The Arizona Department of Transportation will open Highway 67 to the North Rim of Grand Canyon National Park on Thursday, May 15 by 8:00 am; and Grand Canyon Lodge North Rim, a Forever Resorts property, and Grand Canyon Trail Rides will commence their 2014 seasonal operations. https://www.nps.gov/grca/learn/news/grand-canyons-north-rim-to-open-may-15-for-the-2014-summer-season.htm

The staff on the North Rim of Grand Canyon National Park will begin to shut down most visitor services and facilities on Thursday, October 16; the North Rim will remain open to visitors through December 1 or until snow closes Highway 67 leading into the park. https://www.nps.gov/grca/learn/news/2014-north-rim-seasonal.htm

Grand Canyon National Park's North Rim will open Friday, May 15 for the 2015 summer season. All NPS operations will be available by 8 am that day and Grand Canyon Lodge North Rim and Canyon Trail Rides will also commence their operations. https://www.nps.gov/grca/learn/news/north-rim-to-open-may-15-2015.htm

North Rim operations will begin seasonal shut-down of most visitor services on Friday, October 16. https://www.nps.gov/grca/learn/news/north-rim-seasonal-closure.htm

The Arizona Department of Transportation has closed State Route 67 between Jacob Lake and the North Rim of Grand Canyon National Park. The North Rim is now closed to vehicle traffic for the winter. https://www.nps.gov/grca/learn/news/north-rim-winter-closure.htm

The gate at the entrance to North Rim of Grand Canyon National Park will open on Sunday, May 15 at 7:30 am. https://www.nps.gov/grca/learn/news/north-rim-open-2016.htm

North Rim operations will begin seasonal shut-down of most visitor services on Saturday, October 15. https://www.nps.gov/grca/learn/news/season-close-north-rim.htm

North Rim operations will begin seasonal shut-down of most visitor services on Sunday, October 15. https://www.nps.gov/grca/learn/news/north-rim-to-close.htm

The gate at the entrance to the North Rim of Grand Canyon National Park will open on Tuesday, May 15, 2018 at 7:30 am. https://www.nps.gov/grca/learn/news/north-rim-2018-season.htm

North Rim operations will begin seasonal changes on the morning of October 16, 2018. The North Rim transitions to reduced services with the Visitor Center, gift shop, campground and entrance station remaining open for visitor use. The Grand Canyon Lodge, food services, Canyon Trail Rides and park ranger programming will no longer be available. These operations will resume on May 15, 2019. https://www.nps.gov/grca/learn/news/grand-canyon-north-rim-operations-begin-seasonal-changes-oct-16-2018.htm

Following a series of breaks in the Transcanyon Waterline earlier this month, Grand Canyon National Park now has enough water in storage to scale back to Level 1 basic water conservation measures. https://www.nps.gov/grca/learn/news/level-1-water-conservation-seasonal-trail-water.htm

The gate at the entrance to the North Rim of Grand Canyon National Park will open on Wednesday, May 15 at 7:30 a.m. to mark the official opening of the North Rim for the 2019 season. https://www.nps.gov/grca/learn/news/north-rim-2019-season.htm

Grand Canyon National Park's summer season is set to begin in the next few weeks, plan ahead to make the most of your trip! https://www.nps.gov/grca/learn/news/visitation-tips.htm

Grand Canyon National Park would like to invite the public to the eighth annual season of "Echoes from the Canyon". This living history event will feature day time and evening programs August 16 –19th. https://www.nps.gov/grca/learn/news/echoes-from-the-canyon.htm

Grand Canyon National Park's North Rim will begin day use operations on Nov. 1, 2019. Visitors exploring the North Rim after Oct. 31 should plan to be self-sufficient, bringing enough food and water for their stay, as services will not be available. https://www.nps.gov/grca/learn/news/grand-canyon-n-r-to-begin-seasonal-day-use-operations.htm

Similarly to how sauna bathing has been linked to some surprising health benefits, this new study says that regularly taking hot baths is good for you too.

The post Taking Hot Baths Every Day is Linked to Lower Risk of Stroke or Heart Disease appeared first on Good News Network.

Kyoto University researchers said the vaccine for Alzheimer’s was effective and was also shown to have zero side effects observed in the mice.

The post New Alzheimer’s Nasal Spray Shown to Reduce Proteins Which Cause the Disease in Mice appeared first on Good News Network.

This new research has outlined yet another benefit to intermittent fasting—that may arise from the time you eat, rather than what you eat.

