Poile, Nashville's first-ever general manager who retired in 2023, was inducted into the Hockey Hall of Fame alongside former Predators captain Shea Weber.

Recruiters already are offering bonuses, free housing, and airfare to entice teachers to their remote districts—and the competition is about to get worse.

In a case that has drawn the involvement of the Trump administration, a federal judge holds that state rules limiting in-person instruction are not infringing on federal constitutional rights.

Mahsa Altafi
Oct 23, 2024; 44:e0518242024-e0518242024
Systems/Circuits

Danilo De Gregorio
Feb 3, 2021; 41:891-900
Symposium and Mini-Symposium

Thalamocortical pathways from the rodent ventral posterior (VP) thalamic complex to the somatosensory cerebral cortex areas are a key model in modern neuroscience. However, beyond the intensively studied projection from medial VP (VPM) to the primary somatosensory area (S1), the wiring of these pathways remains poorly characterized. We combined micropopulation tract-tracing and single-cell transfection experiments to map the pathways arising from different portions of the VP complex in male mice. We found that pathways originating from different VP regions show differences in area/lamina arborization pattern and axonal varicosity size. Neurons from the rostral VPM subnucleus innervate trigeminal S1 in point-to-point fashion. In contrast, a caudal VPM subnucleus innervates heavily and topographically second somatosensory area (S2), but not S1. Neurons in a third, intermediate VPM subnucleus innervate through branched axons both S1 and S2, with markedly different laminar patterns in each area. A small anterodorsal subnucleus selectively innervates dysgranular S1. The parvicellular VPM subnucleus selectively targets the insular cortex and adjacent portions of S1 and S2. Neurons in the rostral part of the lateral VP nucleus (VPL) innervate spinal S1, while caudal VPL neurons simultaneously target S1 and S2. Rostral and caudal VP nuclei show complementary patterns of calcium-binding protein expression. In addition to the cortex, neurons in caudal VP subnuclei target the sensorimotor striatum. Our finding of a massive projection from VP to S2 separate from the VP projections to S1 adds critical anatomical evidence to the notion that different somatosensory submodalities are processed in parallel in S1 and S2.

The brain's extracellular matrix (ECM) regulates neuronal plasticity and animal behavior. ECM staining shows a net-like structure around a subset of neurons, a ring-like structure at the nodes of Ranvier, and diffuse staining in the interstitial matrix. However, understanding the structural features of ECM deposition across various neuronal types and subcellular compartments remains limited. To visualize the organization pattern and assembly process of the hyaluronan-scaffolded ECM in the brain, we fused a HaloTag to hyaluronan proteoglycan link protein 1, which links hyaluronan and proteoglycans. Expression or application of the probe in primary rat neuronal cultures enables us to identify spatial and temporal regulation of ECM deposition and heterogeneity in ECM aggregation among neuronal populations. Dual-color birthdating shows the ECM assembly process in culture and in vivo. Sparse expression in mouse brains of either sex reveals detailed ECM architectures around excitatory neurons and developmentally regulated dendritic ECM. Our study uncovers extensive structural features of the brain's ECM, suggesting diverse roles in regulating neuronal plasticity.

Neural circuits supporting innate behaviors, such as feeding, exploration, and social interaction, intermingle in the lateral hypothalamus (LH). Although previous studies have shown that individual LH neurons change their firing relative to the baseline during one or more behaviors, the firing rate dynamics of LH populations within behavioral episodes and the coordination of behavior-related LH populations remain largely unknown. Here, using unsupervised graph-based clustering of LH neurons firing rate dynamics in freely behaving male mice, we identified distinct populations of cells whose activity corresponds to feeding, specific times during feeding bouts, or other innate behaviors—social interaction and novel object exploration. Feeding-related cells fired together with a higher probability during slow and fast gamma oscillations (30–60 and 60–90 Hz) than during nonrhythmic epochs. In contrast, the cofiring of neurons signaling other behaviors than feeding was overall similar between slow gamma and nonrhythmic epochs but increased during fast gamma oscillations. These results reveal a neural organization of ethological hierarchies in the LH and point to behavior-specific motivational systems, the dysfunction of which may contribute to mental disorders.

FAO Director-General José Graziano da Silva today called on countries to put nutrition high on their national and international agendas, and to take a lead role in the upcoming Second [...]

Data analyses, policy recommendations, and actions on the ground.

