Styling her brunette locks into an updo, Irina, 34, completed her look for the day with a pair of dark sunglasses

The brilliant choreographer's contemporary take on the tragic love story finally arrives in London.

Kings Of Leon, Rudimental and Little Mix headline the Liverpool festival in Sefton Park. Franz Ferdinand, Dizzee Rascal and Anne-Marie provide support. Fri-Sun

After fleeing Venezuela along with millions of others amid the country's grueling humanitarian crisis, Misael Cocho made his way by bus to Peru where he got odd jobs and sent money home monthly to support his mother and his 5-year-old son. But just after Cocho landed his steadiest work so far in Lima, coronavirus cases skyrocketed. He lost his job, sold his TV to buy food and hasn't been able to wire money for months to Caracas to pay for food for the boy and Cocho's mother. The pandemic's economic fallout left many Venezuelans abroad and the relatives back home who rely on them in dire straits. And as work disappears in countries like Peru and Colombia, humanitarian groups say many Venezuelans who fled hunger are now going hungry. Cocho, 24, faces a dilemma: Should he stay in Peru in case the economy improves, or go back to Caracas where life is precarious but might not get worse? The truth is that this pandemic has really hit me hard, he said. Venezuela's population peaked at 30 ...

Men who think of themselves as allies and supporters of women need to break the culture of silence that surrounds rape, says Radhika Chopra.

India have so far grabbed men's full quota and one individual place in women's category for Tokyo Olympics.

Ayan Mukerji's multi-starrer Brahmastra has delayed its shoot completion and therefore its release, quite a few times. It looks like the film, starring Alia Bhatt, Ranbir Kapoor, Amitabh Bachchan and Mouni Roy, may be delayed yet again due to the Coronavirus

Rakshit Shetty who was busy shooting for 777 Charlie is currently homebound like the rest of us due to the COVID-19 lockdown. However, the Kirik Party and Avane Srimannarayana star, in a recent interview with the Metrolife revealed his childhood memories

Ebola virus disease, also termed Ebola haemorrhagic fever is a disease of the humans caused by four strains of Ebola virus. Ebola was first discovered in the year 1976, and since then there have been many incidences of the diseases with

Chagas diseases (CD) is a silent yet life-threatening disease caused by a protozoan parasite named Trypanosoma cruzi (T.cruzi). The disease is also known as American trypanosomiasis as it is found mainly in rural areas of America where there is a lack

Cancer is a major disease worldwide in both developed as well as developing countries. According to a study, in the year 2008, there were around 7.6 million deaths worldwide due to cancer. [1] The WHO estimate the count to rise above

The coronavirus cases around the globe are at 2,484,301, with 170,501 deaths reported and 652,761 recoveries. The virus outbreak that began in 2019 continues to cause casualties, while health experts around the globe are extensively working on developing a vaccine and

Thyroid cancer is the cancer of the thyroid gland which is found at the neck's front just below Adam's apple. The thyroid gland is a butterfly-shaped gland with two lobes, one at each side joined by a narrow tissue called the

Summer ailments are quite common during the hot summer months. From heat rashes and sunburns to jaundice and food poisoning summer causes a host of health problems. In India, usually May and June are considered the hottest months of the year

Athlete's foot (AF), also known as tinea pedis is a fungal infection of the foot, mostly found between the toes. It is named so as the infection is common in athletes and swimmers. The AF can spread to hands or other

Thalassemia is a group of inherited blood disorders that has a similar characteristic: defective and reduced production of haemoglobin, the iron-containing protein in red blood cells that helps in carrying oxygen throughout the body. Beta-thalassemia (BT) is one of

The styrene gas that got leaked from LG Polymers in Vizag, Andhra Pradesh on Thursday morning has affected over 5,000 people and the death toll mounts to 10. LG Polymers, a chemical plant manufactures polystyrene, high impact polystyrene and coloured polystyrene.

