[Edinburgh] : [publisher not identified], [1862]

London : printed for J. Callow, 1814.

[Place of publication not identified] : [publisher not identified], [201-?]

London (33 Stillness Road, London SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [1989?]

London (33 Stllness Rd, London, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]

London (33 Stillness Rd, London, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]

London : Cleanair, [1988?]

London (33 Stillness Road, London SE23 ING) : Cleanair, [198-?]

[London?], [199-?]

Cracked or broken mobile device screens can be costly to fix, but a few inexpensive DIY strategies can eliminate a repair shop visit and salvage your tablet or phone. It is relatively easy and cheap to replace the glass on a phone once you get the hang of it. Tablets are a bit more involved because of the larger size and added components. Tools might require an additional monetary outlay.

Dopaminergic neurons innervate extensive areas of the brain and release dopamine (DA) onto a wide range of target neurons. However, DA release is also precisely regulated. In Drosophila melanogaster brain explant preparations, DA is released specifically onto α3/α'3 compartments of mushroom body (MB) neurons that have been coincidentally activated by cholinergic and glutamatergic inputs. The mechanism for this precise release has been unclear. Here we found that coincidentally activated MB neurons generate carbon monoxide (CO), which functions as a retrograde signal evoking local DA release from presynaptic terminals. CO production depends on activity of heme oxygenase in postsynaptic MB neurons, and CO-evoked DA release requires Ca²⁺ efflux through ryanodine receptors in DA terminals. CO is only produced in MB areas receiving coincident activation, and removal of CO using scavengers blocks DA release. We propose that DA neurons use two distinct modes of transmission to produce global and local DA signaling.

SIGNIFICANCE STATEMENT Dopamine (DA) is needed for various higher brain functions, including memory formation. However, DA neurons form extensive synaptic connections, while memory formation requires highly specific and localized DA release. Here we identify a mechanism through which DA release from presynaptic terminals is controlled by postsynaptic activity. Postsynaptic neurons activated by cholinergic and glutamatergic inputs generate carbon monoxide, which acts as a retrograde messenger inducing presynaptic DA release. Released DA is required for memory-associated plasticity. Our work identifies a novel mechanism that restricts DA release to the specific postsynaptic sites that require DA during memory formation.

Neonatal stroke is as frequent as stroke in the elderly, but many pathophysiological injury aspects are distinct in neonates, including immune signaling. While myeloid cells can traffic into the brain via multiple routes, the choroid plexus (CP) has been identified as a uniquely educated gate for immune cell traffic during health and disease. To understand the mechanisms of myeloid cell trafficking via the CP and their influence on neonatal stroke, we characterized the phenotypes of CP-infiltrating myeloid cells after transient middle cerebral artery occlusion (tMCAO) in neonatal mice of both sexes in relation to blood-brain barrier permeability, injury, microglial activation, and CX3CR1-CCR2 signaling, focusing on the dynamics early after reperfusion. We demonstrate rapid recruitment of multiple myeloid phenotypes in the CP ipsilateral to the injury, including inflammatory CD45⁺CD11b⁺Ly6c^highCD86⁺, beneficial CD45⁺CD11b⁺Ly6c^lowCD206⁺, and CD45⁺CD11b⁺Ly6c^lowLy6g^high cells, but only minor leukocyte infiltration into acutely ischemic-reperfused cortex and negligible vascular albumin leakage. We report that CX3CR1-CCR2-mediated myeloid cell recruitment contributes to stroke injury. Considering the complexity of inflammatory cascades triggered by stroke and a role for TLR2 in injury, we also used direct TLR2 stimulation as an independent injury model. TLR2 agonist rapidly recruited myeloid cells to the CP, increased leukocytosis in the CSF and blood, but infiltration into the cortex remained low over time. While the magnitude and the phenotypes of myeloid cells diverged between tMCAO and TLR2 stimulation, in both models, disruption of CX3CR1-CCR2 signaling attenuated both monocyte and neutrophil trafficking to the CP and cortex.

SIGNIFICANCE STATEMENT Stroke during the neonatal period leads to long-term disabilities. The mechanisms of ischemic injury and inflammatory response differ greatly between the immature and adult brain. We examined leukocyte trafficking via the choroid plexus (CP) following neonatal stroke in relation to blood-brain barrier integrity, injury, microglial activation, and signaling via CX3CR1 and CCR2 receptors, or following direct TLR2 stimulation. Ischemia-reperfusion triggered marked unilateral CX3CR1-CCR2 dependent accumulation of diverse leukocyte subpopulations in the CP without inducing extravascular albumin leakage or major leukocyte infiltration into the brain. Disrupted CX3CR1-CCR2 signaling was neuroprotective in part by attenuating monocyte and neutrophil trafficking. Understanding the migratory patterns of CP-infiltrating myeloid cells with intact and disrupted CX3CR1-CCR2 signaling could identify novel therapeutic targets to protect the neonatal brain.

