He says he was “beaten into submission” over it.

According to today’s Official Notices, the Bermuda Police Service will be conducting road sobriety checkpoints starting on Friday, April 29th, with the checkpoints set to take place in Hamilton parish, Smiths, Devonshire, Pembroke, Paget, Warwick and Southampton. Road Sobriety Checkpoint Notice 2022 [PDF here] Related Stories Road Sobriety Checkpoints Over Cup Match Road Sobriety Checkpoints Starting On […]

The Bank of N.T. Butterfield & Son Limited notified the Bermuda Stock Exchange that it repurchased and canceled 438,390 common shares at an average price of $31.87 each in April 2024. The filing said, “The Bank of N.T. Butterfield & Son Limited informs the Bermuda Stock Exchange that pursuant to Regulation 6.44of the Bermuda Stock […]

The WER Joell Tennis Stadium will close temporarily to allow for an assessment and building works, effective tomorrow [Aug 28]. A Government spokesperson said, “The Ministry of Tourism, Culture, and Sport has announced the temporary closure of the WER Joell Tennis Stadium, effective tomorrow, August 28, 2024, for approximately one week. “Following an initial assessment, […]

Barracuda Grill re-opened yesterday [June 24] after several months of refurbishments and renovations. A Government spokesperson said, “After several months of refurbishments and renovations, Barracuda Grill formally reopened with a ribbon cutting ceremony yesterday [June 24], and the Premier, the Hon. E. David Burt, JP, MP, a former bartender, was on hand for the Hamilton […]

The Bermuda National Library has invited the public to celebrate National Library Week from April 8th to 12th. A spokesperson said, “Celebrate National Library Week with us from April 8th -12th. Immerse yourself in the enriching world of knowledge and community. Limitless learning at your fingertips all for free with your library card! National Library Outreach […]

The Bermuda National Library’s Youth Library on Church Street in Hamilton will be temporarily closed for roof repairs and structural improvements from August 24th to  October 14th. The Department of Libraries & Archives Director, Joanne Brangman, emphasised the importance of these structural repairs and improvements, stating, “These measures are necessary to enhance the library’s facilities […]

[Written by Stephen Wright] Bermuda rower Dara Alizadeh says he is “over the moon” to have qualified for a second successive Olympic Games in Paris this summer. Alizadeh, who competed in the single skulls at the Tokyo Olympics, needed to finish in the top five of the 19 contenders at the World Rowing Americas Regatta […]

The Bermuda Hospitals Board today announced that it is “starting a major renovation project for its sterile processing department that will run from February to July 2025.” A spokesperson said, “Sterile processing is the sanitisation of equipment and items used in clinical care. The highly specialised cleaning process ensures items are completely safe for use. […]

A workshop to teach professionals about design and installation methods to implement energy efficiency, solar panels and battery technology in Bermuda is being planned for members of The Institute of Bermuda Architects [IBA], Construction Association of Bermuda [CAOB] and Bermuda Association of Professional Engineers [BAPE]. A BE Solar spokesperson said, “This is the third workshop […]

The 2024 MAAC No Frills road race saw Trey Simons and Teresa Ruiz crowned champions of the 10K event, while Philip Woollins and Sarah Ryan secured victory in the 5K race. The event, held in the East End, attracted a strong field of runners competing across both distances. 10K Distance Simons delivered a dominant performance […]

During April 2024, the top 10 ‘most liked’ photos on the Bernews Instagram page included Bermuda’s cosmic beauty, Convex End-To-End & Middle-to-End charity event, Agricultural Exhibition. Glenn Jones interviewing Khano Smith, cruise ships, LeiLanni Nesbeth receiving the Golden Nole Award, CedarBridge Academy’s Annual 5K Fun Walk/Run, Bermuda National Gallery’s Run for the Arts 5K, Evrima […]

Seadrill Limited and Aquadrill LLC announced that they have entered into a definitive merger agreement under which Seadrill will acquire Aquadrill in an all-stock transaction. A spokesperson said, “Upon completion of the transaction Seadrill shareholders and Aquadrill unitholders will own 62% and 38%, respectively, of the outstanding common shares in the Company. The transaction values […]

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If there's one furry series I should be completely behind, but have always been a bit down on, it's Illumination's Sing franchise. The series is set in a completely furry world, with a complete lack of humans – something I can always get behind. And yet, I can't ever quite get behind them.

