Ein Missbrauchsvorwurf gegen Joe Biden stürzt die US-Demokraten ins Dilemma. Seine Kritiker sagen: Würde er an den Standards gemessen, die er selbst aufgestellt hat, müsste er seine Kandidatur zurückziehen.

Fußball-Zweitligist Dynamo Dresden muss nach positiven Corona-Fällen für zwei Wochen in Quarantäne. Das könnte den Plan zur Fortsetzung der Saison gefährden. Denn die Chancengleichheit ist jetzt kaum noch gegeben.

“History doesn’t repeat itself but it often rhymes,” Mark Twain was first credited with saying in 1970, 60 years after reports of his death had ceased to be exaggerated.

The agency announced approval for the diagnostic method on Saturday. Cheaper and easier to administer than genetic tests for the virus, it could potentially expand to daily testing of millions.

Former president Barack Obama harshly criticized U.S. President Donald Trump's handling of the coronavirus pandemic as an 'absolute chaotic disaster' during a conversation with ex-members of his administration, according to a recording obtained by Yahoo News.

A Forbes contributor notes that Belkin abruptly announced the end-of-life for its Wemo NetCams, which will discontinued on May 29 2020. But that's just the beginning... Unlike many other end-of-life announcements which simply render products ineligible for support or upgrades, Belkin is literally pulling the plug on its Cloud service, rendering its NetCam range of home security cameras as useless beige bricks... The question of how Belkin are deliberately bricking their products needs to be called out. When the NetCam was released, users had the option to use the Wemo software (which was lousy) or connect to the cameras using ffmpeg with their favourite NVS platform or even with VLC or equivalent. However, in a firmware update a few years back — Belkin disabled this capability. While workarounds do exist, such as the one published by Vladimir Sobolev in 2018, the whole premise of buying a Belkin product is for ease of use and simplicity. Belkin claim to design 'people inspired products'. All customers of Belkin need to look carefully at these words and see how they match up with their deeds? How many other Belkin products might be switched off on a whim? The criticism can be applied to cloud-enabled products as a whole, but in the main — vendors understand that to alienate customers by bricking their possessions is not a viable long term strategy to maintain trust... Forthcoming European legislation forcing technology companies to make their products easier to repair should go some way to address these concerns. The article points out that even Microsoft gave Windows 7 users five years of warnings about its 2020 end-of-life. And it also complains property owners now face two difficult choices: "Either leaving their property with no security system and zero surveillance capability, or breaking the quarantine orders in order to install new equipment."

Read more of this story at Slashdot.

Reggie Brooks bullish on Notre Dame RB Chris Tyree and the Holtz's Heroes Foundation

Volunteers from six Santa Clarita Valley high schools step forward to help those shut in by the COVID-19 pandemic.

The 26-year-old surfer was pronounced dead at the scene near Manresa State Beach, California parks officials said.

The Duke of Sussex sent a special video message to mark what would have been the opening ceremony of the 2020 Invictus Games.

As tests increase on the Island of Montreal, the city announced Saturday that 33 more people have died and 420 new cases have been confirmed in the past 24 hours.

Deaths and hospitalizations related to COVID-19 could increase dramatically in Montreal if social distancing measures are lifted, according to a new study.

Zookeepers are sharing a new challenge to help lift their spirits during the coronavirus lockdown.

The Most Useful Websites - self published using Amazon KDP.

Bollywood Movies on Zero Dollar Movies

Mail Merge for Gmail to help you send personalized emails.

Filed under: Food and Drink, North America, United States

• Regardless of the area's suitability for growing grapes, plop down a vineyard or winery and travelers will come for a taste and buy a sympathy bottle (pro tip: go for the ice wine as it's harder to mess up)
• Ski resorts looking to attract off-season dollars or stale attractions looking to draw media coverage and visitors hook up a zipline

Continue reading Vineyard and Zipline Trends Collide at the Pinot Express

Vineyard and Zipline Trends Collide at the Pinot Express originally appeared on Gadling on Wed, 11 Dec 2013 16:54:00 EST. Please see our terms for use of feeds.

The ban on cigarette and alcohol sales during the lockdown has created an underground market of rampant deals all over Pietermaritzburg.

Frank Soo, the first and only player of Asian heritage to represent England's national football team, has been honoured by Google.

Surrey director of cricket Alec Stewart has reluctantly accepted there could yet be a long-term good for the county game if it is wiped out in 2020.

Two-time women's World Cup winner Alex Morgan and husband Servando Carrasco have welcomed a new player to their team.

Scottish football descended into fresh acrimony when Hearts owner Ann Budge accused her Premiership counterparts of "appalling disrespect".

The Stormers look set to receive a boost with centre Rikus Pretorius signing a contract extension.

The PGA Tour's Memorial Tournament will use radio frequency identification chips in spectator badges to ensure fans maintain social distance.

French tennis chief Bernard Guidicelli admitted that Roland Garros could be staged behind closed doors.

Manchester United and Everton have been put on alert by the news that Juventus midfielder Adrien Rabiot is willing to move to the Premier League.

Brighton chief executive Paul Barber has warned a premature return to football action from the coronavirus pandemic could "cost lives".

American Justin Gaethje scored a surprise technical knockout victory over Tony Ferguson to win the interim lightweight title at UFC 249.

Lebogang Manyama is the most important player for Kaizer Chiefs in their quest to win the Absa Premiership title, according to Stellenbosch midfielder Mpho Matsi.

SuperSport United winger Aubrey Modiba says a conversation with club CEO Stanley Matthews convinced him to stay despite interest from Mamelodi Sundowns.

Williams driver George Russell is enjoying sim racing online while Formula 1 is suspended but admits he doesn't get the same sense of speed or fear.

Mercedes' Lewis Hamilton has said that holding races without any fans will feel "even worse than a test day".

Borussia Dortmund star Erling Braut Haaland has been backed to sign for Liverpool in the future, while Manchester United have been criticised for missing out on him.

Former captain Paul O'Connell says it will be vital for the British & Irish Lions to pick a leader capable of beating the Springboks at their own game.

With the UK government set to tighten its lockdown restrictions, fresh doubts have been cast over the viability of a British Grand Prix.

Former New Zealand head coach and current England defence chief John Mitchell believes some good may come for rugby union from the coronavirus.

An Amaryllis Azure Butterfly, photographed on Buloke mistletoe, near Stanhope in Victoria.

An Amaryllis Azure Butterfly, photographed today on Buloke mistletoe, near Stanhope in Victoria.

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The post REPORT: Airline to suspend service to nearly a dozen US airports starting next week appeared first on Dennis Michael Lynch.

7 October 2014

29 October 2014

miratumismo posted a photo:

Elizabeth Spiers wrote about an incident where Jared Kushner used the memorial of an employee to congratulate himself for success.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.