In this article we survey key considerations when making a lens selection. Of course, your lensing professional will be happy to advise – but they’ll ask you some of these questions anyway, so it’s helpful to make notes relative to your planned application.
Manufacturing Day gives manufacturers the opportunity to address the skills gaps they face, connect with future generations, take charge of the public image of manufacturing and ensure the ongoing prosperity of the industry as a whole
This show hosted the highest number of exhibiting companies ever (2,407). After move in, the building was 76 million pounds heavier.
Manufacturers open their doors and minds to show students, teachers and parents the truths about modern manufacturing.
Fluke Corp. introduces the Fluke 805 FC Vibration Meter, a portable multifunction vibration screening tool that provides quantifiable information on the bearing and overall health of motors and other rotating equipment, and shares that data in real time via Fluke Connect.
Robotic inspection path planning can be tedious, but ultrasonic testing path programming must be fully automated and user-friendly.
The aerospace industry constantly seeks new technologies for a competitive edge and enhanced capability. AI and maching learning in additive manufacturing offer significant value for meeting industry needs.
We discuss the basics of calibration, its importance, the different methods used for calibration, and the latest developments.
Ensuring high quality in medical device manufacturing requires operational excellence, which optimizes efficiency and enhances product quality and compliance. Let’s explore some of the key elements and best practices.
The NextGen Global Advocacy Committee addresses the needs of young professionals under 40 or with less than four years of experience through a framework of understanding, engaging, and preparing for leadership. Recognizing that Millennials and Gen Z value inclusivity, networking, and technology integration is crucial for organizations like ASQ to meet these evolving needs and maintain a competitive edge.
Calibration is essential for maintaining quality and safety in industries like pharmaceuticals, food and beverage, and chemicals. The future looks to digital certificates and AI technology to make calibration processes faster and more efficient. This article discusses how AI is set to transform calibration.
Three Missouri higher education institutions are working together to modernize the state’s manufacturing industry and develop its workforce, with $9.1 million in Missouri’s fiscal year 2025 budget being awarded to support their efforts.
Equipment failure disrupts routine calibrations, making it hard to verify specifications. Consider the impact on products since the last calibration and document assumptions about equipment tolerance.
Today, Maintenance, Repair, and Overhaul (MRO) operations are a significant sub-industry within manufacturing, valued at $656 billion and projected to exceed $800 billion by 2032. MRO involves maintaining machinery, equipment, and systems in optimal condition through repairs and overhauls to extend their operational life.
Cable tension must be maintained precisely across various industries, and cable tensiometers are crucial for this. However, calibration of these instruments often faces issues due to communication between calibration labs and end users, leading to doubts about equipment functionality.
This article is an adaptation of my popular presentation, “Beyond the Sticker & the Cert (Ensuring Better Measurements & Reducing Risk).” Product manufacturers, testing labs, and calibration labs often overlook the importance of thoroughly reviewing calibration certificates, leading to potential measurement inaccuracies and increased risks.
Liberation Giclee On Canvas by Arian is a(n) Limited Edition. The Edition is Limited to Limited Edition of 45 pcs
Desperation LIMITED EDITION CANVAS by Christina Penescu is a(n) Limited Edition. The Edition is Limited to 75 pcs
This blog was originally prepared by CBR communications and programs coordinator Kaitlyn Chuong and former Canadian Blood Services knowledge broker Dr. Travis Sztainert, with edits provided by Abby Wolfe.
After more than 20 years, the Centre for Blood Research (CBR) and Canadian Blood Services are proud to share that they have renewed their collaboration agreement which supports education, training and knowledge mobilization for the next generation of trainees and researchers in blood science and transfusion at CBR.
The collaboration agreement which is administered by Innovation and Portfolio Management at Canadian Blood Services has recently been extended for three more years to 2027. This agreement formalizes the next iteration of this long-standing partnership and is the result of continued commitment from both organizations to improve blood research.
This partnership emerged in response to recommendations made following Canada’s public inquiry into the contaminated blood crisis of the 1980s and 1990s. Thus, to address a recognized gap in transfusion science knowledge, in 2002, a group of visionary blood researchers at the University of British Columbia (UBC) established Canada’s first interdisciplinary blood research centre — an entirely unique and valuable resource for established and emerging blood scientists. With its creation, the CBR brought together a wide range of multi-talented investigators to develop highly specialized labs to study blood and transfusion science. Since its inception, the CBR has grown to include more than 35 basic science, applied science, social science and clinical investigators in 12 departments, representing 6 faculties at UBC, with a focus on advancing knowledge of transfusion science and medicine in the lab and in the clinic.
