lg Rethinking youth bulge theory in policy and scholarship: incorporating critical gender analysis By feedproxy.google.com Published On :: Thu, 07 May 2020 09:26:03 +0000 7 May 2020 , Volume 96, Number 3 Lesley Pruitt Read online For decades ‘youth bulge’ theory has dominated understandings of youth in mainstream International Relations. Youth bulge theory has also become part of some public media analyses, mainstream political rhetoric, and even officially enshrined in the foreign policy of some states. Through the ‘youth bulge’ lens, youth—especially males—have been presented as current or future perpetrators of violence. However, this article argues that the youth bulge thesis postulated in mainstream IR is based on flawed theoretical assumptions. In particular, supporters of youth bulge theory fail to engage with existing research by feminist IR scholars and thus take on a biological essentialist approach. This has led to theoretical and practical misunderstandings of the roles youth play in relation to conflict, peace and security. These partial and biased understandings have also resulted in less effective policy-making. In critically reflecting on the ‘youth bulge’ thesis, this article argues that applying gender analysis is crucial to understanding the involvement of young people in general—and young men in particular—in conflict. Doing so will contribute to advancing more accurate analysis in scholarship and policy-making. Full Article
lg Undercurrents: Episode 4 – Illegal Hospital Detentions in Africa, and LGBTQ+ Rights in Lebanon By feedproxy.google.com Published On :: Thu, 22 Mar 2018 00:00:00 +0000 Full Article
lg 20 Years On: Removal of the Ban on LGBTIQ+ Personnel Serving in the UK Armed Forces By feedproxy.google.com Published On :: Wed, 29 Jan 2020 00:00:00 +0000 Full Article
lg Hepatic monoamine oxidase B is involved in endogenous geranylgeranoic acid synthesis in mammalian liver cells [Research Articles] By feedproxy.google.com Published On :: 2020-05-01T00:05:28-07:00 Geranylgeranoic acid (GGA) originally was identified in some animals and has been developed as an agent for preventing second primary hepatoma. We previously have also identified GGA as an acyclic diterpenoid in some medicinal herbs. Recently, we reported that in human hepatoma-derived HuH-7 cells, GGA is metabolically labeled from 13C-mevalonate. Several cell-free experiments have demonstrated that GGA is synthesized through geranylgeranial by oxygen-dependent oxidation of geranylgeraniol (GGOH), but the exact biochemical events giving rise to GGA in hepatoma cells remain unclear. Monoamine oxidase B (MOAB) has been suggested to be involved in GGOH oxidation. Here, using two human hepatoma cell lines, we investigated whether MAOB contributes to GGA biosynthesis. Using either HuH-7 cell lysates or recombinant human MAOB, we found that: 1) the MAO inhibitor tranylcypromine dose-dependently downregulates endogenous GGA levels in HuH-7 cells; and 2) siRNA-mediated MAOB silencing reduces intracellular GGA levels in HuH-7 and Hep3B cells. Unexpectedly, however, CRISPR/Cas9-generated MAOB-KO human hepatoma Hep3B cells had GGA levels similar to those in MAOB-WT cells. A sensitivity of GGA levels to siRNA-mediated MAOB downregulation was recovered when the MAOB-KO cells were transfected with a MAOB-expression plasmid, suggesting that MAOB is the enzyme primarily responsible for GGOH oxidation and that some other latent metabolic pathways may maintain endogenous GGA levels in the MAOB-KO hepatoma cells. Along with the previous findings, these results provide critical insights into the biological roles of human MAOB and provide evidence that hepatic MAOB is involved in endogenous GGA biosynthesis via GGOH oxidation. Full Article
lg Algae tasked with producing COVID-19 test kits By phys.org Published On :: Thu, 30 Apr 2020 00:00:00 GMT Researchers at Western and Suncor are teaming up to use algae as a way to produce serological test kits for COVID-19 - a new process that overcomes shortfalls of existing processes while saving money. Full Article
lg CBD News: Déclaration de M. Ahmed Djoghlaf, secrétaire exécutif de la Convention sur la diversité biologique, sur le thème de l'environnement, la paix et la sécurité mondiale, Alger, Algérie, Juillet, 2009. By www.cbd.int Published On :: Thu, 30 Jul 2009 00:00:00 GMT Full Article
lg CBD News: Statement by Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Fifth Intergovernmental Conference on Biodiversity in Europe, 22 September 2009, Liège, Belgium. By www.cbd.int Published On :: Tue, 22 Sep 2009 00:00:00 GMT Full Article
lg CBD News: Message from Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity to the Countdown 2010 Advisory Board Meeting, 13 October 2009, Brussels, Belgium. By www.cbd.int Published On :: Tue, 13 Oct 2009 00:00:00 GMT Full Article
lg CBD News: Statement by Mr Ahmed Djoghlaf,Executive Secretary of the Convention on Biological Diversity, on the occasion of the 39th International Federation of Agricultural Producers (IFAP) World Farmers' Congress,21 May 2010,Algiers, Algeria. By www.cbd.int Published On :: Fri, 21 May 2010 00:00:00 GMT Full Article