Autism spectrum disorder (ASD) is characterized partly by atypical attentional engagement, reflected in exaggerated and variable responses to sensory stimuli. Attentional engagement is known to be regulated by the locus ceruleus (LC). Moderate baseline LC activity globally dampens neural responsivity and is associated with adaptive deployment and narrowing of attention to task-relevant stimuli. In contrast, increased baseline LC activity enhances neural responsivity across cortex and widening of attention to environmental stimuli regardless of their task relevance. Given attentional atypicalities in ASD, this study is the first to evaluate whether, under different attentional task demands, individuals with ASD exhibit a different profile of LC activity compared with typically developing controls. Males and females with ASD and age- and gender-matched controls participated in a one-back letter detection test while task-evoked pupillary responses, an established correlate for LC activity, were recorded. Participants completed this task in two conditions, either in the absence or presence of distractor auditory tones. Compared with controls, individuals with ASD evinced atypical pupillary responses in the presence versus absence of distractors. Notably, this atypical pupillary profile was evident despite the fact that both groups exhibited equivalent task performance. Moreover, between-group differences in pupillary responses were observed specifically in response to task-relevant events, providing confirmation that the group differences most likely were specifically associated with distinctions in LC activity. These findings suggest that individuals with ASD show atypical modulation of LC activity with changes in attentional demands, offering a possible mechanistic and neurobiological account for attentional atypicalities in ASD.

SIGNIFICANCE STATEMENT Individuals with autism spectrum disorder (ASD) exhibit atypical attentional behaviors, including altered sensory responses and atypical fixedness, but the neural mechanism underlying these behaviors remains elusive. One candidate mechanism is atypical locus ceruleus (LC) activity, as the LC plays a critical role in attentional modulation. Specifically, LC activity is involved in regulating the trade-off between environmental exploration and focused attention. This study shows that, under tightly controlled conditions, task-evoked pupil responses, an LC activity proxy, are lower in individuals with ASD than in controls, but only in the presence of task-irrelevant stimuli. This suggests that individuals with ASD evince atypical modulation of LC activity in accordance with changes in attentional demands, offering a mechanistic account for attentional atypicalities in ASD.

When thinking of this fruit we love so much what is the image that first pops to mind? Perhaps a green or a yellow with a greenish tint energy food? Or maybe a banana packaged in a perfect shade of yellow? If that’s the case, then it is time to broaden that perspective. Say hello to the Fe’i banana! This traditional [...]

How the beloved figure has become a lightning rod in a heated environmental debate

For the first time, the indigenous community is allowed to gather the cherished plant on protected land

Illustrators are sharing artwork of Amabie, a spirit first popularized during the Edo period, on social media

Despite historic setbacks similar to today's, Americans have become more dedicated travelers

Press release: CPMI report sets out considerations for developers of wholesale digital tokens, 12 December 2019

The number of people evaluated for signs of stroke at U.S. hospitals has dropped by nearly 40% during the COVID-19 pandemic, according to a study led by researchers from Washington University School of Medicine in St. Louis who analyzed stroke evaluations at more than 800 hospitals across 49 states and the District of Columbia.

OM Chile team member Marloes Achterveld witnesses God change the life of a homeless man.

Former Windsor high school drama teacher John Nabben was found guilty on Thursday, May 7 of professional misconduct, and has had his teaching licence revoked. 

Legislative “reform” is hurting legitimate inventors.

Please be advised that effective Sunday, August 25, 2013 (for the August 26th business date) there will be changes to CME ClearPort API Entity Reference Data that will impact Party Detail List Reports and Party Entitlement Reports for CME ClearPort API Brokers and CME ClearPort API Platforms who request Entity Reference Data on behalf of Brokers.

These changes will be available for testing in the New Release environment on August 14th.

Changes to Existing Reponses

When a Broker (or Platform on behalf of Broker) submits a request for all related accounts using the Party Details List Request message or a request for all related accounts which trade a particular product using the Party Entitlement Request message, the following information is provided for each account in Related Party Detail blocks:  The Clearing ID of the Account’s Clearing Firm (Party Role 1), the Trading Firm / Account Owner’s firm identifier (Party Role 7),  and the Broker Firm’s firm identifier (Party Role 30).

Going forward, when the same requests are submitted, an additional Related Party Detail block will appear on the response if there is an Asset Manager Firm assigned to the account:  the Asset Manager Firm’s identifier (Party Role 49).

