sim

Penny Wong : passion and principle : the biography / by Margaret Simons.

Wong, Penny.




sim

Des maladies simulées et des moyens de les reconnaître / par Edmond Boisseau.

Paris : Bailliere, 1870.




sim

Des moyens simples a employer pour guerir et eviter la tuberculose / par Jeanne Leclerc.

Paris : Société d’éditions scientifiques, 1896.




sim

A description of the genus Cinchona, comprehending the various species of vegetables from which the Peruvian and other barks of a similar quality are taken. Illustrated by figures of all the species hitherto discovered. To which is prefixed Professor Vahl

London : printed for B. and J. White, 1797.




sim

Dictionnaire des drogues simples et composées, ou dictionnaire d'histoire naturelle médicale, de pharmacologie et de chimie pharmaceutique / par A. Chevallier... et A. Richard.

Paris : Béchet jeune, 1827-1829.




sim

Die Gehirnerweichung der Irren (Dementia paralytica) fur Aerzte und Studirende / bearbeitet von Theodor Simon.

Hamburg : Wilhelm Mauke, 1871.




sim

Die Localisation der Hautkrankheiten : histologisch und klinisch / bearbeitet von Oscar Simon.

Berlin : A. Hirschwald, 1873.




sim

Die Meningitis simplex / von Joseph Bierbaum.

Leipzig : F.C.W. Vogel, 1866.




sim

Domestic medicine : a treatise on the prevention and cure of diseases, by regimen and simple medicine. ... With remarks on the properties of food, vaccination, electricity, galvanism, bathing, &c / by William Buchan.

London : printed for the booksellers, 1828.




sim

Domestic medicine : or, a treatise for the prevention and cure of diseases, by regimen and simple medicines : With an appendix, containing a dispensatory for private practitioners. ... containing new treatises on sea-bathing, mineral waters, vaccine, inoc

Halifax : Milner and Sowerby, 1856.




sim

Domestic medicine : or, a treatise for the prevention and cure of diseases, by regimen and simple medicines : With an appendix, containing a dispensatory for private practitioners. ... containing new treatises on sea-bathing, mineral waters, vaccine, inoc

Halifax : Milner and Sowerby, 1860.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix, containing a dispensatory for the use of private practitioners / by William Buchan.

London : printed for A. Strahan, T. Cadell, 1790.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix, containing a dispensatory for the use of private practitioners / by William Buchan.

London : And J. Balfour, and W. Creech, Edinburgh, 1791.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix, containing a dispensatory for the use of private practitioners / by William Buchan.

London : printed for A. Strahan and T. Cadell, London, 1794.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases, by regimen and simple medicines: With an appendix, containing a dispensatory for the use of private practitioners / by William Buchan.

Edinburgh : printed for Thomas Nelson, 1820.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix, containing a dispensatory for the use of private practitioners / by William Buchan.

London : printed for A. Strahan, and T. Cadell jun. and W. Davies, (successors to Mr. Cadell,) in the Strand, 1797.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix, containing a dispensatory for the use of private practitioners. To which are added, observations on the diet of the common people;

London : printed for A. Strahan, T. Cadell jun. and W. Davies, 1800.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix containing a dispensatory for the use of private practitioners. ... to which are added, some important observations concerning sea-

London : And J. Balfour, and W. Creech, Edinburgh, 1805.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix, containing a dispensatory for the use of private practitioners. ... To which are now added, some important observations concerning

London : printed for A. Strahan, T. Cadell and W. Davies, 1803.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases by regimen and simple medicines. With an appendix, containing a dispensatory for the use of private practitioners. ... To which is now added, a complete index / by William Buchan.

Manchester : printed by S. Russell, 1806.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases, by regimen and simple medicines: With observations concerning sea-bathing, and on the use of mineral waters. To which is annexed a dispensatory for the use of private practitioners

London : J. Johnson, 1807.




sim

Domestic medicine : or, a treatise on the prevention and cure of diseases, by regimen and simple medicines : With observations concerning sea-bathing, and on the use of the mineral waters. To which is annexed, a dispensatory for the use of private practit

London : F.C. and J. Rivington, 1813.




sim

Domestic medicine : or, the family physician. A treatise on the prevention and cure of diseases, by regimen and simple medicines: With an appendix, containing a dispensatory for the use of private practitioners / by William Buchan.