lg CBD News: Statement by Mr Ahmed Djoghlaf, the Executive Secretary of the Convention On Biological Diversity, on the occasion of the European Youth Perspective Conference on Biodiversity, 2 July 2010, Geel, Belgium. By www.cbd.int Published On :: Fri, 02 Jul 2010 00:00:00 GMT Full Article
lg CBD Communiqué: The President of Algeria donates to the Museum of Nature and Culture of the Convention on Biological Diversity By www.cbd.int Published On :: Mon, 06 Jun 2011 00:00:00 GMT Full Article
lg CBD News: Statement by Mr. Braulio F. de Souza Dias, CBD Executive Secretary, at the opening of the Regional Workshop for African Countries on the Clearing-House Mechanism and the Coordination Meeting of the Belgian Partnership on the Clearing-House Mecha By www.cbd.int Published On :: Tue, 06 May 2014 00:00:00 GMT Full Article
lg CBD News: Montreal, 12 September 2014 - The Secretary to the International Plant Protection Convention (IPPC) has become the seventh member of the Liaison Group of the Biodiversity-related Conventions (BLG), which includes the Convention on Biological Div By www.cbd.int Published On :: Fri, 12 Sep 2014 00:00:00 GMT Full Article
lg CBD News: A group of scientists and policymakers delivered a declaration to the Minister of the Environment of Peru, Manuel Pulgar Vidal, the president of UNFCCC Cop-20,that calls for integrated research on biodiversity and climate change and increased re By www.cbd.int Published On :: Fri, 05 Dec 2014 00:00:00 GMT Full Article
lg CBD News: Belgium and Bulgaria are the latest countries to ratify the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity (CBD), bringing th By www.cbd.int Published On :: Fri, 19 Aug 2016 00:00:00 GMT Full Article
lg CBD News: The CHM Awards winners were announced at the CHM Award Ceremony held on 9 December 2016 at the margins of COP 13. In the "Existing National CHM" category, Mexico won the Gold Award, Australia the Silver Award, and Belgium the Bronze Aw By www.cbd.int Published On :: Mon, 12 Dec 2016 00:00:00 GMT Full Article
lg CBD Notification SCBD/SSSF/AS/SBG/JA/JG/88518 (2019-107): Expert Workshop to Identify Options for Modifying the Description of Ecologically or Biologically Significant Marine Areas (EBSAs) and Describing New EBSAs, 3 to 5 February 2020 - Brussels, Belgium By www.cbd.int Published On :: Wed, 27 Nov 2019 00:00:00 GMT Full Article
lg Two algorithms to find primes in patterns By www.ams.org Published On :: Tue, 07 Apr 2020 14:09 EDT Jonathan P. Sorenson and Jonathan Webster Math. Comp. 89 (2020), 1953-1968. Abstract, references and article information Full Article
lg ????-theory in Algebra, Analysis and Topology By www.ams.org Published On :: Tue, 21 Apr 2020 07:58 EDT Guillermo Cortiñas and Charles A. Weibel, editors. American Mathematical Society, 2020, CONM, volume 749, approx. 398 pp. ISBN: 978-1-4704-5026-7 (print), 978-1-4704-5594-1 (online). This volume contains the proceedings of the ICM 2018 satellite school and workshop K-theory conference in Argentina. The school was held... Full Article
lg Linear and Multilinear Algebra and Function Spaces By www.ams.org Published On :: Mon, 04 May 2020 06:00 EDT A. Bourhim, J. Mashreghi, L. Oubbi and Z. Abdelali, editors. American Mathematical Society | Centre de Recherches Mathematiques, 2020, CONM, volume 750, approx. 224 pp. ISBN: 978-1-4704-4693-2 (print), 978-1-4704-5607-8 (online). This volume contains the proceedings of the International Conference on Algebra and Related Topics, held from July 2–5, 2018, at Mohammed V... Full Article
lg The Hecke algebra action and the Rezk logarithm on Morava E-theory of height 2 By www.ams.org Published On :: Wed, 08 Apr 2020 11:21 EDT Yifei Zhu Trans. Amer. Math. Soc. 373 (2020), 3733-3764. Abstract, references and article information Full Article
lg Bott vanishing for algebraic surfaces By www.ams.org Published On :: Wed, 08 Apr 2020 11:21 EDT Burt Totaro Trans. Amer. Math. Soc. 373 (2020), 3609-3626. Abstract, references and article information Full Article
lg On the computational complexity of algebraic numbers: the Hartmanis–Stearns problem revisited By www.ams.org Published On :: Wed, 08 Apr 2020 11:21 EDT Boris Adamczewski, Julien Cassaigne and Marion Le Gonidec Trans. Amer. Math. Soc. 373 (2020), 3085-3115. Abstract, references and article information Full Article
lg On 2-local nonlinear surjective isometries on normed spaces and C*-algebras By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Michiya Mori Proc. Amer. Math. Soc. 148 (2020), 2477-2485. Abstract, references and article information Full Article
lg The algebra of bounded-type holomorphic functions on the ball By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Daniel Carando, Santiago Muro and Daniela M. Vieira Proc. Amer. Math. Soc. 148 (2020), 2447-2457. Abstract, references and article information Full Article
lg Deleting or adding arrows of a bound quiver algebra and Hochschild (co)homology By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Claude Cibils, Marcelo Lanzilotta, Eduardo N. Marcos and Andrea Solotar Proc. Amer. Math. Soc. 148 (2020), 2421-2432. Abstract, references and article information Full Article
