Apart from Akshay, his wife Twinkle Khanna also shared a photo of herself lying on the grass with her veteran actor mother Dimple Kapadia and daughter Nitara.

Princeton University-based researchers have found that machine-learning programs can acquire the cultural biases embedded in the patterns of wording, from a mere preference for flowers over insects, to discriminatory views on race and gender.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

This volume, by a former senior counsel to the 9/11 Commission, argues that the U.S. approach to immigration and border security is off-kilter and not keeping pace with the scope and complexity of people’s movement around the world, nor with expectations regarding freedom of movement.

A new imaging technique may give researchers fresh insights into brain development, function, and disease

The human brain is often said to be the most complex object in the known universe, and there’s good reason to believe that it is. That lump of jelly inside your head contains at least 80 billion nerve cells, or neurons, and even more of the non-neuronal cells called glia. Between them, they form hundreds of trillions of precise synaptic connections; but they all have moveable parts, and these connections can change. Neurons can extend and retract their delicate fibres; some types of glial cells can crawl through the brain; and neurons and glia routinely work together to create new connections and eliminate old ones.

These processes begin before we are born, and occur until we die, making the brain a highly dynamic organ that undergoes continuous change throughout life. At any given moment, many millions of them are being modified in one way or another, to reshape the brain’s circuitry in response to our daily experiences. Researchers at Yale University have now developed an imaging technique that enables them to visualise the density of synapses in the living human brain, and offers a promising new way of studying how the organ develops and functions, and also how it deteriorates in various neurological and psychiatric conditions.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

OM Philippines send staff to assess the earthquake damages in Surigao City and provide needed disaster relief training.

In the summer of 2013, a South African member of OM Czech Republic returned to her home country to lead anti-trafficking training and awareness seminars.

Erin Brown and William McCarter were Penn State’s 2020 nominees for the Truman Scholarship, which rewards students for commitments to public service.

Human trafficking grows like a cancer in Ecuador. Boris and Fernanda Salinas are destined to fight it.

There is nothing further the government can do, Kumar said, adding that there is liquidity, partial credit enhancement and interest rates have moderated. Asked about the progress made in the resolution of stressed NBFC Dewan Housing Finance (DHFL), Kumar said: “That you should ask the company.”

Coronavirus COVID 19 vaccine news, latest update, human trials: Sanofi's Pasteur division has an established track record in influenza vaccines. Last month it had teamed with its British rival GSK to produce a vaccine candidate hoping that it will be ready in 2021.

In another release, the ministry said the Institute of Genomics and Integrative Biology (CSIR-IGIB) and Tata Sons have signed a licensing agreement for a paper strip-based test called Feluda for Covid 19's rapid diagnosis.

Kumar said as long as the lockdown continues, economic activity will remain tepid, but "demand should be there in the economy" and the question of logistics can be taken care of. The SBI chairman also said complete easing of the curbs is still some time away.

A recent incident where a Hong Kong citizen forced his maid to travel abroad with him has opened up a wide discussion on the issue of human trafficking. The outcome of the incident has seen a rather curious scenario develop, wherein Hong Kong holidaymakers…

1. Human urine could help make concrete on moon, says European Space Agency  Times Now
2. Human urine could be used to make concrete on moon in the future  Economic Times
3. Ever thought of urine for lunar concrete?  NEWS9 live
4. You Can Now Buy a Piece of the Moon for $2.5 Million  Beebom
5. European Space Agency: Human urine could help make concrete on Moon  The New Indian Express
6. View Full coverage on Google News

Who used to be known as Dileep Kumar, and is now married to Saira Banu?

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Trillions of dollars will be invested in renewable energy over the next 25 years, driving some of the most profound changes yet in how humans get their electricity. That's according to a new forecast by Bloomberg New Energy Finance that plots out global power markets to 2040. 

Trillions of dollars will be invested in renewable energy over the next 25 years, driving some of the most profound changes yet in how humans get their electricity. That's according to a new forecast by Bloomberg New Energy Finance that plots out global power markets to 2040. 

Realisation of security by mortgagees is a hot topic in current economic circumstances, and Horsham Properties Group Ltd v Clark is a case that underlines that mortgagees' powers can sometimes appear draconian. In this case, the mortgagee appointed...

Bishop of Lagos Diocese (Anglican Communion), Rt. Rev. Humphrey Olumakaiye, in this interview, speaks on the coronavirus crisis raging across the world, war against corruption and the security challenge facing Nigeria among other issues. corrupt leaders

The post Some of our corrupt leaders are pastors, vehemently wicked, demonic – Bishop Olumakaiye appeared first on Vanguard News.

Wondering whether the collaboration with the state by spiritual leaders might not be a betrayed of faith in the power of God to reign over the virus

Islamabad : Reduced human activities outside due to COVID-19 lockdown has not only contributed to the revival of nature through lowering pollution level and limiting human interference but also provided an opportunity to the migratory birds to fly freely without any threat of poaching.World...

LAHORE: Chairman of the Pakistan Cricket Board (PCB) Independent Disciplinary Panel retired Justice Fazal-e-Miran Chauhan has said Umar Akmal ‘is not prepared to show remorse and seek apology’ in his detailed judgement in the spot-fixing case that saw the Pakistan batsman slapped with a three-year suspension from all forms of the game.

Umar was provisionally suspended hours before he was to appear for Quetta Gladiators in the opening match of the Pakistan Super League on Feb 20 and was charged with two breaches of Article 2.4.4 of the PCB Anti-Corruption Code on March 17. On April 9, the PCB referred the matter to the chairman of the Independent Disciplinary Committee after the batsman opted not to request for a hearing before the Anti-Corruption Tribunal.

