Dexter Rentz was a rising star.

Critical Issues in Trucking Workforce Development , released by the Mineta Transportation Institute at San Jose State University

A recent study published by the Journal of Clinical Sleep Medicine found a connection between school start times and teen driving accidents. The study found that pushing a 7:20 a.m. start to an 8:10 a.m. start significantly reduced the crash rate of 16– to 18–year–old drivers in the area. According to the researchers, teens who don’t get enough sleep are more likely to make poor decisions—such as distracted driving or forgetting to wear a seat belt.

The American Academy of Sleep Medicine (AASM) has been advocating for middle and high school start times of 8:30 a.m. or later to help promote teen safety, health, and academic performance. The AASM recommends teens get 8 to 10 hours of sleep a day. By getting enough sleep, teens are more alert in the classroom, are less tardy or absent, have better mental health, and have improved safety habits while driving.

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For large electric power storage projects the cost of batteries has plummeted. 2008, when battery prices were 10 times higher than they are today. This advance is timely as photovoltaic electric power prices have dropped so far that in SoCal PV is causing a growing drop in mid-day demand and therefore a much bigger spike in evening demand. Therefore there's a growing need for a cheaper way to store power generated in mid day and deliver it in the evening. You can see how much solar power output surges each day in California by clicking on some of the Daily Renewables Watch links at the Cal ISO site (the organization that manages California's electric grid). The growing supply of wind...

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-responsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies and in murine cancer models. Impaired IFN signaling was associated with poor immunotherapy response. Mechanistically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness. Thus, the interaction between ARID1A and EZH2 defines cancer IFN responsiveness and immune evasion. Our work indicates that cancer epigenetic driver mutations can shape cancer immune phenotype and immunotherapy.

Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly understood. Neuropeptide Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in diverse cancer-related hallmarks including aging and metabolic alterations, but its impact on liver cancer had been unclear. Here, we observed increased expression of NPY5 receptor (Y5R) in HCC, which correlated with tumor growth and survival. Furthermore, we found that its ligand NPY was secreted by peritumorous hepatocytes. Hepatocyte-derived NPY promoted HCC progression by Y5R activation. TGF-β1 was identified as a regulator of NPY in hepatocytes and induced Y5R in invasive cancer cells. Moreover, NPY conversion by dipeptidylpeptidase 4 (DPP4) augmented Y5R activation and function in liver cancer. The TGF-β/NPY/Y5R axis and DPP4 represent attractive therapeutic targets for controlling liver cancer progression.

An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact immunotherapy resistance. Using several preclinical tumor models as well as clinical specimens, we identified a mechanism whereby CD8+ T cell activation in response to programmed cell death 1 (PD-1) blockade induced a programmed death ligand 1/NOD-, LRR-, and pyrin domain–containing protein 3 (PD-L1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs) into tumor tissues, thereby dampening the resulting antitumor immune response. The genetic and pharmacologic inhibition of NLRP3 suppressed PMN-MDSC tumor infiltration and significantly augmented the efficacy of anti–PD-1 antibody immunotherapy. This pathway therefore represents a tumor-intrinsic mechanism of adaptive resistance to anti–PD-1 checkpoint inhibitor immunotherapy and is a promising target for future translational research.

The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we find that androgens suppress CDCP1 expression and that androgen deprivation in combination with loss of PTEN promotes the upregulation of CDCP1 and the subsequent activation of the SRC/MAPK pathway. Moreover, we demonstrate that anti-CDCP1 immunoliposomes (anti–CDCP1 ILs) loaded with chemotherapy suppress prostate cancer growth when administered in combination with enzalutamide. Thus, our study identifies CDCP1 as a powerful driver of prostate cancer progression and uncovers different potential therapeutic strategies for the treatment of metastatic prostate tumors.

Формула 1 обсуждает с создателями сериала Drive to Survive планы съёмок третьего сезона, и по словам Чейза Кэри, переговоры идут весьма успешно...

IBM today announced that Faurecia, one of the world’s leading automotive suppliers, has selected IBM Cloud as a support of a major business transformation designed to accelerate digital manufacturing.

IBM today announced the opening of IBM Studio Groningen, where IBM design, digital and industry experts will work with clients to help them engage with their customers using big data, mobile, cloud and social innovations.