lg Unistructurality of cluster algebras from unpunctured surfaces By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Véronique Bazier-Matte and Pierre-Guy Plamondon Proc. Amer. Math. Soc. 148 (2020), 2397-2409. Abstract, references and article information Full Article
lg On relative Auslander algebras By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Javad Asadollahi and Rasool Hafezi Proc. Amer. Math. Soc. 148 (2020), 2379-2396. Abstract, references and article information Full Article
lg Indecomposable objects determined by their index in higher homological algebra By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Joseph Reid Proc. Amer. Math. Soc. 148 (2020), 2331-2343. Abstract, references and article information Full Article
lg Advances in Representation Theory of Algebras By www.ams.org Published On :: David J. Benson, University of Aberdeen, Henning Krause, University of Bielefeld, and Andrzej Skowronski, Nicolaus Copernicus University, Editors - A publication of the European Mathematical Society, 2013, 378 pp., Hardcover, ISBN-13: 978-3-03719-125-5, List: US$98, Institutional Member: US$78.40, All Individuals: US$78.40, EMSSCR/9 This volume presents a collection of articles devoted to representations of algebras and related topics. Dististinguished experts in this field... Full Article
lg Lecture Notes on Cluster Algebras By www.ams.org Published On :: Robert J. Marsh, University of Leeds - A publication of the European Mathematical Society, 2014, 122 pp., Softcover, ISBN-13: 978-3-03719-130-9, List: US$36, All AMS Members: US$28.80, EMSZLEC/19 Cluster algebras are combinatorially defined commutative algebras which were introduced by S. Fomin and A. Zelevinsky as a tool for studying the dual... Full Article
lg Classification and Identification of Lie Algebras By www.ams.org Published On :: Libor Snobl, Czech Technical University, and Pavel Winternitz, Centre de Recherches Mathematiques, and Universite de Montreal - AMS | CRM, 2014, 306 pp., Hardcover, ISBN-13: 978-0-8218-4355-0, List: US$124, All AMS Members: US$99.20, CRMM/33 The purpose of this book is to serve as a tool for researchers and practitioners who apply Lie algebras and Lie groups to solve problems arising in... Full Article
lg Koszul duality for Iwasawa algebras modulo ???? By www.ams.org Published On :: Tue, 24 Mar 2020 07:34 EDT Claus Sorensen Represent. Theory 24 (2020), 151-177. Abstract, references and article information Full Article
lg Hannah Fry to show strengths and weaknesses of algorithms By www.ams.org Published On :: Tue, 24 Dec 2019 00:00:00 EST "Driverless cars, robot butlers and reusable rockets--if the big inventions of the past decade and the artificial intelligence developed to create them have taught us anything, it's that maths is undeniably cool. And if you’re still not convinced, chances are you’ve never had it explained to you via a live experiment with a pigeon before. Temporary pigeon handler and queen of making numbers fun is Dr Hannah Fry, the host of this year's annual Royal Institution Christmas Lectures." Learn more in "Christmas Lectures presenter Dr Hannah Fry on pigeons, AI and the awesome power of maths," by Rachael Pells, inews, December 23, 2019. Full Article
lg Correction: Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders. [Additions and Corrections] By www.jbc.org Published On :: 2020-04-24T06:08:45-07:00 VOLUME 294 (2019) PAGES 2555–2568Due to publisher error, “150 l/mm” was changed to “150 liters/mm” in the second paragraph of the “Vibrational spectroscopy of samples” section under “Experimental Procedures.” The correct phrase should be “150 l/mm.” Full Article
lg About the cover: The Fine–Petrović Polygons and the Newton–Puiseux Method for Algebraic Ordinary Differential Equations By www.ams.org Published On :: Fri, 13 Mar 2020 16:19 EDT Vladimir Dragović and Irina Goryuchkina Bull. Amer. Math. Soc. 57 (2020), 293-299. Abstract, references and article information Full Article
lg Algae in the oceans often steal genes from bacteria By www.eurekalert.org Published On :: Wed, 29 Apr 2020 00:00:00 EDT (Rutgers University) Algae in the oceans often steal genes from bacteria to gain beneficial attributes, such as the ability to tolerate stressful environments or break down carbohydrates for food, according to a Rutgers co-authored study. Full Article
lg Shrinking snowcaps fuel harmful algal blooms in Arabian Sea By www.eurekalert.org Published On :: Mon, 04 May 2020 00:00:00 EDT (Earth Institute at Columbia University) A uniquely resilient organism all but unheard of in the Arabian Sea 20 years ago has been proliferating and spreading at an alarming pace. New research describes how the continued loss of snow over the Himalayan-Tibetan Plateau region is fueling the expansion of this destructive algal bloom. Full Article