In the following examples, ACCT1 has been assigned an Asset Manager by the Clearing Firm, while ACCT2 has not.

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyDetlListRpt ReqID="123437" RptID="1376864472358" ReqRslt="0" Txt="Valid request">

<Hdr SID="CME" SSub="CPAPI" TID="PLTFM" TSub="username"/>

<PtyDetl ID="ACCT1" Src="C" R="24">

<AltPty ID="A-12345" Src="H"/>

<ReltdPtyDetl ID="123" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm1" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="asset_mgr_firm1" Src="C" R="49">

<Rltnshp Rltnshp="32"/>

</ReltdPtyDetl>

</PtyDetl>

<PtyDetl ID="ACCT2" Src="C" R="24">

<AltPty ID="A-67890" Src="H"/>

<ReltdPtyDetl ID="456" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm2" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

</PtyDetl>

</PtyDetlListRpt>

</FIXML>

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyEntlmntRpt ReqID="123412" RptID="1376865078371" ReqRslt="0" Txt="Valid request">

<Hdr SID="CME" SSub="CPAPI" TID="PLTFM" TSub="username"/>

<PtyEntlmnt>

<PtyDetl ID="ACCT1" Src="C" R="24">

<AltPty ID="A-12345" Src="H"/>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm1" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="asset_mgr_firm1" Src="C" R="49">

<Rltnshp Rltnshp="32"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="123" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

</PtyDetl>

<PtyDetl ID="ACCT2" Src="C" R="24">

<AltPty ID="A-67890" Src="H"/>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm2" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="456" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

</PtyDetl>

<Entlmnt Typ="0" Ind="Y">

<InstrmtScope Oper="1" ID="NN" Src="H" SecTyp="FUT"

Exch="NYMEX"/>

</Entlmnt>

</PtyEntlmnt>

</PtyEntlmntRpt>

</FIXML>

NEW- Broker Requests Asset Manager Users at an Asset Manager Firm

In a previous CME ClearPort API release a change was made to allow Brokers (or Platforms on behalf of Brokers) to specify asset manager users in party role 36 (instead of a trader at the account owner firm) to satisfy the trader individual requirements for applicable market types like energy and metals.  Now Brokers can use ClearPort API reference data to obtain a list of asset manager users for their related accounts.  Once the above responses are received, the Broker or Platform can use each related Asset

Manager Firm (Party Role 49) to request a list of users at the firm:

Request

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyDetlListReq ReqID="123437">

<Hdr SID="PLTFM" SSub="username" TID="CME" TSub="CPAPI"/>

<ReqPty ID="broker_firm1" R="30"/>

<Pty ID="asset_mgr_firm1" R="49"/>

<ReqR R="36"/>

</PtyDetlListReq>

</FIXML>

Response

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyDetlListRpt ReqID="123437" RptID="1376866782295" ReqRslt="0" Txt="Valid request">

<Hdr SID="CME" SSub="CPAPI" TID="PLTFM" TSub="username"/>

<PtyDetl ID="asset_mgr_user1" Src="C" R="36">

<Sub ID="First Last" Typ="9"/>

<ReltdPtyDetl ID="asset_mgr_firm1" Src="C" R="49">

<Sub ID="Company Name" Typ="5"/>

<Rltnshp Rltnshp="6"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="CMD" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="CME" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="DME" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="NYMEX" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="COMEX" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="CBT" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

</PtyDetl>

</PtyDetlListRpt>

</FIXML>

For more detailed information regarding entity reference data retrieval through CME ClearPort API, please see the CME ClearPort API Reference Data Guide:

http://www.cmegroup.com/clearing/files/Clearport_Reference_Data_API_FIXML_Message_Specification_

and_Samples.pdf

If you have questions or need help facilitating your tests in the New Release environment, please contact:

Market Operations Technical Support

24 Hour 6 Days a Week Support available from Sundays at 5PM ET to Fridays at 5PM ET

Phone: 800-275-6215 / 212-301-4720

Email:  thirdpartyservices@cmegroup.com

Such was the truth God gave the Artslink, Dancelink and Bill Drake Band teams for Baja, Hungary, from 10-17 July 2011. The results were eternal.

The Bus4Life brings God's love to the marginalised in Tata, Hungary.

By offering a creative class for women, an OM worker finds ways to transform broken tiles into art and make relationships where she can share God’s truth.

A Fin24 reader looking to invest in a living annuity, was shocked to find that she would have to pay fees of up to R110 000 per annum. She wants to know if there are other options. An investment expert responds.

IF there's one thing that online news proves without any shadow of uncertainty, it's that there's no knowing what will capture the popular imagination.

THE last day of term before recess saw MSPs attempt more jokes than usual at FMQs, some of them even bordering on approaching the mildly funny. Heady days.

