It is rare but not entirely uncommon to see a manatee swimming in the Atlantic waters of Maryland and Virginia. This one was dead, however, […]

The post In face of mass extinctions, Smithsonian’s Global Genome Initiative quietly saves world’s DNA appeared first on Smithsonian Insider.

Because there is no polite way to ask a mite to sit still for its portrait, Gary Bauchan often gives his tiny subjects a shot […]

The post Enjoy Face Time with Seven of Earth’s 3-5 Million Mite Species appeared first on Smithsonian Insider.

Flitting swiftly through the darkness above the tropical forest canopy in Central and South America, a group of cute little bats with dog-like faces have […]

The post More sky puppies! Scientists discover two new species of dog-faced bat appeared first on Smithsonian Insider.

Mycoplasma hyopneumoniae is a prokaryotic pathogen that colonizes the respiratory ciliated epithelial cells in swine. Infected animals suffer respiratory lesions, causing major economic losses in the porcine industry. Characterization of the immunodominant membrane-associated proteins from M. hyopneumoniae may be instrumental in the development of new therapeutic approaches. Here, the crystal structure of P46, one of the main surface-antigen proteins, from M. hyopneumoniae is presented and shows N- and C-terminal α/β domains connected by a hinge. The structures solved in this work include a ligand-free open form of P46 (3.1 Å resolution) and two ligand-bound structures of P46 with maltose (2.5 Å resolution) and xylose (3.5 Å resolution) in open and closed conformations, respectively. The ligand-binding site is buried in the cleft between the domains at the hinge region. The two domains of P46 can rotate with respect to each other, giving open or closed alternative conformations. In agreement with this structural information, sequence analyses show similarities to substrate-binding members of the ABC transporter superfamily, with P46 facing the extracellular side as a functional subunit. In the structure with xylose, P46 was also bound to a high-affinity (Kd = 29 nM) Fab fragment from a monoclonal antibody, allowing the characterization of a structural epitope in P46 that exclusively involves residues from the C-terminal domain. The Fab structure in the complex with P46 shows only small conformational rearrangements in the six complementarity-determining regions (CDRs) with respect to the unbound Fab (the structure of which is also determined in this work at 1.95 Å resolution). The structural information that is now available should contribute to a better understanding of sugar nutrient intake by M. hyopneumoniae. This information will also allow the design of protocols and strategies for the generation of new vaccines against this important swine pathogen.

Victor J. F. Kitano, Yoko Ohyama, Chiyomi Hayashida, Junta Ito, Mari Okayasu, Takuya Sato, Toru Ogasawara, Maki Tsujita, Akemi Kakino, Jun Shimada, Tatsuya Sawamura, and Yoshiyuki Hakeda

Osteoporosis is associated with vessel diseases attributed to hyperlipidemia, and bone resorption by multinucleated osteoclasts is related to lipid metabolism. In this study, we generated low-density lipoprotein receptor (LDLR)/lectin-like oxidized LDL receptor-1 (LOX-1) double knockout (dKO) mice. We found that, like LDLR single KO (sKO), LDLR/LOX-1 dKO impaired cell-cell fusion of osteoclast-like cells (OCLs). LDLR/LOX-1 dKO and LDLR sKO preosteoclasts exhibited decreased uptake of LDL. The cell surface cholesterol levels of both LDLR/LOX-1 dKO and LDLR sKO osteoclasts were lower than the levels of wild-type OCLs. Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. Abrogation of the ATP binding cassette G1 (ABCG1) transporter, which transfers PE to the cell surface, caused decreased PE translocation to the cell surface and subsequent cell-cell fusion. The findings of this study indicate the involvement of a novel cascade (LDLR~ABCG1~PE translocation to cell surface~cell-cell fusion) in multinucleation of OCLs.

The new island visible in the satellite photograph is the top of a giant shield volcano located on the rift axis in the Red Sea where the continental plates of Africa and Arabia are pulling apart.