lg Building LGBTIQ+ Inclusivity in the Armed Forces, 20 Years After the Ban Was Lifted By feedproxy.google.com Published On :: Thu, 16 Jan 2020 12:27:18 +0000 16 January 2020 Will Davies Army Chief of General Staff Research Fellow, International Security Programme @williamhldavies LinkedIn Change was slow to come but progress has since been swift. Not only can a continuing focus on inclusivity benefit service people and the organization, it is also an essential element of a values-based foreign policy. 2020-01-16-Westminster.jpg Crew members from HMS Westminster march through Admiralty Arch as they exercise their freedom of the city in August 2019 in London. Photo: Getty Images. The new UK government will conduct a review of foreign, security and defence policy in 2020. If the UK decides to use values as a framework for foreign policy this needs to be reflected in its armed forces. One area where this is essential is continuing to deepen inclusivity for LGBTIQ+ personnel, building on the progress made since the ban on their service was lifted in 2000.I witnessed the ban first-hand as a young officer in the British Army in 1998. As the duty officer I visited soldiers being held in the regimental detention cells to check all was well. One day a corporal, who I knew, was there awaiting discharge from the army having been convicted of being gay. On the one hand, here was service law in action, which was officially protecting the army’s operational effectiveness and an authority not to be questioned at my level. On the other, here was an excellent soldier in a state of turmoil and public humiliation. How extreme this seems now.On 12 January 2000 Tony Blair’s Labour government announced an immediate lifting of the ban for lesbian, gay and bisexual personnel (LGB) and introduced a new code of conduct for personal relationships. (LGB is the term used by the armed forces to describe those personnel who had been banned prior to 2000.) This followed a landmark ruling in a case taken to the European Court of Human Rights in 1999 by four LGB ex-service personnel – supported by Stonewall – who had been dismissed from service for their sexuality.Up to that point the Ministry of Defence's long-held position had been that LGB personnel had a negative impact on the morale and cohesion of a unit and damaged operational effectiveness. Service personnel were automatically dismissed if it was discovered they were LGB, even though homosexuality had been decriminalized in the UK by 1967.Proof that the armed forces had been lagging behind the rest of society was confirmed by the positive response to the change among service personnel, despite a handful of vocal political and military leaders who foresaw negative impacts. The noteworthy service of LGBTIQ+ people in Iraq and Afghanistan only served to debunk any residual myths.Twenty years on, considerable progress has been made and my memories from 1998 now seem alien. This is a story to celebrate – however in the quest for greater inclusivity there is always room for improvement.Defence Minister Johnny Mercer last week apologized following recent calls from campaign group Liberty for a fuller apology. In December 2019, the Ministry of Defence announced it was putting in place a scheme to return medals stripped from veterans upon their discharge.The armed forces today have a range of inclusivity measures to improve workplace culture including assessments of workplace climate and diversity networks supported by champions drawn from senior leadership.But assessing the actual lived experience for LGBTIQ+ people is challenging due to its subjectivity. This has not been helped by low participation in the 2015 initiative to encourage people to declare confidentially their sexual orientation, designed to facilitate more focused and relevant policies. As of 1 October 2019, only 20.3 per cent of regular service people had declared a sexual orientation.A measure of positive progress is the annual Stonewall Workplace Equality Index, the definitive benchmarking tool for employers to measure their progress on LGBTIQ+ inclusion in the workplace; 2015 marked the first year in which all three services were placed in the top 100 employers in the UK and in 2019 the Royal Navy, British Army and Royal Air Force were placed 15th=, 51st= and 68th respectively.Nevertheless, LGBTIQ+ service people and those in other protected groups still face challenges. The 2019 Ministry of Defence review of inappropriate behaviour in the armed forces, the Wigston Report, concluded there is an unacceptable level of sexual harassment, bullying and discrimination. It found that 26-36% of LGBTIQ+ service people have experienced negative comments or conduct at work because of their sexual orientation.The Secretary of State for Defence accepted the report’s 36 recommendations on culture, incident reporting, training and a more effective complaints system. Pivotal to successful implementation will be a coherent strategy driven by fully engaged leaders.Society is also expecting ever higher standards, particularly in public bodies. The armed forces emphasise their values and standards, including ‘respect for others’, as defining organisational