Ice creams are one of the most preferred deserts as well as one of the most widely consumed dairy products. There are different types of ice creams with different types of flavors available in the market. Though in most of the cases ice...

In the range of commercial coffee machines, Espresso is a name which is worth to rely. This Italian flavor rules the heart of the coffee lovers’ right from its origin. Considering its charm throughout the world, Espresso comes...

This report responds to a request from the G20 that the IMF and OECD assess whether further work is needed on their respective approaches to measures which are both macro-prudential and capital flow measures, taking into account their individual mandates. The report was transmitted to G20 Finance Ministers and Central Bank Governors at their meeting on 16-17 April 2015 in Washington D.C.

This update report by the IMF and the OECD was delivered to G20 in February 2016.

Recent seizures of fake medical supplies being marketed as protection against Covid-19 underscore the need to address a growing international trade in counterfeit pharmaceuticals that is costing billions of euros a year and putting lives at risk, according to the OECD and the EU’s Intellectual Property Office.

Algorithms lie at the heart of machine learning, which, in turn lies at the heart of much of modern life–from online shopping to intelligence gathering. But most of us know little about these powerful tools and how they work. Is this wise?

As autonomous and self-taught machines become part of our everyday lives, what sort of policy and institutional frameworks should guide AI design and use? This event brought together policymakers, civil society representatives and AI experts from industry and academia to discuss the role of policy and international co-operation in ensuring that AI benefits society as a whole.

"Back to the Future" festivities marking 21 October 2015 as the date Marty and Doc travel to the future in the famous film with Michael J. Fox. If only we had a similar time machine allowing us to travel to 2045 to see what the climate has in store to better decide what policies to adopt today. Alas, no time machine has been invented yet but, in the absence of such a cool device, we can rely on climate and economic models...

This paper reviews the existing literature on modelling the macroeconomic consequences of the transition to a circular economy. It provides insights into the current state of the art on modelling policies to improve resource efficiency and the transition to a circular economy by examining 24 modelling-based assessments of a circular economy transition.

Recent seizures of fake medical supplies being marketed as protection against coronavirus (Covid-19) have underscored the need to address a growing international trade in counterfeit pharmaceuticals. The trafficking of fake or defective medicines is costly and puts lives at risk, according to the new OECD and EU reports.

Porsche India on Tuesday launched its new sports utility vehicle (SUV) Porsche Macan, with a basic retail price of Rs.76,84,000 (ex-showroom Maharashtra).

This paper provides a quantitative description of decoupling in OECD countries over the past two decades, with the results suggesting that it is explained by declines in both labour shares and the ratio of median to average wages (a partial measure of wage inequality).

This paper provides a quantitative description of decoupling in OECD countries over the past two decades, with the results suggesting that it is explained by declines in both labour shares and the ratio of median to average wages (a partial measure of wage inequality).

QF171 left Melbourne at just after 9am on Saturday morning but a mechanical issue meant its intended landing in Wellington at 2.35pm was aborted and the plane diverted to an air base with no customs.

2. Himachal Road Transport Corporation Mandi Depot through its Regional Manager at Mandi H.P.

3. Himachal Road Transport Corporation Rohru Depot through its Regional Manager at Rohru H.P.

4. Himachal Road Transport Corporation Shimla through its Managing Director at Shimla H.P. (HRTC Head Office)Shimla-III ......Respondents/Opposite parties Coram Hon'ble Justice P.S. Rana (R) President Hon'ble Ms. Sunita Sharma Member Hon'ble Mr. R.K. Verma Member Whether approved for reporting?1 Yes.

For Appellant : Mr. Amit Kanwar Advocate. For Respondents : Mr. Dhiraj Kanwar Advocate. JUSTICE P.S. RANA (R) PRESIDENT:

2. As stated in the information, the Informant is running a sole proprietorship by the name of M/s Venkateswara Agencies (earlier known as Rohini Agencies) dealing with agricultural machineries, based in West Godavari District of Andhra Pradesh. The Informant has been the authorised dealer of KAMCO from the year 2006, for which dealership agreement dated 28.09.2006 was entered into between Informant and KAMCO. The scope of the agreement included supplying the products of KAMCO to Case No.38 of 2019 1 the customers in West Godavari, East Godavari, Krishna, Srikakulam and Guntur Districts of the state of Andhra Pradesh.

K Sivanesan, 47, and his colleague Rajkumar worked for a herbal medicine company and tested their treatment - a mix of nitric oxide and sodium nitrate - at a home in southern Chennai city.

World and Olympic heptathlon champion Jessica Ennis-Hill inspires kids to do the robot and a dad even to do the worm in a Barnsley shopping centre in Santander's 2015 Christmas commercial.