The post A hot new island has just surfaced in the Red Sea. What’s going on? Smithsonian scientists explain. appeared first on Smithsonian Insider.

We’ve seen a serious series of super moons this summer and the show’s not over yet. Mark your calendars: the next one will light up […]

The post Cutting through the dust: Radar shows moon’s true face for first time appeared first on Smithsonian Insider.

Speeding Up Science from Facebook Stories on Vimeo. In January 2011, Oregon State University ichthyologist Brian Sidlauskas led a research expedition into the little-known Cuyuni […]

The post Facebook comes to rescue of ichythyologists struggling to describe specimens appeared first on Smithsonian Insider.

How do you diagnose a sick stream? Count its insects, according to Smithsonian biologist Don Weller.

The post Streams damaged by too many hard surfaces in urban areas appeared first on Smithsonian Insider.

In the structure of the title salt, second-order Jahn–Teller distortion of the coordination octa­hedra around V ions is reflected by coexistence of short V—O bonds and trans-positioned long V—F bonds, with four equatorial V—F distances being inter­mediate in magnitude. Hydrogen bonding of the anions is restricted to F-atom acceptors only, with particularly strong N–H⋯F inter­actions [N⋯F = 2.5072 (15) Å] established by axial and cis-positioned equatorial F atoms.

The asymmetric unit of the title compound contains two independent mol­ecules, consisting of perimidine and phenol units, which are linked through an N—H⋯O hydrogen bond. Intra­molecular O—H⋯N hydrogen bonds are observed in both independent mol­ecules.

The title compound, 1-(2,5-di­meth­oxy­phen­yl)-2,2,6,6-tetra­methyl­piperidine, was synthesized as a side-product during the synthesis of the inter­mediate, methyl 3,6-dimeth­oxy-2-(2-meth­oxy-2-oxoeth­yl)benzoate, necessary for the total synthesis of the isocoumarin 5,8-dimeth­oxy-3-methyl-1H-isochromen-1-one.

The title compound exhibits exceptionally weak inter­molecular C—H⋯π hydrogen bonding of the ethynyl groups, with the corresponding H⋯π separations [2.91 (2) and 3.12 (2) Å] exceeding normal vdW distances. This bonding compliments distal contacts of the CH (aliphatic)⋯π type [H⋯π = 3.12 (2)–3.14 (2) Å] to sustain supra­molecular layers.

The dihedral angle between the two aromatic rings of the title compound is 64.12 (14)°. The crystal structure is stabilized by a short Cl⋯H contact, C—Cl⋯π and van der Waals inter­actions.

The title complex, Cu(L)2 or [Cu(C15HF10O2)2], comprising one copper ion and two fully fluorinated ligands (L−), was crystallized with 3,4-ethyl­ene­dioxy­thio­phene (EDOT, C6H6O2S) as a guest mol­ecule to give in a di­chloro­methane solution a unique co-crystal, Cu(L)2·3C6H6O2S.

In the title compound, C16H14Cl2FN3, the dihedral angle between the two aromatic rings is 64.12 (14)°. The crystal structure is stabilized by a short Cl...H contact, C—Cl...π and van der Waals interactions. The Hirshfeld surface analysis and two-dimensional fingerprint plots show that H...H (33.3%), Cl...H/H...Cl (22.9%) and C...H/H...C (15.5%) interactions are the most important contributors towards the crystal packing.

The title compound, C14H16, exhibits exceptionally weak intermolecular C—H...π hydrogen bonding of the ethynyl groups, with the corresponding H...π separations [2.91 (2) and 3.12 (2) Å] exceeding normal vdW distances. This bonding complements distal contacts of the CH (aliphatic)...π type [H...π = 3.12 (2)–3.14 (2) Å] to sustain supramolecular layers. Hirshfeld surface analysis of the title compound suggests a relatively limited significance of the C...H/H...C contacts to the crystal packing (24.6%) and a major contribution from H...H contacts accounting 74.9% to the entire surface.