characteristics; individuals are expected to live by them. Only in a genuinely inclusive environment can an individual thrive and operate confidently within a team.The armed forces also recognize as a priority the need to connect to and reflect society more closely in order to attract and retain talent from across all of society. The armed forces’ active participation in UK Pride is helping to break down barriers in this area.In a post-Brexit world, the UK’s values, support for human rights and reputation for fairness are distinctive strengths that can have an impact on the world stage and offer a framework for future policy. The armed forces must continue to push and promote greater inclusivity in support. When operating overseas with less liberal regimes, this will be sensitive and require careful handling; however it will be an overt manifestation of a broader policy and a way to communicate strong and consistent values over time.The armed forces were damagingly behind the times 20 years ago. But good progress has been made since. Inclusion initiatives must continue to be pushed to bring benefits to the individual and the organization as well as demonstrate a values-based foreign policy. Full Article
lg Clinical evaluation of a data-driven respiratory gating algorithm for whole-body positron emission tomography with continuous bed motion By jnm.snmjournals.org Published On :: 2020-02-14T14:01:21-08:00 Respiratory gating is the standard to overcome respiration effects degrading image quality in positron emission tomography (PET). Data-driven gating (DDG) using signals derived from PET raw data are promising alternatives to gating approaches requiring additional hardware. However, continuous bed motion (CBM) scans require dedicated DDG approaches for axially-extended PET, compared to DDG for conventional step-and-shoot scans. In this study, a CBM-capable DDG algorithm was investigated in a clinical cohort, comparing it to hardware-based gating using gated and fully motion-corrected reconstructions. Methods: 56 patients with suspected malignancies in thorax or abdomen underwent whole-body 18F-FDG CBM-PET/CT imaging using DDG and hardware-based respiratory gating (pressure-sensitive belt gating, BG). Correlation analyses were performed on both gating signals. Besides static reconstructions, BG and DDG were used for optimally-gated PET (BG-OG, DDG-OG) and fully motion-corrected PET (elastic motion correction; BG-EMOCO, DDG-EMOCO). Metabolic volumes, SUVmax and SUVmean of lesions were compared amongst the reconstructions. Additionally, the quality of lesion delineation in different PET reconstructions was independently evaluated by three experts. Results: Global correlation coefficients between BG and DDG signals amounted to 0.48±0.11, peaking at 0.89±0.07 when scanning the kidney and liver region. In total, 196 lesions were analyzed. SUV measurements were significantly higher in BG-OG, DDG-OG, BG-EMOCO and DDG-EMOCO compared to static images (P<0.001; median SUVmax: static, 14.3±13.4; BG-EMOCO, 19.8±15.7; DDG-EMOCO, 20.5±15.6; BG-OG, 19.6±17.1; DDG-OG, 18.9±16.6). No significant differences between BG-OG and DDG-OG, and BG-EMOCO and DDG-EMOCO, respectively, were found. Visual lesion delineation was significantly better in BG-EMOCO and DDG-EMOCO than in static reconstructions (P<0.001); no significant difference was found comparing BG and DDG (EMOCO, OG, respectively). Conclusion: DDG-based motion-compensation of CBM-PET acquisitions outperforms static reconstructions, delivering qualities comparable to hardware-based approaches. The new algorithm may be a valuable alternative for CBM-PET systems. Full Article
lg Correction: Graph Algorithms for Condensing and Consolidating Gene Set Analysis Results. [Additions and Corrections] By feedproxy.google.com Published On :: 2020-02-01T00:05:30-08:00 Full Article
lg Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice By feedproxy.google.com Published On :: 2020-04-29 Gernot F. GrabnerApr 29, 2020; 0:jlr.RA119000516v1-jlr.RA119000516Research Articles Full Article
lg Episode 52 - The Internet of Nostalgia (IoN) Nokia 3310, drone taxis and Apple on the telly By play.acast.com Published On :: Fri, 17 Feb 2017 13:58:54 GMT Matt Egan takes us where no other pod has dared gone before (September 2000) and asks Digital Arts Editor Neil Bennett if anyone cares that Nokia is rereleasing the famous 3310. Is it cool to rock one now? Then Techworld Audience Development Editor Christina Mercer lets us know that the future is already here with self driving drone taxis. Would you hitch a lift round Dubai on a massive quadcopter? Finally Deputy Editor at Macworld David Price ruminates on Apple's forecast foray into the world of snackable media content - will it challenge Netflix or try to buy it? See acast.com/privacy for privacy and opt-out information. Full Article podcast technology tech pod nokia nokia 3310 drones automotive Apple
