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[ASAP] Total Synthesis of (+)-Oxo-tomaymycin

Organic Process Research & Development
DOI: 10.1021/acs.oprd.0c00009




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Secondary component continues to dominate IPOs with 80% of total proceeds

For a third year in a row, exits accounted for over 80% of total proceeds




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Fixed-point “blasting” triggered by second near-infrared window light for augmented interventional photothermal therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00372G, Paper
Yongbin Cao, Boshu Ouyang, Xiaowei Yang, Qin Jiang, Lin Yu, Shun Shen, Jiandong Ding, Wuli Yang
Tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage triggered by NIR-II light.
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A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper
Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
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Overview of the application of inorganic nanomaterials in cancer photothermal therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00222D, Review Article
Natanael Fernandes, Carolina F. Rodrigues, André F. Moreira, Ilídio J. Correia
Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect.
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Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00549E, Paper
Tianhong Teng, Ronggui Lin, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang, Heguang Huang
Preparation of Abraxane@MoSe2 and its PTT effect augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode.
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Disulfiram-Gold-Nanorod Integrate for Effective Tumor Targeting and Photothermal-Chemical Synergistic Therapy

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00062K, Paper
Chaoli Xu, Ting Zhang, Guangming Lu, Kun Chen, Jun Tao, Yunlei Zhang, Zhaogang Teng, Bin Yang
Herein, we successfully constructed a combined therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF). The Au-DSF integrates possess a uniform length...
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Fluorescence Imaging-Guided Multifunctional Liposomes for Tumor-Specific Phototherapy for Laryngeal carcinoma

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00249F, Paper
Di Wu, zheng zhao, nan wang, xinrui zhang, honghong yan, xiaoqi chen, yunyun fan, weiwei liu, xuekui liu
Reliable diagnosed and efficient targeted therapy regime is important and may in turn lead to more effective laryngeal carcinoma treatments. Multifunctional nano-theranostic agents demonstrate great potential in tumor theranostic applications....
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Naturally available hypericin undergoes electron transfer for type I photodynamic and photothermal synergistic therapy

Biomater. Sci., 2020, 8,2481-2487
DOI: 10.1039/D0BM00021C, Paper
Zhen Ke, Aize Xie, Jianjiao Chen, Zhenyuan Zou, Lei Shen, Yansong Dai, Dengfeng Zou
Hypericin undergoing electron transfer can be used for type I PDT and PTT.
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Prometryn induces apoptotic cell death through cell cycle arrest and oxidative DNA damage

Toxicol. Res., 2019, 8,833-841
DOI: 10.1039/C9TX00080A, Paper
Qiaoyun Liu, Longsheng Wang, Hanwen Chen, Bo Huang, Jiawei Xu, Ying Li, Paul Héroux, Xinqiang Zhu, Yihua Wu, Dajing Xia
Prometryn induces oxidative stress-mediated DNA damage; Prometryn induces S phase of cell cycle arrest; Prometryn induces Bax-dependent apoptosis in BEAS-2B cells.
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Eco-friendly synthesis of glutathione-capped CdTe/CdSe/ZnSe core/double shell quantum dots: their cytotoxicity and genotoxicity effects on Chinese hamster ovary cells

Toxicol. Res., 2019, 8,868-874
DOI: 10.1039/C9TX00113A, Paper
Neo Mervyn Monaheng, Sundararajan Parani, Mary Gulumian, Oluwatobi Samuel Oluwafemi
In this work, we report green one-pot synthesis, cytotoxicity and genotoxicity of glutathione-capped CdTe/CdSe/ZnSe heterostructured quantum dots (QDs) using a label-free xCELLigence RTCA system as well as the Cytokinesis Blocked Micronucleus assay.
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miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway

Toxicol. Res., 2019, 8,875-884
DOI: 10.1039/C9TX00100J, Paper
Xuan-Ying Chen, Wei-Lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-He Li, Jian-Ping Xiong
Bevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.
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Characteristic synergistic cytotoxic effects toward cells in graphene oxide dressing with cadmium and copper ions

