The crystal structure of Pseudomonas aeruginosa Fis is composed of an N-terminal flexible loop and a C-terminal helix–turn–helix motif.

Eleven bats remain in the National Zoo’s colony. The initial challenge the team faced was how to feed the animals. Virginia big-eared bats, which are a subspecies of the Townsend’s big-eared bat (Corynorhinuss townsendii), eat while flying.

The post Captive colony of Virginia big-eared bats providing valuable lessons in battle against deadly white-nose syndrome appeared first on Smithsonian Insider.

Einstein’s general theory of relativity predicts the emission of gravitational waves by massive celestial bodies moving though space-time. For the past century gravitational waves have […]

The post Astronomers complete First Search for Visible Light Associated with Gravitational Waves appeared first on Smithsonian Insider.

This animation shows how binary neutron stars warp space-time to create gravitational waves, then collide and explode into a visible kilonova, which can be detected […]

The post Astronomers see light show associated with gravitational waves appeared first on Smithsonian Insider.

Death-associated protein kinase 1 (DAPK1) is a serine/threonine protein kinase that regulates apoptosis and autophagy. DAPK1 is considered to be a therapeutic target for amyloid-β deposition, endometrial adenocarcinomas and acute ischemic stroke. Here, the potent inhibitory activity of the natural anthraquinone purpurin against DAPK1 phosphorylation is shown. Thermodynamic analysis revealed that while the binding affinity of purpurin is similar to that of CPR005231, which is a DAPK1 inhibitor with an imidazopyridazine moiety, the binding of purpurin was more enthalpically favorable. In addition, the inhibition potencies were correlated with the enthalpic changes but not with the binding affinities. Crystallographic analysis of the DAPK1–purpurin complex revealed that the formation of a hydrogen-bond network is likely to contribute to the favorable enthalpic changes and that stabilization of the glycine-rich loop may cause less favorable entropic changes. The present findings indicate that purpurin may be a good lead compound for the discovery of inhibitors of DAPK1, and the observation of enthalpic changes could provide important clues for drug development.

Hem Sapkota, Jonathan D. Wren, and Gary J. Gorbsky

Centrosomes focus microtubules to promote mitotic spindle bipolarity, a critical requirement for balanced chromosome segregation. Comprehensive understanding of centrosome function and regulation requires a complete inventory of components. While many centrosome components have been identified, others may yet remain undiscovered. We have used a bioinformatics approach, based on "guilt by association" expression to identify novel mitotic components among the large group of predicted human proteins that have yet to be functionally characterized. Here we identify Chondrosarcoma-Associated Gene 1 (CSAG1) in maintaining centrosome integrity during mitosis. Depletion of CSAG1 disrupts centrosomes and leads to multipolar spindles more effectively in cells with compromised p53 function. Thus, CSAG1 may reflect a class of "mitotic addiction" genes whose expression is more essential in transformed cells.

The backdrop of the stage with the Oscar Award is seen onstage during the 84th Academy Awards announcement held at the Academy of Motion Picture Arts and Sciences Samuel Goldwyn Theater on Jan. 24, 2012 in Los Angeles.; Credit: Kevin Winter/Getty Images

The Academy Awards have made history with breakthroughs for minorities in the past — but with this year's nominations, observers are noting how white the Oscars are, with no actors of color nominated in any of this year's acting categories.

It marks the least diverse nominations since 1998. People have been speaking out about this disconnect, with films like "Selma" being shut out of the acting nominations (though it did pick up a Best Picture nomination).

This content is from Southern California Public Radio. View the original story at SCPR.org.

More targeted aircraft testing and simulation should be conducted to uncover design characteristics in new flight control systems that -- in rare circumstances -- may mislead pilots and result in unstable or dangerous flight conditions, says a new report by a National Research Council committee.

Based on a thorough review of clinical and epidemiological studies, neither the mercury-based vaccine preservative thimerosal nor the measles-mumps-rubella (MMR) vaccine are associated with autism, says a new report from the Institute of Medicine of the National Academies.

A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing high blood pressure in some veterans.

A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinsons disease for Vietnam veterans.

Most Americans and Canadians up to age 70 need no more than 600 international units (IUs) of vitamin D per day to maintain health, and those 71 and older may need as much as 800 IUs, says a new report from the Institute of Medicine.

The National Academy of Engineering (NAE) has elected 67 new members and 11 foreign associates, announced NAE President C.D. (Dan) Mote Jr. today. This brings the total U.S. membership to 2,250 and the number of foreign associates to 214.

The National Academy of Sciences elected 84 new members and 21 foreign associates in recognition of their distinguished and continuing achievements in original research.

The National Academies Keck Futures Initiative (NAKFI) is pleased to announce the publication of Collaborations of Consequence - NAKFI’s 15 Years of Igniting Innovation at the Intersections of Disciplines.

