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Orchard Therapeutics cuts 25% of staffers, rethinks pipeline, closes California site

Tough times at Orchard Therapeutics as it swings the ax across staffers and facilities, phases in new pipeline advances and reduces interest in others.




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Blood: Underappreciated Resource in the Health/Disease?

Alternative title: Pitching a VC on Disruption of Blood Testing You may have seen some recent editorials about the necessary frequency of blood tests for healthy individuals, many of them prompted by a series of tweets from Mark Cuban: Although there are certainly potential dangers in expecting any and all test results to be immediately

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Coronavirus FAQs: Do Temperature Screenings Help? Can Mosquitoes Spread It?

And as summer nears, the question must be asked: Is it risky from a COVID-19 standpoint to go in a swimming pool?




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PTO Cancer Immunotherapy Fast Track

In response to President Obama’s National Cancer Moonshot initiative to eliminate cancer, the USPTO has launched the “Cancer Immunotherapy Pilot Program.” The Pilot Program provides an accelerated review for applications related to cancer immunotherapy and is set to launch in July 2016. According to the USPTO, this initiative: aims to cut the time it takes to...… Continue Reading




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En Banc: Federal Circuit Provides Guidance on Application of On-Sale Bar to Contract Manufacturers

Pharmaceutical and biotech companies breathed a sigh of relief Monday when the Federal Circuit unanimously ruled in a precedential opinion that the mere sale of manufacturing services to create embodiments of a patented product is not a “commercial sale” of the invention that triggers the on-sale bar of 35 U.S.C. § 102(b) (pre-AIA).[1]  The en banc opinion...… Continue Reading




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Column: America's tolerance for mass murder is the coronavirus' best friend

The America that condones mass murder of children is allowing the coronavirus to spread.




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Heat, humidity at edge of human tolerance hitting globe

Researchers found that temperature extremes previously thought to be rare have been recorded more than 1,000 times in 40 years.




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Not enough evidence that e-cigarettes help to stop smoking, surgeon general says

The surgeon general's report is the first in 30 years to focus entirely on quitting tobacco.




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China's road operators left battered by no-toll policy




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China and US must cooperate to lead world out of coronavirus danger




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Vote Results of 2019 Annual General Meeting of Shareholders




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ExRobotics and Yokogawa Collaborate to Accelerate Adoption of Robotics for Inspection of Facilities in Hazardous Environments

ExRobotics B.V., a Netherlands-based developer of robotics technology for hazardous environments, and Yokogawa Electric Corporation (TOKYO: 6841), a global provider of industrial automation, control, and measurement technology, announce the signing of a licensing agreement that will enable Yokogawa to sell and deploy ExRobotics' inspection robot hardware and software platforms worldwide.




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Yokogawa Releases SensPlus Note, an OpreX Operation and Maintenance Improvement Solution for the Digitization of Field Data Using Mobile Devices

Yokogawa Electric Corporation (TOKYO: 6841) and MetaMoJi Corporation announce that they have jointly developed SensPlus Note, a low cost and easy to implement solution for the digitization of plant data on mobile devices. SensPlus Note, a solution in Yokogawa's OpreX Operation and Maintenance Improvement family, improves the efficiency and quality of maintenance work and the precision of post-maintenance analyses by enabling data from plant field work to be used more efficiently. This solution will be released in all markets worldwide on January 31.




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Yokogawa Releases Exaquantum R3.20 Plant Information Management System, a Software Package in the OpreX Asset Operations and Optimization Family

Yokogawa Electric Corporation (TOKYO: 6841) announces the release of Exaquantum R3.20, an enhanced version of its plant information management system (PIMS) software package in the OpreX Asset Operations and Optimization family.




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Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing




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Harnessing the potential of multimodal radiotherapy in prostate cancer




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Treatment of peyronie’s disease with combination of clostridium histolyticum collagenase and penile traction therapy: a prospective, multicenter, single-arm study






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A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome




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Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid (PDL) for COVID-19 in vitro and in vivo




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Signal Transduction and Targeted Therapy




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The <i>RhHB1</i>/<i>RhLOX4</i> module affects the dehydration tolerance of rose flowers (<i>Rosa hybrida</i>) by fine-tuning jasmonic acid levels




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Author Correction: Particle physics at accelerators in the United States and Asia




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Cardiovascular response and sequelae after minimally invasive surfactant therapy in growth-restricted preterm infants




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Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy




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Treating osteoarthritis via gene therapy with rejuvenation factors




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Gene therapy for cardiovascular diseases in China: basic research




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Gene Therapy




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The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells




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Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis




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A stereotyped light chain may shape virus-specific B-cell receptors in HCV-dependent lymphoproliferative disorders




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The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias




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Physical therapy better than steroids for knee OA




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<i>KRAS</i> amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy




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Cost-effectiveness of <i>CYP2C19-</i>guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data




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Identification of gene modules associated with survival of diffuse large B-cell lymphoma treated with CHOP-based chemotherapy




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Association of <i>MICA</i>-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis




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Adoptive immunotherapy for myeloid malignancies




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Abstracts from the 2nd International Norges Teknisk-Naturvitenskapelige Universitet (NTNU) Symposium: Day 1—Immunotherapy and Hematology




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Coronavirus in context: Scite.ai tracks positive and negative citations for COVID-19 literature




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Daily briefing: How desperate measures might shorten the coronavirus vaccine timeline — and at what risk




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Daily briefing: More than 1 billion people face unbearable temperatures within 50 years




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RIC-seq for global in situ profiling of RNA–RNA spatial interactions




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Statin therapy is associated with lower prevalence of gut microbiota dysbiosis




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Coronapod: The overlooked outbreaks that could derail the coronavirus response




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Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma




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HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1α




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The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications’ door




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Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk