AI in practice In his book TinyML, Pete Warden talks about smart stickers that can do limited AI, communicate via radio, and contain sensors so they can easily be put onto machinery or other objects. That technology is here, with disposable bluetooth stickers powered by ambient RF. A year ago, Foster Provost said that causality […]

Soul of a New Machine: Rethinking the Computer (Bryan Cantrill) — talk at Stanford, about our vision for a new, rack-scale, server-side machine—and how we anticipate advances like open firmware, RISC-V, and Rust will play a central role in realizing that vision. Let’s Use Kubernetes: Now You Have 8 Problems — If you’re part of […]

Sno — Distributed version control for geospatial and tabular data. Finally, git for (geo)data done right. Open source. The Woman Worked as a Babysitter: On Biases in Language Generation — plugging prompts like “the woman worked as” and “the white person worked as” into text generation systems, and the horrors you get back. (via Violent […]

MLflow — an open source platform to manage the ML lifecycle, including experimentation, reproducibility, and deployment. It currently offers three components: tracking, projects, and models. Eventing Facets (Tim Bray) — the word “eventing” makes my skin crawl, but this series of posts has A+ info in it. Workbox — JavaScript Libraries for adding offline support […]

Pluralistic — Cory Doctorow’s news site and newsletter, where you can learn about African WhatsApp modders among other things. Mapnik — LGPLed software that combines pixel-perfect image output with lightning-fast cartographic algorithms, and exposes interfaces in C++, Python, and Node. pi node — A π-box is a modular system of radio/streaming broadcast, composed of multiples […]

AWS Bill Analysis — always interesting to see how to approach lowering your costs. In this case, the project owner works for Amazon on AWS, but still there were savings to be had. A Design Guide to Writing Offline-first Apps — In this article, we will be diving into some of the engineering challenges that […]

OpenAM — an open-access management solution that includes authentication, SSO, authorization, federation, entitlements and web services security. Building Relationships as a Remote Engineering Manager — And if you haven’t realized it yet, get used to this—you’re going to spend a lot of time writing. API Security Maturity Model — I’m not sure if I agree […]

The Uncensored Library — Reporters Without Borders built a library in Minecraft, in which you can read banned books. (via Gizmodo) Shmoocon 2020 Talk Recordings — everything from email addresses to Verilog by way of Zero Trust, social media, and choose-your-own-adventure ransomware. Differential Privacy: A Comparison of Libraries — We will have a look at […]

How the Great Firewall Discovers Hidden Circumvention Servers — really interesting CCC talk from a few years ago. The Challenge of Software Liability — Liability for insecure software is already a reality. The question is whether Congress will step in to give it shape and a coherent legal structure. XOXO Talks — video archive of […]

Inklewriter — open source interactive text adventure game creator. (Fun for adults, but also great to give to kids who love to read) (via Andy Baio) The Virus Survival Strategy Guide for Your Startup (Steve Blank) — Unfortunately, it’s no longer a normal market. All your assumptions about customers; sales cycle; and, most importantly, revenue, […]

Dos and Don’ts in Open Source (Olaf Geirsson) — really useful advice to would-be contributors and project owners. It’s tempting to respond to a welcome contribution with a quick, “This looks amazing, I will review tomorrow!” Consider giving a thumbs-up reaction instead and wait with commenting until you complete the review. Promises are estimates and […]

NASCAR Replaces Canceled Races with Esports Featuring Pro Drivers (Engadget) — the world is getting weirder. Firebase Scrutinized By Antitrust Regulators — Firebase tools give Google, the internet’s top ad seller, information on what consumers are doing inside apps that it can exploit to target ads to users, according to makers of Firebase alternatives. Journey […]

Stanza: A Python Natural Language Processing Toolkit for Many Human Languages — Stanza features a language-agnostic fully neural pipeline for text analysis, including tokenization, multi-word token expansion, lemmatization, part-of-speech and morphological feature tagging, dependency parsing, and named entity recognition. Code and models available for 66 languages. Dropbear SSH — Dropbear is a relatively small SSH […]

Rita J. King, co-director and EVP for business development at Science House, recently conducted a series of interviews with business leaders, exploring the challenges and hurdles companies face in evolving business landscapes. In this interview, King chats with James Jorasch, founding CEO of Science House, about the importance of innovation and how to inspire and […]

Rita J. King, co-director and EVP for business development at Science House, recently conducted a series of interviews with business leaders, exploring the challenges and hurdles companies face in evolving business landscapes. In this interview, King chats with Jen Bruno, SVP of culture and human capital at LPL Financial, about mobilizing a change-ready workforce, leadership […]

Potential Distributed Reading Group on Distributed Systems — for some folks, this will be a great time to start reading groups to work through papers. You’ll never get a time with less physical distraction. (Just remember to ration your socials time or you and your time will vanish into the maelstrom.) Jitsi Meet — open […]

Medtronic Releases Ventilator Designs — not open source, as the license is a limited-time limited-purpose license that retains rights. I imagine some corporate lawyers have done some frantic Googling for open meditech licensing clauses. dolt — version history for tabular data. Compare to sno, which is version control for geospatial and tabular data. Toast UI […]

France defender Samuel Umtiti has picked up a calf injury in just the second session since Barcelona returned to training from the cornonavirus quarantine.