The asymmetric unit of the title compound, C17H14N2O, contains two independent molecules each consisting of perimidine and phenol units. The tricyclic perimidine units contain naphthalene ring systems and non-planar C4N2 rings adopting envelope conformations with the C atoms of the NCN groups hinged by 44.11 (7) and 48.50 (6)° with respect to the best planes of the other five atoms. Intramolecular O—H...N hydrogen bonds may help to consolidate the molecular conformations. The two independent molecules are linked through an N—H...O hydrogen bond. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H...H (52.9%) and H...C/C...H (39.5%) interactions. Hydrogen bonding and van der Waals interactions are the dominant interactions in the crystal packing. Density functional theory (DFT) optimized structures at the B3LYP/ 6–311 G(d,p) level are compared with the experimentally determined molecular structure in the solid state. The HOMO–LUMO behaviour was elucidated to determine the energy gap.

In the title compound, C17H27NO2, the piperidine ring has a chair conformation and is positioned normal to the benzene ring. In the crystal, molecules are linked by C—H...O hydrogen bonds, forming chains propagating along the c-axis direction.

In the structure of the title salt, (C7H12N6)[VOF5], second-order Jahn–Teller distortion of the coordination octahedra around V ions is reflected by coexistence of short V—O bonds [1.5767 (12) Å] and trans-positioned long V—F bonds [2.0981 (9) Å], with four equatorial V—F distances being intermediate in magnitude [1.7977 (9)–1.8913 (9) Å]. Hydrogen bonding of the anions is restricted to F-atom acceptors only, with particularly strong N–H...F interactions [N...F = 2.5072 (15) Å] established by axial and cis-positioned equatorial F atoms. Hirshfeld surface analysis indicates that the most important interactions are overwhelmingly H...F/F...H, accounting for 74.4 and 36.8% of the contacts for the individual anions and cations, respectively. Weak CH...F and CH...N bonds are essential for generation of three-dimensional structure.

Features of azimuthal plots for RHEED and its new counterpart, RHEPD, are discussed. The plots, for both electrons and positrons, are determined using dynamical diffraction theory.

The inversion of X-ray reflectivity to reveal the topography of a one-dimensional interface is evaluated through model calculations.

The analytical solution of the problem of X-ray spherical-wave Laue diffraction in a single crystal with a linear change of thickness on the exit surface is derived. General equations are applied to a specific case of plane-wave Laue diffraction in a thick crystal under the conditions of the Borrmann effect.

Facebook’s digital currency project Libra has unveiled HSBC legal chief...

Celo, a competing project to...

Young adults ages 18-26 should be viewed as a separate subpopulation in policy and research, because they are in a critical period of development when successes or failures could strongly affect the trajectories of their lives, says a new report from the Institute of Medicine and National Research Council.

In an August 18 letter, the U.S. Department of the Interior’s Office of Surface Mining Reclamation and Enforcement informed the National Academies of Sciences, Engineering, and Medicine that it should cease all work on a study of the potential health risks for people living near surface coal mine sites in Central Appalachia.

The U.S. is a clear leader in the global bioeconomy landscape, but faces challenges from decentralized leadership, inadequate talent development, cybersecurity vulnerabilities, stagnant investment in fundamental research, and international competition, according to Safeguarding the Bioeconomy, a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine finds K-12 teachers face new expectations and more demands from policymakers, parents, students, and schools, including addressing changes in curriculum standards, the emergence of more explicit teaching goals, and shifts in what it means to support all students in their development.

Senate Majority Leader Mitch McConnell has made filling judicial vacancies his top priority ahead of the 2020 elections.; Credit: J. Scott Applewhite/AP

As new allegations emerge about his motives for retirement, Judge Thomas Griffith says that he faced no political pressure in his decision to leave the bench.