THE market for TV historians is crowded and fiercely competitive. Drop your guard for a second and Dan Snow or Bettany Hughes will be in the door and taking your gig faster than you can don a pair of those special white gloves all in the trade must have. Lucy Worsley made her name by combining immense knowledge – she is the chief curator at Historic Royal Palaces – with a steadfast dedication to raiding the dressing up box.

Lou Grant

In 1951, John A. Stokes joined other black students in a strike over the condition of their school and subsequently became a figure in Brown v. Board of Ed. Hear his story and the message he wants to share with students today.

GLUMNESS settles on a large part of the nation whenever the subject of comedy comes up now. The lockdown has led to a more frenetic search for entertainment, and the current state of humour hasn’t wanted for critics. This week, Royle Family star Ricky Tomlinson, 80, said it was dire, and listed several comedians, adding: “They should be done under the Trade Description Act.”

Secondhand smoke exposure poses a significant health risk to nonsmokers. With the proliferation of comprehensive smoke-free laws prohibiting smoking in worksites and public areas, private areas have become the primary source of secondhand smoke exposure for many individuals, particularly youth.

Secondhand smoke exposure in cars has steadily declined among middle and high school students. However, many remain exposed to secondhand smoke in this environment. Jurisdictions should expand existing comprehensive smoke-free policies to prohibit smoking in vehicles occupied by youth. (Read the full article)

The outcome of status epilepticus in children depends on the etiology. In otherwise normal children who have ≥1 episodes of unprovoked status epilepticus as part of the evolution of their epilepsy, the seizure and intellectual outcome is unclear.

Based on population-based data and 20 to 30 years’ follow-up of normal children with focal epilepsy, one-third with status epilepticus had recurrence of status. Reassuringly, intelligence, seizure control, and rate of remission were not altered compared with those without status epilepticus. (Read the full article)

A small number of studies have found that the introduction of smoke-free legislation has been associated with a reduction in hospital admissions and emergency department visits for asthma.

The implementation of smoke-free legislation in England was associated with an immediate 8.9% reduction in hospitalizations for asthma along with a decrease of 3.4% per year. (Read the full article)

Among youth with asthma, tobacco smoke exposure causes increased asthma morbidity. Little is known about changes over time in tobacco smoke exposure among youth with asthma in a national sample.

Our analysis reveals a decrease in environmental tobacco smoke exposure among children and adolescents with current asthma in the United States from 1988–1994 to 2005–2010, but a majority of youth with asthma remain exposed to environmental tobacco smoke. (Read the full article)

Impaired visual development has been reported in infants born to mothers prescribed methadone in pregnancy. Immature visual evoked potentials have been reported in this population, but data were confounded by gestation, growth restriction, and illicit drug use.

Visual evoked potentials are small and immature in infants exposed to methadone and other drugs of misuse in utero. These changes are independently associated with methadone exposure and persist after controlling for gestation, socioeconomic deprivation, alcohol consumption, and cigarette smoking. (Read the full article)

Active smoking and secondhand smoke are associated with chronic kidney disease in adults. No data are available for children.

Secondhand smoke and active smoking were associated with decreased estimated glomerular filtration rate in US adolescents. These findings support that tobacco smoke effects on kidney function begin in childhood. (Read the full article)

Despite declines in cigarette smoking, smokeless tobacco use among youth has remained unchanged in the United States. Modified or novel smokeless tobacco products are being increasingly promoted to youth in the United States as an alternative to smoking.

Among US students in grades 6 through 12, 5.0% used snuff or chewing or dipping tobacco, whereas 2.2% used snus or dissolvable tobacco products. Approximately two-thirds of smokeless tobacco users concurrently smoked combustible tobacco; risk perception of all tobacco products was protective of smokeless tobacco use. (Read the full article)

The World Health Organization estimates that ~700 million children breathe tobacco smoke polluted air, particularly at home. Educational strategies either directly or indirectly targeting household decision-makers through other family members are effective in reducing children's exposure in private homes.

Intensive intervention was effective in decreasing children’s personal exposure to secondhand smoke (SHS), educating mothers about SHS, and promoting smoking restrictions at home. However, superiority over minimal intervention to decrease children’s personal exposure to SHS was not statistically significant. (Read the full article)

Little is known about how thirdhand smoke beliefs are related to smoking and quitting behaviors, and how parental smokers’ thirdhand smoke beliefs influence behaviors to protect children. A previous study suggests thirdhand smoke beliefs are associated with home smoking bans.

This is the first study to show that parents’ beliefs about thirdhand smoke are associated with multiple smoking-related attitudes and behaviors that affect the health of children. (Read the full article)