"We are delighted to extend our partnership with the Centre for Blood Research through 2027. This renewal highlights our shared commitment to advancing education, training, and research in transfusion science. Together, we aim to drive innovation and improve transfusion practices, ensuring a safer and more effective future for the Canadian blood system."
Dr. Chantale Pambrun
Senior Medical Director, Innovation & Portfolio Management
“The long-term relationship of Canadian Blood Services and the CBR has been nothing less than fantastic! By combining resources and sharing knowledge, education and research outputs, this unique partnership has resulted in more rapid and meaningful advances that are recognized locally, nationally and internationally. The entire transfusion medicine community has benefitted and will continue to do so.”
Dr. Ed Conway
Director of the Centre for Blood Research
The partnership of Canadian Blood Services was integral to creating the Centre for Blood Research, providing essential start-up funding and continuing to support infrastructure for the centre and its training and education programs. Several Canadian Blood Services scientists are active members within the Centre for Blood Research including senior scientist Dr. Ed Pryzdial and adjunct scientists Dr. Ed Conway, Dr. Hongshen Ma and Dr. Jay Kizhakkedathu.
Learn more about some of the research these scientists and members of their labs undertake in our previous R.E.D. blogs and videos:
The CBR is grateful for Canadian Blood Services’ continuous support, without which its many educational, training and research programs would not be possible. This includes, for example, CBR’s Graduate Award Program and Summer Studentship Program, as well as the CBR's weekly seminar series and the annual Earl W. Davie and Norman Bethune symposia.
Canadian Blood Services – Driving world-class innovation
Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.
The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.
The Centre for Blood Research (CBR) Norman Bethune Symposium gathers scientists, clinicians, healthcare professionals, and trainees to discuss advancements in the field of blood research. The 12th Annual event, held in April 2024, consisted of expert talks on thalassemia, thrombocytopenia, sickle cell disease, and other bleeding disorders, demonstrating the breadth of ongoing research.
The 2024 Canadian Blood Services’ Lay Science Writing Competition is open for submissions from research trainees in Canadian Blood Services’ research network until Friday, June 14, 2024. The theme this year is: “Connecting science with society”. Additional competition details available in this post!
In this blog post, read about the 2023 Earl W. Davie Symposium held at the Centre for Blood Research (CBR) - a research event that brings together scientists, medical doctors, healthcare professionals, and trainees in the field of blood research and beyond.
As the Principal Investigator for the SexMatters trial described in this blog, Dr. Mickey Zeller is an Associate Professor in the Department of Medicine at McMaster University. She is also a Medical Officer at Canadian Blood Services.
Around 2018, Dr. Mickey Zeller's grandmother asked her a question that she couldn’t fully answer at the time. It’s a question that Dr. Zeller continues to keep top-of-mind in her roles as an Associate Professor at McMaster University and a Medical Officer at Canadian Blood Services. Having sustained a pelvic fracture at the age of 94, she asked her granddaughter, “If I need a blood transfusion, could it come from a man... and if it does, would that be safe?”. As Dr. Zeller describes, “I looked at her and, in that moment, I said, ‘Grandma, no one knows! But it’s on my list to find out!’.”
In fact, questions about whether selecting products based on the sex of donor and recipient could improve outcomes following blood transfusions have been around for years. However, there is not yet been enough evidence to definitively answer whether this strategy would help optimize hospital and blood operator practices.
After much perseverance, collaboration with researchers across Canadian Blood Services’ extended research network, and a successful bid for CIHR funding, a research team led by Dr. Zeller is embarking on a new research journey they hope will finally provide the evidence to answer questions about whether sex matters in red blood cell transfusion.
When a patient requires a transfusion of red blood cells (RBCs), the matching of product to patient is based on compatibility testing that looks at whether the blood is group A, B, AB or O, whether it is Rh positive or negative, and what other antibodies are present. Canadian Blood Services’ Rare Blood Program also helps ensure patients with specific combinations of antigens – proteins that appear on the surface of red blood cells – can be matched with appropriate blood components. Laboratory studies on donor factors such as age and sex have looked at their impact on characteristics of RBCs in terms of hematocrit, cell volume, hemoglobin content, and deformability – that is, the flexibility or “squeeze-ability” of the cells. However, currently available evidence has not demonstrated a need for red blood cells for transfusion to be matched based on the sex of either donor or recipient.
The principal research question being posed by this study is: In adults admitted to the ICU who require RBC transfusions, do donor-recipient sex-matched RBC transfusions result in improved 30-day mortality compared with sex-mismatched RBC transfusions? Answering this question has a large potential for impact because of the substantial number of blood transfusions that occur throughout Canada every year.
“If there was a risk identified [from the sex of the donor and recipient], even moving the needle a little bit to improve the matching of blood product to recipient could add another layer of safety to current practices,” Dr. Zeller explains.
