Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 8th Greater Mekong Subregion Summit, Leaders’ Retreat, 7 November 2024

Does competition enhance productivity growth of a developing economy? Is global competition conducive to economic development? Answers as evidenced from Korean microdata.

In a case study on Korea, a VAR model is used to investigate the effects of capital flows on asset prices.

This paper is part of a cross-country study on corporate governance in Asia. A consensus has yet to be reached about exactly what factors were behind the crisis of 1998 and how these factors interacted in bringing about the crisis.

This edition of the ASEAN+3 Bond Market Guide series focuses on updates in the Republic of Korea’s (ROK) market since the publication of the previous guide for the ROK in 2018.

There may be ways to work with your body’s natural daily and monthly cycles to get the maximum benefits from workouts and avoid injury

Title: Whey Protein May Beat Casein After Workouts
Category: Health News
Created: 8/20/2011 11:01:00 AM
Last Editorial Review: 8/22/2011 12:00:00 AM

Title: Salmonella Outbreak in 4 States Linked to Kosher Chicken: CDC
Category: Health News
Created: 8/30/2018 12:00:00 AM
Last Editorial Review: 8/30/2018 12:00:00 AM

Title: Want to Maintain Muscle? Frequency of Workouts Is Key
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM

Title: gotu kola
Category: Medications
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM

BACKGROUND:Opioids are known to cause respiratory depression, aspiration, and to suppress the immune system. This study aimed to investigate the relationship between short- and long-term opioid use and the occurrence and clinical outcomes of pneumonia in South Korea.METHODS:The data for this population-based retrospective cohort analysis were obtained from the South Korean National Health Insurance Service. The opioid user group consisted of those prescribed opioids in 2016, while the non-user group, who did not receive opioid prescriptions that year, was selected using a 1:1 stratified random sampling method. The opioid users were categorized into short-term (1–89 d) and long-term (≥90 d) users. The primary end point was pneumonia incidence from January 1, 2017–December 31, 2021, with secondary end points including pneumonia-related hospitalizations and mortality rates during the study period.RESULTS:In total, 4,556,606 adults were enrolled (opioid group, 2,070,039). Opioid users had a 3% higher risk of pneumonia and an 11% higher risk of pneumonia requiring hospitalization compared to non-users. Short-term users had a 3% higher risk of pneumonia, and long-term users had a 4% higher risk compared to non-users (P < .001). Additionally, short-term users had an 8% higher risk of hospital-treated pneumonia, and long-term users had a 17% higher risk compared to non-users (P < .001).CONCLUSIONS:Both short- and long-term opioid prescriptions were associated with higher incidences of pneumonia and hospital-treated pneumonia. In addition, long-term opioid prescriptions were linked to higher mortality rates due to pneumonia.

During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions. We found here that knockout of YY1 at the pro-B-cell stage eliminates B lineage commitment. YY1 knockout pro-B cells can generate T lineage cells in vitro using the OP9-DL4 feeder system and in vivo after injection into sublethally irradiated Rag1^–/– mice. These T lineage-like cells lose their B lineage transcript profile and gain a T-cell lineage profile. Single-cell RNA-seq experiments showed that as YY1 knockout pro-B cells transition into T lineage cells in vitro, various cell clusters adopt transcript profiles representing a multiplicity of hematopoietic lineages, indicating unusual lineage plasticity. In addition, YY1 KO pro-B cells in vivo can give rise to other hematopoietic lineages in vivo. Evaluation of RNA-seq, scRNA-seq, ChIP-seq, and scATAC-seq data indicates that YY1 controls numerous chromatin-modifying proteins leading to increased accessibility of alternative lineage genes in YY1 knockout pro-B cells. Given the ubiquitous nature of YY1 and its dual activation and repression functions, YY1 may regulate commitment in multiple cell lineages.

The diagnosis of maturity-onset diabetes of the young (MODY), a monogenic form of diabetes mellitus caused by a mutation in a single gene, is often uncertain until genetic testing is performed. We report a 13-yr-old Korean boy who was initially diagnosed with type 2 diabetes (T2DM). MODY was suspected because of his nonobese body habitus and family history of multiple affected members. Targeted panel sequencing of all MODY-related genes was performed using the NextSeq 550Dx platform (Illumina). Sanger sequencing was performed using blood samples from the parents, siblings, and other relatives. A frameshift variant in the 3' region of the last exon of PDX1 was detected in the patient and his family members with diabetes. PP1_Moderate criterion was applied and this variant was confirmed to be the genetic cause of diabetes in the family and classified as likely pathogenic. The study highlights the importance of genetic testing for nonobese, early-onset diabetic patients with multiple affected family members. Increased awareness and aggressive genetic testing for MODY are needed.

