Promising new vaccines are designed to be given to patients at risk of developing Alzheimer's disease. If they perform well in clinical trials, they have the potential to one day rid society of dementia

Experiments show that effect doesn’t always follow cause in the weird world of subatomic particles, offering fresh clues about the quantum origins of space-time

Title: Egg Recall: Trail Leads to Iowa Firm
Category: Health News
Created: 8/24/2010 10:55:00 AM
Last Editorial Review: 8/24/2010 10:55:55 AM

Title: What's in Your CBD Product? Labels Often Mislead
Category: Health News
Created: 7/26/2022 12:00:00 AM
Last Editorial Review: 7/26/2022 12:00:00 AM

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared with vehicle 0.3 ± 0.1 (P = 0.01) as determined by tissue mass spectrometry imaging analysis. We hypothesized that increased plasma and kidney levels of IDS could be caused by the simultaneous inhibition of both Slc6a19 and a kidney IDS transporter responsible for excretion of IDS into urine. To test this, we first confirmed the formation of IDS through tryptophan metabolism by feeding rats a Trp-free diet. Inhibiting Slc6a19 with RA836 led to increased IDS in these rats. Next, RA836 and its key metabolites were evaluated in vitro for inhibiting kidney transporters such as organic anion transporter (OAT)1, OAT3, and breast cancer resistance protein (BCRP). RA836 inhibits BCRP with an IC₅₀ of 0.045 μM but shows no significant inhibition of OAT1 or OAT3. Finally, RA836 analogs with either potent or no inhibition of SLC6A19 and/or BCRP were synthesized and administered to rats fed a normal diet. Plasma and kidney samples were collected to quantify IDS using liquid chromatography–mass spectrometry. Neither a SLC6A19 inactive but potent BCRP inhibitor nor a SLC6A19 active but weak BCRP inhibitor raised IDS levels, whereas compounds inhibiting both transporters caused IDS accumulation in rat plasma and kidney, supporting the hypothesis that rat Bcrp contributes to the excretion of IDS. In summary, we identified that inhibiting Slc6a19 increases IDS formation, while simultaneously inhibiting Bcrp results in IDS accumulation in the kidney and plasma.

Alveolar capillary dysplasia (ACD) is a fatal disorder that typically presents in the neonatal period with refractory hypoxemia and pulmonary hypertension. Lung biopsy is traditionally required to establish the diagnosis. We report a 22-mo-old male who presented with anemia, severe pulmonary hypertension, and right heart failure. He had a complicated hospital course resulting in cardiac arrest and requirement for extracorporeal membrane oxygenation. Computed tomography of the chest showed a heterogenous pattern of interlobular septal thickening and pulmonary edema. The etiology of his condition was unknown, lung biopsy was contraindicated because of his medical fragility, and discussions were held to move to palliative care. Rapid whole-genome sequencing (rWGS) was performed. In 2 d it resulted, revealing a novel FOXF1 gene pathogenic variant that led to the presumptive diagnosis of atypical ACD. Cases of atypical ACD have been reported with survival in patients using medical therapy or lung transplantation. Based on the rWGS diagnosis and more favorable potential of atypical ACD, aggressive medical treatment was pursued. The patient was discharged home after 67 d in the hospital; he is currently doing well more than 30 mo after his initial presentation with only one subsequent hospitalization and no requirement for lung transplantation. Our case reveals the potential for use of rWGS in a critically ill child in which the diagnosis is unknown. rWGS and other advanced genetic tests can guide clinical management and expand our understanding of atypical ACD and other conditions.

"Kate Forbes still has her own leadership ambitions, setting them aside this Spring in the interest of party unity to accept Mr Swinney's offer to become Deputy First Minister."

Tencent Games subsidiary LightSpeed Studios has announced Hideaki Itsuno, who recently left Capcom after 30 years working for the company, will be leading a new video game studio called LightSpeed Japan Studio.

LightSpeed Japan Studio will have two locations in Tokyo and Osaka and is focused on developing original AAA games.

"Joining LightSpeed Studios is an exciting new chapter for me," said Hideaki Itsuno. "With LightSpeed’s strong development capability and global network, I look forward to creating original AAA action game titles together with the amazing team and building aesthetic and innovative experiences for the global player community. We welcome all talented and passionate game creators from the world over to join our vision."

LightSpeed Studios president Jerry Chen added, "It is our great honor to have Hideaki Itsuno join LightSpeed Studios. The establishment of LightSpeed Japan Studio is a significant step in LightSpeed Studios’ expansion and demonstrates our commitment to bringing the best possible games to our players."