lg Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice [Research Articles] By feedproxy.google.com Published On :: 2020-04-29T07:33:43-07:00 Bis(monoacylglycero)phosphate (BMP), also known as lysobisphosphatidic acid (LBPA), is a phospholipid that promotes lipid sorting in late endosomes/lysosomes by activating lipid hydrolases and lipid transfer proteins. Changes in the cellular BMP content therefore reflect an altered metabolic activity of the endo-lysosomal system. Surprisingly, little is known about the physiological regulation of BMP. In this study, we investigated the effects of nutritional and metabolic factors on BMP profiles of whole tissues and parenchymal and non-parenchymal cells. Tissue samples were obtained from fed, fasted, two-hours refed, and insulin-treated mice, as well as from mice housed at 5°C, 22°C, or 30°C. These tissues exhibited distinct BMP profiles, which were regulated by the nutritional state in a tissue-specific manner. Insulin treatment was not sufficient to mimic refeeding-induced changes in tissue BMP levels indicating that BMP metabolism is regulated by other hormonal or nutritional factors. Tissue fractionation experiments revealed that fasting drastically elevates BMP levels in hepatocytes and pancreatic cells. Furthermore, we observed that the BMP content in brown adipose tissue strongly depends on housing temperatures. In conclusion, our observations suggest that BMP concentrations adapt to the metabolic state in a tissue-and cell type-specific manner in mice. Drastic changes observed in hepatocytes, pancreatic cells, and brown adipocytes suggest that BMP possesses a role in the functional adaption to nutrient starvation and ambient temperature. Full Article
lg Algeria’s Perfect Storm: COVID-19 and Its Fallout By feedproxy.google.com Published On :: Wed, 06 May 2020 19:19:54 +0000 6 May 2020 Adel Hamaizia Associate Fellow, Middle East and North Africa Programme Yahia H. Zoubir Senior Professor of International Studies, KEDGE Business School; Visiting Fellow, Brookings Doha Center Coronavirus is a godsend for Algeria’s government to introduce restrictive measures beyond those needed to contain COVID-19. But its new leaders are missing a chance to gain legitimacy, which will offset the socio-economic fallout of the drop in oil prices. 2020-05-06-Algeria-Health-Covid Algerian volunteers prepare personal protection equipment (PPE) to help combat the coronavirus epidemic in the capital Algiers. Photo by RYAD KRAMDI/AFP via Getty Images. Although protests successfully ended Abdelaziz Bouteflika’s 20-year sultanistic rule a little over one year ago, demands have been continuing to dismantle the system, get rid of the old personnel, and institute democracy.The controversial election in December of Abdelmadjid Tebboune — who has inherited a disastrous situation — has not tempered the determination of the Hirak protest movement. As a former minister and prime minister under Bouteflika, the new president has won little legitimacy, and protests have continued.Now COVID-19 is worsening already dire economic conditions, such as a sharp drop in oil prices. By the beginning of May, statistics showed 10% of confirmed cases have ended in fatality, the highest percentage in the region.Maintaining an authoritarian styleHirak had already called for the suspension of the marches — mobilising online instead — before the government’s measures, which include curfews and lockdowns, demonstrating a high sense of duty. But instead of appeasing Hirak’s demands, the government has maintained the authoritarian style of its predecessors.Tebboune released more than 5,000 prisoners on March 31 but kept prisoners of conscience and leaders of the hirak imprisoned, then subsequently imprisoned journalists and activists. It even passed a controversial penal law, that also covers fake news, and may be used to justify actions against journalists.The regime wishes to see an end to the Hirak, and rejects accusations of totalitarianism by insisting freedom and a democratic climate exist in Algeria.Tebboune’s actions contradict his praise for the ‘blessed’ hirak and his promises of instituting the rule of law. In proclaiming the measures, the government has shown disappointing leadership, acting in an authoritarian fashion.Tebboune also declared proudly that Algeria was fully prepared to fight the coronavirus epidemic, an optimistic claim given the country has only 400 intensive care unit (ICU) beds, or one per 100,000 people. Despite hundreds of billions of hydrocarbon dollars accumulating during the Bouteflika-era, Algeria’s health system ranks 173 out of 195 countries.Algerians often refer to hospitals as ‘mouroirs’, meaning ‘places for the dying’. Not only has the state failed to build modern hospitals but basic hygienic conditions are lacking, and government officials prefer being treated overseas. A 2014 project to build five university hospitals was abandoned, leaving the health sector in deplorable shape.Before Chinese assistance arrived, the glaring lack of equipment to protect caregivers and care for the sick was evident. Prime Minister Abdelaziz Djerad admitted the health system required a ‘total overhaul’. The president recently stated Algeria’s doctors are among