I think if I had to put my finger on what's wrong, it's that the Sing movies feel like the Illumination version of Oscar bait, being behind the scenes musicals that ostensibly celebrate the performing arts, something Academy Awards voters should, in theory, love; and yet, they can't even get the easy lay up of Best Original Song, which is straightforwardly embarrassing for movies called, well, Sing. It's not that they're failed Oscar Bait, it's that they're not going for Best Picture, or even Best Animated Feature, but simply seem to be aiming to be nominated in that category. They're not aiming for the top, and they're still missing!

Or maybe I'm just being too hard on them, and displacing my own Oscar obsessions on this otherwise innocuous series of jukebox musicals with no higher goal than to be entertaining bits of fluff. The newest entry in the franchise, if it can be called that, is just that. Sing: Thriller is a short available on Netflix, and it features a simple take on a nightmare zombie apocalypse, but furry and kid-friendly; an obvious homage to Michael Jackson's Thriller. It's definitely for kids, with a rating of TV-Y, for "fear", which I think would only apply to the absolute youngest viewers.

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The CRUMB Circuit Simulator, a breadboard simulator Deep Fried Coffee Beans Conserve the Sound: “Your Museum for endangered sounds.” Furby source code What is the price of a Big Mac across the country? Floppy disk costumes for SD cards De visdeurbel (Fish Doorbell; Dutch language.) When a fish in the canals needs the lock opened, … Continue reading Linkdump: April 2023 →

City Hall [US, Frederick Wiseman, 4] The latest of Wiseman’s distinctive epic-length observational documentaries studies the quotidian, procedural and human moments of human life as seen through the processes of municipal government in Boston, as held together by the thoughtful charisma of Mayor Martin Walsh. Improbably absorbing as always, this institutional cross-section offers a beguiling vision of an oasis of good government in the USA.

In a normal year I’d wait for the four and a half hour Wiseman documentary to arrive on television rather than taking up two time slots to watch it from the confines of a cinema seat at TIFF. But this is not such a year and with a digital screening you get a pause button when you need it. This is bound for PBS and due to the breadth of its subject matter will serve as an excellent introduction to those unfamiliar with this pillar of the documentary form. Or track down 2017’s Ex Libris, about the New York Public Library. In North America Wiseman’s filmography can be found on the Kanopy platform, which you may be able to access through your public library system.

The Father [UK, Florian Zeller, 4] Retired engineer (Anthony Hopkins) struggles to piece together the confusing reality of his living circumstances as his daughter (Olivia Colman) copes with his progressing dementia. Impeccably performed stage play adaptation puts the viewer inside the contradictory shifts of the protagonist’s subjective viewpoint.

Forget Draculas and Cthulhus. This is the real terror.

Summer of 85 [France, Francois Ozon, 4] Love between two young men in a French beach town leads to a bizarre crime. Teen emotions run high in a sunlit melodrama of Eros and Thanatos.

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Capsule review boilerplate: Ratings are out of 5. I’ll be collecting these reviews in order of preference in a master post the Monday after the fest. Films shown on the festival circuit will appear in theaters, disc and/or streaming over the next year plus.

Oops! Usually when I fail to post on time and then illegally backdate the post, yielding a penalty of -1,000 points, it's shortly after midnight. Like, as I'm trying to fall asleep (which of course involves and involuntary inventory of everything I may have failed to do), I'm struck with a panic and then get back out of bed to write some dumb pro-forma apology post. This time I just went to bed and actually fell asleep and now here I am noticing that it is May 1. Still, the whole point of doing this every month is to make the grid of months line up nicely, so the post is backdated by 9 hours and nets -1,000 points.