“It appears that he [Umar Akmal] is not prepared to show remorse and seek apology, make admission that he failed to fulfill his responsibility under Anti-Corruption Code, Article 2.4.4, rather he tried to take refuge under the pretext that in the past whenever any such approaches were made, the matter was reported by him,” said Justice Chauhan in his remarks.

“As far as Charge No.1 is concerned, I do not see any circumstances to mitigate the nature of offence, particularly, when the participant [Umar Akmal] has not cooperated with the PCB Vigilance and Security Department and the investigating team.

“In view of the admission of the participant that he failed to disclose to PCB Vigilance and Anti-Corruption Department, the details of the approaches and invitations extended to him without unnecessary delay.

The charge as framed is proved and the participant has rendered himself liable to be punished for breach of Article 2.4.4.

“Charge No.2, breach of Article 2.4.4 of the Code by failing to disclose to the PCB Vigilance and Anti-Corruption Department of the PCB, full details of the approaches and invitations received by you [Umar Akmal] to engage in corrupt conduct under the Code in respect of matches in PSL 2020.

“It is also admitted by him [Umar Akmal] that he failed to report the approaches and invitation to the PCB Vigilance and Anti-Corruption Depart­ment, as required by the PCB Code, Article 2.4.4. In view of the above charge as framed, stood proven and participant has rendered himself to be punished under Article 6.2 of the PCB Code.”

Umar’s elder brother and Pakistan Test discard Kamran had already announced that his brother would file an appeal against the punishment. Umar has to file the appeal within 14 days as the PCB then will appoint an independent adjudicator to hear that.

Published in Dawn, May 10th, 2020

Mercedes' Michael Schumacher felt he could have qualified higher than eighth at the Brazilian Grand Prix, but lost tyre temperature making way for traffic ahead of his flying lap

Michael Schumacher said that he let team-mate Nico Rosberg past because he was in a better position to challenge Jenson Button ahea

Mercedes boss Ross Brawn admitted that a gamble in trying to use Michael Schumacher's softer tyres for too long cost his team more points the Canadian Grand Prix

Michael Schumacher was not penalised for his part in colliding with Felipe Massa while racing for position towards the end of the Canadian Grand Prix

Mercedes CEO Nick Fry has no concerns about the performance of Michael Schumacher at the season-opening Bahrain Grand Prix

Two races into his much-publicised comeback and Michael Schumacher is already feeling the heat after finishing tenth out of 14 finishers at the Australian Grand Prix.

Fernando Alonso has revealed that Michael Schumacher suspected he deliberately held up the German during qualifying in Melbourne

Michael Schumacher said that sixth place was the best he could have achieved after achieving his best result of the season to date

Michael Schumacher and Ross Brawn said they were confident there would be no penalty after Schumacher's last-lap overtake of Fernando Alonso

Mercedes will appeal the stewards' decision to penalise Michael Schumacher for overtaking Fernando Alonso at the final corner of the Monaco Grand Prix

Mercedes has not decided whether to proceed with its appeal against the decision of the stewards at the Monaco Grand Prix

My name is Kuma. I live in Manhattan. Don't worry, I get a lot of exercise and I make sure my parents keep the home at a balmy 60 degrees! My sister, Chloe, and I wrestle all the time. I also have a girlfriend, Riley, that I snuggle, kiss, and play with. I'm looking forward to winter to play in the snow and pull my sister in a sled. Some of my favorite things are peanut butter, ice cubes, howling, and leaves blowing in the wind.

07/11/12 - the OECD and the International Coordinating Committee of National Human Rights Institutions concluded a Memorandum of Understanding to promote respect by multinational enterprises of the new human rights chapter of the OECD Guidelines for Multinational Enterprises and the UN Guiding Principles for Business and Human Rights upon which the OECD Guidelines are based.

70 years after the Universal Declaration of Human Rights, our recognition of the “inherent dignity of all members of the human family as the foundation of freedom, justice and peace in the world” has further strengthened the alignment between responsible business conduct and human rights.

The truth is that human rights are not sustainable, or in some places even possible, in today’s networked society unless public and private actors take responsibility. Governments and corporations alike must commit to design, manage, and govern technologies in a manner that is consistent with international human rights standards.

This report summarizes major policy and practical issues discussed by international and Asian experts at the 4th Roundtable on Labour Migration (ADBI/OECD/ILO, Tokyo, 27-28 January 2014). The report outlines the trends in labor migration within Asia and between Asia and some OECD countries. It reviews the links between migration and human capital development and presents the impact of migration on family members "left behind".

The current humanitarian crisis is unprecedented with an appalling and unacceptable human cost. This issue of Migration Policy Debates looks at the most recent developments in the humanitarian migration crisis and what makes this crisis different from previous ones.

This edition of Migration Policy Debates scrutinises the factors that facilitate human trafficking, as well as the smuggling routes to OECD countries. It synthesises available evidence and reviews existing policy tools for tackling such crime.

OECD recommendations for the integration of Humanitarian migrants

Natural resources provide essential raw materials and other commodities, and are an important source of income and jobs. They also support the provision of ecosystem services necessary to develop human and social capital.

Economic and social reforms over the past two decades have enabled Peru to significantly improve growth and well-being while raising incomes and reducing poverty.

The global economic crisis has had a profound impact on people’s well-being, reaching far beyond the loss of jobs and income, and affecting citizens’ satisfaction with their lives and their trust in governments, according to a new OECD report.