While it seems like a basic question to remain unanswered, Dr. Zeller acknowledges the investments of energy, expertise, and funding to get the study to this point.
“Sometimes these basic questions remain for a long time because it is challenging to get the funding and infrastructure in place to be able to answer them in a scientifically rigorous way; even if they’re basic-level questions, it’s only by investing that you are able to gather the evidence to answer the question.” Dr. Zeller says.
That’s part of the reason why Canadian Blood Services’ investments in networks like CTTG are important. The Canadian Transfusion Trials Group (CTTG) is funded by Canadian Blood Services with the aim of supporting and accelerating clinical trials that can inform best practices in transfusion medicine in Canada. CTTG reviewed and endorsed this SexMatters study and provided support through its development, making it the second RCT since CTTG’s inception to earn CIHR funding following participation in their review process.
"I had the opportunity to present to CTTG twice and receive feedback that improved this study design and my application to CIHR for its funding. Having it reviewed by people like Dr. Donald Arnold, Dr. Jeannie Callum, Dr. Nadine Shehata – people with world-recognized expertise in this area – really led to the success of this application,” Dr. Zeller says. “We were able to have really rich discussions on tough questions about study design and impact, including details like how we would account for patients that are pre-transfused entering the study.”
Says Dr. Zeller, “Each time the application went through reviews, I could present to these colleagues to essentially say, 'Here are the criticisms it has received and here’s how I’ve handled them.' And they would provide me advice and encouragement to resubmit. It is really valuable having people across the country who are cheering for you, and who are hand-in-hand with you to celebrate your success!”
“It’s an absolute privilege to do high quality research because you have to be surrounded by an incredible group of humans. Academic curiosity and commitment by those that have mentored me have enabled me to do this work. It’s out of a generosity of spirit that people have shared their expertise with me for this work, and it takes a lot of time and effort.”
Dr. Mickey Zeller, Principal Investigator for the SexMatters trial
Before this study received CIHR support, the research team undertook an exploratory analysis, a systematic review and meta-analysis, and a pilot trial which took place in 2022 across five Ontario-based hospitals to establish feasibility of the randomized controlled trial. Findings of retrospective observational studies indicated potential association between sex-mismatched transfusions and mortality, but some aspects remained unclear due to low certainty of evidence, inconsistencies or contradictory subgroup analyses in the available literature.
Much previous research involving Canadian Blood Services researchers has also supported the need for this randomized controlled trial. This includes:
| Read the Research Unit summarizing some of MCTR’s research on blood.ca (2019): Sex-mismatched red blood cell transfusions and mortality | Canadian Blood Services |
Earlier publications involving these and other researchers have also investigated the impact that blood donor age and sex have on outcomes for transfusion recipients, summarized evidence related to sex-matched versus mismatched transfusions and mortality, and the biological mechanisms implicated in adverse outcomes of sex-mismatched transfusions. There is still room for more investigation to build on this previously completed research, and that aligns with Canadian Blood Services' emphasis on the importance of research that spans the continuum from bench-to-bedside to continuously improve our processes, products and services. As Dr. Zeller describes: “There are biological studies and retrospective data, but we only have one existing RCT. There’s a real importance to pursue a prospective, RCT so we can look forward as opposed to looking back.”
“As every blood donor is unique, the challenge we have is to understand which donor-specific factors can be better matched to improve patient outcomes. Differences in the biology of blood cells from male and female blood donors are well defined, but what we do not understand is if these differences affect health outcomes in transfused patients. This is very important question that the SexMatters clinical trial is proposing to address.”
Dr. Jason Acker, Co-Investigator in the SexMatters trial
Focusing on transfusions in the ICU is a significant distinguishing feature of this study. The iTADS trial was completed as a multicentre, double-blind trial, but it looked at mortality rates across the whole hospital. This new trial will look at transfusions received by patients in the intensive care unit (ICU) specifically.
“In the hospital, we know that mortality rate is much higher in a transfused ICU patient compared to a patient in another part of the hospital,” Dr. Zeller says. “We’ve chosen to focus this study on the sickest population of patients – those in the ICU – with the idea that any impact will be seen most prominently in this group. The analysis will include consideration to dosage so we can adjust for the specific number of units transfused to each patient.”
The study is also designed so that participants will not know whether a blood transfusion is matched or mismatched based on the sex of donor or recipient – a method used to prevent potential bias in the trial.
“At the hospital, you always get a list with each shipment of blood product that says what units you have received from the blood operator”, Dr. Zeller explains. “As part of this study’s protocol, participating hospitals will see an additional colour-coding noted on this inventory, and this is what will be used when it comes time for us to do our analysis.”
Dr. Zeller is glad to have Canadian Blood Services involved in this research, acknowledging that changing policy related to matching of blood products would be a significant change for hospitals and blood suppliers, requiring strong evidence from RCTs like this one.