Dunbar : printed by and for G. Miller, 1817.




sim

Dr. Buchans Domestic medicine; or a treatise on the prevention and cure of diseases, by regimen and simple medicines. To which is added, characteristic symptoms of diseases, from the nosology of the late celebrated Dr. Cullen of Edinburgh. With an appendi

Newcastle : printed by K. Anderson, 1812.




sim

The Edinburgh stereoscopic atlas of obstetrics / edited by G.F. Barbour Simpson and Edward Burnet ; with a preface by Sir J. Halliday Croom.

London : Caxton Pub. Co, 1908-1909.




sim

An elementary description of the anatomy and physiology of the brain, viscera of the thorax, abdomen, &c. ... / by W. Simpson.

London, 1826.




sim

Paul brings herbs to refresh Virginie after she has performed a long walk barefoot. Stipple engraving by J.P. Simon after C.P. Landon.

A Paris (rue St Denis No. 214) : chez Bance aîné, [1810?]




sim

Integrating behavioral therapies with medications in the treatment of drug dependence / editors, Lisa Simon Onken, Jack D. Blaine, John J. Boren.

Rockville, Maryland : National Institute on Drug Abuse, 1995.




sim

Recovery of simultaneous low rank and two-way sparse coefficient matrices, a nonconvex approach

Ming Yu, Varun Gupta, Mladen Kolar.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 413--457.

Abstract:
We study the problem of recovery of matrices that are simultaneously low rank and row and/or column sparse. Such matrices appear in recent applications in cognitive neuroscience, imaging, computer vision, macroeconomics, and genetics. We propose a GDT (Gradient Descent with hard Thresholding) algorithm to efficiently recover matrices with such structure, by minimizing a bi-convex function over a nonconvex set of constraints. We show linear convergence of the iterates obtained by GDT to a region within statistical error of an optimal solution. As an application of our method, we consider multi-task learning problems and show that the statistical error rate obtained by GDT is near optimal compared to minimax rate. Experiments demonstrate competitive performance and much faster running speed compared to existing methods, on both simulations and real data sets.




sim

Nonparametric false discovery rate control for identifying simultaneous signals

Sihai Dave Zhao, Yet Tien Nguyen.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 110--142.

Abstract:
It is frequently of interest to identify simultaneous signals, defined as features that exhibit statistical significance across each of several independent experiments. For example, genes that are consistently differentially expressed across experiments in different animal species can reveal evolutionarily conserved biological mechanisms. However, in some problems the test statistics corresponding to these features can have complicated or unknown null distributions. This paper proposes a novel nonparametric false discovery rate control procedure that can identify simultaneous signals even without knowing these null distributions. The method is shown, theoretically and in simulations, to asymptotically control the false discovery rate. It was also used to identify genes that were both differentially expressed and proximal to differentially accessible chromatin in the brains of mice exposed to a conspecific intruder. The proposed method is available in the R package github.com/sdzhao/ssa.




sim

Simultaneous transformation and rounding (STAR) models for integer-valued data

Daniel R. Kowal, Antonio Canale.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1744--1772.

Abstract:
We propose a simple yet powerful framework for modeling integer-valued data, such as counts, scores, and rounded data. The data-generating process is defined by Simultaneously Transforming and Rounding (STAR) a continuous-valued process, which produces a flexible family of integer-valued distributions capable of modeling zero-inflation, bounded or censored data, and over- or underdispersion. The transformation is modeled as unknown for greater distributional flexibility, while the rounding operation ensures a coherent integer-valued data-generating process. An efficient MCMC algorithm is developed for posterior inference and provides a mechanism for adaptation of successful Bayesian models and algorithms for continuous data to the integer-valued data setting. Using the STAR framework, we design a new Bayesian Additive Regression Tree model for integer-valued data, which demonstrates impressive predictive distribution accuracy for both synthetic data and a large healthcare utilization dataset. For interpretable regression-based inference, we develop a STAR additive model, which offers greater flexibility and scalability than existing integer-valued models. The STAR additive model is applied to study the recent decline in Amazon river dolphins.




