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Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
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Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Supreme Court stays order for CBI probe into sexual assault of minor in Chennai

Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre




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Amaran is a film about a soldier’s life, nothing more: Seeman




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Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers

Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme




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IIT-M students develop robot for O.P. Jindal university’s Constitution Museum

It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says




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Southern Railway refuses to share inquiry report of Perumon train tragedy

105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988




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Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India

There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff




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Delhi airport sees seven flight diversions owing to bad weather

The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi




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Delhi’s air quality turns ‘severe’ for first time this season: CPCB

According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418




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Wall Street makes wagers on the likely winners and losers in a second Trump term

Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets




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Sensex, Nifty hit a five-month low

Fifth straight losing session at the bourses; shares in the midcap, small cap segments plunged harder than large companies’ stocks in what some called ‘correction mode’




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Incessant rains cause landslides on Tirumala ghat road




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SEIL Energy bags seven awards from QCFI




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All set for Urus festival at Pedda Dargah in Kadapa

Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16




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Centre’s nod sought for Vizag Metro, MA&UD Minister informs A.P. Assembly

The revised cost estimate stands at ₹17,232 crore; the project is initially proposed to come up in two phases with four corridors spanning a total length of 76 km




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Water supply from Pampa Reservoir to be paused this rabi

IAB makes decision to allow reservoir gate repairs and aqueduct construction works; water to affected lands to be supplied from the Eastern Godavari Delta, Pithapuram Branch Canal and Yeleru Reservoir instead




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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New road proposed from IIT-Tirupati campus to Rachagunneri

Rachagunneri is home to the massive 400/220/132kV electrical substation and also a private steel plant




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PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget

Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department




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RLDA invites bids for commercial land use in Tirupati railway station

The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side




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Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister 

Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister




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Jagan dares govt. to arrest him, says will continue to ‘expose failures’




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Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




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Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’




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Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional

The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling




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IMD forecasts onset of winter in Telangana by November-end




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Peddapalli goods train derailment: Several trains cancelled or diverted

Three railway lines were affected in the derailment. Some trains skipped stoppages.




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Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM




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Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening

Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care




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Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur

Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka




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Karnataka High Court dismisses Union Bank of India’s petition seeking transfer of Valmiki corporation case to CBI

‘Banking Regulations Act does not empower banks to seek transfer of probe into criminal cases registered by States to agency of its choice’




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Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency

Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them.




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KEA opposes fee reduction for recruitment examinations in Karnataka

Points out that the government does not provide any grant for conducting recruitment examinations




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ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah




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Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts




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Union and State governments should set up Sanatana Board, demand seers




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Marakumbi atrocity case: 99 persons granted bail by High Court Dharwad Bench




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Byelections: Polling passes off peacefully in Sandur




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Kannada has survived because of native speakers from North Karnataka: Horatti




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After hosting World Cup, Qatar praised by U.N. rights body for labour law reforms but urged to do more

In Qatar, better labour law protections have been passed in recent years relating to a minimum wage, freedom to change employers and combating forced labor and trafficking




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Carlsen in focus as top stars vie for honours

The focus, of course, will be very much on Carlsen, who is returning to the tournament that he won in convincing fashion in 2019




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Final Call, Trevalius, Densetsu, Once You Go Black and Champions Way catch the eye




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667 UK-owned businesses in India generated over ₹5 lakh crores in revenue: report

According to the report, fifteen UK companies have achieved triple-digit turnover growth rates, with Vedanta leading as the largest UK company in India by revenue, generating over ₹1,50,100 crores in 2023




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SoftBank swings to profit of $7.7 billion for September quarter on back of strong listings

Vision Funds (SVF1 and SVF2) sold investments totalling $1.85 billion for the six-month period ended September 30




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MobiKwik sees no business impact due to RBI’s P2P diktat, Co-Founder Taku says

Revenue likely to grow over 50 per cent for many years, Taku says




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Ennoventure bags $8.9 million in Series A led by Tanglin Venture Partners

The round included participation from existing investors, such as Fenice Investment Group and additional SAFE investors