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Changes on tap at U.S. Chemical Safety Board

Chair departs, investigators leave, staff fears changing mission




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A question on ethics




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Graphene-based device enables active thermal camouflage

Smart, flexible skins measure and adapt to ambient temperatures




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Fetal gene therapy could treat genetic diseases in the womb

Researchers are working to fix genetic conditions like Gaucher disease before birth by testing experimental therapies on fetal animals




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Targeting immune cells could relieve chronic pain

Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage




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HotSpot Therapeutics debuts with $45 million to pursue allosteric inhibitors

The company claims its technology will allow it to access previously undruggable targets




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Chemistry in Pictures: Ruthenium rubies




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Sanofi pays $50 million for Revolution Medicines’ SHP2 inhibitor

The partners expect to begin clinical studies of the compound later this year




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Chemistry in Pictures: Tiny house




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Un patógeno recluta bacterias buenas en la piel para iniciar infecciones

Un estudio hace que los científicos se replanteen cómo se desarrollan las infecciones bacterianas




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Antitrust regulators increasingly probe chemical deals

Following scrutiny, companies are proposing remedies for mergers that will consolidate the titanium dioxide and industrial gas industries




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Verge Genomics raises $32 million for machine learning-backed neuroscience drug discovery




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Bill Gates backs Alzheimer’s diagnostics with new Diagnostics Accelerator venture fund




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Letting nanoparticles hitchhike on red blood cells

Particles adsorbed on cells accumulate in the first organ downstream from injection site




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Membrane knocks out antibiotic-resistant bacteria

Combining UV disinfection with a photocatalytic membrane helps to reduce the bacteria and their genes in wastewater




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EU members agree to restrict 4 phthalates




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Spero wins government funding for antibiotic




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AGC boosts active pharmaceutical ingredient production




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AkzoNobel buys Brazilian organic peroxides firm




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Ionic liquids boost gas uptake in MOFs

Postsynthesis modification of common MOF improves its CO2 uptake and selectivity




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Low-dose aspirin improves memory in mice with Alzheimer’s symptoms

Study suggests activating PPAR receptor leads to increased cellular connections in hippocampus




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CBD: Medicine from marijuana

Epidiolex earns FDA’s blessing, moving cannabidiol into the medical mainstream




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Graphene-based device enables active thermal camouflage

Smart, flexible skins measure and adapt to ambient temperatures




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Targeting immune cells could relieve chronic pain

Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage




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HotSpot Therapeutics debuts with $45 million to pursue allosteric inhibitors

The company claims its technology will allow it to access previously undruggable targets




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Chemistry in Pictures: Flag column chromatography




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What’s ice cream, and why do we scream for it?

Innovations in food science continually improve on this classic sweet treat




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Paper describing piperlongumine anticancer activity retracted

Some coauthors dissent from withdrawal of report, for which key findings have been independently confirmed




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Fish struggle to smell in acidic oceans

Rising CO2 levels could stop fish finding food and detecting predators




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Injections of botulinum conjugate relieves chronic pain in mice

Modified toxin targets and silences nerves that transmit pain, offering a potential nonaddictive alternative to opioids




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Chemical toxicity assessments by U.S. EPA to be reshaped, if bill passes

Congressional committee votes to give industry and other agencies greater input and to shift responsibility for IRIS program from research office




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Insect sodium channels visualized with cryo-electron microscopy

Structures of voltage-gated channel with toxins suggest strategies for drug development




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Chemistry in Pictures: Forming good habits




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GSK, 23andMe to apply personal genetics to drug discovery

New partnership is part of GSK’s R&D face-lift, which includes an increased focus on immune system targets




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Hope and skepticism abound around Biogen and Eisai Alzheimer’s trial

An antibody called BAN2401 cleared amyloid-β proteins and slowed cognitive decline in people with mild Alzheimer’s disease




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Platform sells crop chemicals business to UPL




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China tariff plan slammed by chemical industry

Chemical producers claim customs duties will harm U.S. competitiveness, threaten employment




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Science is in the (baseball) cards and comic books




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DARPA announces first round of $1.5 billion grants to revitalize electronics industry




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U.S. pediatricians group calls for tougher food additive regulation by FDA




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FDA considers imports to tackle high U.S. drug prices




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Liquid water detected beneath Mars ice cap

Discovery confirms decades-old hypothesis




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Paper describing piperlongumine anticancer activity retracted

Some coauthors dissent from withdrawal of report, for which key findings have been independently confirmed




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Membrane knocks out antibiotic-resistant bacteria

Combining UV disinfection with a photocatalytic membrane helps reduce the bacteria and their genes in wastewater




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Easy-to-make polymer stretches, sticks, self-heals

Material’s features attributed to bonds that readily break and re-form




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C&EN’s Global Top 50 chemical companies

Chemical profits continue to rise as the global economy booms




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Technique tracks carbon as soil microbes munch plastic

Isotope labeling and spectroscopy allow scientists to watch how soil microbes break down a mulch product used in agriculture




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Chemistry in Pictures: Drop test




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Strong, aliphatic C–H bonds succumb to direct arylation

Dual-catalyst approach allows chemists to construct connections between a vast array of aliphatic and aromatic molecules




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Michigan declares state of emergency in town with high PFOS, PFOA levels in drinking water

Source of perfluorocarbon pollution as yet unknown, state says