Iggy Azalea has made a surprise return to Instagram to show off her washboard abs, following unconfirmed reports she had a baby with Playboi Carti less than two weeks ago. 

Shimla, May 10 () Himachal Pradesh reported two fresh cases of COVID-19, taking the total virus count in the state to 55, officials said on Sunday.Two people quarantined at Swarghat in Bilaspur district along the HP-Punjab border have tested positive, Bilaspur deputy commissioner Rajeswar Goel said. The two are taxi drivers and had recently ferried two families from Gujarat's Ahmedabad and Haryana's Gurgaon to their native places in Mandi and Kangra districts respectively.As the two showed symptoms during screening at the border, the two were quarantined and their samples were taken, he added.One of them is from Gujarat. They are being shifted to Nerchowk's Shri Lal Bahadur Shastri Government Medical College and Hospital (SLBSGMC) in Mandi, he added.Samples of their contacts will also be taken

Himachal Pradesh reported two fresh cases of COVID-19, taking the total virus count in the state to 55, officials said on Sunday. Two people quarantined at Swarghat in Bilaspur district along the HP-Punjab border have tested positive, Bilaspur deputy commissioner Rajeswar Goel said. The two are taxi drivers and had recently ferried two families from Gujarat's Ahmedabad and Haryana's Gurgaon to their native places in Mandi and Kangra districts respectively. As the two showed symptoms during screening at the border, the two were quarantined and their samples were taken, he added. One of them is from Gujarat. They are being shifted to Nerchowk's Shri Lal Bahadur Shastri Government Medical College and Hospital (SLBSGMC) in Mandi, he added. Samples of their contacts will also be taken for testing. The number of active cases in Himachal Pradesh now stands at 13 three each in Chamba and Kangra, two in Hamirpur, Bilaspur each and one each in Mandi, Una and Shimla districts. While 35 patients

There is no right or wrong, With the combination of hardware and software as well as subscriptions that work for you, you'll not get sidetracked every now and then by annoying eccentricities. Things need to simply work and work well.

Archives, Room Use Only - TK5547.D45 1895

Archives, Room Use Only - QC573.M47 1874

Archives, Room Use Only - TK455.P67 1880

Archives, Room Use Only - HE7676.M173 1919

Archives, Room Use Only - QC16.K3 K56 1925

Archives, Room Use Only - TK5262.M23 1914

Archives, Room Use Only - PR4461.C2 B98 1890z

Archives, Room Use Only - TK145.M334 1919

Archives, Room Use Only - HE7814.M33 1930

Archives, Room Use Only - TK5269.C73 1880z

Thomas Aylott has come up with a clever script that allows you to easily create Mac apps from shell scripts. Here’s how it works.

It’s trivial to find colliding passwords when hashing with PBKDF2-HMAC-anything. This post explains why that is.

We want a level playing field for all sellers: RSS affiliate.

The Communist Party of India (Marxist) has opposed a proposal to set up a Tamil Nadu State Marketing Corporation (Tasmac) outlet in the vicinity of Ho

Tamil Nadu government rushes to SC against Madras HC ruling on Tasmac closure

Detection of heavy elements, such as metals, in macromolecular crystallography (MX) samples by X-ray fluorescence is a function traditionally covered at synchrotron MX beamlines by silicon drift detectors, which cannot be used at X-ray free-electron lasers because of the very short duration of the X-ray pulses. Here it is shown that the hybrid pixel charge-integrating detector JUNGFRAU can fulfill this function when operating in a low-flux regime. The feasibility of precise position determination of micrometre-sized metal marks is also demonstrated, to be used as fiducials for offline prelocation in serial crystallography experiments, based on the specific fluorescence signal measured with JUNGFRAU, both at the synchrotron and at SwissFEL. Finally, the measurement of elemental absorption edges at a synchrotron beamline using JUNGFRAU is also demonstrated.

A review of recent and ongoing development and results within the field of biological solution small-angle X-ray scattering (BioSAXS), with a focus on the increasing complexity of biological samples, data collection and data evaluation strategies.

From the perspective of a young(ish) structural biologist who currently specialises in macromolecular X-ray crystallography, are the best years of crystallography over? Some evidence and hopefully thought-provoking analysis is presented here on the subject.

The crystal structure of pirfenidone, C12H11NO [alternative name: 5-methyl-1-phenyl­pyridin-2(1H)-one], an active pharmaceutical ingredient (API) approved in Europe and Japan for the treatment of Idiopathic pulmonary fibrosis (IPF), is reported here for the first time. It was crystallized from toluene by the temperature gradient technique, and crystallizes in the chiral monoclinic space group P21. The phenyl and pyridone rings are inclined to each other by 50.30 (11)°. In the crystal, mol­ecules are linked by C–H⋯O hydrogen bonds involving the same acceptor atom, forming undulating layers lying parallel to the ab plane.

