TROY, Mich., Nov. 12, 2024 — Altair, a global leader in computational intelligence, has entered into collaboration agreement with the European Space Agency (ESA) through the ESA Partnership Initiative for […]

The post Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation appeared first on HPCwire.

Distinguished educators are assigned by the state to help low-scoring districts in Pennsylvania. Part of Education Week's special annual report, Leading for Learning.

The lawsuit, filed in 2014, alleges that the state was severely underfunding schools, forcing school districts to lean heavily on property taxes, which especially disadvantages students in property-poor areas.

Pennsylvania Gov. Tom Wolf, a Democrat, has become increasingly critical of charter schools this year, and his new proposals for charters would change how they operate and how they are funded.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

Building science lessons around phenomena that students know equally and can see in their own lives is making the subject more relevant and interesting.

U.S. Secretary of Education Betsy DeVos is not famous for pressuring states into desired outcomes, but did put at least two states' Title I funding on "high-risk" status last year.

Building science lessons around phenomena that students know equally and can see in their own lives is making the subject more relevant and interesting.

The Vancouver Canucks take on the Calgary Flames on Tuesday night.

The Calgary Flames' fifth game in eight nights and three time zones was a tough one they need to learn from

The principal of an elementary school in Washington, DC, describes how she and her staff broadened the focus of the school towards broader, more holistic goals for students.

It was Louisville women's basketball vs UT Martin at the Kathleen and Tom Elam Center. See score updates and highlights from the road clash.

Large-scale genome-wide association studies (GWASs) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine the effects of PDE4B variation on phenotypes with translational relevance to psychiatric disorders, we focused on PDE4B missense variant M220T, which is present in the human genome as rare coding variant rs775201287. When expressed in HEK-293 cells, PDE4B1-M220T exhibited an attenuated response to a forskolin-elicited increase in the intracellular cAMP concentration. In behavioral tests, homozygous Pde4b^M220T male mice with a C57BL/6JJcl background exhibited increased reactivity to novel environments, startle hyperreactivity, prepulse inhibition deficits, altered cued fear conditioning, and enhanced spatial memory, accompanied by an increase in cAMP signaling pathway-regulated expression of BDNF in the hippocampus. In response to a traumatic event (10 tone–shock pairings), neuronal activity was decreased in the cortex but enhanced in the amygdala and hippocampus of Pde4b^M220T mice. At 24 h post-trauma, Pde4b^M220T mice exhibited increased startle hyperreactivity and decreased plasma corticosterone levels, similar to phenotypes exhibited by PTSD patients. Trauma-exposed Pde4b^M220T mice also exhibited a slower decay in freezing at 15 and 30 d post-trauma, demonstrating enhanced persistence of traumatic memories, similar to that exhibited by PTSD patients. These findings provide substantive mouse model evidence linking PDE4B variation to PTSD-relevant phenotypes and thus highlight how genetic variation of PDE4B may contribute to PTSD risk.

Today we celebrate the cultural heritage, health benefits and economic importance of tea.

The European Inland Fisheries and Aquaculture Advisory Commission (EIFAAC) is dedicated to the sustainable development and responsible management of European inland fisheries and aquaculture. In line with the [...]

After his start capturing the horrors of the Civil War for Mathew Brady's studio, 19th century photographer Timothy O'Sullivan uncovered the beauty of the great expanses of the American west

A blockbuster exhibition in London examines the Dutch Post-Impressionist's creative output between 1888 and 1890, which was one of the most productive periods of his career

Researchers say that the iconic painting's swirling sky lines up with Kolmogorov's theory of turbulence, suggesting that the artist was a careful observer of the world around him

Two members of Just Stop Oil staged the original demonstration in late 2022. Group members say the harsh penalties will not deter their efforts

A man is expected to plead guilty for trafficking the print, which reappeared at a Dallas auction house shortly after it went missing from a California residence

At a new park in Bosnia and Herzegovina, two dozen gardeners have spent years replicating the Dutch artist's masterpiece using the land as their canvas

The HMS "Trooper" likely sank after hitting an underwater German mine off the coast of an island in the Aegean Sea in 1943

Shallaway Youth Choir is bringing a program of music to the Basilica in downtown St. John’s on Remembrance Day. Artistic director Kellie Walsh says the choir will sing about such topics as the Unknown Soldier and schoolchildren who care for Newfoundland graves in London. Where Once They Stood will be performed at 2 p.m. and 7 p.m. on Monday.

The bronze wreath immortalized the moment when the members of the Honor Guard removed their hats and placed them on the president's grave during his burial

The British explorer named dozens of geographical features and sites in the region, ignoring the traditions of the Indigenous peoples who’d lived there for millennia

LAFC opened the series with a narrow 2-1 victory in California and Vancouver replied with a decisive 3-0 win at home to set up a do-or-die matchup on Friday, but they failed to overcome L.A. and suffered a 1-0 defeat.

The Winnipeg Blue Bombers will face the Toronto Argonauts in their fifth straight Grey Cup appearance. The Bombers advanced to the CFL title game after disposing of the Saskatchewan Roughriders 38-22 in the West final Saturday night in Winnipeg.

A blaze at an apartment building has displaced residents and led to two injuries, almost two years after a fire at the same building displaced dozens.

Several firearms, body armour, diamonds and fentanyl shaped like dog treats were among the items seized in a recent bust, say Metro Vancouver Transit Police.

Vanessa James and Eric Radford withdrew from the pairs competition at the Canadian figure skating championships before Saturday's free program in Ottawa.

The Edmonton Oilers may have found the break they were looking for. After struggling through the first month of the NHL season, the Oilers trounced the Vancouver Canucks 7-3 on Saturday.

With 3D CAD, Company Reduces Design Cycle from Three Weeks to Three or Four Days

New Licensing, Support Programs For Certification Accompany Software Upgrades

3D CAD software helps U.K. retail display company compete on creativity, time to market

Teacher: 'We're growing engineers here'

See how to use CVOL to navigate volatile markets with its unique methodology and comprehensive suite of metrics.

Lisa Davis, director of the Pennsylvania Office of Rural Health and outreach associate professor of health policy and administration at Penn State, was presented with the 2024 Calico Leadership Award and the Rural Sociological Society Distinguished Service to Rural Life Award.

Advanced configuration parameters control how your Mac stores cached content. Here's how to change the settings.

St. Patrick's Day celebrates the patron saint of Ireland known for bringing Christianity to Ireland. Hundreds of years later, OM Ireland brings the same message.