the 'best in the world' but didn't address why almost 15,000 Algerian doctors practice in France.Strict containment measures are in sync with most countries but implementation is challenging when most people live in overcrowded urban dwellings (the average household consists of 5.9 members).Water shortages in many areas makes good hygiene and decontamination impossible, while schools and universities find online teaching difficult when many students do not possess laptops or internet connections. And only 20% of Algerians have debit cards in a cash-dominated economy because of low trust in the public-dominated banking sector, making online shopping capability low.An already declining macroeconomic situation is worsening due to COVID-19. The IMF revised its 2020 estimates for Algeria, forecasting a catastrophic contraction of -5.2% in a country where hydrocarbons account for 93% of export revenues and 60% of its budget.Foreign currency reserves are now an estimated $55 billion (expected to fall to $44billion by the end of 2020), down from $200 billion in 2014, and Algerian crude has recently traded close to production costs, with the fiscal breakeven oil price at $157.In line with its historic aversion to external borrowing, Tebboune recently ruled out seeking financial support from the ‘IMF or other foreign banks’, as he argued such borrowing undermines sovereign foreign policy because - when indebted - ‘we cannot talk about either Palestine or Western Sahara’, two causes dear to Algeria. ‘Friendly countries’ - most likely a reference to China - are said to have offered to grant loans which have been declined for now.The government is forecasted to face a 20% budget shortfall this year, but Algeria’s fiscal response to COVID-19 is actually the largest among the regional hydrocarbon exporters at an estimated 8% of GDP, compared to an average of 3.2%. However, the government revised downwards its 2020 public spending by 50% (a second cut in a month, from an initial 30% reduction), halting state projects and slashing its $41 billion import bill by 25% while expanding agricultural production. National oil company SONATRACH will also cut planned investment by half to $7 billion but plans have been revealed to develop other natural resources including gold, uranium and phosphates.But recent growth rates are insufficient to create jobs for those entering the labour market. Despite government attempts to support a rather anaemic ‘formal’ private sector, estimates are 700,000 jobs could be lost due to potential bankruptcies from reduced activity and a loss of markets abroad.Facing potential social unrest and the quasi-preservation of a tired social contract, the government has committed to upholding public sector wages - including for 50% of the civil servants told to stay home - protecting sacrosanct, unsustainable subsidies, and increasing health expenditure to strengthen the capacity to combat COVID-19.A supplementary finance law will include various measures that support businesses and the economic fallout. However, while the government is to be commended for its efforts to aid businesses, supporting large swathes of the population is challenging as approximately 50% of the workforce operate in the informal economy.Weak administrative capacity and insufficient data to implement cash transfers makes the planned ‘solidarity allowance’ of 10,000 dinars ($80) for Ramadan difficult to allocate to those who most need it (especially those in the informal sector). Families, communities, and religious organisations continue to be a social safety net.So COVID-19 has not created new problems, it has merely magnified and exacerbated the numerous inequalities and failures of the Bouteflika regime to sufficiently invest in human security (economic, food, health environmental, personal, community, and political). Typically, whenever oil prices and related earnings dwindle, the political system promises to reform and diversify the economy. Tebboune is repeating this same old tune.There are positive elements, such as the government’s realization it must initiate genuine reforms. And local enterprises have been successfully producing artificial respirators, surgical masks, and other materials. Algerians, including the Hirak, are showing great social solidarity.But the government must capitalize on these positive actions by introducing real change. Because, if not, Hirak will certainly be back in force once the crisis is over, and operating in an environment of worsening socioeconomic problems. The medicine of the past will not work. Full Article
lg Algeria: Tired of Waiting By feedproxy.google.com Published On :: Mon, 06 Apr 2020 11:36:32 +0000 1 January 2008 , Number 10 At the beginning of December, media reports put the violence which had plagued Algeria since the 1990s at an all time low. Only six people had been killed in November and four of those were armed Islamist militants. Then on December 11, two car bombs exploded in the capital Algiers, killing some 67 people, including at least eleven United Nations officials in the largely destroyed offices of the UN’s High Commission for Refugees. What lies beneath this return to high-level, targeted attacks? Claire Spencer Head, Middle East Programme, Chatham House algeria 2008.jpg Algerian policemen and bomb experts in front of the destroyed building of the Supreme Court, Algiers. One explosion targeted the offices of the UN refugee agency in Algiers, while the other bomb was triggered near the Algerian Supreme Court building. Full Article