Speaking of lining up nicely: I did get my SIGBOVIK papers in on time and gave a lightning talk at the conference. SIGBOVIK was very popular this year, with our longest-ever proceedings (see SIGBOVIK 2024 PDF or bound volume). This year my project is a paper about a new typesetting system that I wrote to produce the paper (and the talk's slides). That system is called BoVeX and the paper is called Badness 0, which you can read as Badness 0 (Knuth's version) and/or Badness 0 (Epsom's version). You can also maybe find a recorded livestream of the breakneck 5 min presentation, but I would wait for the proper video (in progress now!), which is the same content with much better pacing and details.

Speaking of details: I also presented at An Evening of Unnecessary Detail, which is one of Matt Parker ("Standup Maths")'s live shows. Other than the part where I tried to pack a dense months-long technical project about details into 12 minutes, this was a blast! Lots of cool, interesting people. This took place in a proper comedy club in Brooklyn, like with posters of people that I watch on TV (e.g. Taskmaster legend Fern Brady is performing there in a few weeks, so it seems I'm a mere 5 or 6 steps away from my dream of being a contestant on Taskmaster now), and was sold out (due exclusively to the eminence of others, since it was sold out before I even joined the bill). I finally hung out with Grant Sanderson ("3blue1brown") and told him about math. The audience was amazingly attentive and wholesome, and quite a few of them recognized me and wanted to talk after the show, which is fun. (I do not envy the queue that Matt and Grant endured, though!) Enjoy my technically deficient vacation photography:

I'm photobombing, but Matt is so used to this act that he is reflexively crouching down so as not to appear twice my height

Speaking of technically deficient photography: An additional reason why my video is not done yet (or indeed, why it currently has status Filming 0) is that I finally pulled the shutter release on a new video camera. After much deliberation (and visiting the B&H showroom while in NY, etc.), including on far more ridiculous options, I settled on the Canon R5C. After a complex week-long courtship ritual with the FedEx guy, that finally arrived last night, at which point I immediately realized that I need further accessories. But I'm excited to shoot on this thing and to make my computer suffer with 8k video. It seems to have gotten too complacent with "Full HD."

Finally, I think the main reason I failed to post on time last night was that I was up late playing Balatro. This game is all over the place so you probably don't need me to tell you about it, but it is indeed a good (and addictive) deck-building game that I am enjoying instead of sleep. I am not interested in 100%ing this one, but there are still lots of appealing challenges left for me to do. I'd recommend it if you have the self control to avoid firing it up "for a quick game" when you should be working on your projects or sleeping.

It makes hosting less stressful and more joyful. READ MORE...

The Better Breaks funding programme is focused on improving the range and availability of short break opportunities for disabled children and young people, particularly those with multiple support needs, including short break opportunities that families can enjoy together, or which allow parents and siblings to have time away from their caring responsibilities. This is the summary report.

April Fools Day is coming up!

Time to order your coffee-table book of April Fools RFCs!

More info here: https://www.rfchumor.com

Makes a great gift for nerds that own coffee-tables!

Order it today!

This is the first solo exhibition of my work! I am very pleased and honored that the La Conner Quilt & Textile Museum offered me a show in their new Local Artist Exhibit Program's first-floor Landmarks Gallery.

Every Child Should Have Her Own Tree, hand-dyed, beaded, embroidered fabric collage

I hope some of you will be able to come see my work, as well as the work of the other two featured quilt artists in the upper floor galleries.
A couple of readers have contacted me asking if the above work, or any of the other pieces will be for sale...  Nope, afraid not... exhibition only, although the museum's excellent gift shop does carry my books.

Three-time Oscar nominee Torill Kove, who won the Academy Award for her short 'The Danish Poet,' is back in the Oscars race this year with a new film about her memories of growing up in Kenya.

Nowadays, gas barbecues have supplanted standard charcoal flame broils in numerous family units. And happiness is when you find the Best gas grills under 300.