March 2020 Pending Home Sales

The Delivery Man Synopsis The Delivery Man is a comedy television series produced by ITV that premiered in April of 2015. The Delivery Man follows the story of Matthew (played by Darren Boyd – Spy), a police officer who decides to switch careers in his mid-thirties and becomes a midwife. The Delivery Man is currently […]

Other Space Synopsis Other Space is a Science Fiction comedy television series produced by Yahoo that premiered in April of 2015. Created by Paul Feig (Freaks and Geeks) Other Space is set in the early 22nd century and follows the story of the inexperienced crew aboard UMP Cruiser on a routine space exploratory mission. In […]

Peter Kay’s Car Share Synopsis Peter Kay’s Car Share is a situation comedy television series produced by BBC One that premiered in April of 2015. Peter Kay’s Car Share follows the story of John (played by Peter Kay), an assistant manager in a supermarket and his co-worker and promotions rep Kayleigh (played by Sian Gibson). […]

Meet the Smiths Synopsis Meet the Smiths is a scripted reality television series produced by TBS that premiered in April of 2015. Meet the Smiths follows the daily lives of Kenny Smith, an NBA analyst for TNT and his wife Gwendolyn Osborne-Smith, a model for The Price is Right. The couple has five children together […]

Arranged Synopsis Arranged is a reality television series produced by the FYI Network that premiered in April of 2015. Arranged follows the story of the three American couples who all come from different backgrounds, but their cultural traditions allow for arranged marriages. The series chronicles their lives in the lead up to the wedding and […]

Wayward Pines Synopsis Wayward Pines is a mystery thriller television series produced by Fox Network and set to premiere in May of 2015. Based on the book Pines written by Blake Crouch and produced by M. Night Shyamalan Wayward Pines follows the story of an FBI agent Ethan Bruke (played by Matt Dillon), who travels […]

Miles from Tomorrowland Synopsis Miles from Tomorrowland is an animated television series produced by the Disney Channel that premiered in February of 2015. Miles from Tomorrowland is an American animated TV series about the adventures of an inquisitive, if somewhat reckless boy named Miles who travels the universe with his family. Miles from Tomorrowland is […]

The Protectors (1972) Synopsis The Protectors (1972) was an action thriller television series produced by ITV that premiered in September of 1972. The Protectors (1972) was a British action thriller series created by Gerry Anderson (Thunderbirds) about an international group of rich troubleshooters. Contessa di Contini (played by Nyree Dawn Porter), Paul Buchet (played by […]

Wormwood Synopsis Wormwood was a children’s television series produced by Network Ten and ABC1 that premiered in October of 2007. Made as a joint Canadian-Australian production, Wormwood was a TV series about a quirky town where a group of kids investigated strange events. The series was based on the stories written by Paul Jennings. Wormwood […]

A Sharp Intake Of Breath Synopsis A Sharp Intake Of Breath was a situation comedy television series produced by ITV that premiered in February of 1978. Created by Ronnie Taylor A Sharp Intake Of Breath followed the story of Peter Barnes (played by David Jason – Only Fools And Horses), an ordinary man who made […]

Technology has come a long way, and cyber protection is the most crucial factor in advancing the future of digital defense. Interestingly enough, cybersecurity was not always an issue in backup and storage; but as technology advances, so do the methods of hackers. Saying this, let’s take a walk down memory lane. The 1900s: Where […]

The post How Backup And Storage Led To Cybercrime appeared first on Dumb Little Man.

Technology is continuously leaving an indelible mark on many conceivable fields and industries, and education hasn’t been left behind either. Today, you no longer need to take admission classes and physically attend all your classes to earn a degree. All that is required of you is a working web connection and an incontestable thirst for […]

The post 9 Online Resources for Effective Learning appeared first on Dumb Little Man.

Amazon’s share of US ecommerce approaches 40% February 24, 2020 (New York, NY) — Target’s increased focus on building its ecommerce business has been paying off. The big-box retailer, which […]

Despite strong growth, D2C companies are facing more headwinds   April 2, 2020 (New York, NY) — For the first time, we are breaking out direct-to-consumer (D2C) ecommerce sales. We define […]

Before I start recapping the month, let me begin with a greeting: “Hey, Kate from the future! Hey, people who were curious! I knew you’d look up this post! How are you doing? By the way, just how long is this going to last?!” Because this is the recap for March 2020 — a month …

AK Monthly Recap: March 2020 Read More »

The post AK Monthly Recap: March 2020 appeared first on Adventurous Kate.

