Gulshan Grover spoke at length about the demise of Irrfan Khan and Rishi Kapoor and its personal impact

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ISLAMABAD: Senate Chairman Muhammad Sadiq Sanjrani Friday condoled the passing away of the mother of Senator Faisal Javed, who is also chairman of the Senate Standing Committee on Information and...

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The stuntwoman died while filming a scene for an actress

“His ultimate passion was for good governance and his advocacy was to help save the environment. He was a highly principled man who sought refuge in his faith.”

The post Dumaguete mourns death of broadcaster 2 days after World Press Freedom Day appeared first on Bulatlat.

The death of a 5-year-old New York boy is challenging assumptions that children are less susceptible to COVID-19 complications, Gov.

Truth can be a casualty when President Donald Trump talks about deaths from the coronavirus in the United States.

ISLAMABAD: At least 274,625 people have died of the novel coronavirus since the epidemic surfaced in China late last year, according to international media reports.There have been more than 3,984,488 officially recorded cases spanning 195 countries and territories. The United States is the...

Few images conjure the 1930s Depression like people standing in soup lines while farmers dump food they can't sell. That is a tragedy Southeast Asia is fighting to avoid, though it is starting to happen in pockets around the world in the midst of COVID-19. Supply chain disruptions, driven by the pan...

Rawalpindi : It was really a horrible experience to bury a confirmed patient of COVID-19, the disease caused by 2019 novel coronavirus as it was painful for the family members including sons who were unable to attend the funeral that was managed in a sense as a crime was committed, at least the...

Lebanon confirms one new coronavirus death, 12 more infections

Lebanon registered one new death due to coronavirus Friday, and 12 new infections, raising the total number of registered cases to 796.

"Nigeria is a secular state and freedom of speech is one of the fundamental characteristics of a modern democratic state. Criticizing a religion is not a criminal offence."

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week. This report produced by Jillian Kitchener.

Dozens of people have died in Indonesia and Mozambique as a result of storms and flooding, possibly driven by climate change

The number of deaths from the coronavirus in Mexico's best-known border city, Tijuana, has soared and the COVID-19 mortality rate is twice the national average, the health ministry says, after medical staff quickly fell ill as the outbreak rampaged through hospital wards.

Pandemics of the past can teach us about the current one, says John Troyer, who studies how we use technology to alter the experience of death

U.S. deaths from the novel coronavirus topped 60,000 on Wednesday and the outbreak will soon be deadlier than any flu season since 1967, according to a Reuters tally.

A unique dodo specimen kept under lock and key in Oxford may have what it takes to resurrect the iconic species... but can we solve its grisly murder?

VIc Reynolds, director of the Georgia Bureau of Investigation, told reporters on Friday that there is "sufficient probable cause" to charge Gregory and Travis McMichaels with felony murder and aggravated assault in February's shooting death of an unarmed black man.

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week. This report produced by Jillian Kitchener.

Title: Bioartificial Kidney Cuts Death Risk, Improves Outcomes
Category: Health News
Created: 5/1/2008 2:00:00 AM
Last Editorial Review: 5/1/2008 12:00:00 AM

Title: Rates of Premature Adult Death Declining Worldwide
Category: Health News
Created: 4/30/2010 8:10:00 AM
Last Editorial Review: 4/30/2010 12:00:00 AM

Title: Low Testosterone Raises Heart Death Rates in Impotent Men
Category: Health News
Created: 4/29/2010 2:10:00 PM
Last Editorial Review: 4/30/2010 12:00:00 AM

Title: Death Rate Declines for Americans With Hypertension
Category: Health News
Created: 4/26/2011 1:54:00 PM
Last Editorial Review: 4/27/2011 12:00:00 AM

Title: Heart Test Spots Sudden Death Risk in Young Athletes
Category: Health News
Created: 4/27/2012 2:05:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Implants May Delay Breast Cancer Detection, Raise Death Risk
Category: Health News
Created: 4/30/2013 8:35:00 PM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: Poor Fitness in Middle Age Tied to Early Death Risk in Study
Category: Health News
Created: 4/30/2014 9:35:00 AM
Last Editorial Review: 4/30/2014 12:00:00 AM

Title: Wider Use of Naloxone Could Cut Deaths From Drug Overdoses: CDC
Category: Health News
Created: 4/24/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM

Title: COPD Tied to Raised Risk for Sudden Cardiac Death
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

Title: Breast-Feeding May Lower Breast Cancer Recurrence, Death: Study
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

Title: Blood Type May Play Role in Death Risk After Trauma
Category: Health News
Created: 5/2/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: Fentanyl Now Drives Drug Overdose Deaths in U.S.
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: First Death Reported in E. Coli Outbreak Tied to Romaine Lettuce
Category: Health News
Created: 5/2/2018 12:00:00 AM
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Title: U.S. Motorcycle Deaths Dropped 6 Percent Last Year
Category: Health News
Created: 5/4/2018 12:00:00 AM
Last Editorial Review: 5/4/2018 12:00:00 AM

Title: Nearly 700,000 Infant Rocking Sleepers Recalled Due to Infant Deaths
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM

Title: As Sense of Smell Fades, Does Death Come Closer?
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM

Title: AHA News: A Father's Death at 37 Reveals a Hidden History of Cholesterol
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM

Title: U.S. Teen Opioid Deaths Soaring
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM

Title: Not Just Opioids: Deaths Tied to Cocaine, Meth Are Soaring, Too
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Title: AHA News: Traumatic Childhood Increases Lifelong Risk for Heart Disease, Early Death
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/29/2020 12:00:00 AM

Title: COVID-19 Pandemic May Lead to 75,000 'Deaths of Despair'
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Title: Religion Helps Protect Against 'Deaths of Despair': Study
Category: Health News
Created: 5/6/2020 12:00:00 AM
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Title: U.S. Deaths From High Blood Pressure Soar, Especially in the South: Study
Category: Health News
Created: 3/23/2020 12:00:00 AM
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Title: Many Car Crash Deaths Involve Alcohol Levels Below Legal Limit: Study
Category: Health News
Created: 3/16/2020 12:00:00 AM
Last Editorial Review: 3/17/2020 12:00:00 AM

TNF-related apoptosis-inducing ligand (TRAIL) and an agonistic antibody against the death-inducing TRAIL receptor 5, DR5, are thought to selectively induce tumor cell death and therefore, have gained attention as potential therapeutics currently under investigation in several clinical trials. However, some tumor cells are resistant to TRAIL/DR5–induced cell death, even though they express DR5. Previously, we reported that DR5 is transported into the nucleus by importin β1, and knockdown of importin β1 upregulates cell surface expression of DR5 resulting in increased TRAIL sensitivity in vitro. Here, we examined the impact of importin β1 knockdown on agonistic anti-human DR5 (hDR5) antibody therapy. Drug-inducible importin β1 knockdown sensitizes HeLa cells to TRAIL-induced cell death in vitro, and exerts an antitumor effect when combined with agonistic anti-hDR5 antibody administration in vivo. Therapeutic importin β1 knockdown, administered via the atelocollagen delivery system, as well as treatment with the importin β inhibitor, importazole, induced regression and/or eradication of two human TRAIL-resistant tumor cells when combined with agonistic anti-hDR5 antibody treatment. Thus, these findings suggest that the inhibition of importin β1 would be useful to improve the therapeutic effects of agonistic anti-hDR5 antibody against TRAIL-resistant cancers.

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.