WASHINGTON — Secretary of State Rex Tillerson says diplomatic efforts aimed at resolving the North Korean crisis “will continue until the first bomb drops.”

That statement comes despite President Donald Trump’s tweets a couple of weeks ago that his chief envoy was “wasting his time” trying to negotiate with “Little Rocket Man,” a mocking nickname Trump has given the nuclear-armed nation’s leader, Kim Jong Un.

“I think he does want to be clear with Kim Jong Un and that regime in North Korea that he has military preparations ready to go and he has those military options on the table. And we have spent substantial time actually perfecting those,” Tillerson told CNN’s “State of the Union” on Sunday. “But be clear: The president has also made clear to me that he wants this solved diplomatically. He’s not seeking to go to war.”

Recent mixed messaging from the top of the U.S. government has raised concerns about the potential for miscalculation amid the increasingly bellicose exchange of words by Trump and the North Korean leader.

Trump told the U.N. General Assembly last month that if the U.S. is “forced to defend itself or its allies, we will have no choice but to totally destroy North Korea.” Trump also tweeted that Korea’s leadership “won’t be around much longer” if it continued its provocations, a declaration that led the North’s foreign minister to assert that Trump had “declared war on our country.”

Tillerson acknowledged during a recent trip to Beijing that the Trump administration was keeping open direct channels of communications with North Korea and probing the North’s willingness to talk. He provided no elaboration about those channels or the substance of any discussions.

Soon after, Trump took to Twitter, saying he had told “our wonderful Secretary of State, that he is wasting his time trying to negotiate with Little Rocket Man … Save your energy Rex, we’ll do what has to be done!” Trump offered no further explanation, but he said all military options are on the table for dealing with North Korea’s nuclear and missile programs.

Analysts have speculated about whether the president and his top diplomat were playing “good cop, bad cop” with North Korea, and how China might interpret the confusing signals from Washington. Beijing is the North’s main trading partner, and the U.S. is counting on China to enforce U.N. sanctions.

“Rest assured that the Chinese are not confused in any way what the American policy towards North Korea (is) or what our actions and efforts are directed at,” Tillerson said.

Asked if Trump’s tweets undermined Tillerson, the secretary said: “I think what the president is doing is he’s trying to motivate action on a number of people’s part, in particular the regime in North Korea. I think he does want to be clear with Kim Jong Un and that regime in North Korea that he has military preparations ready to go and he has those military options on the table and we have spent substantial time perfecting those.”

He added that Trump “has made it clear to me to continue my diplomatic efforts, which we are, and I’ve told others those diplomatic efforts will continue until the first bomb drops.”

North Korea has launched missiles that potentially can strike the U.S. mainland and recently conducted its largest ever underground nuclear explosion. It has threatened to explode another nuclear bomb above the Pacific.

The post Rex Tillerson says continue diplomacy with North Korea ‘until first bomb drops’ appeared first on PBS NewsHour.

TOKYO — U.S. and Japanese diplomats agreed Tuesday to maximize pressure on North Korea to resolve tensions over its nuclear program, while citing the need to be prepared for the worst if diplomacy fails.

U.S. Deputy Secretary of State John Sullivan, after meeting his Japanese counterpart, Shinsuke Sugiyama, told reporters that the focus at the State Department is still on diplomacy to solve the problem and eventually denuclearize the Korean Peninsula.

“We must, however, with our allies in Japan and South Korea and elsewhere, be prepared for the worst should diplomacy fail,” he said. The U.S. must be prepared to defend itself and its allies, he said.

Sugiyama, briefing reporters separately, reiterated Japan’s support for President Donald Trump’s policy of keeping all options open, but stressed the need for a diplomatic solution by bolstering cooperation among Japan, U.S. and South Korea, as well as via cooperation with China and Russia.

The two diplomats will join their South Korean counterpart in Seoul for further talks Wednesday on North Korea.

READ MORE: Rex Tillerson says continue diplomacy with North Korea ‘until first bomb drops’

The talks come as the U.S. and South Korea hold joint naval drills this week. They regularly conduct joint exercises, though North Korea condemns them as an invasion rehearsal.

North Korea’s deputy U.N. ambassador warned on Monday that the situation on the peninsula “has reached the touch-and-go point and a nuclear war may break out any moment.”