Part of the Antarctic diary promo for the BBC UK Homepage

Part of the Antarctic diary promo for the BBC UK Homepage

Part of the Antarctic diary promo for the BBC UK Homepage

To mark International Polar Year, BBC science producer Martin Redfern is spending a month on board a research ship in the Antarctic. Follow his exploits online.

An eight-year-old boy with good intentions sparked a missing person search on Tuesday.

Grey Bruce provincial police say the OPP canine unit found human remains in Meaford, and one person is under arrest.

The following article, Univ of Pittsburg Researcher, China Native, Dr. Bing Liu, “On the verge” of COVID19 Breakthrough Is Murdered…Alleged Gunman, Hao Gu, Kills Himself, was first published on 100PercentFedUp.com.

A 37-year-old China native and "outstanding researcher" at the University of Pittsburgh...

Continue reading: Univ of Pittsburg Researcher, China Native, Dr. Bing Liu, “On the verge” of COVID19 Breakthrough Is Murdered…Alleged Gunman, Hao Gu, Kills Himself ...

The following article, BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order, was first published on 100PercentFedUp.com.

Will the mainstream media report about the senseless death of a 43-year-old father of nine, who would have been alive today if it were not for VP wannabe, Gretchen Whitmer's executive order that forced him to respond to a customer not wearing a face mask? 

Continue reading: BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order ...

The following article, ‘Schiff in Panic Mode’: Sources Say Russia Probe Transcripts Affirm Officials Found Nothing on Collusion, was first published on 100PercentFedUp.com.

Transcripts of House Intelligence Committee interviews have been cleared for release, and Adam Schiff is reportedly in panic mode. Unfortunately for Schiff, top law enforcement and intel officials said they saw no evidence of collusion between the Trump campaign and Russia in the transcripts. Republicans sought and got approval for the release of the transcripts […]

Continue reading: ‘Schiff in Panic Mode’: Sources Say Russia Probe Transcripts Affirm Officials Found Nothing on Collusion ...

The following article, BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her, was first published on 100PercentFedUp.com.

Michigan was the first state to see protests against draconian lockdown measures by an overreaching governor. On April 15, the Michigan Conservative Coalition organized an in-vehicle protest in Lansing, MI that drew an estimated 15,000 vehicles. Since that time, several protests by Michigan workers who are being devastated by the one-size-fits-all shut down of the […]

Continue reading: BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her ...

The following article, Busted! Late-Night Hack Comedian, Jimmy Kimmel Is Forced To Apologize For Sharing Highly Edited Video Of VP Pence To Make Him Look Bad, was first published on 100PercentFedUp.com.

Last night, Jimmy Kimmel, host of the low-rated, late-night Jimmy Kimmel Show, shared a deceptively edited video clip of Vice President Pence delivering PPE to a nursing home. Today, liberal activist Matt McDermott tweeted the videotaped segment on VP Pence that was edited to make the vice president look like he was faking a delivery […]

Continue reading: Busted! Late-Night Hack Comedian, Jimmy Kimmel Is Forced To Apologize For Sharing Highly Edited Video Of VP Pence To Make Him Look Bad ...

The following article, Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut, was first published on 100PercentFedUp.com.

When Dallas, Texas salon owner Shelley Luther opened her salon in defiance of the lockdown order in Texas, she was visited numerous times by the local police and then sentenced to 7 days in jail with a fine of $7,000. After public outrage at her punishment, the Texas Supreme Court stepped in to demand her […]

Continue reading: Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut ...

Any plans to visit the Narcisse Snake Dens this Mother's Day weekend will have to be put on hold, after the province announced they are closed until further notice.

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.

The cell surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both biotic and abiotic surfaces. Surface adherence is facilitated by the exquisite selectivity of the adhesins for their cognate ligands or receptors and is a key step in niche or host colonization and pathogenicity. Streptococcus gordonii is a primary colonizer of the human oral cavity and an opportunistic pathogen, as well as a leading cause of infective endocarditis in humans. The fibrillar adhesin CshA is an important determinant of S. gordonii adherence, forming peritrichous fibrils on its surface that bind host cells and other microorganisms. CshA possesses a distinctive multidomain architecture comprising an N-terminal target-binding region fused to 17 repeat domains (RDs) that are each ∼100 amino acids long. Here, using structural and biophysical methods, we demonstrate that the intact CshA repeat region (CshA_RD1–17, domains 1–17) forms an extended polymeric monomer in solution. We recombinantly produced a subset of CshA RDs and found that they differ in stability and unfolding behavior. The NMR structure of CshA_RD13 revealed a hitherto unreported all β-fold, flanked by disordered interdomain linkers. These findings, in tandem with complementary hydrodynamic studies of CshA_RD1–17, indicate that this polypeptide possesses a highly unusual dynamic transitory structure characterized by alternating regions of order and disorder. This architecture provides flexibility for the adhesive tip of the CshA fibril to maintain bacterial attachment that withstands shear forces within the human host. It may also help mitigate deleterious folding events between neighboring RDs that share significant structural identity without compromising mechanical stability.