drug

China Stocks fall after poor coronavirus drug trial results

Risk sentiment deteriorated after a news report, citing inadvertently released results, said the closely watched antiviral drug remdesivir had had no effect on patients in its first randomised clinical test.




drug

Hong Kong Market slips on doubts over coronavirus drug

Risk sentiment deteriorated after a news report, citing inadvertently released results, said the closely watched antiviral drug remdesivir had had no effect on patients in its first randomised clinical test.




drug

Zydus Cadila launches affordable prostate cancer treatment drug 'Obnyx'

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drug

New antiviral drug combo shows promise against COVID-19: Study

A two-week course of an antiviral therapy, started within seven days of experiencing COVID-19 symptoms, may improve clinical recovery of patients and reduce their hospital stay duration, according to the first randomised trial of this triple drug combination. The study, published in the journal The Lancet, involved 127 adults from six public hospitals in Hong Kong, and tested the effectiveness of an antiviral drug combination in reducing the load of the novel coronavirus in their bodies. According to the researchers, including those from the University of Hong Kong, treatment involving combination of the drugs interferon beta-1b, plus the antiviral therapy lopinavir-ritonavir and ribavirin, is better at reducing the viral load than lopinavir-ritonavir alone. They stressed on the need for larger phase 3 trials to examine the effectiveness of this triple combination in critically ill patients, adding that these early findings were only observed in patients with mild to moderate ...




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Got drug controller nod for Favipiravir's clinical trial on COVID-19 patients: CSIR DG

The Drug Controller of India has allowed clinical trial of Favipiravir medicine, developed indigenously a CSIR laboratory, on coronavirus patients, Director General Shekhar Mande said on Friday. He said the Indian Institute of Chemical Technology (IICT), Hyderabad has developed the technology to make the drug Favipiravir. The technology has been transferred to a private company, IICT Director S Chandrashekar said. The company will now tie up with hospitals for clinical trials so that the drug could be tested on patients suffering from COVID-19. Approval from patients will be necessary as per the protocols, he said. Mande said Favipiravir is used in countries such as China and Japan to treat influenza. Whenever, a virus enters a cell, it tries to create multiple replicas. Favipiravir stops the replication process, he explained. The CSIR has already tied up with Cadila Pharmaceuticals Ltd to evaluate Mycobacterium W (Mw) for faster recovery of hospitalised COVID-19 patients and minimise




drug

Nifty, Sensex Soar on Covid-19 Drug Hopes, Set for Best Month Since 2009

The NSE Nifty 50 index advanced 3.11 per cent to 9,850.3 by 0455 GMT, while the benchmark S&P BSE Sensex was up 3.1 per cent at 33,734.26. Both indexes were on course for their fourth straight session of gains in a holiday shortened week.




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Glenmark to Conduct Trials for Potential Covid-19 Drug, Shares Jump

On Wednesday, another Indian pharmaceutical company, Strides Pharma Science Ltd, said it had developed and commercialised favipiravir antiviral tablets, and had applied to Indian drug authorities to start trials.




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Vaccine, Therapeutic Drug Development for Covid-19 Going on: DRDO Chairman

The DRDO is making special N-99 masks, besides personal protective gear for chemical, biological, radiation and nuclear-related activities, and working on software, including one that will track people under quarantine.




drug

Trial of New Drug to Control Blood Pressure Kills Senior Developer in Chennai

A police official said a post-mortem will be done after tests for coronavirus infection is done, which is the practice now.




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Antiviral Favipiravir Developed in Hyderabad to be Tried on Covid-19 Patients After Drug Controller Nod

The company will now tie up with hospitals for clinical trials so that the drug could be tested on patients suffering from COVID-19. Approval from patients will be necessary as per the protocols, the Director-General said.




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Punjab Drug Kingpin Wanted for 532 Kilo Heroin Haul Arrested, Cops Probe Pak Route

The police said that the duo is suspected to have smuggled heroin in and other drugs from Pakistan by camouflaging as many as six rock salt consignments through the Indo-Pak border at Attari in Amritsar between 2018 and 2019.




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Japan Approves Gilead Sciences' Remdesivir as Covid-19 Drug

Japan reached the decision just three days after the US drugmaker filed for fast-track approval for the treatment.




