Seasonal and pandemic influenza causes 650,000 deaths annually in the world. The emergence of drug-resistance to specific anti-influenza drugs such as oseltamivir and baloxavir marboxil highlights the urgency of novel anti-influenza chemical entity discovery. In this study, we report a series of novel thiazolides derived from an FDA-approved drug nitazoxanide with antiviral activity against influenza and a broad range of viruses. The preferred candidates 4a and 4d showed significantly enhanced anti-influenza potentials with 10-fold improvement, compared with nitazoxanide, and were effective against a variety of influenza subtypes including oseltamivir-resistant strains. Notably, the combination using of compounds 4a/4d and oseltamivir carboxylate or zanamivir displayed synergistic antiviral effect against oseltamivir-resistant strain. Mode of action analysis demonstrated that compounds 4a/4d acted at the late phase of viral infection cycle through inhibiting viral RNA transcription and replication. Further experiments showed that treatment with compounds 4a/4d significantly inhibited influenza virus infection in human lung organoids, suggesting the druggability of the novel thiazolides. In-depth transcriptome analysis revealed a series of up-regulated cellular genes that may contribute to the antiviral activities of 4a/4d. Together, our study pointed the optimization direction of nitazoxanide as anti-influenza drug, and discovered two novel-structured candidates 4a/4d with relatively broad-spectrum antiviral potential.

BACKGROUND:

Current guidelines from the American Academy of Pediatrics recommend screening children for developmental problems by using a standardized screening tool and referring at-risk patients to early intervention (EI) or subspecialists. Adoption of guidelines has been gradual, with research showing many children still not being screened and referred.

Rural families are less likely to use special education or early intervention services than children living in urban areas, a new Centers for Disease Control survey reveals.

Despite being rebuked by Congress in its bid to do so last year, the U.S. Department of Education says it will use Education Innovation and Research funds for teacher professional development vouchers.

Maureen Hack
Aug 1, 2005; 116:333-341
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Coleen A. Boyle
Jun 1, 2011; 127:1034-1042
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Richard A. Ehrenkranz
Apr 1, 2006; 117:1253-1261
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Betty R. Vohr
Jun 1, 2000; 105:1216-1226
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Faculty from six campuses were awarded a grant from Penn State’s Schreyer Institute for Teaching Excellence to seek a multi-campus approval as a Certified Family Life Educator program.

The Association for Clinical and Translational Science recently recognized Steven Hicks for his achievements. Hicks received the Early (Faculty) Career Development Award.

Some of the most important pre-literacy skills begin in infancy. This timeline shows examples of the milestones children meet on their path to fluent reading.

Cape Town's East City Precinct - between the CBD and District Six - are undergoing a revival and the new The Harri residential development is an example of this trend.

Construction work on FWJK's R800 million residential development known as 16 on Bree has topped out with the 36th floor having been cast.

Downtown revitalization efforts in Wilmington, Dover and Seaford continue to gain momentum, with new projects in all three counties slated to receive funding from Delaware’s Downtown Development Districts program.

Wilmington, DE – Highlighting ongoing efforts to revitalize Delaware’s downtowns, Governor Jack Markell and Delaware State Housing Authority Director Anas Ben Addi presented a grant check on Monday to the owners of Tonic Bar and Grille, money that helped Tonic fund extensive renovations throughout the restaurant. Tonic’s grant rebate was funded by Delaware’s Downtown Development […]

$4.5 million in grant funding for 11 projects will leverage $130 million in private investment DOVER, DE — Building on progress in Delaware’s downtowns, Governor Jack Markell and the Delaware State Housing Authority announced on Monday that 11 new downtown revitalization projects in Wilmington, Dover and Seaford will receive $4.5 million in grant funding through […]

Governor Jack Markell on Wednesday announced a statewide expansion of Delaware's Downtown Development Districts program, significantly building on the state's efforts to redevelop Delaware’s commercial business districts and drive private investment in towns and cities. Five new Downtown Development Districts were officially designated in Smyrna, Harrington, Milford, Georgetown and Laurel. Investors who make qualified improvements to residential, commercial, or industrial properties in those districts now may qualify for state and local development incentives, including 20 percent state grant rebates.

$3.6 million in grant funding for 16 projects to leverage $38.6 million in private investment MILFORD – Building on progress in Delaware’s downtowns, Governor Jack Markell and the Delaware State Housing Authority announced on Tuesday that sixteen new downtown revitalization projects in Harrington, Milford, Dover, Smyrna and Wilmington will receive $3.56 million in grant funding […]

Projects in Dover, Georgetown, Harrington, Laurel, Milford, Seaford, Smyrna and Wilmington Eligible For Funding DOVER — The Delaware State Housing Authority is accepting applications through December 15 for large project grants through the Downtown Development District Program. The grants provide up to 20 percent rebates on qualified real property investments in one of the eight […]