“This study will help to inform health-care professionals who prescribe and administer blood products, along with patients, donors, and the blood operator, too. One of the important questions if it does turn out to have a significant difference is ‘Then what?’ We already divide our inventory by group (ABO) and by Rh status (+/-). Would the need to be matching by sex further impact inventory? We don’t know yet, but that’s why it’s important to have the blood supplier involved,” Dr. Zeller says.
The study will require a total sample size of approximately 11,000 patients across an expected nine hospital sites in Ontario.
“We’ve designed this study to be very efficient; it’s got components of what would be considered a pragmatic study design,” Dr. Zeller says. “In terms of the products, Canadian Blood Services does not have to provide anything different than they already do for this study (other than the colour-coded markers) and we will use electronic capture to pull data, so we don’t need to collect study information at bedside. These were processes leveraged from the earlier iTADS study as the iTADS research team was very supportive of us learning from what they did.”
“Whether transfusions should be matched for donor sex is a question that has been percolating in people’s minds for many years. Dr. Zeller has had the courage and perseverance to tackle this important question, which could have important policy implications. I’m excited for Dr. Zeller to embark on this journey and advance knowledge on best transfusion practices.”
Dr. Donald Arnold, Co-Director of CTTG and Co-Investigator in the SexMatters trial
Canadian Blood Services – Driving world-class innovation
Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.
The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.
When doctors select compatible red blood cell units for transfusion into a patient, they don’t consider the sex of the patient and whether the donor is the same (sex-matched) or opposite sex (sex-mismatched). But a study led by Dr. Michelle Zeller, Canadian Blood Services medical officer and assistant professor in the department of medicine at McMaster University, suggests that the role of donor sex in red blood cell compatibility may be worth a closer look.
In this six-part series, Dr. Jeannie Callum, a hospital-based transfusion specialist, shares her real-life experience witnessing the impact of blood donation on patient lives. She provides some fascinating insight into blood transfusion, past and present, and emphasizes the need for male donors and why some donors may be safer for patients. Read the complete series here.
Recent research involving Canadian Blood Services researchers highlights the relationship between donor age and the quality of blood products like red blood cells, while considering the complex interplay between storage conditions, oxidative stress, and genetic factors. Though the clinical implications remain uncertain, these findings underscore the importance of ongoing research in optimizing blood storage practices and continuing to improve the efficacy of blood transfusions for patients in need.
Italy’s Fincantieri on Tuesday signed a memorandum of Understanding (MoU) with the United Arab Emirates’ EDGE Group to expand their cooperative work on naval systems to include underwater systems for […]
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Bacharach Inc., a manufacturer of refrigerant gas detection and combustion analyzers, is implementing an enhanced 24 hour priority calibration and repair service option out of their New Kensington, Pennsylvania, location to build upon the company’s current service support capabilities.
Greenbuild 2023 will celebrate the U.S. Green Building Council’s 30th anniversary and newest version of LEED.
The Fluke 810 helps you locate and diagnose common mechanical problems and prioritize repairs. Tester includes laser tachometer, triaxial accelerometer and quick disconnect cable.
With early exposure to the trades, a young girl found inspiration from the women she saw working in the industry, and now she wants to encourage more women to get into the business.
Audax Private Equity announced that it has partnered with management to acquire Source Refrigeration & HVAC Inc. from Arsenal Capital Partners. Source, headquartered in Anaheim, California, is a leading independent provider of commercial refrigeration and HVAC services in North America.
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Darren Gibula is familiar with LG, the company said, having spent nearly six years with the company in the Air Conditioning Technologies division in operations and customer experience roles.
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At the AHR Expo, refrigeration manufacturers displayed their latest equipment and components that are geared toward the commercial refrigeration market.
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NASRC to offer free training event for refrigeration technicians in St. Louis who want to learn more about natural refrigerants, such as CO₂ and propane.
Speaking to several high school students at AHR, David Richardson offered some advice and wisdom that he’s gathered over his career.
This product introduces two fan speeds to evaporator fans: low speed when no refrigerant is needed and high speed only during active cooling.
Here is the potential problem: A contractor quotes a customer on the compressor replacement, and he agrees to repair the cooler at the quoted price. Then, as the technician is completing the job — or even after he has finished replacing the compressor — he finds out there is another system problem.
Refrigeration systems can become restricted in both their high and low sides for a variety of reasons.
With over 20 years of experience in natural refrigerants, Embraco’s compressor portfolio features products for commercial food service, food retail, merchandisers, and aftermarket segments. Conveniently, the booth was sectioned into these four different segments, so AHR Expo attendees could easily find the R-290 solution they were looking for.