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GSK Tests Experimental Arthritis Drug to Treat Pneumonia from Covid-19

Drug otilimab - in which GSK acquired rights from German biotech firm Morphosys in 2013 - may possibly ease the devastating effect of the virus on the lungs, while not suppressing the virus directly, a company spokesman said.




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New Study Finds No Benefit from Malaria Drug HCQ for Coronavirus Treatment

Hydroxychloroquine did not lower the risk of dying or needing a breathing tube in a comparison that involved nearly 1,400 patients treated at Columbia University in New York, researchers reported Thursday in the New England Journal of Medicine.




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Anti-viral Drug Trio Found to Shorten Covid-19 Illness in Patients with Mild Symptoms: Study

Scientists are racing to identify effective medicines to use against the new coronavirus, but there is currently no treatment, cure or vaccine.




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Iran-linked Hackers Recently Targeted Coronavirus Drugmaker Gilead Sciences, Says Report

Two other cybersecurity researchers, who were not authorized to speak publicly about their analysis, confirmed that the web domains and hosting servers used in the hacking attempts were linked to Iran.




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Hepatitis C drugs may help fight COVID-19, supercomputer simulations suggest

Berlin, May 5: Several drugs approved for the treatment of hepatitis C viral infection have been identified as potential candidates against COVID-19 caused by the SARS-CoV-2 coronavirus, according to a study based on extensive calculations using supercomputer simulations.




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Chinese researcher on verge of making significant COVID-19 drug shot dead

Washington, May 07: A Chinese medical researcher on the "verge of making very significant" coronavirus findings has been found shot dead in the US state of Pennsylvania, media reports said on Wednesday. University of Pittsburgh professor Bing Liu, 37, was found




drug

New drug to protect against Alzheimer: Study

This drug could help activate these mechanisms that support nerve health and prevent dementia.




drug

COVID-19: HIV Drug Could Be Beneficial For Coronavirus Patients

The world is together in the fight against the global pandemic of coronavirus or covid-19, which has 1,700,870 cases and caused 102,789 deaths since its advent in December 2019. With hundreds of medical agencies and health experts crucially working on the




drug

COVID-19: Head Lice Drug For Treating Coronavirus

Scientists and medical research facilities around the world are jointly working towards developing a vaccine for the coronavirus pandemic which has caused 114,270 deaths and a total of 1,853,604 cases as of today [1]. From hydroxychloroquine to HIV drugs,




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COVID-19 & Remdesivir: Coronavirus Patients Recover With Gilead’s Drug

An experimental antiviral drug developed by a research-based biopharmaceutical company, Gilead Sciences showed positive results on its application, where more than half of a group of severely ill coronavirus patients improved. UPDATE: On 29 April, Gilead Sciences Inc. announced that in Phase




drug

Justin Bieber Detained At Airport During Drug Search

Singer Justin Bieber along with his entourage were detained at the Brisbane airport during a drug search conducted by customs agents. A member of his entourage was reportedly carrying weed, reports tmz.com. While customs agents searched for drugs, they asked Bieber




drug

Wall Street jumps on hopes of potential coronavirus drug

The Dow Jones Industrial Average rose 388.82 points, or 1.61 percent, at the open to 24,490.37.




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Wall Street rallies on promising coronavirus drug

The Dow Jones Industrial Average rose 532.31 points, or 2.21%, to 24,633.86, the SP 500 gained 76.12 points, or 2.66%, to 2,939.51 and the Nasdaq Composite added 306.98 points, or 3.57%, to 8,914.71.




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Iran-linked hackers recently targeted coronavirus drugmaker Gilead: Sources

In one case, A fake email login page designed to steal passwords was sent in April to a top Gilead executive involved in legal and corporate affairs, according to an archived version on a website used to scan for malicious web addresses. Reuters was not able to determine whether the attack was successful.




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Exclusive: Iran-linked hackers recently targeted coronavirus drugmaker Gilead - sources

Hackers linked to Iran have targeted staff at U.S. drugmaker Gilead Sciences Inc in recent weeks, according to publicly-available web archives reviewed by Reuters and three cybersecurity researchers, as the company races to deploy a treatment for the COVID-19 virus.




