In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development.

Massive distribution efforts by OM teams in Bangladesh over more than 10 years sowed gospel seeds and made the Bengali New Testament a #1 best seller.

This phase IIb randomized controlled trial demonstrates greater efficacy of phenobarbital than levetiracetam in the treatment of neonatal seizures; more adverse events occurred with phenobarbital.

With sports at a complete standstill, David Warner has found a new way of keeping his fans entertained during the coronavirus lockdown.

Tamil Nadu has announced major relaxations in coronavirus lockdown guidelines starting Monday, including re-opening of standalone and neighbourhood shops and private companies.

Bruno Pietzsch, Sebastian Fiedler, Kai G. Mertens, Markus Richter, Cédric Scherer, Kirana Widyastuti, Marie-Christin Wimmler, Liubov Zakharova and Uta Berger: The recent advancement of agent-based modeling is characterized by higher demands on the parameterization, evaluation and documentation of these computationally expensive models. Accordingly, there is also a growing request for "easy to go" applications just mimicking the input-output behavior of such models. Metamodels are being increasingly used for these tasks. In this paper, we provide an overview of common metamodel types and the purposes of their usage in an agent-based modeling context. To guide modelers in the selection and application of metamodels for their own needs, we further assessed their implementation effort and performance. We performed a literature research in January 2019 using four different databases. Five different terms paraphrasing metamodels (approximation, emulator, meta-model, metamodel and surrogate) were used to capture the whole range of relevant literature in all disciplines. All metamodel applications found were then categorized into specific metamodel types and rated by different junior and senior researches from varying disciplines (including forest sciences, landscape ecology, or economics) regarding the implementation effort and performance. Specifically, we captured the metamodel performance according to (i) the consideration of uncertainties, (ii) the suitability assessment provided by the authors for the particular purpose, and (iii) the number of valuation criteria provided for suitability assessment. We selected 40 distinct metamodel applications from studies published in peer-reviewed journals from 2005 to 2019. These were used for the sensitivity analysis, calibration and upscaling of agent-based models, as well to mimic their prediction for different scenarios. This review provides information about the most applicable metamodel types for each purpose and forms a first guidance for the implementation and validation of metamodels for agent-based models.

NEW CASTLE (May 28, 2018) – Department of Health and Social Services (DHSS) Secretary Dr. Kara Odom Walker is warning people in active substance use in Delaware that two people have died from suspected overdoses in a 24-hour period that involve heroin packets with the same stamp. DHSS is not identifying the stamp so people […]

NEW CASTLE (March 13, 2019) – Health and public safety officials are urging people in active use of heroin or other opioids and their families to seek immediate treatment and acquire the overdose-reversing medication naloxone on hand in the wake of three suspected heroin overdose deaths in five days in Sussex County involving the same […]

The stricter lockdown measures in select cities are in the wake of increasing number of Covid-19 cases in the state, especially in the urban areas.

Eight contractual workers were injured in Tamil Nadu's Cuddalore district on Thursday in a boiler explosion in a central government-owned Lignite mining and power-generation company's plant.

The Madras high court has ordered the Tamil Nadu government to close all liquor shops in the state, saying the social distancing protocol implemented to stem coronavirus growth are being violated. It...

The Tamil Nadu government has constituted a high-level committee, headed by Dr C Rangarajan, former RBI Governor, to assess the overall immediate and medium-term impact of coronavirus on the state's...

The Indian government in March put a hold on exports of several drugs including paracetamol to secure supplies for its people after the coronavirus outbreak disrupted the industry's supply chain globally. COVID-19 is the respiratory disease caused by the novel coronavirus.

No patient was discharged on Thursday and the number of cured people stood at 109, leaving 93 active cases in the district, the officials said.

Gautam Buddh Nagar recorded 202 positive cases of coronavirus till Thursday evening, and official figures for Friday were awaited.

Injury-plagued former champ Dominick Cruz makes his return from another extended absence from the cage to challenge Henry Cejudo for bantamweight gold at UFC 249, knowing that a win will mark him out as the best of all time.
Read Full Article at RT.com

The unprecedented situation created by Covid–19 pandemic and lockdown announced by both the Union and state governments from March 24 has led to severe disruptions affecting the economy and impacting people at large and the MSME spinning mills.

Tamil Nadu chief minister Edappadi K Palaniswami on Monday requested Prime Minister Narendra Modi for ad-hoc grant of Rs 1,000 crore from National Disaster Relief Fund (NDRF).

The Tamil Nadu government has decided to hike prices of liquor by up to Rs 20, as it is readying itself to open liquor outlets on Thursday.

The Tamil Nadu government has sought a special assistance of Rs 4,000 crore and a slew of other financial support from the Centre to help the state fight the Covid-19 pandemic.

Manufacturers have been told to commence production before July 31, 2020.

The 38-year-old Gambhir picked KL Rahul, who has been keeping in ODIs, as an "apt replacement" for Dhoni.

Talking further about Kohli and Rohit, the 2011 World Cup winner said, "It is very difficult to compare both of them. Virat Kohli is unbelievable. His stats prove that. "But when your reputation is such that when you get out after a hundred, people say he has missed out on double hundred, that speaks volumes about you."

Tamil Nadu has so far reported only one COVID-19 case and the 45-year old man unuder treatment in Chennai has recovered and two subsequent tests returned negative.

Lockdown in India has brought some positive environmental news from clean rivers to clean air at many places. Pollution has declined drastically and as a result, people are able to see distant things.

According to the study published in the Indian Journal of Medical Research, there is no evidence or research to claim that these bat coronaviruses can cause disease in humans.