A new report from the National Academies of Sciences, Engineering, and Medicine recommends ways to make supply chains -- the systems that provide populations with critical goods and services, such as food and water, gasoline, and pharmaceuticals and medical supplies – more resilient in the face of hurricanes and other disasters, drawing upon lessons learned from the 2017 hurricanes Harvey, Irma, and Maria.

On the 10th Anniversary of the Deepwater Horizon Explosion, Marcia McNutt Reflects on How Science Helped Solve the Crisis, and Its Lessons for the COVID-19 Pandemic

Two workers approach the entrance to Life Care Center in Kirkland, Wash., on March 13. An association that represents nursing homes is asking for billions of dollars in federal relief funds to cope with the coronavirus crisis.; Credit: Ted S. Warren/AP

With more than 11,000 resident deaths, nursing homes have become the epicenter of the COVID-19 crisis. Now, they're asking the federal government for help — $10 billion worth of help.

The American Health Care Association, the trade organization for most nursing homes, called the impact on long-term care facilities "devastating." In a letter sent this week to the Federal Emergency Management Agency and Health and Human Services Secretary Alex Azar, they ask for the federal government to designate relief funding from the CARES Act for nursing homes the way it has for hospitals.

The money would be used for personal protective equipment, salaries for expanded staff, and hazard pay. In addition, some of the funds would make up lost revenue for nursing homes that have been unable to admit new residents because of the outbreak.

The AHCA also wants nursing homes to have more access to testing and some members of Congress want that too. This week, 87 members of the House of Representatives sent their own letter to Azar, as well as to Seema Verma, the administrator of the Centers for Medicare and Medicaid Services, which regulates nursing homes. The letter asks those agencies to direct states — which have received billions of dollars for increased testing — to give priority to long-term care facilities.

The letter also notes that nursing homes are now required to report their numbers of COVID-19 infections and deaths to the Centers for Disease Control and Prevention, but that they can't meaningfully do this unless they can test everyone in the facility.

Democrats in both the House and the Senate have also introduced legislation intended to make things safer for both nursing home staff and residents. The bill would require nursing homes to take a range of actions, from providing better infection prevention, to supplying sufficient protective gear, to protecting a resident's right to return to the nursing home after they've been treated for COVID-19 at a hospital.

This content is from Southern California Public Radio. View the original story at SCPR.org.

; Credit: Michelle Lanz/KPCC

Someone just told me that pink and gray were Vassar’s colors. I would say, “Go Vassarettes!” but, one, Vassarette is a line of brassieres, and, two, the Vassar mascot is The Brewer, for the profession of its founder, Matthew Vassar. You go, Seven Sisters girls and guys!

The scarf is one of two I picked up on vacation – for some reason insect themes are big just now. This one has little gray ants marching over a pink field, a reminder of – what? Teamwork? Conformity? Time to call the exterminator? The other scarf, which I’ll wear presently, is the color of a ripe nectarine, with a pattern of vividly colored beetles. Scarabus chic. Dashing, no?

The glittery pink shirt is one more example of that contrast that I like, against the matte gray knit of the sweater (indoor-outdoor wear for L.A. summers, going from AC to Fahrenheit in a flash). Which explains the vast and shady hat – like a veranda on my head!

I was surprised at myself for buying these shoes – silver and bright pink; when would I ever be wearing that? But there they are, slingbacks made by “Emma Hope’s shoes, Regalia for feet,” an irresistible name.

The oval seal with the maker’s name reminded me of the oval seal on shoes made by Rayne, the 19th-century London shoemaker that had shod the women of the royal family for decades (but not the last two generations of those chic ladies: Diana, Princess of Wales, and Katherine, Duchess of Cambridge).

Please don’t blame Rayne for the Queen’s inordinate fondness for platform peeptoe shoes – her mother made her do it. Literally. Those royal ladies – the Queen, her late mother and late sister, Margaret – were quite short, and those shoes boosted their height. But still …

Here is Rayne’s website for a look at some of the glamorous and glorious shoes for feet past and present – including Anna Pavlova’s, prima ballerina assoluta. Mary Quant designed for Rayne. And before you look, that old caution:  If you have to ask how much …  

A pair of Rayne shoes is on my fantasy list for thrift-store finds, along with a Fortuny dress and a wild Schiaparelli hat. I believe, I believe...

This content is from Southern California Public Radio. View the original story at SCPR.org.

Improved public communications and standardised collection systems can greatly increase uptake of safe and sustainable waste electrical and electronic equipment (WEEE) disposal and recycling. This is according to new insights from Italy and Romania, where WEEE collection rates have risen in response to these measures.

Increasing resource efficiency is a central aim of European environmental policy, and effective waste management must play a key role in this. A new report assesses waste management in 32 European countries, and identifies key lessons. Landfill taxes and mandatory separate collections of different waste types are highlighted as particularly successful policy instruments.