sim

Latent Simplex Position Model: High Dimensional Multi-view Clustering with Uncertainty Quantification

High dimensional data often contain multiple facets, and several clustering patterns can co-exist under different variable subspaces, also known as the views. While multi-view clustering algorithms were proposed, the uncertainty quantification remains difficult --- a particular challenge is in the high complexity of estimating the cluster assignment probability under each view, and sharing information among views. In this article, we propose an approximate Bayes approach --- treating the similarity matrices generated over the views as rough first-stage estimates for the co-assignment probabilities; in its Kullback-Leibler neighborhood, we obtain a refined low-rank matrix, formed by the pairwise product of simplex coordinates. Interestingly, each simplex coordinate directly encodes the cluster assignment uncertainty. For multi-view clustering, we let each view draw a parameterization from a few candidates, leading to dimension reduction. With high model flexibility, the estimation can be efficiently carried out as a continuous optimization problem, hence enjoys gradient-based computation. The theory establishes the connection of this model to a random partition distribution under multiple views. Compared to single-view clustering approaches, substantially more interpretable results are obtained when clustering brains from a human traumatic brain injury study, using high-dimensional gene expression data.




sim

Agnostic tests can control the type I and type II errors simultaneously

Victor Coscrato, Rafael Izbicki, Rafael B. Stern.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 230--250.

Abstract:
Despite its common practice, statistical hypothesis testing presents challenges in interpretation. For instance, in the standard frequentist framework there is no control of the type II error. As a result, the non-rejection of the null hypothesis $(H_{0})$ cannot reasonably be interpreted as its acceptance. We propose that this dilemma can be overcome by using agnostic hypothesis tests, since they can control the type I and II errors simultaneously. In order to make this idea operational, we show how to obtain agnostic hypothesis in typical models. For instance, we show how to build (unbiased) uniformly most powerful agnostic tests and how to obtain agnostic tests from standard p-values. Also, we present conditions such that the above tests can be made logically coherent. Finally, we present examples of consistent agnostic hypothesis tests.




sim

Simple step-stress models with a cure fraction

Nandini Kannan, Debasis Kundu.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 2--17.

Abstract:
In this article, we consider models for time-to-event data obtained from experiments in which stress levels are altered at intermediate stages during the observation period. These experiments, known as step-stress tests, belong to the larger class of accelerated tests used extensively in the reliability literature. The analysis of data from step-stress tests largely relies on the popular cumulative exposure model. However, despite its simple form, the utility of the model is limited, as it is assumed that the hazard function of the underlying distribution is discontinuous at the points at which the stress levels are changed, which may not be very reasonable. Due to this deficiency, Kannan et al. ( Journal of Applied Statistics 37 (2010b) 1625–1636) introduced the cumulative risk model, where the hazard function is continuous. In this paper, we propose a class of parametric models based on the cumulative risk model assuming the underlying population contains long-term survivors or ‘cured’ fraction. An EM algorithm to compute the maximum likelihood estimators of the unknown parameters is proposed. This research is motivated by a study on altitude decompression sickness. The performance of different parametric models will be evaluated using data from this study.




sim

Simple tail index estimation for dependent and heterogeneous data with missing values

Ivana Ilić, Vladica M. Veličković.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 1, 192--203.