Kim In Ryong told the U.N. General Assembly’s disarmament committee that North Korea has been subjected to a direct nuclear threat from the United States and has the right to possess nuclear weapons in self-defense.

He pointed to military exercises and what he called a U.S. plan to stage a “secret operation aimed at the removal of our supreme leadership.”

Kim’s speech follows increasingly tough U.N. sanctions. Russian President Vladimir Putin said his country is curtailing economic, scientific and other ties with North Korea in line with U.N. sanctions, and the European Union announced new sanctions as well.

The post U.S., Japan agree to maximize diplomatic pressure on North Korea appeared first on PBS NewsHour.

Anna Marie wonders why we can't be friends. Jonathan becomes a Marbula One fan. Kelley engages "pants off, games on" mode. And Chris learns that the only person he's cheating is himself...and his dire gryphon.

The post RPG Cast – Episode 584: “A Crater Sized Hole Filled with Funko Pops!” appeared first on RPGamer.

Chris has a normal amount of coffee on his shirt. Kelley conks her cat on the head with a controller. And Josh thinks Maglam Lord is a contraceptive device.

The post RPG Cast – Episode 617: “Yoko Taro Made This While Queuing for His Raid” appeared first on RPGamer.

Chris performs a ritual that needs more hands. Kelley has to clean just one more car. Ryan likes to think he can't be replaced by Bing yet. And Jason just keeps yelling, "Barrel!"

The post RPG Cast – Episode 668: “Nacho Chakotay” appeared first on RPGamer.

Sam brings the sexy back to RPG Cast. Chris goes down the rabbit hole of Skyrim Mods. Kelley's cannon stuffs kids into itself. And Josh collects a series of progressively larger vegetables.

The post RPG Cast – Episode 676: “Sending All Our Love to the Korok Down the Well” appeared first on RPGamer.

Chris gets ready for his favorite part of FFXIV, the benchmark. Kelley complains about her hotel bed while waiting for a tow truck. Josh is force feeding his army desserts. Meanwhile...wait...Robert...wake up, Robert!

The post RPG Cast – Episode 720: “Self Checkout Bouncers” appeared first on RPGamer.

Nintendo today hosted a Super Nintendo World Direct livestream that featured Shigeru Miyamoto giving a deep dive look into the Donkey Kong Country-themed land.

The new land will feature a family roller coaster, called Mine-Cart Madness, congas you can hit to a rhythm, letters that can found throughout the land that can be scanned on the new Donkey Kong Power-Up Band, character meet and greets, and new food options.

Donkey Kong Country will open at Universal Studios Japan on December 11, 2024, and will also be a part of Super Nintendo World at Epic Universe in Florida when the theme park opens in May 2025.

View the Direct below:

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463038/super-nintendo-world-direct-dives-into-the-donkey-kong-country-themed-land/

I first played Taiko no Tatsujin in an arcade (in Japan, because I am very cool), where it's controlled by hitting a recreation of an actual taiko drum. It was fun enough that I wish there was a taiko drum peripheral available for PC now the series is on our platform.

Taiko no Tatsujin: Rhythm Festival is out now via Steam, where it offers over 70 songs to drum through, and a subscription service through which to unlock over 700 more. Maybe I should try to get my Donkey Konga drums working on PC, but I'll probably settle for playing it with a gamepad.

Read more

President-elect Donald Trump has tapped Steven Witkoff to be special envoy to the Middle East, marking another key position for his incoming administration.

ROGER FEDERER has explained why he gets injured less than rivals Rafael Nadal and Novak Djokovic..

President-elect Trump announced that he had picked real estate investor and campaign donor Steve Witkoff to be his special envoy to the Middle East.

Dispute risks damage to Canada's reputation as reliable trade partner, says Steven Mackinnon

President-elect Trump announced on Tuesday that Kristi Noem is his pick for secretary of the Department of Homeland Security.

Shop these deep discounts of up to 50% off of loads of styles of Rebecca Minkoff handbags at Amazon's Big Summer Sale.

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

Shop stylish diaper bags that busy moms won't mind carrying.

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

President-elect Donald Trump announced that he has picked businessman and real estate investor Steven Witkoff to serve as Special Envoy to the Middle East.

The post President-Elect Donald Trump Picks Businessman Steven Witkoff to Be Special Envoy to Middle East appeared first on Breitbart.

The conflict in Syria rages on, the United States' relationship with Iran remains strained, and China is taking hold as an emerging superpower. As part of TOTN's "Looking Ahead" series, NPR commentator Ted Koppel looks to the future of international relations.