"My decision was driven entirely by personal concerns and involved no discussions with the White House or the Senate," he said in a statement provided to NPR.

Griffith said that his wife was diagnosed 11 years ago with a "debilitating chronic illness" and that her health was "the sole reason for my retirement." He said he made the decision to retire in June 2019 and privately informed his family and law clerks at the time. His retirement was announced publicly in March.

Griffith, 65, is a circuit court judge on the U.S. Court of Appeals for the District of Columbia. Appointed by President George W. Bush, he has served since 2005.

On Monday, The New York Times reported that Demand Justice, a liberal judicial advocacy group, filed a complaint that raises questions about whether Griffith's decision was tied to efforts by Senate Majority Leader Mitch McConnell to encourage older, conservative judges to retire in order to fill their vacancies with younger, conservative judges ahead of the 2020 election, when control of the White House and the Senate will be in play.

Griffith's retirement has paved the way for Justin Walker's nomination to fill the vacancy. Walker, 37, is a longtime McConnell ally who is currently serving as a U.S. district judge of the Western District of Kentucky, McConnell's home state.

The Demand Justice complaint was directed to the U.S. Court of Appeals, where the court's chief judge, Sri Srinivasan, has asked Chief Justice John Roberts to assign another circuit to look into the complaint about whether any ethical improprieties occurred. Griffith's statement refutes the core allegation — that his decision was fueled by political considerations or the result of a pressure campaign.

These allegations are likely to come up at Walker's confirmation hearing on Wednesday before the Senate Judiciary Committee.

Democrats broadly oppose Walker's nomination. He was rated "not qualified" by the American Bar Association. However, unless support for him is diminished among Republicans — unlikely with McConnell's backing — he is likely to be confirmed.

This content is from Southern California Public Radio. View the original story at SCPR.org.

People wait in line to receive food at a food bank on April 28, 2020 in the Brooklyn borough of New York City.; Credit: Spencer Platt/Getty Images

United States unemployment has reached record numbers with more than 30 million Americans applying for benefits in just six weeks, according to the Guardian. Economists expect the labor market to take another unprecedented blow for the month of April. 

Roughly one in five people in California's workforce have applied for initial unemployment insurance benefits, including a "staggering" 37% of workers with no more than a high school diploma. That's the estimate of a  study from the California Policy Lab that analyzed unemployment insurance claims from March 15-April 11. According to the California Economic Development Department (EDD), L.A. County's unemployment rate jumped from 4.3% in February to 6.3% in March. The state of California launched its Pandemic Unemployment Assistance program last week, giving many independent contractors their first chance to apply for benefits.But applicants have had a tough time getting through the system because of technical difficulties with the state's website.

Today on AirTalk we check in on unemployment in the state. Plus, some people are making more money through unemployment benefits than when they were working. We talk to the writer of a recent Wall Street Journal piece that looks at the challenges that presents for businesses as states look to slowly reopen. Do you have questions about unemployment across the state or the application process? Join the conversation by calling 866-893-5722. 

With files from LAist. Read more from David Wagner here. 

Guests:

Eric Morath, labor economics and policy reporter for the Wall Street Journal, he’s based in Washington D.C.; he tweets @EricMorath

George Warner, attorney in the Wage Protection Program at Legal Aid at Work, a San Francisco based nonprofit law firm that assists low-income, working families throughout California; he tweets @readerznriderz

This content is from Southern California Public Radio. View the original story at SCPR.org.

The temperature of a Bolivian child is measured in front of Bolivian embassy during a demonstration requesting repatriation on April 28, 2020 in Santiago, Chile. ; Credit: Marcelo Hernandez/Getty Images

As of Wednesday afternoon, L.A. County has at least 1,367 deaths and 28,646 confirmed cases of coronavirus. Meanwhile, parts of the state are slowly reopening some industries. 

