad weather By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:39:37 +0530 The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi Full Article Delhi
se Delhi’s air quality turns ‘severe’ for first time this season: CPCB By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:52:21 +0530 According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418 Full Article Delhi
se Wall Street makes wagers on the likely winners and losers in a second Trump term By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:55:27 +0530 Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets Full Article Business
se Sensex, Nifty hit a five-month low By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:11:22 +0530 Fifth straight losing session at the bourses; shares in the midcap, small cap segments plunged harder than large companies’ stocks in what some called ‘correction mode’ Full Article Business
se Incessant rains cause landslides on Tirumala ghat road By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:56:12 +0530 Full Article Andhra Pradesh
se SEIL Energy bags seven awards from QCFI By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:35:31 +0530 Full Article Andhra Pradesh
se All set for Urus festival at Pedda Dargah in Kadapa By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:11 +0530 Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16 Full Article Andhra Pradesh
se Centre’s nod sought for Vizag Metro, MA&UD Minister informs A.P. Assembly By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:55:45 +0530 The revised cost estimate stands at ₹17,232 crore; the project is initially proposed to come up in two phases with four corridors spanning a total length of 76 km Full Article Andhra Pradesh
se Water supply from Pampa Reservoir to be paused this rabi By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:59:48 +0530 IAB makes decision to allow reservoir gate repairs and aqueduct construction works; water to affected lands to be supplied from the Eastern Godavari Delta, Pithapuram Branch Canal and Yeleru Reservoir instead Full Article Andhra Pradesh
se Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:11 +0530 It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion Full Article Andhra Pradesh
se New road proposed from IIT-Tirupati campus to Rachagunneri By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:18:24 +0530 Rachagunneri is home to the massive 400/220/132kV electrical substation and also a private steel plant Full Article Andhra Pradesh
se PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:16 +0530 Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department Full Article Andhra Pradesh
se RLDA invites bids for commercial land use in Tirupati railway station By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:29:31 +0530 The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side Full Article Andhra Pradesh
se Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:30:46 +0530 Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister Full Article Andhra Pradesh
se Jagan dares govt. to arrest him, says will continue to ‘expose failures’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:16:05 +0530 Full Article Andhra Pradesh
se Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:31 +0530 Full Article Andhra Pradesh
se Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:30:39 +0530 Full Article Andhra Pradesh
se Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 11:31:53 +0530 The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling Full Article News
se IMD forecasts onset of winter in Telangana by November-end By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:22:39 +0530 Full Article Telangana
se Peddapalli goods train derailment: Several trains cancelled or diverted By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:43:36 +0530 Three railway lines were affected in the derailment. Some trains skipped stoppages. Full Article Telangana
se Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:18:36 +0530 Full Article Hyderabad
se Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:04:48 +0530 Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care Full Article Health
se Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:45:12 +0530 Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka Full Article Karnataka
se Karnataka High Court dismisses Union Bank of India’s petition seeking transfer of Valmiki corporation case to CBI By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:28:26 +0530 ‘Banking Regulations Act does not empower banks to seek transfer of probe into criminal cases registered by States to agency of its choice’ Full Article Karnataka
se Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:31:09 +0530 Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them. Full Article Karnataka
se KEA opposes fee reduction for recruitment examinations in Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:47:00 +0530 Points out that the government does not provide any grant for conducting recruitment examinations Full Article Karnataka
se ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:12:55 +0530 Full Article Karnataka
se Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:21:10 +0530 Full Article Karnataka
se Union and State governments should set up Sanatana Board, demand seers By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:27:24 +0530 Full Article Karnataka
se Marakumbi atrocity case: 99 persons granted bail by High Court Dharwad Bench By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:34:18 +0530 Full Article Karnataka
se Byelections: Polling passes off peacefully in Sandur By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:51:08 +0530 Full Article Karnataka
se Kannada has survived because of native speakers from North Karnataka: Horatti By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:05:42 +0530 Full Article Karnataka
se After hosting World Cup, Qatar praised by U.N. rights body for labour law reforms but urged to do more By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:06:56 +0530 In Qatar, better labour law protections have been passed in recent years relating to a minimum wage, freedom to change employers and combating forced labor and trafficking Full Article World
se Carlsen in focus as top stars vie for honours By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:19:50 +0530 The focus, of course, will be very much on Carlsen, who is returning to the tournament that he won in convincing fashion in 2019 Full Article Sport
se Final Call, Trevalius, Densetsu, Once You Go Black and Champions Way catch the eye By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:29:08 +0530 Full Article Races
se 667 UK-owned businesses in India generated over ₹5 lakh crores in revenue: report By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:21:12 +0530 According to the report, fifteen UK companies have achieved triple-digit turnover growth rates, with Vedanta leading as the largest UK company in India by revenue, generating over ₹1,50,100 crores in 2023 Full Article Companies
se SoftBank swings to profit of $7.7 billion for September quarter on back of strong listings By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:49:56 +0530 Vision Funds (SVF1 and SVF2) sold investments totalling $1.85 billion for the six-month period ended September 30 Full Article Companies
se MobiKwik sees no business impact due to RBI’s P2P diktat, Co-Founder Taku says By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:57:54 +0530 Revenue likely to grow over 50 per cent for many years, Taku says Full Article Companies
se Ennoventure bags $8.9 million in Series A led by Tanglin Venture Partners By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 10:50:10 +0530 The round included participation from existing investors, such as Fenice Investment Group and additional SAFE investors Full Article Companies