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Exclusive: Bangladesh's Beximco to begin producing COVID-19 drug remdesivir - COO

One of Bangladesh's largest drugmakers, Beximco Pharmaceuticals, will start production this month of the experimental antiviral drug remdesivir, which has shown promise in fighting the new coronavirus, a senior company executive said on Tuesday.




drug

Exclusive: Iran-linked hackers recently targeted coronavirus drugmaker Gilead - sources

Hackers linked to Iran have targeted staff at U.S. drugmaker Gilead Sciences Inc in recent weeks, according to publicly-available web archives reviewed by Reuters and three cybersecurity researchers, as the company races to deploy a treatment for the COVID-19 virus.




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Pfizer to outsource some drug production, focus on coronavirus vaccine

Pfizer Inc said on Friday it is in talks to shift more of its medicine production to outside contractors as it prepares for large-scale production of an experimental vaccine to prevent COVID-19, should it prove safe and effective.




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Two top drug smugglers with alleged Hizb-ul-Mujahideen links arrested from Sirsa

Punjab Police juggernaut moved to arrest Ranjeet Rana, one of the biggest drug smugglers of India from Sirsa




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Novel drug delivery technologies [Electronic book] : innovative strategies for drug re-positioning / Ambikanandan Misra, Aliasgar Shahiwala, editors.

Singapore : Springer, 2019.




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NOVEL DRUG DELIVERY TECHNOLOGIES [Electronic book] : innovative strategies for drug re.

[Place of publication not identified], SPRINGER Verlag, SINGAPOR, 2019.




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Cancer drug delivery systems based on the tumor microenvironment [Electronic book] / edited by Yasuhiro Matsumura, David Tarin.

Tokyo : Springer, 2019.




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Children and drug safety: balancing risk and protection in twentieth century America / Cynthia A. Connolly

Hayden Library - RJ560.C66 2018




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Hydrogen-bonded supramolecular micelle-mediated drug delivery enhances the efficacy and safety of cancer chemotherapy

Polym. Chem., 2020, 11,2791-2798
DOI: 10.1039/D0PY00082E, Paper
Chih-Chia Cheng, Ya-Ting Sun, Ai-Wei Lee, Shan-You Huang, Wen-Lu Fan, Yu-Hsuan Chiao, Chih-Wei Chiu, Juin-Yih Lai
Multiple hydrogen-bonded supramolecular polymers tend to form stable spherical micelles with oppositely charged anticancer drugs in biological environments, which improves cellular drug uptake and more effectively induces apoptosis in cancer cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Polymerization of dopamine accompanying its coupling to induce self-assembly of block copolymer and application in drug delivery

Polym. Chem., 2020, 11,2811-2821
DOI: 10.1039/D0PY00085J, Paper
Yudian Qiu, Zongyuan Zhu, Yalei Miao, Panke Zhang, Xu Jia, Zhongyi Liu, Xubo Zhao
The polymerization of dopamine and its coupling occur in succession, which synergistically induces the self-assembly of block copolymer to yield ordered structures, including micelles and vesicles.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation

Polym. Chem., 2020, Advance Article
DOI: 10.1039/D0PY00068J, Paper
S. Salimi, Y. Wu, M. I. Evangelista Barreiros, A. A. Natfji, S. Khaled, R. Wildman, L. R. Hart, F. Greco, E. A. Clark, C. J. Roberts, W. Hayes
Prototype drug eluting implants have been 3D printed using a supramolecular polyurethane-PEG formulation. The implants are capable of releasing a pharmaceutical active with effective drug release over a period of up to 8.5 months.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Development and disassembly of single and multiple acid-cleavable block copolymer nanoassemblies for drug delivery

Polym. Chem., 2020, 11,2934-2954
DOI: 10.1039/D0PY00234H, Review Article
Arman Moini Jazani, Jung Kwon Oh
Acid-degradable block copolymer-based nanoassemblies are promising intracellular candidates for tumor-targeting drug delivery as they exhibit the enhanced release of encapsulated drugs through their dissociation.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

The effects of aloe emodin-mediated antimicrobial photodynamic therapy on drug-sensitive and resistant Candida albicans