The post 15 Best Gas Grills Under 300 2024 – Propane Grills For Every Budget appeared first on Star Two.

Epidemic situation in the World has influenced all of us a lot. Many businesses started paying more attention to their online presence as many people started to look for more opportunities to make additional money online. Affiliate marketing is what comes to mind in such a situation. Following this trend we decided to enrich our […]

The post RSS Ground Changelog April 2020 appeared first on RSSground.com.

We are excited to share news about our latest updates and upcoming plans. A lot has been done to improve Personal Feeds functionality and  interactions with the Facebook Platform.   Personal feeds media files We have improved processing of media files in personal feeds. You can now see if your personal feed item contains media […]

The post RSS Ground Changelog April 2021 appeared first on RSSground.com.

Eastwood takes measured aim at the American justice system in a film that centers on a murder trial — and a juror who realizes he may be implicated in the crime.

Gadot will play a lawyer whose son is kidnapped. Her character must run all over London, carrying out demands from a mysterious caller who has taken her child. 

Cate Blanchett intepreta Catherine Ravenscroft, uma famosa jornalista investigativa que recebe anonimamente um romance no qual ela é, indiscutivelmente, a personagem central

A cúpula climática da ONU deste ano em Baku, Azerbaijão, está sendo chamada de 'uma COP de financiamento climático'. Mas quanto dinheiro será prometido?

Rwanda is one of the world’s poorest and most densely-populated countries, with population growth placing pressure on forests and natural habitat. But despite that, mountain gorillas are making a comeback in Rwanda. The World Economic Forum explains: In the 1980s, fewer than 300 mountain gorillas in Rwanda remained in the Virunga mountains. Today, thanks to […]

The post Mountain gorillas are making a comeback in Rwanda appeared first on Liberty Unyielding.

Analyst Alex de Waal looks at how the US president-elect could deal with conflicts on the continent.

Riley, who has cancer, is surprised after an online appeal to meet the Marvel star.

The Gauteng education department has postponed the appointment of new office-based staff as well as teachers who applied to be promoted as heads of department, deputy principals and principals until April because of budget constraints.

A Louisiana law that sought to post the Ten Commandments in every schoolroom in the state has been shelved by a federal judge. U.S. District Court Judge John W. deGravelles, […]

The post Obama-Appointed Federal Judge Temporarily Blocks Ten Commandments Law appeared first on The Western Journal.

January 12, 2022 (New York, NY) – The total value of residential mortgage debt in the US will continue to experience solid growth into 2022 and 2023. In our inaugural […]

Amazon’s share declines for first time; Apple surpasses eBay in online sales June 14, 2022 (New York, NY) – This year will mark a major US retail milestone, as ecommerce […]

EJ Blanchette-Mackie
Jun 1, 1995; 36:1211-1226
Articles

Dawn L. Brasaemle
Dec 1, 2007; 48:2547-2559
Thematic Reviews

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we studied the fibril structure of a recombinant light chain fragment corresponding to the fibril protein from patient FOR005, together with fibrils formed by protein sequence variants that are derived from the closest germline (GL) sequence. Both analyzed fibril structures were seeded with ex-vivo amyloid fibrils purified from the explanted heart of this patient. We find that residues 11-42 and 69-102 adopt β-sheet conformation in patient protein fibrils. We identify arginine-49 as a key residue that forms a salt bridge to aspartate-25 in the patient protein fibril structure. In the germline sequence, this residue is replaced by a glycine. Fibrils from the GL protein and from the patient protein harboring the single point mutation R49G can be both heterologously seeded using patient ex-vivo fibrils. Seeded R49G fibrils show an increased heterogeneity in the C-terminal residues 80-102, which is reflected by the disappearance of all resonances of these residues. By contrast, residues 11-42 and 69-77, which are visible in the MAS solid-state NMR spectra, show 13Cα chemical shifts that are highly like patient fibrils. The mutation R49G thus induces a conformational heterogeneity at the C terminus in the fibril state, whereas the overall fibril topology is retained. These findings imply that patient mutations in FOR005 can stabilize the fibril structure.