May 3-9 is Arson Awareness Week 2020, which focuses on the crucial role that firefighters play in the community to protect the public in emergency situations. Fire accidents can occur anywhere unexpectedly including homes, factories and health-care facilities. In the United

Archives, Room Use Only - KF51 1842

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The Hall of Famer is repaying the money after an audit of funds alleged that Mississippi officials improperly spent $94 million in federal money.

HTML5 standardizes the oninput event handler, which should be used to detect user input in JavaScript. Sure, you could use onkeydown or onkeyup instead, but those were never really designed for this particular use case, and it shows.

Apparently inspired by how Kerala used umbrellas to ensure physical distancing, a residents welfare association at Sai Nagar in Thoraipakkam has reque

Final Olympic archery qualification event in June next year

Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for therapeutic intervention in allergic disease. Omalizumab is a clinically approved anti-IgE monoclonal antibody that binds to free IgE, also with high affinity, preventing its interaction with Fc∊RI. All attempts to crystallize the pre-formed complex between the omalizumab Fab and the Fc region of IgE (IgE-Fc), to understand the structural basis for its mechanism of action, surprisingly failed. Instead, the Fab alone selectively crystallized in different crystal forms, but their structures revealed intermolecular Fab/Fab interactions that were clearly strong enough to disrupt the Fab/IgE-Fc complexes. Some of these interactions were common to other Fab crystal structures. Mutations were therefore designed to disrupt two recurring packing interactions observed in the omalizumab Fab crystal structures without interfering with the ability of the omalizumab Fab to recognize IgE-Fc; this led to the successful crystallization and subsequent structure determination of the Fab/IgE-Fc complex. The mutagenesis strategy adopted to achieve this result is applicable to other intractable Fab/antigen complexes or systems in which Fabs are used as crystallization chaperones.

Scientists and local dive operators first noticed coral bleaching in the waters surrounding Isla Colon, in Panama’s Bocas del Toro province in July. Smithsonian staff scientist Nancy Knowlton and colleagues documented an extensive bleaching event in late September.

The post Coral bleaching event caused by warming ocean waters is documented in Panama appeared first on Smithsonian Insider.

The crustaceans are much more effective when they fight together than when they fight alone, a process McKeon calls the Multiple Defender Effect. “It is a clear example of synergy, and one that underscores the importance of biodiversity in the ocean.”

The post Preventing home invasions means fighting side-by-side for coral-dwelling crabs and shrimp appeared first on Smithsonian Insider.

They observed that no plugs were ever formed during mating trials, but instead, females exposed to many males produced the amorphous plugs during the egg-laying process.

The post Female spiders produce mating plugs to prevent unwanted sex from males appeared first on Smithsonian Insider.

A new study by Florida State University and Smithsonian Institution biologists shows that bleaching events brought on by rising sea temperatures are having a detrimental […]

The post Study: Bleaching events impair long-term coral reproduction appeared first on Smithsonian Insider.

Most people think of black holes as giant vacuum cleaners sucking in everything that gets too close. But the supermassive black holes at the centers […]

The post Event Horizon Telescope Reveals Magnetic Fields at Milky Way’s Central Black Hole appeared first on Smithsonian Insider.

With over 138 million collection objects, 2.1 million library volumes, and 137,000 cubic feet of archives, the stories of how our collections have made their […]

The post Seventeen Objects for 170 Years (Happy Birthday to us!) appeared first on Smithsonian Insider.

Liza Botros MD., Manon C. A. Pronk PhD., Jenny Juschten MD., John Liddle, Sofia K. S. H. Morsing, Jaap D. van Buul PhD., Robert H. Bates, Pieter R. Tuinman MD. PhD., Jan S. M. van Bezu, Stephan Huveneers PhD., Harm Jan Bogaard MD. PhD., Victor W. M. van Hinsbergh PhD., Peter L. Hordijk PhD., and Jurjan Aman MD. PhD.

