In this week's Match of Their Day, former Manchester United and Everton player Phil Neville selects his three favourite Premier League games.

In this week's Match of Their Day, former Manchester United and Everton player Phil Neville selects his three favourite Premier League games.

♥..Nomyens..♥ posted a photo:

Custom faceup

Angel Philia TS.

www.nomyens.com

♥..Nomyens..♥ posted a photo:

Custom faceup

Angel Philia TS.

www.nomyens.com

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Immigration from the Caribbean to the United States is a relatively recent phenomenon, beginning largely after 1965. This report provides a demographic profile of the 1.7 million Caribbean immigrants in the United States: their geographic settlement, education and workforce characteristics, earnings, modes of entry, and more.

OM SportsLink hosts a local R4TW race to engage those involved with OM Philippines-Cebu Ministries and encourage people to pray for the nations.

One of the strongest typhoons ever to hit land slammed the Philippines on Friday, 15 November, forcing millions to take shelter. OM Philippines responds.

OM Philippines celebrates 25 years of transforming lives and communities.

One hundred Filipino teens, aged 12-18 are expected to come to the five-day event of fun, learning and life-changing encounters in Cebu.

After over 10 years of praying, the Philippines had its first-ever TeenStreet!

What's up with Apple Wallet?

In addition to the prizes and rewards, Hero MotoCorp may also make it a memorable experience for the participants by putting some of the entries into production.

What's up with Apple Wallet?

Extending the lockdown well beyond mid-May would shave 8-9% off the real GDP. but, the damage being done doesn’t seem to be filtering up to those in charge

Too many B2B marketers are sleeping on the job when it comes to maintaining the consistency and quality of their data.

Data protection appears to be many companies' Achilles' heel.

For most marketers, personalization is the cure for ineffective content.

The median salary for male email marketers is $15,000 more than that of females'.

The discipline is projected to mature into a rich blend of social media and mobile engagement.

Poor data quality and integration can cause a marketing mess.

Back-to-school serves as a reminder that digital channels not only drive digital purchases, but in-store purchases too

Hong Kong announces the first phase of visa sanctions for PhilippinesAmbassadorial passport holders and the government officials of Philippines will not be able to visit Hong Kong without a visa effective February 5, 2014. This was announced by the Hong…

1 Ugandan Shilling = 0.0133 Philippine Peso

1 Salvadoran Colon = 5.7698 Philippine Peso

1 Romanian Leu = 11.3385 Philippine Peso

1 Ukrainian Hryvnia = 1.8815 Philippine Peso

1 Tanzanian Shilling = 0.0218 Philippine Peso

1 Venezuelan Bolivar Fuerte = 5.0558 Philippine Peso

1 Yemeni Rial = 0.2017 Philippine Peso

1 Paraguayan Guarani = 0.0077 Philippine Peso

1 Hong Kong Dollar = 6.5013 Philippine Peso

1 Kuwaiti Dinar = 163.2288 Philippine Peso

1 Saudi Riyal = 13.4429 Philippine Peso

1 Tunisian Dinar = 17.3373 Philippine Peso

1 South African Rand = 2.7516 Philippine Peso

1 Norwegian Krone = 4.9423 Philippine Peso

1 Argentine Peso = 0.7596 Philippine Peso

1 Moroccan Dirham = 5.1394 Philippine Peso

1 US Dollar = 50.495 Philippine Peso

1 Icelandic Krona = 0.3453 Philippine Peso

1 Kazakhstan Tenge = 0.1197 Philippine Peso