BACKGROUND AND PURPOSE:

Prediction of aneurysm instability is crucial to guide treatment decisions and to select appropriate patients with unruptured intracranial aneurysms (IAs) for preventive treatment. High-resolution 4D MR flow imaging and 3D quantification of aneurysm morphology could offer insights and new imaging markers for aneurysm instability. In this cross-sectional study, we aim to identify 4D MR flow imaging markers for aneurysm instability by relating hemodynamics in the aneurysm sac to 3D morphologic proxy parameters for aneurysm instability.

We present a unique case of a single patient presenting with two mutationally distinct, PD-L1⁺ diffuse large B-cell lymphomas (DLBCLs). One of these DLBCLs demonstrated exceptionally high mutational burden (eight disease-associated variants and 41 variants of undetermined significance) with microsatellite instability (MSI) and an acquired PMS2 mutation with loss of PMS2 protein expression, detected postchemotherapy. This report, while highlighting the extent of possible tumor heterogeneity across separate clonal expansions as well as possible syndromic B-cell neoplasia, supports the notion that, although rare, PD-L1 expression and associated states permissive of high mutational burden (such as mismatch repair gene loss of function/MSI) should be more routinely considered in DLBCLs. Appropriate testing may be predictive of outcome and inform the utility of targeted therapy in these genetically diverse and historically treatment-refractory malignancies.

Pitched as a mix of ‘Blade Runner’ and ‘Jurassic Park,’ Neom is the world’s biggest construction project. Twenty-one thousand people have died so far to make it happen.

A Labour minister confirmed that the application process for Personal Independence Payment is being 'kept under review'

If we want to terraform the Red Planet to make it better able to host microbial life, tiny rods of iron and aluminium may be the answer

A 6000-kilogram spacecraft will embark on a six-year journey to Jupiter to explore whether its icy moon Europa has the conditions to support life

Devices that let people with paralysis walk and talk are rapidly improving. Some see a future in which we alter memories and download skills – but major challenges remain

House Republicans on Tuesday demanded that each member of President Biden's cabinet preserve all relevant documents and communications, a move that signals future investigations into the Biden administration.

President-elect Trump has made six selections to serve in his Cabinet in the week since the election, a faster pace than he set when elected to the presidency in 2016.

Despite his own isolationist musings, the first picks of President-elect Donald Trump's incoming administration hail from a decidedly more traditionalist wing of the Republican Party.

Brianna Ghey's mother, Esther Ghey, is now campaigning to raise awareness about the dangers of social media and the "toxic" online world which her daughter came to inhabit. She wants tighter regulation on internet access and more parental controls.

An Ottawa high school principal has apologized for playing an Arabic song about peace during a Remembrance Day ceremony after facing swift backlash from critics calling it inappropriate and hurtful to members of the Jewish community.

1. Top Roles For Elon Musk, Vivek Ramaswamy In Donald Trump's Cabinet  NDTV
2. Trump’s 'Manhattan Project' of government reform: Musk and Ramaswamy to lead efficiency crusade  The Times of India
3. Donald Trump Picks Elon Musk, Vivek Ramaswamy For Cabinet: Internet Has This To Say  News18
4. A dope for DOGE (and Dogecoin): Trump taps Musk in efficiency team, crypto fans rejoice  The Economic Times
5. Video | Elon Musk In Trump's New Cabinet, UK Church Abuse Scandal, Saudi Megacity in Trouble  NDTV

Managing roughly $7 trillion in assets gives BlackRock's decisions a major impact.

Sibert and Red Cloud, black-footed ferret siblings at the Smithsonian’s National Zoo and Conservation Biology Institute, are the first members of an endangered species born to a cloned animal.

Brightmark CEO Bob Powell discusses Plastics Renewal technology and how to bring sustainability into the medical industry.

Nick Guerin, CSP, director of environmental, health & safety at Tessy Plastics highlights how contract manufacturers are driving sustainability in the medical plastics industry.

Today’s cannabis plant is highly cultivated and incredibly potent. Treating it like a commodity, and not a testable, regulated medicine, is hurting people

<p> <b>BIOSIMILAR RED TAPE ELIMINATION ACT (S2305):</b><br /> <b><i>Weakening FDA Regulatory Standards for Biosimilars, Undermining Physician Confidence and Jeopardizing Patient Health</i></b><br /><b>31 October 2024&nbsp;|&nbsp;</b><b><a href="https://youtu.be/X6-dYZ7fjhM" target="_blank">WATCH REPLAY</a></b></p>

Donald Trump has begun the process of choosing a cabinet and selecting other high-ranking administration officials following his presidential election victory. Here are the early picks and top contenders for some of the key posts overseeing defence, intelligence, diplomacy, trade, immigration and economic policymaking. Some are in contention for a range of posts. Susie Wiles, chief of staff Susie Wiles reacts as Republican presidential nominee and former US President Donald Trump speaks, following early results from the 2024 US presidential election in Palm Beach County Convention Center, in West Palm Beach, Florida, US on Nov 6, 2024. PHOTO: Reuters Trump announced last week that Wiles, one of his two campaign managers, will be his White House chief of staff.

Nov 17, 2022

The speakers included Yale Law School professor Harold H. Koh ’75, and Patrick W. Pearsall, Director of the International Claims and Reparations Project at Columbia Law School. Koh and Pearsall discussed their experiences representing Ukraine in legal proceedings against Russia before the International Court of Justice.

Al Maryah Island lights up Abu Dhabi with Spectacular New Year�s Eve Celebrations

Philippe Jourdan: Partner - Promise Consulting

West and HealthPrize are collaborating to provide an end to end connected health solution for pharmaceutical companies and the patients they serve.

Gillette Children's Specialty Healthcare is launching Emojability. Learn more about this one-of-a-kind emoji keyboard app for Android and Apple.

My client purchased a property from an NRI and we have deducted 20% Plus Cess and Surcharge. Later the TDS processed with defaults and intimated that the applicable rate is 30%. They have raised demand for short deduction.1.What is the actual rate of TDS when we are buying

Businesses can adjust their tax liabilities by issuing credit notes to adjust output tax liabilities, claiming unclaimed ITC and correcting any errors or omissions in GSTR-1 and GSTR-3B.<

The Hon'ble Delhi High Court in the case of M/s Sanjay Sales India v. Principal Commissioner of Department of Trade and Taxes, Government of NCT, Delhi [Writ Petition (Civil) No. 10234 of 2024 dated July 26, 2024] held that the application for the cancellation of the GST registration cannot be denie

If assessee had agriculture income in inheritance, then such agriculture land converted into non-agriculture land i.e. commercial land and make his sub plots and sale to others, so what is treatment of such income arise on sale whether capital gain applicable in such case or consider in PGBP, if considered in PGBP, then how to provide effect in that i.e. Treat as direct income under Trading account or treat as indirect income in P&L Account?