Neurodegeneration in Parkinson's disease (PD) can be recapitulated in animals by administration of α-synuclein preformed fibrils (PFFs) into the brain. However, the mechanism by which these PFFs induce toxicity is unknown. Iron is implicated in PD pathophysiology, so we investigated whether α-synuclein PFFs induce ferroptosis, an iron-dependent cell death pathway. A range of ferroptosis inhibitors were added to a striatal neuron-derived cell line (STHdhQ7/7 cells), a dopaminergic neuron–derived cell line (SN4741 cells), and WT primary cortical neurons, all of which had been intoxicated with α-synuclein PFFs. Viability was not recovered by these inhibitors except for liproxstatin-1, a best-in-class ferroptosis inhibitor, when used at high doses. High-dose liproxstatin-1 visibly enlarged the area of a cell that contained acidic vesicles and elevated the expression of several proteins associated with the autophagy-lysosomal pathway similarly to the known lysosomal inhibitors, chloroquine and bafilomycin A1. Consistent with high-dose liproxstatin-1 protecting via a lysosomal mechanism, we further de-monstrated that loss of viability induced by α-synuclein PFFs was attenuated by chloroquine and bafilomycin A1 as well as the lysosomal cysteine protease inhibitors, leupeptin, E-64D, and Ca-074-Me, but not other autophagy or lysosomal enzyme inhibitors. We confirmed using immunofluorescence microscopy that heparin prevented uptake of α-synuclein PFFs into cells but that chloroquine did not stop α-synuclein uptake into lysosomes despite impairing lysosomal function and inhibiting α-synuclein toxicity. Together, these data suggested that α-synuclein PFFs are toxic in functional lysosomes in vitro. Therapeutic strategies that prevent α-synuclein fibril uptake into lysosomes may be of benefit in PD.

Stacey N Keenan
Dec 17, 2020; 0:jlr.RA120001126v1-jlr.RA120001126
Research Articles

Perilipin (PLIN) 5 is a lipid droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. We detected phosphorylation on S155, S161 and S163 of recombinant PLIN5 by PKA in vitro and identified S155 as a functionally important site for lipid metabolism. Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation compared with cells expressing wildtype PLIN5. These differences in lipid metabolism were not associated with differences in the cellular distribution of PLIN5. Rather, FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase (ATGL) at the lipid droplet, but not with the co-activator of ATGL, α-β hydrolase domain-containing 5 (ABHD5). Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis when compared to mice with wildtype PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism, such as fatty acid oxidation, de novo lipogenesis and triglyceride secretion. Furthermore, glycemic control was impaired in mice with expression of PLIN5 S155A compared with mice expressing PLIN5. Together, these studies demonstrate that PLIN5 S155 is required for PKA-mediated lipolysis and builds on the body of evidence demonstrating a critical role for PLIN5 in coordinating lipid and glucose metabolism

Dance of the Trillions: Developing Countries and Global Finance Book sysadmin 6 July 2018

David Lubin tells the story of what makes money flow from high-income countries to lower-income ones; what makes it flow out again; and how developing countries have sought protection against the volatility of international capital flows.

Selected by the Financial Times as one of the best economics books of 2018, Dance of the Trillions traces an arc from the 1970s, when developing countries first gained access to international financial markets, to the present day.

Underlying this story is a discussion of how the relationship between developing countries and global finance appears to be moving from one governed by the ‘Washington Consensus’ to one more likely to be shaped by Beijing.

This book is part of the Insights series.

 

 

 

Praise for Dance of the Trillions

About the author

David Lubin is managing director and head of emerging markets economics at Citi, an American bank, where he is responsible for a team of more than 30 economists in 15 locations globally.

Purchase

• UK (via Amazon)
• Rest of world (via Brookings Institution Press)
• Students (via Browns Books)

Belarusians’ views on the political crisis - April 2021 Other resource NCapeling 11 June 2021

Results of a public opinion poll conducted between 20 and 30 April 2021.