See the process involved when a massive specimen arrives at the Smithsonian

The Director of the Smithsonian's Hirshhorn Museum predicts what the museum's collections will hold in the next 40 years Read more at http://www.smithsonianmag.com/specialsections/40th-anniversary/Arts-Bold-New-Direction.html

Read more about Haleakala: http://j.mp/ufv44s The Hawaiian volcano, with its unique vegetation and meditative winds, has a spiritual connection to the native population

Courtesy of GoPro

Read more about sperm whales: http://j.mp/sOSais Watch underwater footage of the mammal and hear its strange clicking sounds that are crucial to their survival

Senior historian Sid Hart discusses the highlights of the National Portrait Gallerys Hall of Presidents. (Filmed and Edited by Ryan Reed / Produced by Beth Py-Lieberman, Megan Gambino and Jesse Rhodes). Read more at https://www.smithsonianmag.com/smithsonian-institution/tour-the-portrait-gallerys-hall-of-presidents-on-presidents-day-39165669/

Autodesk vice president Brian Mathews talks with the NASA science communicator about the search for life on other planets and why it’s important

Lola, a Lagotto Romagnolo trained to sniff out and dig up black truffles in her native Washington, is ready for a challenge: to find truffles out of season on a hot day where their distinctive odor dissipates really quickly. Video courtesy of Smithsonian Channel.

Watch a selection from the Smithsonian Institution's submission for the UNESCO Memory of the World Register of historic artifacts

A ring could explain a mysterious arrangement of impact craters near the equator and might even have caused an ice age, according to a new study

A $1 million grant from the U.S. is the latest effort to support Ukraine's fight to preserve its rich past

Across the country, revelers are dressing in costumes and gliding across bodies of water on stand-up paddleboards to ring in the spooky season

This year, celebrants will likely be channeling characters from hit franchises like "Beetlejuice," "Inside Out" and "Deadpool"

The team traveled from New Zealand to Tonga along a humpback highway to collect environmental DNA and raise awareness of the plight of the marine mammals

From Setsubun in Japan to Fèt Gede in Haiti, these festivals relish in the macabre

The artificial waste could fertilize the ocean and sequester carbon

A researcher studying the rise of extremism in Atlantic Canada warns Ku Klux Klan Halloween costumes are just one example of an insidious effort by far-right groups to normalize hateful attitudes.

Independent Elizabeth Smith-McCrossin is back on the campaign trail in Cumberland North, but opponents say the riding would be better represented by an MLA from an official party. 

About a thousand people stood solemnly in the rain at a cenotaph in downtown Halifax on Monday morning to pay tribute to veterans on Remembrance Day.

Building highways isn't the only solution to the growing problem of traffic congestion in and around the Halifax Regional Municipality, says the head of an organization that advocates for rail-based public transit.

The bronze wreath immortalized the moment when the members of the Honor Guard removed their hats and placed them on the president's grave during his burial

Buenos Aires, Argentina :: Logos Hope's crew joins Youth With A Mission to show God's love to elderly people.

The City of Winnipeg is advising residents of alternative options to access several city-run services that could be disrupted by the end of this week in the event of a work stoppage at Canada Post. 

The city said in a news release on Thursday that the Mayor’s Task Force on Transparency, Access and Accountability — which is in charge of reviewing community concerns about openness at the city — is looking for your feedback.

Three weeks after the death of another beluga whale at Marineland, the Ontario government is speaking publicly about its ongoing investigation of the park, saying water troubles are under control after a recent investment.

Two-time Olympian Gabrielle Daleman was victorious in Sunday's free skate to win the women's event at the 2022 Skate Canada Challenge in Regina.

A clean, fifth-place performance in Saturday's free skate was enough for Canada's Keegan Messing to hold off Russia's Andrei Mozalev for the win at figure skating's Golden Spin of Zagreb in Croatia.

The Town of Tecumseh will be getting six new EV charging stations, the province announced Tuesday, in a bid to "support the electrification of transportation across the province."

A young Toronto Maple Leafs fan has caught the attention of the NHL with his Halloween costume this year. With the help of his dad, Grayson Haire, of Trenton, Ont., will wear a 3D version of an Upper Deck MVP Auston Matthews hockey card.

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Indiana University took first place, with the rest of the top five from outside the United States Record participation from nearly 570 teams across 24 countries CHICAGO, Nov. 7, 2024 /PRNewswire/...

Solutions Catch Problems Early and Drive Cost Out of Designs

SOLIDWORKS Corporation joins effort, pledging financial support for FIRST Robotics mentorship program

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The Freedom Climb becomes The Freedom Challenge to include more women in a movement to raise awareness, prayer and funds to combat slavery.

Seeing how little it takes to make a difference and experiencing that God can use them, young Moldovans get passionate about sharing the gospel.