lg Rethinking youth bulge theory in policy and scholarship: incorporating critical gender analysis By feedproxy.google.com Published On :: Thu, 07 May 2020 09:26:03 +0000 7 May 2020 , Volume 96, Number 3 Lesley Pruitt Read online For decades ‘youth bulge’ theory has dominated understandings of youth in mainstream International Relations. Youth bulge theory has also become part of some public media analyses, mainstream political rhetoric, and even officially enshrined in the foreign policy of some states. Through the ‘youth bulge’ lens, youth—especially males—have been presented as current or future perpetrators of violence. However, this article argues that the youth bulge thesis postulated in mainstream IR is based on flawed theoretical assumptions. In particular, supporters of youth bulge theory fail to engage with existing research by feminist IR scholars and thus take on a biological essentialist approach. This has led to theoretical and practical misunderstandings of the roles youth play in relation to conflict, peace and security. These partial and biased understandings have also resulted in less effective policy-making. In critically reflecting on the ‘youth bulge’ thesis, this article argues that applying gender analysis is crucial to understanding the involvement of young people in general—and young men in particular—in conflict. Doing so will contribute to advancing more accurate analysis in scholarship and policy-making. Full Article
lg Russia's Imperial Nostalgia: Implications for the West By feedproxy.google.com Published On :: Thu, 16 Jan 2020 14:50:01 +0000 Invitation Only Research Event 31 January 2020 - 11:00am to 12:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Sergei Medvedev, Professor, Faculty of Social Sciences, Higher School of Economics (Moscow) Vladimir Putin’s goal of restoring Russia’s status as a great power has led to an aggressive foreign policy and confrontation with its immediate neighbours as well as Western countries.Sergei Medvedev, author of The Return of the Russian Leviathan, will discuss the forces shaping Russian politics and society today as well as how a nostalgia for empire – still widespread in contemporary Russia - has shaped Moscow’s foreign policy.Attendance at this event is by invitation only. Event attributes Chatham House Rule Department/project Russia and Eurasia Programme, Russian Foreign Policy, The Drivers of Russian Foreign Policy Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
lg Erratum: Unequivocal evidence for endogenous geranylgeranoic acid biosynthesized from mevalonate in mammalian cells [Errata] By feedproxy.google.com Published On :: 2020-04-01T00:05:29-07:00 Full Article
lg Hepatic monoamine oxidase B is involved in endogenous geranylgeranoic acid synthesis in mammalian liver cells [Research Articles] By feedproxy.google.com Published On :: 2020-05-01T00:05:28-07:00 Geranylgeranoic acid (GGA) originally was identified in some animals and has been developed as an agent for preventing second primary hepatoma. We previously have also identified GGA as an acyclic diterpenoid in some medicinal herbs. Recently, we reported that in human hepatoma-derived HuH-7 cells, GGA is metabolically labeled from 13C-mevalonate. Several cell-free experiments have demonstrated that GGA is synthesized through geranylgeranial by oxygen-dependent oxidation of geranylgeraniol (GGOH), but the exact biochemical events giving rise to GGA in hepatoma cells remain unclear. Monoamine oxidase B (MOAB) has been suggested to be involved in GGOH oxidation. Here, using two human hepatoma cell lines, we investigated whether MAOB contributes to GGA biosynthesis. Using either HuH-7 cell lysates or recombinant human MAOB, we found that: 1) the MAO inhibitor tranylcypromine dose-dependently downregulates endogenous GGA levels in HuH-7 cells; and 2) siRNA-mediated MAOB silencing reduces intracellular GGA levels in HuH-7 and Hep3B cells. Unexpectedly, however, CRISPR/Cas9-generated MAOB-KO human hepatoma Hep3B cells had GGA levels similar to those in MAOB-WT cells. A sensitivity of GGA levels to siRNA-mediated MAOB downregulation was recovered when the MAOB-KO cells were transfected with a MAOB-expression plasmid, suggesting that MAOB is the enzyme primarily responsible for GGOH oxidation and that some other latent metabolic pathways may maintain endogenous GGA levels in the MAOB-KO hepatoma cells. Along with the previous findings, these results provide critical insights into the biological roles of human MAOB and provide evidence that hepatic MAOB is involved in endogenous GGA biosynthesis via GGOH oxidation. Full Article