Chatham House surveyed a total of 937 respondents between 20 and 30 April 2021. Our survey sample corresponds to the general structure of Belarus’s urban population and is corrected and weighted by gender, age, size of respondents’ town of residence and education level.

Summary

• After Lukashenka, the most known political figures in Belarus are pro-protest politicians: Tsikhanouskaya, Babaryka, Tsikhanouski, Kalesnikava, Tsapkala and Latushka. Viktar Babaryka is the most popular presidential candidate among Belarusian urban citizens, and Lukashenka comes second to him.
• State organizations and bodies are still mistrusted by more than half the population, while the army is slightly more popular than other bodies. Independent media, labour unions and human rights organizations are trusted far more than state ones.
• Russia leads when it comes to positive attitudes to foreign states: one in three Belarusians feel very positive about their neighbour and 79 per cent feel positive in general. 71 per cent Belarusians feel positive about China, which is the next highest indicator. Despite propaganda efforts, Ukraine, Lithuania, Poland and EU states in general are still perceived positively by more than 60 per cent of Belarusians, with fewer than 20 per cent feeling negative about them.
• The position on Russian interference in the Belarusian political crisis is consolidated enough: 58 per cent think that Russia should remain neutral. The rest are almost equally divided between those who think Russia should support the protest movement (19 per cent) and those who think Russia should support Lukashenka (23 per cent).
• 40 per cent have changed their attitude to the Russian government since it supported Lukashenka in the crisis, and 73 per cent are sure that Russia is his sole support.
• While 32 per cent of Belarusians see union with Russia as the most appropriate foreign policy, 46 per cent would like to be in a union with both Russia and the EU simultaneously.
• Almost half the population thinks that Belarusian foreign policy in the event of a pro-protest government coming to power would be oriented toward friendship and cooperation with both Russia and the West, which correlates with how the majority thinks it should be. Although 42 per cent expect foreign policy would lean toward the EU in that situation, which is less acceptable: only 25 per cent think it ‘should’.
• The proportion of respondents who think Belarus should remain in the Collective Security Treaty Organization is 58 per cent, while 35 per cent would like to see Belarus not belonging to any military bloc and a small share (seven per cent) would prefer Belarus to join NATO.
• Almost half of the population considers Lukashenka to be the major obstacle for political stability and economic development and is sure he does not care about, and in fact is a threat to, independence.
• In general, most Belarusians have a consolidated opinion that the authorities should start negotiating with opponents and free all political prisoners.
• More than half of Belarusians think that Lukashenka must leave immediately or before the end of 2021, while 27 per cent think he should leave when his term ends in 2025. The opinion that Lukashenka should rule for another term beginning in 2025 is marginal – only ten per cent support this.
• Expectations are not so optimistic though: only 26 per cent believe he will leave office this year. One in three thinks he will leave in 2025; a further 19 per cent say that he will stay on for further terms in office.
• If Lukashenka doesn’t leave, people expect an increase in emigration and unemployment, the continuation of repression in all areas of life, falling exchange rates and the tightening of dependency on Russia.
• Opinion on abortions is still consolidated, with only 19 per cent thinking they should be banned in most or all cases. The same applies to Lukashenka’s infamous statement that society in Belarus is not ready to have a female president: only 20 per cent agree with the opinion.
• 52 per cent don’t think there is a problem of wage inequality between men and women in Belarus, while 37 per cent do see an issue.

Download a presentation of the survey’s main findings

Tesla Friday reached a $1 trillion market capitalization value for the first time since 2022 in a post-election stock rally.

Oct. 25, 2024 — Aggregation of proteins underlies many human disorders, including Alzheimer’s. Teams from the New Jersey Institute of Technology and Princeton University joined forces to study how the amyloid […]

The post PSC: Anton Simulations Reveal How Alzheimer’s Fibril Growth May Accelerate appeared first on HPCwire.