Abstract:
Financial returns are known to be nonnormal and tend to have fat-tailed distribution. Also, the dependence of large values in a stochastic process is an important topic in risk, insurance and finance. In the presence of missing values, we deal with the asymptotic properties of a simple “median” estimator of the tail index based on random variables with the heavy-tailed distribution function and certain dependence among the extremes. Weak consistency and asymptotic normality of the proposed estimator are established. The estimator is a special case of a well-known estimator defined in Bacro and Brito [ Statistics & Decisions 3 (1993) 133–143]. The advantage of the estimator is its robustness against deviations and compared to Hill’s, it is less affected by the fluctuations related to the maximum of the sample or by the presence of outliers. Several examples are analyzed in order to support the proofs.




sim

Heavy metalloid music : the story of Simply Saucer

Locke, Jesse, 1983- author.
9781771613682 (Paper)




sim

A simulation study of disaggregation regression for spatial disease mapping. (arXiv:2005.03604v1 [stat.AP])

Disaggregation regression has become an important tool in spatial disease mapping for making fine-scale predictions of disease risk from aggregated response data. By including high resolution covariate information and modelling the data generating process on a fine scale, it is hoped that these models can accurately learn the relationships between covariates and response at a fine spatial scale. However, validating these high resolution predictions can be a challenge, as often there is no data observed at this spatial scale. In this study, disaggregation regression was performed on simulated data in various settings and the resulting fine-scale predictions are compared to the simulated ground truth. Performance was investigated with varying numbers of data points, sizes of aggregated areas and levels of model misspecification. The effectiveness of cross validation on the aggregate level as a measure of fine-scale predictive performance was also investigated. Predictive performance improved as the number of observations increased and as the size of the aggregated areas decreased. When the model was well-specified, fine-scale predictions were accurate even with small numbers of observations and large aggregated areas. Under model misspecification predictive performance was significantly worse for large aggregated areas but remained high when response data was aggregated over smaller regions. Cross-validation correlation on the aggregate level was a moderately good predictor of fine-scale predictive performance. While the simulations are unlikely to capture the nuances of real-life response data, this study gives insight into the effectiveness of disaggregation regression in different contexts.




sim

A simple, consistent estimator of SNP heritability from genome-wide association studies

Armin Schwartzman, Andrew J. Schork, Rong Zablocki, Wesley K. Thompson.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2509--2538.

Abstract:
Analysis of genome-wide association studies (GWAS) is characterized by a large number of univariate regressions where a quantitative trait is regressed on hundreds of thousands to millions of single-nucleotide polymorphism (SNP) allele counts, one at a time. This article proposes an estimator of the SNP heritability of the trait, defined here as the fraction of the variance of the trait explained by the SNPs in the study. The proposed GWAS heritability (GWASH) estimator is easy to compute, highly interpretable and is consistent as the number of SNPs and the sample size increase. More importantly, it can be computed from summary statistics typically reported in GWAS, not requiring access to the original data. The estimator takes full account of the linkage disequilibrium (LD) or correlation between the SNPs in the study through moments of the LD matrix, estimable from auxiliary datasets. Unlike other proposed estimators in the literature, we establish the theoretical properties of the GWASH estimator and obtain analytical estimates of the precision, allowing for power and sample size calculations for SNP heritability estimates and forming a firm foundation for future methodological development.




sim

Microsimulation model calibration using incremental mixture approximate Bayesian computation

Carolyn M. Rutter, Jonathan Ozik, Maria DeYoreo, Nicholson Collier.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2189--2212.

Abstract:
Microsimulation models (MSMs) are used to inform policy by predicting population-level outcomes under different scenarios. MSMs simulate individual-level event histories that mark the disease process (such as the development of cancer) and the effect of policy actions (such as screening) on these events. MSMs often have many unknown parameters; calibration is the process of searching the parameter space to select parameters that result in accurate MSM prediction of a wide range of targets. We develop Incremental Mixture Approximate Bayesian Computation (IMABC) for MSM calibration which results in a simulated sample from the posterior distribution of model parameters given calibration targets. IMABC begins with a rejection-based ABC step, drawing a sample of points from the prior distribution of model parameters and accepting points that result in simulated targets that are near observed targets. Next, the sample is iteratively updated by drawing additional points from a mixture of multivariate normal distributions and accepting points that result in accurate predictions. Posterior estimates are obtained by weighting the final set of accepted points to account for the adaptive sampling scheme. We demonstrate IMABC by calibrating CRC-SPIN 2.0, an updated version of a MSM for colorectal cancer (CRC) that has been used to inform national CRC screening guidelines.




sim

On the probability distribution of the local times of diagonally operator-self-similar Gaussian fields with stationary increments

Kamran Kalbasi, Thomas Mountford.