These kits will help the state in quick screening of suspected Covid-19 patients. The chief minister said RTKs will be sent to all districts the very next day.

The fashion e-commerce portal’s cross-platform game creates awareness about the disease while keeping people engaged amidst the lockdown

The Tamil Nadu government on Saturday moved the Supreme Court challenging a Madras High Court order for closure of state-run liquor outlets on grounds of violations of COVID-19 guidelines, arguing that it would lead to "grave losses" in revenue and complete halt in commercial activities.

Rajendra Pal Gautam, the minister of social welfare in the incumbent Delhi government, will on Sunday take oath as a minister in the new Arvind Kejriwal government.

Curious about what’s going on behind the scenes with verification? Bernard Murphy, Jim Hogan, and our own Paul Cunningham are on the case with the “Innovation in Verification” blog stream over at semiwiki.com. Every month, this trio reviews a newly-published paper in academia that pertains to verification and discusses its implications. Be sure to stop by—it’s a great place to see what might be coming down the pipeline someday.

This month, they discuss the implications of metamorphic testing. The purpose of metamorphic testing is to define a verification approach where is there is no “golden reference.” This situation comes up a lot now as designs grow in complexity, and it begs the question: “how does one know the design is verified if there is no standard to compare to?”. Metamorphic testing addresses the problem of not having a “gold standard” to compare to by comparing the results of related tests instead. The paper reviewed by this team used metamorphic testing to study methods of managing JavaScript tags.

Paul saw this as a valuable new class of coverage. Metamorphic testing represents a way to create better distribution analyses through understanding the relationships among tests. This can reveal critical-but-complex issues that traditional verification methods may overlook. He saw this as an emerging class of coverage that new verification tools could be built around. Paul asserted that a future metamorphic-testing-based tool’s main contribution to the field of verification would be to better analyze noisy performance results where the noise is multi-modal. It could be useful in detecting race conditions and similar hard-to-debug anomalies. Paul also sees metamorphic testing as ripe for ML techniques. Overall—Paul sees a bright future for metamorphic testing in verification.

Jim is reminded of Solido and Spice—these metamorphic testing capabilities are “more than just a feature”—they might be a product. Maybe even a whole new class of verification tools, as Paul said.

Bernard says that this topic is “too rich to address in one blog”, so be sure to head over to the post to see more of what the future has in store for verification.

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macOS and iOS suffers from an out-of-bounds timestamp write in IOAccelCommandQueue2::processSegmentKernelCommand().

Trend Micro Maximum Security is vulnerable to arbitrary code execution as it allows for creation of registry key to target a process running as SYSTEM. This can allow a malware to gain elevated privileges to take over and shutdown services that require SYSTEM privileges like Trend Micros "Asmp" service "coreServiceShell.exe" which does not allow Administrators to tamper with them. This could allow an attacker or malware to gain elevated privileges and tamper with protected services by disabling or otherwise preventing them to start. Note administrator privileges are required to exploit this vulnerability.

Building solar and wind energy projects on potentially contaminated lands can be a golden opportunity, both effective and cost-effective, for developers. The 120-acre Reilly Tar & Chemical Corporation Superfund site was recently redeveloped with a utility-scale solar farm and is a prime example of the reuse potential inherent in thousands of Superfund sites, brownfields, retired power plants, and landfills.

The government of Argentinian province San Juan signed an agreement with PowerChina earlier this week for financing of the 75-MW El Tambolar hydropower project.

Building solar and wind energy projects on potentially contaminated lands can be a golden opportunity, both effective and cost-effective, for developers. The 120-acre Reilly Tar & Chemical Corporation Superfund site was recently redeveloped with a utility-scale solar farm and is a prime example of the reuse potential inherent in thousands of Superfund sites, brownfields, retired power plants, and landfills.

Latin America’s abundant and varied mineral resources attract a large portion of the global mining investment.

As originally published in React News Beijing is determined all outgoing investment will align with China’s strategic goals Stockholm - home of ABBA and fermented herring. A fish so pongy, the Swedes o...

In its concern to block tax avoidance, HMRC is planning to make Stamp Duty Land Tax (SDLT) ever more complicated, as two recent consultations show. Residential properties held by companies The first consultation proposes the imposition of SDLT on ...

The UK HMRC Stamp Office has released details of how it will temporarily change its procedures to allow for the submission and payment of stamp duty in respect of transfers of shares in UK companies. The standard requirements of HMRC in order to st...

The former member representing Warri Federal Constituency at the Federal House of Representatives Hon.Daniel Reyenieju has condoled with the Sokoto State Governor Aminu Tambuwal over the death of his father Sheikh Haruna .

The post Reyenieju condole with Tambuwal over Father’s death appeared first on Vanguard News.

Sheikh Haruna Tambuwal, father of Sokoto State Governor, Aminu Tambuwal is dead. He died on Friday at the age of 96 after a brief illness at his residence in Tambuwal Council of Sokoto. The 96-year-old is survived by children, including the governor, as well as grandchildren and great grandchildren. Being a devout Muslim, he has […]

Sheikh Tambuwal is dead, Atiku, Peter Obi react

Sokoto Governor, Aminu Tambuwal has hailed President Muhammadu Buhari for commitment to tackling the COVID-19 pandemic. Tambuwal spoke on Friday at the inauguration of the State COVID-19 Volunteers. He noted that coronavirus was being properly addressed by Buhari and the Presidential Task Force on COVID-19. “I personally want to appreciate the president and the Task […]

Tambuwal sends message to Buhari

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.