Itsuno directed entries in the Rival Schools, Power Stone, Capcom VS. SNK, Devil May Cry, and Dragon’s Dogma franchises.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463041/hideaki-itsuno-to-lead-new-aaa-developer-lightspeed-japan-studio/

The PlayStation 5 was the best-selling console in the UK in October, according to GfK Entertainment data reported by GamesIndustry. 

The Xbox Series X|S was the second best-selling console for the month, followed by the Nintendo Switch in third. The Xbox Series X|S has also surpassed the Switch in year-to-date sales.

Sales for the PS5 are up 27 percent month-on-month and down 18 percent year-on-year. Sales for the Switch are up 13 percent month-on-month and down 18 percent year-on-year. Sales for the Xbox Series X|S are down seven percent month-on-month and down 17 percent year-on-year. 

Overall, there were just under 144,000 video game consoles sold (NielsenIQ/GfK panel data) in the UK in October 2024. This is down 18 percent year-on-year.

GSD data shows there were 2.9 million games sold in October 2024, which is up 3.2 percent year-on-year. 

Call of Duty: Black Ops 6 debuted in first place on the software charts (digital and physical combined). Sales are 11 percent lower than the launch month of 2023's 2023's Call of Duty: Modern Warfare III, however, this is most likely due to the number of people playing the game via Xbox Game Pass.

Sales of Call of Duty: Black Ops 6 are up 24 percent year-on-year on PlayStation consoles, while sales dropped on Xbox consoles and PC. 75 percent of total sales were on PlayStation consoles, followed by 15 percent on PC, and just under 11 percent on Xbox consoles.

Dragon Ball: Sparking! Zero debuted in third place with the first four week of sales up 80 percent compared to 2020's Dragon Ball Z: Kakarot.

Undisputed debuted in fourth place and had the second biggest launch for a sports title in 2024. Only EA Sports FC 24 had a bigger launch.

The remake of Silent Hill 2 debuted in fifth place. Launch sales are 32 percent lower than the remake of Dead Space and 62 percent lower than the remake of Resident Evil 4.

Super Mario Party Jamboree debuted in ninth place. Sales are 11 percent higher than 2018's Super Mario Party, but are four percent lower than 2021's Mario Party Superstar. It should be noted Nintendo doesn't share digital sales with these charts.

Sonic X Shadows Generations debuted in 10th place. Sales for the game are 150 percent compared to 2023's Sonic Superstars, but are down 21 percent compared to 2022's Sonic Frontiers.

Metaphor: Refantazio debuted in 12th place and the new version of Until Dawn debuted in 30th place.

EA Sports FC 25 came in second place with sales down 14 percent year-on-year.

There were over 681,000 accessories and add-on products sold in the UK in October, which is up nearly 16 percent year-over-year, but is down over eight percent month-on-month.

The White DualSense controller was the best-selling accessory, followed by the Midnight Black DualSense controller. The PlayStation Portal Remote Player is up four spots to take fourth place.

Here are the top 10 best-selling games in the UK (Digital + Physical):

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463042/ps5-best-seller-in-the-uk-in-october-black-ops-6-leads-strong-month-of-new-releases/

A 61-year-old San Antonio man pleaded guilty to two federal charges in the human smuggling incident that led to the deaths of 10 undocumented immigrants this summer.

James Matthew Bradley Jr., who appeared before a U.S. magistrate judge Monday, pleaded guilty to “one count of conspiracy to transport aliens resulting in death and one count of transporting aliens resulting in death,” according to a statement from the U.S. Attorney’s Office for the Western District of Texas.

The office added that Bradley’s “admission of guilt” meant he packed dozens of unauthorized immigrants into a tractor-trailer for financial gain, adding that the suspect confirmed that details from court documents were “factually correct.”

On July 23, San Antonio Police Department officers responded to a call from a Walmart employee shortly past midnight. Once officers arrived, they found 39 immigrants at the scene. Of those carried in the tractor-trailer, eight were found dead in the rear of the trailer, while two died later at nearby hospitals, the statement said.

Survivors of the incident said there was no air conditioning in the overheated trailer and had to take turns to breath through a hole in the back of the truck for air. Bradley also initially told investigators that he was unaware of the immigrants in the trailer until he had stopped at the Walmart in San Antonio for bathroom break.

The attorney’s office also said Bradley faces up to life in prison with the charges and that he is scheduled to be sentenced in January 2018. Immigrants said there were up to 200 people transported on the trailer and that different fees were quoted to them for the ride north from the U.S.-Mexico border, the statement added.