Source: Bernoulli, Volume 26, Number 2, 1504--1534.

Abstract:
In this paper, we study the local times of vector-valued Gaussian fields that are ‘diagonally operator-self-similar’ and whose increments are stationary. Denoting the local time of such a Gaussian field around the spatial origin and over the temporal unit hypercube by $Z$, we show that there exists $lambdain(0,1)$ such that under some quite weak conditions, $lim_{n ightarrow+infty}frac{sqrt[n]{mathbb{E}(Z^{n})}}{n^{lambda}}$ and $lim_{x ightarrow+infty}frac{-logmathbb{P}(Z>x)}{x^{frac{1}{lambda}}}$ both exist and are strictly positive (possibly $+infty$). Moreover, we show that if the underlying Gaussian field is ‘strongly locally nondeterministic’, the above limits will be finite as well. These results are then applied to establish similar statements for the intersection local times of diagonally operator-self-similar Gaussian fields with stationary increments.




sim

Linearity and Normalization in Simple Cells of the Macaque Primary Visual Cortex

Matteo Carandini
Nov 1, 1997; 17:8621-8644
Articles




sim

The expectations on central banks are simply too great

Original quotes from interview with Mr Claudio Borio, Head of the Monetary and Economic Department of the BIS, in Germany's Boerzen-Zeitung, conducted by Mr Mark Schroers and published on 21 November 2019.




sim

Neural Evidence for the Prediction of Animacy Features during Language Comprehension: Evidence from MEG and EEG Representational Similarity Analysis

It has been proposed that people can generate probabilistic predictions at multiple levels of representation during language comprehension. We used magnetoencephalography (MEG) and electroencephalography (EEG), in combination with representational similarity analysis, to seek neural evidence for the prediction of animacy features. In two studies, MEG and EEG activity was measured as human participants (both sexes) read three-sentence scenarios. Verbs in the final sentences constrained for either animate or inanimate semantic features of upcoming nouns, and the broader discourse context constrained for either a specific noun or for multiple nouns belonging to the same animacy category. We quantified the similarity between spatial patterns of brain activity following the verbs until just before the presentation of the nouns. The MEG and EEG datasets revealed converging evidence that the similarity between spatial patterns of neural activity following animate-constraining verbs was greater than following inanimate-constraining verbs. This effect could not be explained by lexical-semantic processing of the verbs themselves. We therefore suggest that it reflected the inherent difference in the semantic similarity structure of the predicted animate and inanimate nouns. Moreover, the effect was present regardless of whether a specific word could be predicted, providing strong evidence for the prediction of coarse-grained semantic features that goes beyond the prediction of individual words.

SIGNIFICANCE STATEMENT Language inputs unfold very quickly during real-time communication. By predicting ahead, we can give our brains a "head start," so that language comprehension is faster and more efficient. Although most contexts do not constrain strongly for a specific word, they do allow us to predict some upcoming information. For example, following the context of "they cautioned the...," we can predict that the next word will be animate rather than inanimate (we can caution a person, but not an object). Here, we used EEG and MEG techniques to show that the brain is able to use these contextual constraints to predict the animacy of upcoming words during sentence comprehension, and that these predictions are associated with specific spatial patterns of neural activity.




sim

Prince Edward and Wallis Simpson's Sprawling Bahamas Estate Is Up for Sale

After abdicating the British throne, Edward was appointed governor of the Bahamas, where he temporarily lived in a lavish home in Nassau




sim

No magic bullet: Former head of AIDS Thunder Bay talks about similarities between HIV, COVID-19

A virus that spreads fear and stigma, as well as disease. It’s the story of HIV/AIDS as well as COVID-19. The former executive director of AIDS Thunder Bay reflects on the similarities he sees between HIV 35 years ago, and the coronavirus now.