Photochem. Photobiol. Sci., 2020, 19,485-494
DOI: 10.1039/C9PP00352E, Paper
Wenpeng Ma, Chengcheng Liu, Jiao Li, Ming Hao, Yanhong Ji, Xiaoyan Zeng
Aloe emodin-mediated antimicrobial photodynamic therapy effectively inactivated drug-sensitive and resistant C. albicans and caused damage to the cell wall, cytoplasm, and nucleus.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Functional peptide-based drug delivery systems

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00713G, Highlight
Zheng Lian, Tianjiao Ji
Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Multi-Stimuli Responsive Polymeric Prodrug Micelles for Combined Chemotherapy and Photodynamic Therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00539H, Paper
Cheng Hu, Weihua Zhuang, Tao Yu, Liang Chen, Zhen Liang, Gaocan Li, Yunbing Wang
Nowadays, cancer therapy faces severe challenges on boosting therapeutic efficiency and reducing the side effects of drugs. To overcome these challenges, herein multifunctional polymeric prodrug micelles with combining chemotherapy and...
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02156F, Paper
Mohammad-Ali Shahbazi, Neha Shrestha, Malgorzata Karolina Pierchala, Firoz Babu Kadumudi, Mehdi Mehrali, Masoud Hasany, Véronique Préat, Sander Leeuwenburgh, Alireza Dolatshahi-Pirouz
A polymeric gum has been developed herein, which combines high stretchability and self-healing capacity with a bioactivity that can target and eliminate bacterial infections and inflammations.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Glutathione- and light-controlled generation of singlet oxygen for triggering drug release in mesoporous silica nanoparticles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00636J, Paper
Roy C. H. Wong, Dennis K. P. Ng, Wing-Ping Fong, Pui-Chi Lo
An activatable phthalocyanine-based photosensitiser and a singlet-oxygen-triggered doxorubicin releasing system have been incorporated into mesoporous silica nanoparticles, which can release the encapsulated doxorubicin in a controllable manner.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy

J. Mater. Chem. B, 2020, 8,3772-3788
DOI: 10.1039/D0TB00262C, Review Article
Yu Huang, Feng Qiu, Rongjun Chen, Deyue Yan, Xinyuan Zhu
In this Review, recent advances in fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy are described, and the current challenges and perspectives in this emerging field are also discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Redox-responsive amphiphilic camptothecin prodrug nanoparticles for targeted liver tumor therapy

J. Mater. Chem. B, 2020, 8,3918-3928
DOI: 10.1039/D0TB00285B, Paper
Lu Lu, Bing Li, Chuanchuan Lin, Ke Li, Genhua Liu, Zengzilu Xia, Zhong Luo, Kaiyong Cai
A redox-responsive drug carrier with asialoglycoprotein receptor (ASGPR) targeting is fabricated for liver tumor therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

“Watson–Crick GC”-inspired supramolecular nanodrug of methotrexate and 5-fluorouracil for tumor microenvironment-activatable self-recognizing synergistic chemotherapy

J. Mater. Chem. B, 2020, 8,3829-3841
DOI: 10.1039/D0TB00468E, Paper
Meijin Chen, Shiduan Chen, Fukai Zhu, Fanfan Wang, Haina Tian, Zhongxiong Fan, Sunkui Ke, Zhenqing Hou, Yang Li
The “Watson–Crick G≡C”-inspired carrier-free nanodrug have excellent tumor microenvironment-triggered active self-targeting ability and enhanced synergistic chemotherapeutic effects.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

J. Mater. Chem. B, 2020, 8,3939-3948
DOI: 10.1039/D0TB00327A, Paper
Boya Zhang, Shiyu Wan, Xinyu Peng, Mingying Zhao, Sai Li, Yuji Pu, Bin He
A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00735H, Paper
Long Wu, Wei Xie, Hui-Ming Zan, Zhongzhong Liu, Ganggang Wang, Yanfeng Wang, Wei Liu, Wenfei Dong
Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




drug

Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00052C, Paper
Javad Foroughi, Sepehr Talebian , In Kyoung Shim, Kara Vine, Song Cheol Kim, Geoffrey M Spinks
Biopolymer-based hydrogels have emerged as promising platforms for drug delivery systems (DDSs) due to their inherent biocompatibility, tunable physical properties and controllable degradability. Yet, drug release in majority of these...
The content of this RSS Feed (c) The Royal Society of Chemistry