Toxicol. Res., 2019, 8,908-917
DOI: 10.1039/C9TX00146H, Paper
Yiyang Dong, Yulin Chang, Haidi Gao, Victoria Arantza León Anchustegui, Qiang Yu, Haifang Wang, Jia-Hui Liu, Shihui Wang
Cadmium ions exerted synergistic toxic effects with graphene oxide on Hela cells.
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Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats

Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
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Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae

Toxicol. Res., 2019, 8,1009-1015
DOI: 10.1039/C9TX00215D, Paper
S. J. Sudharshan, Raghavendra Tirupathi, Madhu Dyavaiah
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
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Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway

Toxicol. Res., 2019, 8,1028-1034
DOI: 10.1039/C9TX00220K, Paper
Yan Yan, Kang Wang, Xu Tang, Jun-feng Gao, Bin-yu Wen
Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified.
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Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

Toxicol. Res., 2019, 8,1042-1049
DOI: 10.1039/C9TX00240E, Paper
Yuexiang Niu, Engong Tang, Qingan Zhang
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.
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The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells

Toxicol. Res., 2019, 8,1050-1056
DOI: 10.1039/C9TX00235A, Paper
Zahra Karimi, Maryam Ghaffari, Jafar Ezzati Nazhad Dolatabadi, Parvin Dehghan
2-tert-Butyl-4-hydroquinone (TBHQ) is used for inhibition of oxidative rancidity in the food industry.
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Single-wavelength phototheranostics for colon cancer via thiolytic reaction

Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR02393K, Paper
Yucheng Zhu, Chao Chen, Qinghua Wu, Guoliang Yang, Zhiyong Liu, Erhong Hao, Hongliang Cao, Yun Gao, Weian Zhang
It’s a huge challenge to develop effective nanosystems combined the capabilities of diagnoses and therapies together for colon cancer in clinic. Herein, we constructed a far-red absorbing phototheranostic nanosystem (FR-H2S)...
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Main entrance, El Marasol, residence of E. T. Stotesbury, Palm Beach, Fla




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Montoto, Ralph, Jr




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San Luis housing : Prototypical community




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San Luis housing : Prototypical housing I




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San Luis housing : Prototypical housing 2




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San Luis housing : Prototypical cabin




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A prototypical computer museum




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Efforts toward the first enantioselective total synthesis of praziquantel and synthetic model studies on ecteinascidin 743 by novel aromatic C-H insertion methodology




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Studies in rhodium catalyzed intramolecular C-H insertion of amino acid derived α-diazo-β-(substituted)acetamides and its application to the total synthesis of clasto-lactacystin β-lactone




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Total evaporative resistance of selected clothing ensembles




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Design and testing of a marsupial/companion robot prototype for a powered wheelchair




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Design and testing of a prototype gripper for a wheelchair mounted robot




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Attenuation of bromobenzene-induced hepatotoxicity by poly(adp-ribose) polymerase inhibitors




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The theoretical modeling, design, and synthesis of key structural units for novel molecular clamps and pro-apoptotic alpha helix peptidomimetics




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Prototype and testing of a MEMS microcooler based on magnetocaloric effect




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Dynamic monitoring of cytotoxicity by using electric cell substrate impedance sensing




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B-Raf is an essential component of the mitotic machinery critical for activation of MAPK signaling during mitosis in Xenopus egg extracts




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Asymptotes and metaphors




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Cultural response to totalitarianism in select movies produced in Czechoslovakia, Hungary and Poland between 1956 and 1989




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Christoffel function asymptotics and universality for Szego weights in the complex plane




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ECIS assessment of cytotoxicity and trans-endothelial migration of metastatic cancer cells




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Total internal reflection holographic microscopy (tirhm) for quantitative phase characterization of cell-substrate adhesion




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Photothermal studies of carboxymyoglobin




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Apparent total evaporative resistance values from human trials over a range of heat stress levels




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Total destruction of a village in Darfur




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Behavioral transitions during metamorphosis: Skototropism’s successors




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Spectrophotometric determinations of the pH and total alkalinity of sea water utilizing sulfonephthalein indicators




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Resource partitioning between Trigona fulviventris and Scaptotrigona mexicana with overlapping flight ranges




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An interview with Stephen Cartotto




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The Armenian Genocide as Prototype




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Specimen USF 06121 Lithostotionella