The post New Intermittent Fasting Program Shown to Suppress Cancer and Metabolic Disease in Mice and Humans appeared first on Good News Network.

Iceland's two whaling companies have cancelled hunting for a second straight year as demand drops and the COVID-19 pandemic poses difficulties.

The post Harpoons Are Silenced: Iceland’s Whaling Boats Spend Second-Straight Season Tied Up in Port appeared first on Good News Network.

Visibility in parts of southern Ontario, Canada, was severely affected as a snow squall blanketed areas of the province — including the town of Barrie — on May 9, reports said . A frost advisory notice was issued for the area by the Canadian government, warning that “near or below freezing temperatures” were expected through Wednesday, May 13. Reports said that the unseasonable snowfall can be attributed to a polar vortex sweeping over the region. Canadian astronaut Chris Hadfield posted a video of snow falling outside his Ontario home, saying, “It’s May 9. Cut it out.” This video, filmed by local resident Tom Eves, shows a snow squall in Barrie, north of Toronto. “Well what can you do but laugh,” wrote Eves on Twitter. Credit: Tom Eves via Storyful

Societies use biologically active chemicals as medicines and pesticides to protect human and agricultural health. But widespread use of synthetic compounds raises concerns about their safety, and resistance development in targeted pests.

Diameter growth is seasonal in Douglas-fir, the evergreen tree found in much of western Washington, Oregon, and northern California. Initiation and cessation of diameter growth are both triggered by environmental cues. The tree responds to these cues to improve its chances of growing under favorable conditions. As environmental conditions change, however, land managers want to know how warmer summers and falls may affect diameter growth in Douglas-fir.

In the mid-1990s, forest managers on the Malheur National Forest were concerned about their prescribed fire program. Although they have only a few weeks of acceptable conditions available in the spring and fall, they were worried that spring-season prescribed burning might be exacerbating black stain root disease and having negative effects on understory plants.

Mule deer populations in central Oregon are in decline, largely because of habitat loss. Several factors are likely contributors. Encroaching juniper and invasive cheatgrass are replacing deer forage with high nutritional value, such as bitterbrush and sagebrush. Fire suppression and reduced timber harvests mean fewer acres of early successional forest, which also offer forage opportunities. Human development, including homes and roads, is another factor. It is this one that scientists with the Pacific Northwest Research Station and their collaborators investigated in a recent study.

Jackie Pexton, who is part of the Macmillian Toon Angels, has raised over £52,000 to show her support for the charity that has been a lifeline for her

Premier League clubs will also hold a videoconference on Monday to discuss Project Restart

Statement Highlights: New developments in identifying and treating the increased risk of premature heart disease in children and teens with certain medical conditions associated with increased cardiovascular risk are discussed in a scientific statement from the American Heart Association. Obesity and severe obesity are now considered significant risk factors for an increased risk of cardiovascular disease in children and teens.

Statement Highlights: People living with HIV face a higher risk of developing diseases of the heart and blood vessels compared to people without the disease. Seventy-five percent of people living with HIV are over age 45 and face significant health challenges at earlier ages than people who don’t have HIV.

Research Highlights: People who reported work-related stress were more likely to be hospitalized for treatment of peripheral artery disease compared to those who did not report work-related stress. Work-related stress, or job strain, refers to...

Research Highlights: People who had the best heart health, defined as having healthy sleep in addition to meeting the AHA Life Simple 7, were less likely to have a diagnosis of a heart disease and were less likely to develop heart disease in the ...

Research Highlights: Black immigrants from Africa and from the Caribbean differ from U.S.-born blacks in rates of high blood pressure, diabetes, smoking and overweight/obesity. The research supports a more detailed look at black populations and the...

Research Highlights: Consuming more than half a tablespoon of olive oil daily was associated with a 15% lower risk of having any type of cardiovascular disease and a 21% lower risk of having coronary heart disease. Replacing one teaspoon of butter, ...

DALLAS and ARLINGTON, April 23, 2020 — As emerging science around COVID-19 highlights elevated danger for people with diabetes, heart disease and stroke[1], the American Heart Association and the American Diabetes Association urge people living with type...

DALLAS, May 4, 2020 — Tomorrow, on #GivingTuesdayNow, a global day of philanthropic action to address the COVID-19 pandemic, the American Heart Association – the leading global public health organization devoted to a world of longer healthier lives – is...