‘Payment for ecosystem services’ (PES) has become a commonly used term in recent years, yet the concept is not well defined. A new study reviewing PES theory, concepts and practice from around the world provides a valuable overview, concluding that more can be done to share learning.

By analysing previous disasters, lessons learnt can be incorporated into policies and plans to manage the effects of future disasters. A recent study examining the 2009 L’Aquila earthquake in Italy suggests that although the national response effectively dealt with the emergency, longer-term measures to help local populations cope with the aftermath of the disaster need to be set out more clearly.

The European Directive on the assessment and management of flood risks1 (the Floods Directive) represents a shift towards holistic and catchment-oriented management of flood risk and is likely to prompt changes to policy in many Member States. New research from Germany suggests that effective implementation of the Floods Directive is likely to be greatly aided by the participation of stakeholders and communication between groups.

28 Aug 2016: The Mediterranean diet is associated with a reduced risk of death in patients with a history of cardiovascular disease, according to results from the observational Moli-sani study presented at ESC Congress 2016 today.1

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New research has reviewed the Irish implementation of the first phase of the EU Noise Directive. So far 31 different organisations have been involved and this will increase throughout the second phase of the Directive's implementation. More standardisation is needed to harmonise activities, perhaps by establishing a national expert steering group.

Improved public communications and standardised collection systems can greatly increase uptake of safe and sustainable waste electrical and electronic equipment (WEEE) disposal and recycling. This is according to new insights from Italy and Romania, where WEEE collection rates have risen in response to these measures.

Increasing resource efficiency is a central aim of European environmental policy, and effective waste management must play a key role in this. A new report assesses waste management in 32 European countries, and identifies key lessons. Landfill taxes and mandatory separate collections of different waste types are highlighted as particularly successful policy instruments.

5G will cover more than 20 percent of the global population six years from now, according to the latest Ericsson Mobility Report

Long-distance travelling accounts for a significant number of miles travelled per person, but estimates of its greenhouse gas emissions are lacking. Using data from Belgium and the Netherlands, this study estimates that long-distance journeys account for 40–50% of total mileage and 50% of greenhouse gas emissions of all people transport in Western Europe.

I did not bad mouth my predecessor. However, I never attempted to defend him or any of his actions. I fixed them!

Rural areas are changing, with tourism playing an ever greater part in a multifunctional countryside. A recent study has looked at the role that sustainable rural tourism can play in rural development in Europe and some of the challenges to be overcome if a truly integrated approach to rural development is to be realised.

To restore a river site to good ecological status involves comparing it to similar sites that have been far less affected by human activity. A recent study has established a set of guidelines that define an acceptable level of human pressure that can be used to identify these minimally disturbed sites and ensure consistent ecological assessment among EU Member States.

The pathways for removal of dissolved phosphorus within biofiltration systems have been examined in a new study. Over 95% of phosphorus was removed over the study period, with the majority of phosphorus stored within plants. The researchers say the findings demonstrate the value of using suitable plant species within biofiltration systems to treat polluted water.

The 2010 deadline for the Gothenburg Protocol ceilings for transboundary air pollutants is fast approaching and new ceilings may soon be set for 2020. Recent research indicates that, although the ceilings have been effective, they could benefit from more flexibility to allow for the inherent uncertainty in modelling future energy use, technologies and growth.

A study in the Czech Republic has found a link between exposure to certain air pollutants and an increase in DNA damage for people exposed to high levels of the pollution. They found that breathing small quantities of a polycyclic aromatic hydrocarbon (PAH), called benzo[a]pyrene (B[a]P), caused an increase in the number of certain ‘biomarkers’ in DNA associated with a higher risk of diseases, including cancer.

Long-term exposure to air pollution may increase the risk of developing type-2 diabetes, a Swiss study has found. The results also suggest that the association between type-2 diabetes and air pollution occurs at concentrations below World Health Organization (WHO) air quality guidelines.

Long-term exposure to traffic-related air particle pollution is linked with type 2 diabetes, a new study in Germany has found. Furthermore, the study found that people living close to busy roads were at greater risk of developing the disease than those living further away.

Research using the Environmental Quality Index (EQI) linked increased risk of preterm birth with poor air quality, but not with overall low environmental quality. The study is one of the first to explore the relationship between preterm birth and environmental quality across a range of different environmental domains (including water, air, land, built environment and sociodemographic aspects).

NPR radio host Scott Simon has been touching people across the country by tweeting from his mother’s deathbed in a Chicago hospital.

Not in the mood for fair trade chocolates and underpants? Consider these home design picks to please any sustainability minded sweetie this Valentine's Day.

Sex. Many (but not all) animals do it.

Actress Scarlett Johansson once again says she would enjoy being an organic farmer when her Hollywood career is over.

The enchanting yet highly controversial 'magical new green space' has many Londoners fired up over issues of funding, aesthetics and accessibility.