Jason Buch of San Antonio Express-News told the NewsHour earlier this year that Border Patrol agents in Laredo, Texas, reported an uptick of immigrants using tractor-trailers to get pass checkpoints at the border.

“People are usually going on to major metropolitan areas or regions of the country that employ a lot of immigrant laborers, so, areas with large agriculture industries or construction booms,” Buch said.

The NewsHour’s John Yang learned more about the July human smuggling case and immigration politics from Jason Buch of San Antonio Express News.

Shane M. Folden, special agent in charge of homeland security investigations in San Antonio, said in the statement that the proceeding “helps to close the door on one of the conspirators responsible for causing the tragic loss of life and wreaking havoc on those who survived this horrific incident.”

“This case is a glaring reminder that alien smugglers are driven by greed and have little regard for the health and well-being of their human cargo, which can prove to be a deadly combination,” he added.

Bradley’s co-defendant Pedro Silva Segura was also indicted last month with faces two counts of conspiracy and two counts of transporting undocumented immigrants resulting in serious bodily injury and placing lives in jeopardy.

Segura, 47, is an undocumented immigrant who resides in Laredo, Texas.

The post San Antonio truck driver pleads guilty in fatal human smuggling case appeared first on PBS NewsHour.

Our Future Chronicles column explores an imagined history of inventions and developments yet to come. This time, Rowan Hooper takes us to the early 2030s, when a technological step change enabled us to produce all the food we needed without the use of animals

If artificial intelligence chatbots are fine-tuned to improve their responses using human feedback, they can become more likely to give deceptive answers that seem right but aren’t

Ronnie O'Sullivan has agreed to compete in new snooker events.

Hours after Donald Trump wins the most conclusive mandate in 40 years, Mitch McConnell engineers a coup against his agenda by calling early leadership elections in the senate.

Oakland's mayor and district attorney were both sent packing in a recall vote. Leaders in other Democratic-run cities should take notice.

Zeiger is president of the Jack Miller Center, an educational venture to advance the history, documents and ideals we hold in common as Americans.As a nation, we are failing to prepare citizens for leadership in our constitutional republic. According to a September 2023 Pew Research Center study, 72...

Senate Republicans cannot be led by someone who is openly hostile to the agenda of their party's president and the base who elected him.

Who Will Fill the Democratic Vacuum?

Senate Republicans on Wednesday will elect a new party leader for the first time in nearly two decades.

President-elect Donald Trump on Tuesday announced that Tesla founder Elon Musk and businessman Vivek Ramaswamy will a new Department of Government Efficiency, a White House office given the task of cutting the federal budget.

The spy writing star, whose series has become a huge television hit starring Gary Oldman, is to chair the Theakston Old Peculier Crime Writing Festival 2025

Promising new vaccines are designed to be given to patients at risk of developing Alzheimer's disease. If they perform well in clinical trials, they have the potential to one day rid society of dementia

Israeli President Isaac Herzog says hostages are "going through hell in the dungeons of Gaza" during meeting with President Biden at White House.

President-elect Trump announced that billionaire Elon Musk and former GOP presidential candidate Vivek Ramaswamy will lead the Department of Government Efficiency.

Senate Republicans met on Tuesday night to hear from the three candidates to succeed Mitch McConnell, and Rick Scott left with two new endorsements.

The former soldier Daniel Khalife has changed his plea to guilty and admitted escaping from Wandsworth prison.

Wildfires have been raging in New York and New Jersey. People in some areas have been asked to prepare for possible evacuations.

Congress reconvenes this week with a top priority: electing the leaders of each chamber. Here's a look at the contenders. And, top priorities for Trump's Justice Department.

The Federal Emergency Management Agency supervisor fired for telling workers to avoid homes with Trump signs or flags said in an interview Tuesday that "senior leadership" at FEMA was well-aware of this guidance and it was not an isolated incident.

The post Ex-FEMA Worker Claims Leadership Knew Workers Were Avoiding Homes with Trump Signs appeared first on Breitbart.

Republicans need a "bold Senate GOP leader," Sen. Mike Lee (R-UT) said on Tuesday as three Republican senators -- Sen. Rick Scott (R-FL), Senate Republican Whip John Thune (R-SD), and Sen. John Cornyn (R-TX) -- vie for the position of Senate Majority Leader.

The post Sen. Mike Lee: ‘We Need a Bold Senate GOP Leader’ appeared first on Breitbart.

Sen. Marsha Blackburn (R-TN) told Breitbart News exclusively on Tuesday evening that she is supporting Sen. Rick Scott (R-FL) for Senate GOP leader in the upcoming vote on Wednesday morning in the Senate GOP conference.