  • News/Canada/Thunder Bay

sim

A Simple Method To Detect Point Mutations in Aspergillus fumigatus cyp51A Gene Using a Surveyor Nuclease Assay [Analytical Procedures]

One of the main mechanisms of azole resistance of Aspergillus fumigatus is thought to be a reduction in the drug’s affinity for the target molecule, Cyp51A, due to its amino acid mutation(s). It is known that the azole resistance pattern is closely related to the mutation site(s) of the molecule. In this study, we tried to develop a simple and rapid detection method for cyp51A mutations using the endonuclease Surveyor nuclease. The Surveyor nuclease assay was verified using several azole-resistant strains of A. fumigatus that possess point mutations in Cyp51A. For validation of the Surveyor nuclease assay, blind tests were conducted using 48 strains of A. fumigatus (17 azole-resistant and 31 azole-susceptible strains). The Surveyor nuclease assay could rapidly detect cyp51A mutations with one primer set. Also, all the tested strains harboring different cyp51A single point mutations could be clearly distinguished from the wild type. The Surveyor nuclease assay is a simple method that can detect cyp51A mutations rapidly.




sim

Efficient Simulation Workflows

SOLIDWORKS 2020 continues our mission of delivering powerful Simulation Capabilities with enhancements that provide increased power, more realistic simulations, and more efficient workflows. When running simulation on Weldment Structures, beam elements are typically used since they are fast to setup

Author information

Andrew Gross

Andrew is a Senior Territory Technical Manager at SOLIDWORKS, and lives in Los Angeles, CA. He has years of experience working with resellers and customers, and has a strong background in Engineering Simulation and Design Validation. More recently, Andrew has expanded his interest and passion into Industrial Design. Andrew holds a Master’s Degree in Mechanical Engineering from UCLA.

The post Efficient Simulation Workflows appeared first on SOLIDWORKS Tech Blog.




sim

Introduction to SOLIDWORKS Simulation – Finite Element Analysis

Have you ever been interested in SOLIDWORKS Simulation but didn’t know where to start? With such a wide variety of design analysis solutions, Simulation can be an intimidating product for someone newer to the SOLIDWORKS suite of products. Well we

Author information

Alignex, Inc. is the premier provider of SOLIDWORKS software and partner products to the mechanical engineering industry in Minnesota, Wisconsin, Iowa, North Dakota, South Dakota, Nebraska, Colorado, Wyoming and Illinois. With more than 25 years of technical experience, Alignex offers consulting services, training and support for SOLIDWORKS as well as support for partner products. For more information, visit alignex.com.

The post Introduction to SOLIDWORKS Simulation – Finite Element Analysis appeared first on SOLIDWORKS Tech Blog.




sim

Solving “The Hook Debate” with a 3D Scanner and SOLIDWORKS Simulation

This case study seeks to find the answer to a common question: Which way should you affix hooks to your fence so they can properly handle the load of a hanging flower basket? Javelin’s Application Engineer; Colin Murphy CSWE, takes

Author information

Javelin Technologies is a provider of technology solutions since 1997. We are experts in 3D design and have helped thousands of companies with solutions for mechanical design, electrical design and 3D printing.

Large or small, we have the skills, experience, and services to propel your organization to new heights so you can aim high.

The post Solving “The Hook Debate” with a 3D Scanner and SOLIDWORKS Simulation appeared first on SOLIDWORKS Tech Blog.




sim

Linear Static FEA Productivity with Simulation Professional

Read to learn about the features and functionality of Simulation Professional that could significantly increase your linear static productivity.

Author information

Brian Zias
Senior Territory Technical Manager at Dassault Systemes SOLIDWORKS

Brian is a 15-year, expert SOLIDWORKS CAD, FEA, and CFD user and community advocate. His interests include engineering, simulation, team leadership, and predictive analytics. Brian holds a BS in Aerospace Engineering and an MBA in Data Science.

The post Linear Static FEA Productivity with Simulation Professional appeared first on The SOLIDWORKS Blog.