A rational way to find the appropriate conditions to grow crystal samples for bio-crystallography is to determine the crystallization phase diagram, which allows precise control of the parameters affecting the crystal growth process. First, the nucleation is induced at supersaturated conditions close to the solubility boundary between the nucleation and metastable regions. Then, crystal growth is further achieved in the metastable zone – which is the optimal location for slow and ordered crystal expansion – by modulation of specific physical parameters. Recently, a prototype of an integrated apparatus for the rational optimization of crystal growth by mapping and manipulating temperature–precipitant–concentration phase diagrams has been constructed. Here, it is demonstrated that a thorough knowledge of the phase diagram is vital in any crystallization experiment. The relevance of the selection of the starting position and the kinetic pathway undertaken in controlling most of the final properties of the synthesized crystals is shown. The rational crystallization optimization strategies developed and presented here allow tailoring of crystal size and diffraction quality, significantly reducing the time, effort and amount of expensive protein material required for structure determination.

This paper recounts the first successful cryo-cooling of protein crystals that demonstrated the reduction in X-ray damage to macromolecular crystals. The project was suggested by David C. Phillips in 1965 at the Royal Institution of Great Britain and continued in 1967 at the Weizmann Institute of Science, where the first cryo-cooling experiments were performed on lysozyme crystals, and was completed in 1969 at Purdue University on lactate dehydrogenase crystals. A 1970 publication in Acta Crystallographica described the cryo-procedures, the use of cryo-protectants to prevent ice formation, the importance of fast, isotropic cryo-cooling and the collection of analytical data showing more than a tenfold decrease in radiation damage in cryo-cooled lactate dehydrogenase crystals. This was the first demonstration of any method that reduced radiation damage in protein crystals, which provided crystallographers with suitable means to employ synchrotron X-ray sources for protein-crystal analysis. Today, fifty years later, more than 90% of the crystal structures deposited in the Protein Data Bank have been cryo-cooled.

Innovative new crystallographic methods are facilitating structural studies from ever smaller crystals of biological macromolecules. In particular, serial X-ray crystallography and microcrystal electron diffraction (MicroED) have emerged as useful methods for obtaining structural information from crystals on the nanometre to micrometre scale. Despite the utility of these methods, their implementation can often be difficult, as they present many challenges that are not encountered in traditional macromolecular crystallography experiments. Here, XFEL serial crystallography experiments and MicroED experiments using batch-grown microcrystals of the enzyme cyclophilin A are described. The results provide a roadmap for researchers hoping to design macromolecular microcrystallography experiments, and they highlight the strengths and weaknesses of the two methods. Specifically, we focus on how the different physical conditions imposed by the sample-preparation and delivery methods required for each type of experiment affect the crystal structure of the enzyme.

Current software tools for the automated building of models for macro­molecular X-ray crystal structures are capable of assembling high-quality models for ordered macromolecule and small-molecule scattering components with minimal or no user supervision. Many of these tools also incorporate robust functionality for modelling the ordered water molecules that are found in nearly all macromolecular crystal structures. However, no current tools focus on differentiating these ubiquitous water molecules from other frequently occurring multi-atom solvent species, such as sulfate, or the automated building of models for such species. PeakProbe has been developed specifically to address the need for such a tool. PeakProbe predicts likely solvent models for a given point (termed a `peak') in a structure based on analysis (`probing') of its local electron density and chemical environment. PeakProbe maps a total of 19 resolution-dependent features associated with electron density and two associated with the local chemical environment to a two-dimensional score space that is independent of resolution. Peaks are classified based on the relative frequencies with which four different classes of solvent (including water) are observed within a given region of this score space as determined by large-scale sampling of solvent models in the Protein Data Bank. Designed to classify peaks generated from difference density maxima, PeakProbe also incorporates functionality for identifying peaks associated with model errors or clusters of peaks likely to correspond to multi-atom solvent, and for the validation of existing solvent models using solvent-omit electron-density maps. When tasked with classifying peaks into one of four distinct solvent classes, PeakProbe achieves greater than 99% accuracy for both peaks derived directly from the atomic coordinates of existing solvent models and those based on difference density maxima. While the program is still under development, a fully functional version is publicly available. PeakProbe makes extensive use of cctbx libraries, and requires a PHENIX licence and an up-to-date phenix.python environment for execution.