Certain businesses and recreational spaces in Los Angeles County will be allowed to reopen beginning Friday, county officials announced at a media briefing. Those include hiking trails, golf courses, florists, car dealerships and certain retail stores. School districts continue to work through challenges as they consider how to reopen. Kids and teens are coming down with an inflammatory syndrome that experts believe could be linked to COVID-19, NPR News reports. Today on AirTalk, we get the latest on the pandemic with a noted physician, plus we’ll look at the expanding list of symptoms associated with the coronavirus. Are you a parent who has questions about the virus and kids? We want to hear from you. Join the conversation by calling 866-893-5722. 

With files from LAist

Guest:

Richard Jackson, M.D., pediatrician, epidemiologist and professor emeritus at the UCLA Fielding School of Public Health, he’s served in many leadership positions with the California Health Department, including as the State Health Officer, for nine years he served as director of the CDC’s National Center for Environmental Health

This content is from Southern California Public Radio. View the original story at SCPR.org.

Opah fish are hauled onto a dock for sale last week in San Diego. Fishermen coming home to California after weeks at sea are finding strict anti-coronavirus measures, and nowhere to sell their catch.; Credit: Gregory Bull/AP

Commercial fishermen in the U.S. who have already faced challenges in recent years to make it in an increasingly globalized and regulated industry, are now struggling to find customers during the coronavirus crisis.

"This is totally unprecedented. This is the biggest crisis to hit the fishing industry ever, no question about that," Noah Oppenheim, executive director of The Pacific Coast Federation of Fishermen's Associations told NPR in a phone interview. The federation is a trade association representing commercial fishermen along the West Coast.

On Tuesday, seafood industry leaders, processors and fishermen sent a letter to House and Senate leaders requesting $4 billion in aid for the industry.

The closings of restaurants due to the coronavirus pandemic has hit commercial fishermen particularly hard.

An estimated 50% to 60% of wild seafood caught in the U.S. is exported, says Oppenheim. Those international markets have dried up. He says, of the seafood that's not exported, around 80% of that is sold to restaurants.

"Both of those sectors of the seafood economy are largely nonfunctional at the moment, so we're going to have to make up for approximately 90% of our markets ... through either new supply pipelines or new sets of customers."

Jerid Rold, a fishermen in Moss Landing, Calif., tells NPR, he's been out of work for a month, since South Korea stopped taking imports of hagfish. Further damaging profits, Dungeness crab prices on the West Coast have fallen from up to $7 dollars a pound to $2, says Oppenheim.

In Eureka, Calif., "there are no buyers purchasing products at the harbor there. You can't move the Dungeness crab out of the Humboldt bay," Oppenheim said. "It's actually extraordinary how similar these impacts are playing out across the country. They are palpable, they are profound and they are severe."

On the North Atlantic coast, Sam Rosen, a 30-year-old lobsterman based in Vinalhaven, Maine, said he and others are "selling lobster for amounts they shouldn't be sold for."

That's been close to $2.50 a pound, compared to a usual $10 a pound this time of year, Rosen said.

"It's definitely a shock to the system," Rosen said. "This is uncharted territory right now. I don't think anyone thought it was going to be as bad as it's getting."

If aid isn't provided to fishermen soon, "I think we could see hundreds to thousands of fishermen leave the industry nationwide," Oppenheim said.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Eight-year-old Mariana Aceves is doing her math homework — subtraction by counting backwards — while sitting on the bed she shares with her mom, Lorena Aceves.

They're sitting on the bed because they have nowhere else to go: they live in an 8-foot-by-12-foot room called a tiny house. It's part of Seattle's transitional housing where people experiencing homelessness can live until they find a job and a place of their own.

There's room for the bed they share, a TV shelf, "and a little tiny plastic dresser, and then all of our clothing and our food goes underneath our bed," Lorena Aceves says.