The post Exclusive—Marsha Blackburn Backs Rick Scott for Senate GOP Leader appeared first on Breitbart.

Republican Senators huddled for over two hours Tuesday night for a family meeting over who will take the reins from Sen. Mitch McConnell (R-KY).

The post Republican Senators Hold Leader Candidate Forum Hours Before Consequential Vote appeared first on Breitbart.

President-elect Donald Trump announced he has picked Tesla CEO and X owner Elon Musk and entrepreneur and former Republican presidential candidate Vivek Ramaswamy to "lead the Department of Government Efficiency."

The post Donald Trump Selects Elon Musk, Vivek Ramaswamy to ‘Lead the Department of Government Efficiency’ appeared first on Breitbart.

1. Trump Tracker: Fox News Anchor Nominated To Lead Pentagon  NDTV
2. Trump nominates Army veteran and Fox News host Pete Hegseth for defence secretary  The Hindu
3. Trump's defense choice stuns the Pentagon, raises questions about the Fox News host's experience  Hindustan Times
4. 'We are in a new place': Bernstein reacts to Hegseth's comments about women in combat roles  CNN
5. Pete Hegseth: Ex-Army man, Fox News host, is US's 2nd youngest Defence Secretary  India Today

Subscription music app gives Nintendo new reason to crack down on third-party music uploads.

Peruvanam Satheesan Marar recalls his initiation into the percussion ensemble and how he gained expertise in playing different instruments

​​​​​​​Jocelyne Larocque scored less than 4 minutes into the game, Sarah Nurse added a goal midway through the first period and Canada cruised to a 4-1 win over the United States in Boston on Sunday to take a 2-1 lead in the five-game Rivalry Series.

President-elect Trump announced a "Department of Government Efficiency," or DOGE, that will be led by Tesla CEO Elon Musk and entrepreneur Vivek Ramaswamy, focused on shrinking the federal government.

President-elect Donald Trump announced Tesla CEO Elon Musk and Republican primary candidate Vivek Ramaswamy will lead a new agency he's calling the "Department of Government Efficiency."

His early personnel choices indicate his incoming administration would be willing to use sticks as well as carrots to deal with Russia.

President-elect Donald Trump has named Elon Musk as the leader of a new “Department of Government Efficiency," that will “dismantle Government Bureaucracy, slash excess regulations, cut wasteful expenditures, and restructure Federal Agencies.” The Tesla CEO and owner of X will spearhead the effort along with former presidential candidate Vivek Ramaswamy, Trump announced in a statement on Truth Social.

The scope of the role isn’t exactly clear. Trump’s press release said that “the Department of Government Efficiency will provide advice and guidance from outside of Government, and will partner with the White House and Office of Management & Budget to drive large scale structural reform, and create an entrepreneurial approach to Government never seen before.” It also stated that “their work will conclude no later than July 4, 2026.”

Musk shared the news on X, but didn’t indicate how the role might impact his obligations at his various other companies. Musk, who poured millions of dollars into Super Pac boosting Trump’s campaign, has previously talked about his desire to work with Trump to cut government spending. He did, however, joke about potential "merch" for the operation. "Republican politicians have dreamed about the objectives of 'DOGE' for a very long time," Trump's statement said. 

Beyoncé leads the 2025 Grammy Award nominations with 11, bringing her career total to 99 nominations. That makes her the most-nominated artist in Grammy history.

Former Liberal senator Sean Edwards has continued to fuel speculation he is set to make a bid to enter state politics.

In this episode of The MedTalk Podcast, we're bringing you something a little different. One of our sister publications, European Pharmaceutical Manufacturer, secured an interview with Thermo Fisher Scientific's Urmi Prasad Richardson.

<p> <b>Abstract</b><br />CinnaGen, the largest biopharmaceutical company in the MENA region, is a leader in developing follow-on biologicals/biosimilars. Dr&nbsp;Haleh Hamedifar, Chairperson of CinnaGen, spoke to GaBI<i>&nbsp;</i>(Generics and Biosimilars Initiative) about the company’s strategic focus, which includes expanding its product portfolio, entering highly regulated global markets, and advancing affordable treatments for conditions such as multiple sclerosis and&nbsp;immunological diseases—transforming healthcare in underserved regions.</p><p><b>Keywords</b>: Biosimilars, clinical development, commercialization, MENA</p>

By Arthur O. Tzianabos, PhD, CEO of Lifordi Immunotherapeutics, as part of the From the Trenches feature of LifeSciVC As the biotech industry continues to pick up steam, I have been getting a number of phone calls from folks in

The post Stars and Scars… Some Lessons Learned About Leadership appeared first on LifeSciVC.