$4.3 million in rebates will leverage $53 million in economic investment LAUREL – Ten downtown revitalization projects in Laurel, Georgetown, Dover and Wilmington have been selected for Delaware’s Downtown Development District Program rebates, with $4.3 million in rebates leveraging $53 million in total investment, Governor John Carney and the Delaware State Housing Authority announced Monday. […]

SMYRNA – Building on progress in Delaware’s downtowns, Governor John Carney and the Delaware State Housing Authority (DSHA) announced today that eight new downtown revitalization projects in Milford, Dover and Wilmington will receive $4.6 million in rebate funding through Delaware’s Downtown Development Districts (DDD) program. Established in May 2014, the DDD program was created to […]

DOVER – Twelve downtown revitalization projects in Milford, Smyrna and Wilmington have been selected to receive funding through Delaware’s Downtown Development Districts (DDD) program, with $5.5 million in rebates leveraging $103 million in total investment, Governor John Carney and the Delaware State Housing Authority (DSHA) announced today. Established in May 2014, the DDD program was […]

Seven affordable housing projects statewide will receive a total of $1 million from Delaware’s Housing Development Fund (HDF), Governor John Carney announced today joined by Delaware State Housing Authority (DSHA) Director Anas Ben Addi, New Castle County Executive Matt Meyer, elected officials and community leaders from across Delaware.

Penn State University Police and Public Safety  Deputy Chief Tom Sowerby was recently appointed as the commander of a new University-wide Criminal Investigation Unit, to better serve 22 Penn State campuses where University Police and Public Safety provides police services.

Dover, Del. (October 23, 2017) – The state of Delaware wants to hear from small business owners, community leaders and interested citizens as the new Division of Small Business, Development & Tourism charts a path forward. There will be three listening sessions this week – one in each county – to allow the public to […]

A company working to make NASA spacesuits stronger and safer and another providing data to millions of drivers to help them avoid traffic jams are both growing in Delaware. Assistance from the state Division of Small Business, Development & Tourism is helping STF Technologies and TrafficCast take their businesses to the next level. “Growth in […]

Building on efforts to revitalize downtown areas statewide, Governor Jack Markell announced on Wednesday that the state will accept new applications from local governments interested in being designated as Downtown Development Districts. Residential, commercial and industrial development in designated districts may qualify for a menu of local and state incentives, including grant rebates to offset the cost of private investment. Governor Markell made the announcement Wednesday morning in Wilmington at the 2016 Downtown Delaware “Revitalize!” Conference.

Governor Carney officially designated four new Downtown Development Districts – in Delaware City, Middletown, New Castle and Clayton. Investors who make qualified improvements to residential, commercial or industrial properties in those districts now may qualify for state and local development incentives, including a rebate of up to 20 percent of eligible costs upon completion of the project.

Middletown’s FFA Chapter won the 2016 Forestry Career Development Event (CDE) – a challenging test of tree identification skills, forestry knowledge, and math abilities – held this week at Brecknock Park in Camden. Middletown will go on to compete in the forestry event at the 89th National FFA Convention & Expo from Oct. 19 to 22, 2016 in Indianapolis, IN. The Milford FFA Chapter placed second and will go on to compete in the forestry competition at the Eastern States Exposition or “The Big E!,” scheduled to take place in Springfield, MA on September 17.

Woodbridge High School's FFA took the top spot at the 2018 Forestry Career Development Event (CDE) held in Camden, Delaware this week.  Woodbridge was followed by Middletown, Smyrna, and Sussex Central. Woodbridge will now go on to represent Delaware at the 91st Annual FFA Convention & Expo in Indianapolis from October 24 to 27, 2018. For the first time, the 2018 challenge included a total of eight middle and high school teams competing in separate events at the same location. Smyrna Middle School's FFA took first place in their event, beating out teams from Walters Middle School (Appoquinimink), Meredith Middle School (Appoquinimink) and Millsboro Middle School.

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Agency: HSS Closing Date: 5/12/2020

NEW CASTLE (June 12, 2019) – The Division of Developmental Disabilities Services (DDDS) will host two sessions later this month for families interested in applying for the Lifespan Waiver, which is designed to enable individuals with intellectual/developmental disabilities, autism spectrum disorder or Prader-Willi Syndrome who have left school to live safely in the community. The […]

DOVER – Delaware State Housing Authority (DSHA) is accepting applications through June 1 for large project rebate reservations through the Downtown Development Districts (DDD) program. Investors who make qualified real property investments in one of 12 designated districts can apply for a rebate of up to 20 percent of eligible costs. The designated districts are: […]

The stakes in finding a vaccine against the coronavirus couldn’t be higher. In just a few months the disease has claimed more than a quarter of a million lives and shattered economies worldwide.

  Last month, Pokémon GO officially launched in… Oh, wait! Not again! Not another article about augmented reality starting with Pokémon GO! It almost seems as if Pokémon GO a...

She also encouraged the NDB to take appropriate steps to join the G-20 forum, along with the multilateral development banks and international financial institutions.

Technology will play a crucial role in developing the EV ecosystem including in design, simulation, manufacturing and developing the overall vehicle cycle.