Tens of millions of kids are taking classes online at home right now because of the coronavirus pandemic. That's hard enough for most families. But, if you're homeless and have no computer, sketchy wifi, and no quiet place to study, it's even more difficult. That's the case for the one and a half million school kids currently experiencing homelessness across the U.S.

When Seattle's schools closed in March, Aceves had to quit her new job, because she couldn't find childcare. She and her daughter have been holed up in their tiny house ever since.

"It's the boredom," Aceves says, "and me trying to reach out and find resources — work, a car, things like that — while also making sure that she's entertained."

Aceves and her daughter have a tiny amount of private space. Other homeless families have no privacy at all.

Sixteen-year-old Capelle Belij is living with his parents at a shelter, part of a network of family shelters in the Seattle area run by the nonprofit Mary's Place.

The Belijes share a room with two other families, divided only by curtains.

"My friends, like, come up to my bed space and ask if I want to play or something," Belij says. "If we had our own place, I could learn better."

Three-quarters of children and youth considered homeless live doubled-up with another family. That's the situation for the family of 17-year-old Michelle Aguilar. She's part of KUOW's youth reporting program, called RadioActive.

"I can't really find a specific space where it's like quiet and calm and I can actually have wifi," Aguilar says.

Since Aguilar's shared bedroom doesn't have wifi, she ends up in the living room or kitchen with the rest of her family.

"And they just, like, continue their chaotic life of yelling and screaming and, like, playing music and listening to the TV and cooking," she says.

"Whenever I'm, like, in the environment of it being really loud," Aguilar says, "I tend to, like, read over and over and over and over the assignment."

"We're definitely very concerned with there being an achievement gap during this time," says Tisha Tallman, the executive director of the National Center for the Education of Homeless Children and Youth. "The longer this goes, the more likely our children are to fall behind."

And, Tallman adds, schools provide much more than an education: many homeless kids get two meals per day there, and they rely on it as a safe and stable place to be.

Back in her tiny house, Lorena Aceves is trying to keep her daughter's education on track with a strict schedule of math, reading, and typing.

"Even though this is frustrating," Aceves says, "we are having this time together and that's something typically that we don't have."

Aceves says it's good to feel close to her daughter during a time that she has to stay far away from nearly everyone else.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Maurice Jackson of Proven and Probable discusses the future of DNI Metals with the company's executive chairman.

Sea surface temperatures in the North Atlantic may be significantly influenced by air pollution, with knock-on effects for climatic events, such as drought and hurricanes, according to a new study. The findings indicate that estimates of man-made aerosol emissions over coming decades should be refined within climate models to improve predictions of future climate change.

Microsoft is now stating that they will fix mysterious and spontaneous cracks in Surface Laptop 3 displays as they may have been caused by a "foreign particle" introduced during manufacturing. [...]

A recent report has reviewed research on the effectiveness of low-noise road surfaces, taking into account acoustic performance, safety, skidding resistance and cost. It concludes they could have substantial acoustic and financial benefits, but their durability and safety must be taken into account.

Tech giants Google and Facebook allowing most of their workforces to WFH through the end of this year.

Water trading is the buying and selling of access to water and can be an effective tool for water resource management, particularly in relation to the allocation of water among different users. A new tool that evaluates the long-term impacts of climate change on water trading has indicated that such a scheme could be effective in the future but will depend on factors including water demand and availability.

Water extraction from the ground using pumps and wells may have significant impacts on the flow of water in streams on the surface, according to new research. Results suggest that groundwater pumping has caused total stream flow in one Hawaiian stream to decline by 5.4mm per year since 1960.

The Baltic Sea is likely to be warmer, lower in oxygen and more acidic in the future, warn Swedish scientists in a recent study. Current strategies for managing the Sea will need to change if they are to meet marine protection objectives.

Over the past year, social networking giant Facebook has been actively investing in the Indian tech and startup ecosystem

Amazon India has announced a Rs 10 crore investment to sign up, train and help businesses catalogue products.