Aims: Endothelial barrier dysfunction leads to edema and vascular leak, carrying high morbidity and mortality. Previously, Abl kinase inhibition was shown to protect against vascular leak. Using the distinct inhibitory profiles of clinically available Abl kinase inhibitors, we aimed to provide a mechanistic basis for novel treatment strategies against vascular leakage syndromes.

Methods & Results: Bosutinib most potently protected against inflammation-induced endothelial barrier disruption. In vivo, bosutinib prevented LPS-induced alveolar protein extravasation in an acute lung injury mice model. Mechanistically, Mitogen-activated Protein 4 Kinase 4 (MAP4K4) was identified as important novel mediator of endothelial permeability, which signals via ezrin, radixin and moesin proteins to increase turnover of integrin-based focal adhesions. The combined inhibition of MAP4K4 and Arg by bosutinib preserved adherens junction integrity and reduced turnover of focal adhesions, which synergistically act to stabilize the endothelial barrier during inflammation.

Conclusion: MAP4K4 was identified as important regulator of endothelial barrier integrity, increasing focal adhesion turnover and disruption of cell-cell junctions during inflammation. Inhibiting both Arg and MAP4K4, the clinically available drug bosutinib may form a viable strategy against vascular leakage syndromes.

George Smith, a marine biologist at the Smithsonian Environmental Research Center, explains his work of finding ways to prevent invasive species from being released in Baltimore Harbor in the ballast water of large ships.

The post Preventing ballast-water invasions of alien species appeared first on Smithsonian Insider.

Nearly 60 million years ago rainforests prospered at temperatures that were 3-5 degrees higher and at atmospheric carbon dioxide levels 2.5 times today’s levels.

The post Plant diversity in tropical forests increased during ancient global warming event appeared first on Smithsonian Insider.

The new edition of the Fraud Prevention and Online Authentication Report 2019/2020 offers an overview of the latest challenges, innovations, and perspectives in the fraud landscape.

The GDC Compliance Advisory Board (CAB) provides insight into how to interpret the Strong Consumer Authentication (SCA) mandate described in PSD 2 without jeopardizing data privacy concerns protected by GDPR. 

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A new study shows that graphene sheets can block the signals mosquitoes use to identify a blood meal, potentially enabling a new chemical-free approach to mosquito bite prevention. Researchers showed that multilayer graphene can provide a twofold defense against mosquito bites. The ultra-thin yet strong material acts as a barrier that mosquitoes are unable to bite through. At the same time, experiments showed that graphene also blocks chemical signals mosquitoes use to sense that a blood meal is near, blunting their urge to bite in the first place. The findings suggest that clothing with a graphene lining could be an effective mosquito barrier.

Image credit: Hurt Lab/Brown University

Reducing one of the nations leading causes of death and injury – medical errors – will require rigorous changes throughout the health care system, including mandatory reporting requirements.

Insufficient evidence exists to support claims that taking megadoses of dietary antioxidants, such as selenium and vitamins C and E, or carotenoids, including beta-carotene, can prevent chronic diseases, says the latest report on Dietary Reference Intakes (DRIs) from the Institute of Medicine of the National Academies.

Scientific evidence links mold and other factors related to damp conditions in homes and buildings to asthma symptoms in some people with the chronic disorder, as well as to coughing, wheezing, and upper respiratory tract symptoms in otherwise healthy people, says a new report from the Institute of Medicine of the National Academies.

The high rate of premature births in the United States constitutes a public health concern that costs society at least $26 billion a year, according to a new report from the Institute of Medicine of the National Academies.

Although most people who receive and manage Social Security benefits on behalf of other individuals perform their duties well.

The numerous technical and operational breakdowns that contributed to the Deepwater Horizon oil rig explosion and spill from the Macondo well in the Gulf of Mexico suggest the lack of a suitable approach for managing the inherent risks.

Every year, approximately 100 million* adult Americans experience chronic pain, a condition that costs the nation between $560 billion and $635 billion annually, says a new report from the Institute of Medicine.