The Iowa high school softball season was supposed to start practice Monday. Instead, the coronavirus pandemic has everything delayed until June 1, or maybe longer. Or, perhaps, canceled. But since...

CEDAR RAPIDS — This was his alma mater, a place he had a ton of success at as a player. The future of the program is clearly bright. But Matt Lesan has a clear plan for his own future, which...

Seasonal Worker Programme and Pacific Labour Scheme workers can extend their stay for up to 12 months to work for approved employers as long as pastoral care and accommodation needs of workers are met to minimise health risks to visa holders and the community. Approved employers under the Seasonal Worker Programme and Pacific Labour Scheme […]

The post What can I do if I am on a working holiday or seasonal worker visa in the Coronavirus (COVID-19) crisis? appeared first on Visa Australia - Immigration Lawyers & Registered Migration Agents.

By David Suzuki David Suzuki Foundation The fossil fuel era must end, or it will spell humanity’s end. The threat isn’t just from pollution and accelerating climate change. Rapid, wasteful exploitation of these valuable resources has also led to a … Continue reading →

Recently, the outbreak of Coronavirus Disease 2019 (COVID-19) has spread rapidly across the world. Due to the large number of affected patients and heavy labor for doctors, computer-aided diagnosis with machine learning algorithm is urgently needed, and could largely reduce the efforts of clinicians and accelerate the diagnosis process. Chest computed tomography (CT) has been recognized as an informative tool for diagnosis of the disease. In this study, we propose to conduct the diagnosis of COVID-19 with a series of features extracted from CT images. To fully explore multiple features describing CT images from different views, a unified latent representation is learned which can completely encode information from different aspects of features and is endowed with promising class structure for separability. Specifically, the completeness is guaranteed with a group of backward neural networks (each for one type of features), while by using class labels the representation is enforced to be compact within COVID-19/community-acquired pneumonia (CAP) and also a large margin is guaranteed between different types of pneumonia. In this way, our model can well avoid overfitting compared to the case of directly projecting highdimensional features into classes. Extensive experimental results show that the proposed method outperforms all comparison methods, and rather stable performances are observed when varying the numbers of training data.

You'll be forgiven if, during the daily deluge of COVID-19-related updates, you didn't notice that some seriously great musicians recently booked shows in and around Spokane for later in the year.…

We've known that Hamilton was going to be part of the 2020-21 STCU Best of Broadway season for a while, but now we finally know the exact dates, as well as the rest of the featured shows for the season. Granted, the whole world has changed since WestCoast Entertainment announced Hamilton was coming to town back when they announced their 2019-20 season — a season that's been roiled, along with the rest of our lives, by the coronavirus pandemic.…

A catastrophic loss in biodiversity, reckless destruction of wildland and warming temperatures have allowed disease to explode. Ignoring the connection between climate change and pandemics would be “dangerous delusion,” one scientist said. The scientists who study how diseases emerge in a changing environment knew this moment was coming.…

It’s March. The regular season is now in the rearview mirror.…

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H;R2 is ONO2, CH2ONO2, Cn'H2n'+1OH, Cn'H2n'+1OH, CH2CH2CH3 or H; andR3 is ONO2, CH2ONO2, Cn'″H2n″+1OH, Cn″H2n″+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n' is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n'+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.

A pharmaceutical composition comprising lectins is anti-tumorigenic and anti-viral, bacterial or protozoan. The composition, termed BiOmune is also useful for imaging, diagnosis and therapy of cancer.

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N4, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula where R1 is H, R3, R4, 2'-deoxyribosyl, R4 is alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then R5 is no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then R5 and R6 are independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

Provided are methods for the treatment of a rheumatic disease, such as rheumatoid arthritis, ankylosating spondylitis and/or polymyalgia rheumatic, by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks. Also provided are methods for the treatment of osteoarthritis by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks.

It is reported herein that certain muscle diseases and conditions, including forms of muscular dystrophy, are characterized by impaired insulin-dependent signaling in the muscle tissue, in essence, a form of insulin resistance. The present disclosure relates to therapeutic agents, compositions and methods for treating a muscle disease or condition characterized by impaired insulin-dependent signaling by targeting components of the defective insulin signaling pathway. The disease or condition may be treated by administering a therapeutic agent that activates the insulin signaling pathway, in particular, therapeutic agents that act post-insulin receptor to modulate intracellular effector molecules. An exemplary modulator is metformin. Metformin may be administered alone or may be coadministered with another therapeutic agent for treating the muscle disease or condition, such as a corticosteroid.