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Urate-lowering therapy exerts protective effects against hypertension development in patients with gout




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Effects of chronic type 5 phosphodiesterase inhibition on penile microvascular reactivity in hypertensive patients with erectile dysfunction: a randomized crossover placebo-controlled trial




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Apixaban therapy is effective and safe for cancer-associated VTE




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The new scope of virus taxonomy: partitioning the virosphere into 15 hierarchical ranks




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Principal Investigator/Professor Positions at Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, GDL

With a generous support from the Guangzhou City Government and the Guangdong Provincial Government, Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL) was launched in 2017. GRMH-GDL aims to bring together multiple leading scientific research units from Guangdong, Hong Kong, Macao and well-known international research institutes to achieve the vital goal of "Healthy China" and to cooperatively tackle the scientific and technical problems and challenges. GRMH-GDL is focused…




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Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children




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Viral contamination in biologic manufacture and implications for emerging therapies




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Surrogate endpoints for overall survival for patients with metastatic hormone-sensitive prostate cancer in the CHAARTED trial




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Exposure to direct-to-consumer advertising is associated with overestimation of benefits regarding ultrahypofractionated radiation therapy for prostate cancer




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PARP inhibitors as a new therapeutic option in metastatic prostate cancer: a systematic review




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Protein structural changes on a CubeSat under rocket acceleration profile

npj Microgravity, Published online: 23 April 2020; doi:10.1038/s41526-020-0102-3

Protein structural changes on a CubeSat under rocket acceleration profile




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Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




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Simultaneous quantification of protein–DNA interactions and transcriptomes in single cells with scDam&amp;T-seq




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Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system




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Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i>




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Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration




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Safety and efficacy of chimeric antigen receptor T-cell therapy in relapsed/refractory multiple myeloma with renal impairment




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NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma




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NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




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RNAi against therapeutic targets with short interfering ribonucleic neutrals (siRNNs)

siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA.




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Topoisomerase II binding protein 1 (TOPBP1)

Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer.




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Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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Cancer Gene Therapy




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy




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Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions




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Inducing senescence sensitizes pancreatic tumours to therapies




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Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




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Combining radiolabelled therapies for neuroendocrine neoplasms




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Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why?




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Development of a skin temperature map for dermatomes in individuals with spinal cord injury: a cross-sectional study




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Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




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Age influences structural brain restoration during weight gain therapy in anorexia nervosa




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Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders




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Efficient generation of mouse models with the prime editing system




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Mendelian neurodegenerative disease genes involved in autophagy




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Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors




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Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea




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Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis




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High-risk additional chromosomal abnormalities at low blast counts herald death by CML




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Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial




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Double rooted lateral?




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Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke




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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders




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Parkinson disease and the immune system — associations, mechanisms and therapeutics