IBM today announced sweeping advances in its all-flash storage solutions and software to significantly drive down the costs of data and extend its solutions for hybrid and private cloud environments.

IBM (NYSE: IBM) today announced a new collaboration with Thiess, one of the world’s largest contract miners, to use Big Data to improve machine availability and operational productivity utilizing predictive analytics and modeling technologies. This initial collaboration focuses on Thiess’ Mining haul trucks and excavators, and will help unify asset management and business operations.

IBM Australia (NYSE: IBM) and The Sauce, today published the first Australian BPO Report 2012 (ABPO Report), which investigates the current state of business process outsourcing in Australia and points to future trends. Global expansion is seen to be the key driver and benefit of outsourcing decisions amongst 71 percent of organisations surveyed. The report also showed significant anticipated growth in business process outsourcing activity among large organisations with between 1,000 to 5,000 employees (this constituted one-third of all respondents). This group of Australian organisations is expecting an increase of 20 percent over the next two years.

Power outage? Grab a length of steel automotive brakeline tubing, the straw from a box of Yoo-Hoo, D-cell batteries to make a 6V. Also may require generous amounts of duct tape, electrical tape, bell wire, and boredom.

Cybersecurity researchers from ESET on Thursday said they took down a portion of a malware botnet comprising at least 35,000 compromised Windows systems that attackers were secretly using to mine Monero cryptocurrency. The botnet, named "VictoryGate," has been active since May 2019, with infections mainly reported in Latin America, particularly Peru accounting for 90% of the compromised

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My virtual trip has taken me to Denmark . Another country added to the list and another magnet purchased for the board in the kitchen . So thoughts on Denmark . I wonder what the roads will be like. Will they resemble the de dum de dum roads of Belgium or

This new entertainment series should get the motor running for movie and music fans.

Gov. Cuomo is down with Robert De Niro portraying him in a movie about the coronavirus pandemic, should there be one, and he also took a moment to play the role of the Manhattan-born actor.

The victim, believed to be in her 40s, was hit at the intersection of Atlantic Ave. and Pennsylvania Ave. in East New York about 4:30 a.m., cops said.

The on-duty driver was heading south on Flatbush Ave. near Avenue R in Marine Park around 6 p.m. when he lost control of his truck, said police.

A driver abandoned his wrecked vehicle and left one of his passengers to die after a drunken off-duty cop in a muscle car t-boned his vehicle in Brooklyn early Sunday, police said. NYPD Officer Rohan Shaw was driving a white 2019 Nissan GT-R, zooming east on Foster Ave. just before 5 a.m., when a black 2016 Mazda 6 rolled through a stop sign on E. 55th St. and right into the cop’s path, police said.

The 8:15 a.m. crash at Pennsylvania and Blake Aves. in East New York happened just paces from three neighborhood schools and about two miles from where a 10-year-old girl was fatally struck by a school bus Tuesday, officials said.

More than 200 mourners filed into the Love Fellowship Tabernacle church in East New York Thursday night for Payson Lott’s wake and funeral. The youngster was struck and killed by an unlicensed driver as he crossed a street in his neighborhood.

Two thousand workers from the Amalgamated Transit Union’s Local 1181 voted overwhelmingly to authorize the strike against their employer, which operates about 900 of the city’s more than 8,000 school bus routes.

Our Corporate edition now supports tying your database to a fully customisable template for automatic display of database information.

A fomer-long haul truck driver behind bars for allegedly killing three women in Tennessee and Wyoming in the 1990s is now being investigated for any ties he may have to other cold murder cases, police said.

Gov. Cuomo is down with Robert De Niro portraying him in a movie about the coronavirus pandemic, should there be one, and he also took a moment to play the role of the Manhattan-born actor.

Are you lucky enough to have trails in your backyard, or do you need to drive to ride?
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Dennehy, who died April 15, plays a suburban widower who befriends a mother and her son in one of his last films. It's the kind of deeply lived-in performance that Dennehy was known for.

Dennehy, who died April 15, plays a suburban widower who befriends a mother and her son in one of his last films. It's the kind of deeply lived-in performance that Dennehy was known for.