Team at Kolkata institute engineers bacteria to solve maths problems  The Hindu

1. Magnus Carlsen returns to Kolkata after almost five years at Tata Steel India Rapid and Blitz 2024  ChessBase India
2. "It's Chaotic": Chess World No. 1 Magnus Carlsen Reveals Why He Does Not Play In India  NDTV Sports
3. King Carlsen hails growth of Indian chess, praises Praggnanandhaa's fighting spirit  Telegraph India
4. Tata Steel Chess set for a Carlsen-Pragg opening  Hindustan Times
5. Tata Steel Chess India Rapid & Blitz 2024: Schedule, Venue, Players, Tickets, Prize Money  Firstpost

1. RG Kar rape case: Bengal governor seeks report from CM after Sanjay Roy made big allegation against ex-Kolkata top cop  Hindustan Times
2. RG Kar rape case: Bengal Guv seeks report from Mamata govt after accused Sanjay Roy claims ‘Vineet Goel is threatening…’  Mint
3. Video | RG Kar Case News | Kolkata Horror: Prime Accused Sanjay Roy's 'Shocking Revelation' On Camera  NDTV
4. RG Kar rape-murder victim’s dad deposes on day 1 of trial  The Times of India
5. RG Kar case: CM Mamata asked to submit report on prime accused's claim  CNBCTV18

The buzz surrounding his post even caused a temporary block on his Instagram account due to a surge in user engagement

This follow-up to last year’s ‘Mission: Impossible — Dead Reckoning Part One’, which earned over $571 million globally, is expected to draw blockbuster attention as one of the summer’s biggest releases

Although Avneet hasn’t confirmed any involvement in the film, fans are hopeful this could mark her Hollywood debut, following in the footsteps of Anil Kapoor, who appeared in ‘Mission: Impossible — Ghost Protocol’ in 2011

South Korean actor Song Jae Rim, known for his roles in popular K-Dramas, passed away at 39 in Seoul

‘Singham Again’ had an ensemble cast which includes Ajay Devgn, Akshay Kumar, Ranveer Singh, Tiger Shroff, Kareena Kapoor Khan, Deepika Padukone, Arjun Kapoor and Jackie Shroff

Later this month on September 27th, NIS America will release FuRyu’s action RPG Reynatis for Switch, Steam, PS5, and PS4 …

Continue reading "Reynatis Interview: Creative Producer TAKUMI, Scenario Writer Kazushige Nojima, and Composer Yoko Shimomura discuss the game, coffee, and more"

The two-term governor of South Dakota has been a loyal Trump ally. In her new role, Noem would oversee immigration, an issue Trump campaigned heavily on.

After weeks of hurricanes and blackouts have left many in Cuba reeling, an earthquake has left people shaken as rumbling was felt across the eastern stretch of the island, including in bigger cities like Santiago de Cuba, as well as Holguin and Guantanamo.

Nintendo is set to show off the Donkey Kong Country expansion of its Super Nintendo World theme park today (Monday, November 11) at 5PM ET, the company revealed in a post on X. That means the new Universal Studios Japan area might finally open soon, after being delayed from the previously announced launch window of Spring 2024. 

The new park attraction featuring Mario's barrel-throwing nemesis was first revealed in 2021. The centerpiece is a ride called Mine Cart Madness, named after the best level in the 1994 SNES game Donkey Kong Country. After being blasted out of a barrel cannon, you'll take a mine cart ride through the jungle that includes a "leap across a collapsed track" as Nintendo showed in a render earlier this year.  

The direct livestream appears to be focused on Donkey Kong world alone, and Nintendo specifically pointed out that "no game information will be featured" — so don't expect any news on the next-gen Switch 2 console either. 

Donkey Kong Country will expand the park size by up to 70 percent, Nintendo said when it was announced. Current attractions at the Japan park are the Mario Kart: Kuppa's Challenge rollercoaster and Yoshi Adventure. Nintendo recently announced that it would open a Super Nintendo World attraction at Universal Studios Orlando on May 22nd, 2025 with the same attractions as the park in Osaka. 

The employers' association is threatening to lock out workers at 9 p.m. Sunday if a deal isn't reached.

Contract negotiations in a labour dispute that has paralyzed container cargo shipping at British Columbia's ports since Monday have been called off. It comes as more than 100 organizations representing industries from automotive and fertilizer to retail and mining urged the government to do whatever it takes to end the work stoppage.

A lockout at the Port of Montreal began Sunday night. The CEO of the Montreal Port Authority says if the dispute between dockworkers and the Maritime Employers Association drags on, it will have disastrous consequences for the economy.